b4061e4b0d88fa62e10d23e8018f43bb  pmc_25247303.pdf
13bd996284c6fe95fd70d3cf64a49fb24ae6eef1  pmc_25247303.pdf
bdcd79395d9b3986d59d01d756ad6420c85467b4ce0ec6f563cda4b8a4d5fc24  pmc_25247303.pdf

Title:          pone.0108004 1..15
Creator:        3B2 Total Publishing System 7.51n/W
Producer:       Acrobat Distiller 9.0.0 (Windows); modified using iText 5.0.3 (c) 1T3XT BVBA
CreationDate:   Thu Sep  4 15:39:32 2014 CEST
ModDate:        Wed Sep 17 09:08:58 2014 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      612.283 x 790.866 pts
Page rot:       0
File size:      1756953 bytes
Optimized:      no
PDF version:    1.5

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HALPIP+AdvP40319B                    Type 1C           WinAnsi          yes yes no      65  0
HALPJP+AdvP41461E                    Type 1C           MacRoman         yes yes no      31  0
HALPKA+AdvP403A40                    Type 1C           Custom           yes yes no      13  0
HALPLH+AdvP3EAA99                    Type 1C           WinAnsi          yes yes no      12  0
HALPKB+AdvP4041BD                    Type 1C           WinAnsi          yes yes no      47  0
HALPMI+AdvT377                       Type 1C           Custom           yes yes no      40  0
HALPLC+AdvP497E3                     Type 1C           WinAnsi          yes yes no      14  0
HALPLD+AdvP497E2                     Type 1C           WinAnsi          yes yes no      15  0
HALPLG+AdvP40798                     Type 1C           Custom           yes yes yes     18  0
HALPLF+AdvPi1                        Type 1C           WinAnsi          yes yes no      20  0
HALPMJ+AdvP49811                     Type 1C           Custom           yes yes no      19  0
HALPLE+AdvP43B38B                    Type 1C           WinAnsi          yes yes no      33  0
HAMAIG+AdvP4068C                     Type 1C           WinAnsi          yes yes no      16  0
HAMAIH+AdvP4980C                     Type 1C           Custom           yes yes yes     17  0
HAMAIF+AdvP497E4                     Type 1C           WinAnsi          yes yes no      21  0
HAMAJK+AdvP4C4E51                    Type 1C           Custom           yes yes yes     22  0
HAMAKK+AdvPi2                        Type 1C           WinAnsi          yes yes no      23  0
HAMAII+AdvPECF830                    Type 1C           WinAnsi          yes yes no      24  0
HAMAJJ+AdvP4C4E74                    Type 1C           Custom           yes yes yes     25  0
HAMANK+AdvP4980F                     Type 1C           WinAnsi          yes yes no      32  0
HAMAPK+AdvP4C4E59                    Type 1C           Custom           yes yes yes     41  0
HAMBAL+AdvP4C4E46                    Type 1C           Custom           yes yes yes     42  0
HBFNNJ+AdvP42B8DE                    Type 1C           WinAnsi          yes yes no      60  0
HBJFGE+AdvP497E5                     Type 1C           WinAnsi          yes yes no      70  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-11-11 06:12:59 CET
 RepresentationInformation: pmc_25247303.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2018-01-29 05:44:48 CET
  Size: 1756953
  Format: PDF
  Version: 1.5
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: ISO PDF/A-1, Level B
  PDFMetadata: 
   Objects: 463
   FreeObjects: 3
   IncrementalUpdates: 3
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
   Info: 
    Title: pone.0108004 1..15
    Creator: 3B2 Total Publishing System 7.51n/W
    Producer: Acrobat Distiller 9.0.0 (Windows); modified using iText 5.0.3 (c) 1T3XT BVBA
    CreationDate: Thu Sep 04 15:39:32 CEST 2014
    ModDate: Wed Sep 17 09:38:58 CEST 2014
   ID: 0x667f4afb730a6a0dd4d4d66770a300a0, 0x21eed1d5f9b57740b94ec163df458531
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
    FilterPipeline: CCITTFaxDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 104
      ImageHeight: 103
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/tiff
      CompressionScheme: CCITT Group 4
      ImageWidth: 48
      ImageHeight: 52
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     ImageMask: true
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1763
      ImageHeight: 1060
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 27
      ImageHeight: 26
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2055
      ImageHeight: 1621
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/tiff
      CompressionScheme: CCITT Group 4
      ImageWidth: 48
      ImageHeight: 52
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     ImageMask: true
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2054
      ImageHeight: 1630
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2054
      ImageHeight: 1656
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 990
      ImageHeight: 759
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 27
      ImageHeight: 26
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2054
      ImageHeight: 1639
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2055
      ImageHeight: 1505
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 27
      ImageHeight: 26
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2054
      ImageHeight: 1629
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 27
      ImageHeight: 26
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 990
      ImageHeight: 759
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 990
      ImageHeight: 761
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 990
      ImageHeight: 792
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 990
      ImageHeight: 779
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HAMANK+AdvP4980F
      FontSubset: true
      FirstChar: 40
      LastChar: 168
      FontDescriptor: 
       FontName: HAMANK+AdvP4980F
