7249d3693698828d31bebdc3a40c9e3c Joutramed_a2015v13n60pe12967-015-0392-5iENG.pdf ffd31ccbd69bcaaec36b08430931cad1ff100657 Joutramed_a2015v13n60pe12967-015-0392-5iENG.pdf ea7060a6917b045904403dea53786a148ee8a62f733bc2014806e98df6061010 Joutramed_a2015v13n60pe12967-015-0392-5iENG.pdf Title: A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques Subject: 2015, :. doi:10.1186/s12967-015-0392-5 Keywords: HIV-1ŁT-cell immunogen,HIV-1 specific CTL,HLA,Immunogenicity,Subdominant,Viral fitness,CTL escape,T-helper epitope,Population coverage Author: Beatriz Mothe Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Feb 21 14:32:25 2015 ModDate: Sat Feb 21 14:14:11 2015 Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 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Invalid destination object Offset: 3167596 MIMEtype: application/pdf PDFMetadata: Objects: 788 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e26e44 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11b532d0 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@f1afec5 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@354c3f42 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@20cd2164 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b4b3d0e Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@895a15f Children: Item: Title: HIV-1 infected patients and human PBMC samples for ELISPOT analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17956860 Item: Title: DNA.HTI and MVA.HTI vaccines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51f782b8 Item: Title: HTI DNA expression upon transient transfection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50a72812 Item: Title: Vaccination of C57BL/6 mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e37df1c Item: Title: Overlapping peptides and distribution of peptide pools Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7618ae8e Item: Title: Murine IFN-γ ELISPOT assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e6c2934 Item: Title: Humoral immune response analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f053d25 Item: Title: Vaccination of rhesus macaques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@10f1580c Item: Title: Intracellular cytokine staining of macaque PBMC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@54cb8484 Item: Title: Humoral immune responses of vaccinated macaques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7d692199 Item: Title: Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11d0422 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17fa54c0 Item: Title: Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33d2158c Children: Item: Title: Design of the HIVACAT T-cell immunogen (HTI) covering targets of effective antiviral T cell responses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2584b4e8 Item: Title: Expression of HTI plasmid DNA from HEK293 cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2b80fe96 Item: Title: DNA plasmid vaccination in C57BL/6 mice elicits broad and balanced T-cell responses to all protein components of HTI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21ca402a Item: Title: MVA.HTI boost increases responses after DNA prime Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@653a96ba Item: Title: HTI vaccination induces robust antigen-specific memory T cells in rhesus macaques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@697dc141 Item: Title: HTI vaccine induces antigen-specific memory T cells with cytotoxic potential Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3f1ac882 Item: Title: HTI vaccine induces broadly distributed responses in rhesus macaques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7761ef2b Item: Title: HTI vaccine induces humoral responses in rhesus macaques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3e9d2d48 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4107f215 Item: Title: Additional file Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@70a6620d Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3b6f7d42 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1488968a Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1353488e Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@40c06c8b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@19163ae3 Info: Title: A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques Author: Beatriz Mothe Subject: 2015, :. doi:10.1186/s12967-015-0392-5 Keywords: HIV-1ŁT-cell immunogen,HIV-1 specific CTL,HLA,Immunogenicity,Subdominant,Viral fitness,CTL escape,T-helper epitope,Population coverage Creator: Arbortext Advanced Print Publisher 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doi:10.1186/s12967-015-0392-5 2015-02-21T14:32:25+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode 2015-02-21T14:14:11+01:00 2015-02-21T14:14:11+01:00 application/pdf http://dx.doi.org/10.1186/s12967-015-0392-5 � 2015 Mothe et al.; licensee BioMed Central. 2015, :. doi:10.1186/s12967-015-0392-5 HIV-1ŁT-cell immunogen HIV-1 specific CTL HLA Immunogenicity Subdominant Viral fitness CTL escape T-helper epitope Population coverage A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques Beatriz Mothe True Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) HIV-1ŁT-cell immunogen,HIV-1 specific CTL,HLA,Immunogenicity,Subdominant,Viral fitness,CTL escape,T-helper epitope,Population coverage uuid:3e395807-45c3-42b2-9d28-9e0a1f70ecda uuid:d55e3585-6ec6-4bf8-a3ef-59028a82a53b default 1 converted uuid:3e395807-45c3-42b2-9d28-9e0a1f70ecda converted to 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