       Flags: Serif, Nonsymbolic
       FontBBox: -145, -250, 1145, 708
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPLE+AdvP43B38B
      FontSubset: true
      FirstChar: 97
      LastChar: 121
      FontDescriptor: 
       FontName: HALPLE+AdvP43B38B
       Flags: Serif, Nonsymbolic
       FontBBox: -260, -239, 1041, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPIP+AdvP40319B
      FontSubset: true
      FirstChar: 58
      LastChar: 122
      FontDescriptor: 
       FontName: HALPIP+AdvP40319B
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1197, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HBJFGE+AdvP497E5
      FontSubset: true
      FirstChar: 120
      LastChar: 120
      FontDescriptor: 
       FontName: HBJFGE+AdvP497E5
       Flags: Serif, Nonsymbolic
       FontBBox: -260, -250, 1072, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPMI+AdvT377
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: HALPMI+AdvT377
       Flags: Symbolic
       FontBBox: -187, -218, 1010, 979
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: HAMAPK+AdvP4C4E59
      FontSubset: true
      FirstChar: 35
      LastChar: 95
      FontDescriptor: 
       FontName: HAMAPK+AdvP4C4E59
       Flags: Serif, Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HAMBAL+AdvP4C4E46
      FontSubset: true
      FirstChar: 2
      LastChar: 240
      FontDescriptor: 
       FontName: HAMBAL+AdvP4C4E46
       Flags: Serif, Symbolic
       FontBBox: -15, -2959, 1387, 744
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HALPLH+AdvP3EAA99
      FontSubset: true
      FirstChar: 68
      LastChar: 108
      FontDescriptor: 
       FontName: HALPLH+AdvP3EAA99
       Flags: Serif, Nonsymbolic
       FontBBox: -156, -239, 1000, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPKA+AdvP403A40
      FontSubset: true
      FirstChar: 25
      LastChar: 184
      FontDescriptor: 
       FontName: HALPKA+AdvP403A40
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: HALPLC+AdvP497E3
      FontSubset: true
      FirstChar: 65
      LastChar: 122
      FontDescriptor: 
       FontName: HALPLC+AdvP497E3
       Flags: Serif, Nonsymbolic
       FontBBox: -260, -239, 1093, 708
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPLD+AdvP497E2
      FontSubset: true
      FirstChar: 37
      LastChar: 120
      FontDescriptor: 
       FontName: HALPLD+AdvP497E2
       Flags: Serif, Nonsymbolic
       FontBBox: -83, -239, 1000, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPKB+AdvP4041BD
      FontSubset: true
      FirstChar: 46
      LastChar: 116
      FontDescriptor: 
       FontName: HALPKB+AdvP4041BD
       Flags: Nonsymbolic
       FontBBox: -104, -239, 1083, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAMAIG+AdvP4068C
      FontSubset: true
      FirstChar: 68
      LastChar: 84
      FontDescriptor: 
       FontName: HAMAIG+AdvP4068C
       Flags: Serif, Nonsymbolic
       FontBBox: -208, -322, 958, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAMAIH+AdvP4980C
      FontSubset: true
      FirstChar: 118
      LastChar: 167
      FontDescriptor: 
       FontName: HAMAIH+AdvP4980C
       Flags: Serif, Symbolic
       FontBBox: -72, -343, 1187, 1031
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HALPLG+AdvP40798
      FontSubset: true
      FirstChar: 122
      LastChar: 126
      FontDescriptor: 
       FontName: HALPLG+AdvP40798
       Flags: Serif, Symbolic
       FontBBox: -20, -218, 1239, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HALPMJ+AdvP49811
      FontSubset: true
      FirstChar: 25
      LastChar: 184
      FontDescriptor: 
       FontName: HALPMJ+AdvP49811
       Flags: Serif, Nonsymbolic
       FontBBox: -156, -250, 1000, 666
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: HALPLF+AdvPi1
      FontSubset: true
      FirstChar: 33
      LastChar: 146
      FontDescriptor: 
       FontName: HALPLF+AdvPi1
       Flags: Serif, Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAMAIF+AdvP497E4
      FontSubset: true
      FirstChar: 120
      LastChar: 120
      FontDescriptor: 
       FontName: HAMAIF+AdvP497E4
       Flags: Serif, Nonsymbolic
       FontBBox: -187, -239, 1062, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAMAJK+AdvP4C4E51
      FontSubset: true
      FirstChar: 37
      LastChar: 63
      FontDescriptor: 
       FontName: HAMAJK+AdvP4C4E51
       Flags: Symbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HAMAKK+AdvPi2
      FontSubset: true
      FirstChar: 63
      LastChar: 91
      FontDescriptor: 
       FontName: HAMAKK+AdvPi2
       Flags: Serif, Nonsymbolic
       FontBBox: 16, -335, 981, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAMAII+AdvPECF830
      FontSubset: true
      FirstChar: 45
      LastChar: 146
      FontDescriptor: 
       FontName: HAMAII+AdvPECF830
       Flags: Nonsymbolic
       FontBBox: -166, -270, 1177, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAMAJJ+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 240
      FontDescriptor: 
       FontName: HAMAJJ+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBFNNJ+AdvP42B8DE
      FontSubset: true
      FirstChar: 53
      LastChar: 53
      FontDescriptor: 
       FontName: HBFNNJ+AdvP42B8DE
       Flags: Nonsymbolic
       FontBBox: -41, -333, 1031, 1020
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HALPJP+AdvP41461E
      FontSubset: true
      FirstChar: 40
      LastChar: 252
      FontDescriptor: 
       FontName: HALPJP+AdvP41461E
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1354, 750
       FontFile3: true
      Encoding: MacRomanEncoding
   XMP: <x:xmpmeta xmlns:x='adobe:ns:meta/' x:xmptk='Image::ExifTool 8.15'>
<rdf:RDF xmlns:rdf='http://www.w3.org/1999/02/22-rdf-syntax-ns#'>

 <rdf:Description rdf:about=''
  xmlns:crossmark='http://crossref.org/crossmark/1.0/'>
  <crossmark:CrossMarkDomains>www.plosone.org</crossmark:CrossMarkDomains>
  <crossmark:CrossmarkDomainExclusive>false</crossmark:CrossmarkDomainExclusive>
  <crossmark:DOI>10.1371/journal.pone.0108004</crossmark:DOI>
  <crossmark:MajorVersionDate>2014-09-23</crossmark:MajorVersionDate>
 </rdf:Description>

 <rdf:Description rdf:about=''
  xmlns:dc='http://purl.org/dc/elements/1.1/'>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>doi:10.1371/journal.pone.0108004</dc:identifier>
  <dc:title>
   <rdf:Alt>
    <rdf:li xml:lang='x-default'>pone.0108004 1..15</rdf:li>
   </rdf:Alt>
  </dc:title>
 </rdf:Description>

 <rdf:Description rdf:about=''
  xmlns:pdf='http://ns.adobe.com/pdf/1.3/'>
  <pdf:Producer>Acrobat Distiller 9.0.0 (Windows); modified using iText 5.0.3 (c) 1T3XT BVBA</pdf:Producer>
 </rdf:Description>

 <rdf:Description rdf:about=''
  xmlns:prism='http://prismstandard.org/namespaces/basic/2.1/'>
  <prism:url>
   <rdf:Bag>
    <rdf:li>http://dx.doi.org/10.1371/journal.pone.0108004</rdf:li>
   </rdf:Bag>
  </prism:url>
 </rdf:Description>

 <rdf:Description rdf:about=''
  xmlns:xap='http://ns.adobe.com/xap/1.0/'>
  <xap:CreateDate>2014-09-04T21:39:32+08:00</xap:CreateDate>
  <xap:CreatorTool>3B2 Total Publishing System 7.51n/W</xap:CreatorTool>
  <xap:MetadataDate>2014-09-17T12:38:58+05:30</xap:MetadataDate>
  <xap:ModifyDate>2014-09-17T12:38:58+05:30</xap:ModifyDate>
 </rdf:Description>

 <rdf:Description rdf:about=''
  xmlns:xapMM='http://ns.adobe.com/xap/1.0/mm/'>
  <xapMM:DocumentID>uuid:86531219-eb68-4b33-9328-dd55b71a8f21</xapMM:DocumentID>
  <xapMM:InstanceID>uuid:8aa506fb-6e96-49ed-a1f1-8961639e6854</xapMM:InstanceID>
 </rdf:Description>
</rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 374, 388, 491, 394
      Annotation: 
       Subtype: Link
       Rect: 565, 732, 602, 695
    Page: 
     Sequence: 2
    Page: 
     Sequence: 3
    Page: 
     Sequence: 4
    Page: 
     Sequence: 5
    Page: 
     Sequence: 6
    Page: 
     Sequence: 7
    Page: 
     Sequence: 8
    Page: 
     Sequence: 9
    Page: 
     Sequence: 10
    Page: 
     Sequence: 11
    Page: 
     Sequence: 12
    Page: 
     Sequence: 13
    Page: 
     Sequence: 14
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 517, 644, 554, 651
      Annotation: 
       Subtype: Link
       Rect: 328, 636, 475, 643
  Checksum: d884f107
   Type: CRC32
  Checksum: b4061e4b0d88fa62e10d23e8018f43bb
   Type: MD5
  Checksum: 13bd996284c6fe95fd70d3cf64a49fb24ae6eef1
   Type: SHA-1