c53d39deafa93e336ebdb3f8b5060454 biomaterials_a2015v53p437.pdf a325c3b35ad759b11cfbf30222d12c04a7fb6f6b biomaterials_a2015v53p437.pdf a8c2d3125d05d954ae40dca3d26a674d6a76bb291de4c2c2e8e26471f17b6fe6 biomaterials_a2015v53p437.pdf Title: The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo Subject: Biomaterials, 53 (2015) 437-452. doi:10.1016/j.biomaterials.2015.02.083 Author: Houmam Kafa Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Apr 7 19:53:54 2015 CEST ModDate: Tue Apr 7 19:54:36 2015 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 4917659 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EGHJEL+AdvOT863180fb Type 1C WinAnsi yes yes no 989 0 EGHJEM+AdvOTb92eb7df.I Type 1C WinAnsi yes yes no 991 0 EGHJEN+AdvP4C4E59 Type 1C Custom yes yes no 995 0 EGHJEO+AdvTT5843c571 Type 1C WinAnsi yes yes no 997 0 EGHJEP+AdvPS44A44B Type 1C WinAnsi yes yes no 1002 0 EGHJFA+AdvOTc4d0b532 Type 1C WinAnsi yes yes no 1004 0 EGHJFB+AdvP4C4E74 Type 1C Custom yes yes yes 1009 0 EGHJGC+AdvOT863180fb+fb Type 1C Custom yes yes yes 1000 0 EGHJGD+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 1016 0 EGHJGE+AdvOTb83ee1dd.B Type 1C WinAnsi yes yes no 1019 0 EGHJJE+AdvPSA35D Type 1C WinAnsi yes yes no 1024 0 EGHJLE+AdvOTb0c9bf5d+21 Type 1C WinAnsi yes yes no 698 0 EGHJLF+AdvP3F4C13 Type 1C WinAnsi yes yes no 701 0 EGHJLG+AdvOTb92eb7df.I+fb Type 1C Custom yes yes yes 696 0 EGHJNG+AdvOT6bc95374.I+21 Type 1C WinAnsi yes yes no 711 0 EGHJNH+AdvPS3F4C13 Type 1C WinAnsi yes yes no 714 0 EGHJNI+AdvP4721B4 Type 1C WinAnsi yes yes no 708 0 EGHKOG+AdvOT404f8e91.BI Type 1C WinAnsi yes yes no 725 0 EGHKOH+AdvP4C4E3A Type 1C WinAnsi yes yes no 723 0 EGHKLE+Arial-BoldMT TrueType WinAnsi yes yes no 728 0 EGHKMG+ArialMT TrueType WinAnsi yes yes no 731 0 EGHOBD+AdvOTb83ee1dd.B+20 Type 1C WinAnsi yes yes no 741 0 EGIDMP+AdvPS3FDD77 Type 1C WinAnsi yes yes no 748 0 EGIEAO+AdvOT863180fb+20 Type 1C WinAnsi yes yes no 754 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-05-16 05:43:15 CEST RepresentationInformation: biomaterials_a2015v53p437.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-06-07 15:47:01 CEST Size: 4917659 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fna' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnb' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 4884192 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 4884192 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1084 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@768debd Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@490d6c15 Item: Title: 2. Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7d4793a8 Children: Item: Title: 2.1. Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@449b2d27 Item: Title: 2.2. Functionalization of MWNTs derivatives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5479e3f Item: Title: 2.3. Radio-labelling of DTPA-MWNTs with 111Indium Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@27082746 Item: Title: 2.4. The modified lactate dehydrogenase (LDH) assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66133adc Item: Title: 2.5. Isolation of primary porcine brain endothelial cells (PBEC) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7bfcd12c Item: Title: 2.6. Culturing and maintenance of PBEC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42f30e0a Item: Title: 2.7. Isolation of primary rat astrocytes from post-natal rat pups Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@24273305 Item: Title: 2.8. Setting up the BBB co-culture Transwell™ system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5b1d2887 Item: Title: 2.9. Transport of f-MWNT across the BBB by electron microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46f5f779 Item: Title: 2.10. Sample processing of the Transwell™ filters and astrocytes for electron microscopy imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c2c22f3 Item: Title: 2.11. Electron microscopy imaging of processed Transwell™ filters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18e8568 Item: Title: 2.12. Transport studies of [111In]DTPA-MWNTs and [14C]sucrose across PBEC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33e5ccce Item: Title: 2.13. Tissue bio-distribution of [111In]DTPA-MWNTs in mice by γ-scintigraphy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5a42bbf4 Item: Title: 2.14. Brain capillary depletion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@270421f5 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52d455b8 Children: Item: Title: 3.1. Chemical functionalization of MWNTs-NH3+ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4f4a7090 Item: Title: 3.2. Assessing the toxicity of MWNTs-NH3+ on PBEC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18ef96 Item: Title: 3.3. The interaction of MWNTs-NH3+ and PBEC monolayer by low voltage scanning transmission electron microscopy (STEM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6956de9 Item: Title: 3.4. The interaction of individual MWNTs-NH3+ with the PBEC monolayer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@769c9116 Item: Title: 3.5. Uptake inhibition of MWNTs-NH3+ in PBEC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6aceb1a5 Item: Title: 3.6. MWNTs-NH3+ localization within astrocytes after crossing the BBB Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2d6d8735 Item: Title: 3.7. Transport of radiolabelled MWNTs-DTPA across the PBEC monolayer in an in vitro BBB model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ba4d54 Item: Title: 3.8. Bio-distribution of [111In]DTPA-MWNTs in mice following i.v. administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bc6874 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@de0a01f Item: Title: 5. Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4c75cab9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1ef7fe8e Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6f79caec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@67117f44 Info: Title: The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo Author: Houmam Kafa Subject: Biomaterials, 53 (2015) 437-452. doi:10.1016/j.biomaterials.2015.02.083 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Apr 07 20:23:54 CEST 2015 ModDate: Tue Apr 07 20:24:36 CEST 2015 ID: 0x5a037dc9bb260ba6d42deedb41b5fd92, 0x4b9dc1cbac478b46ab81cb4a5c49e5a4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 107 ImageHeight: 107 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 299 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 254 ImageHeight: 278 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 449 ImageHeight: 576 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 449 ImageHeight: 576 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 432 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 449 ImageHeight: 145 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 593 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 446 ImageHeight: 584 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 594 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1629 ImageHeight: 148 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 593 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 594 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 593 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 593 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 446 ImageHeight: 584 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 446 ImageHeight: 584 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 594 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 594 ImageHeight: 438 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 444 ImageHeight: 588 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 444 ImageHeight: 588 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1181 ImageHeight: 148 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 591 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 444 ImageHeight: 588 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 444 ImageHeight: 588 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 437 ImageHeight: 585 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 437 ImageHeight: 585 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 440 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 437 ImageHeight: 585 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 437 ImageHeight: 294 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 437 ImageHeight: 585 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 439 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 582 ImageHeight: 439 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2067 ImageHeight: 1233 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2064 ImageHeight: 1524 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: EGHJJE+AdvPSA35D FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: EGHJJE+AdvPSA35D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJEN+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EGHJEN+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EGHJNI+AdvP4721B4 FontSubset: true FirstChar: 68 LastChar: 103 FontDescriptor: FontName: EGHJNI+AdvP4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJEO+AdvTT5843c571 FontSubset: true FirstChar: 42 LastChar: 174 FontDescriptor: FontName: EGHJEO+AdvTT5843c571 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHOBD+AdvOTb83ee1dd.B+20 FontSubset: true FirstChar: 147 LastChar: 148 FontDescriptor: FontName: EGHOBD+AdvOTb83ee1dd.B+20 Flags: Nonsymbolic FontBBox: 9, -208, 1125, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJNG+AdvOT6bc95374.I+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: EGHJNG+AdvOT6bc95374.I+21 Flags: Nonsymbolic FontBBox: -93, -218, 1052, 677 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJGC+AdvOT863180fb+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EGHJGC+AdvOT863180fb+fb Flags: Symbolic FontBBox: 40, 0, 895, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EGHJEP+AdvPS44A44B FontSubset: true FirstChar: 101 LastChar: 101 FontDescriptor: FontName: EGHJEP+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJNH+AdvPS3F4C13 FontSubset: true FirstChar: 85 LastChar: 85 FontDescriptor: FontName: EGHJNH+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJFA+AdvOTc4d0b532 FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: EGHJFA+AdvOTc4d0b532 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGIDMP+AdvPS3FDD77 FontSubset: true FirstChar: 122 LastChar: 122 FontDescriptor: FontName: EGIDMP+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJFB+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: EGHJFB+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EGIEAO+AdvOT863180fb+20 FontSubset: true FirstChar: 147 LastChar: 148 FontDescriptor: FontName: EGIEAO+AdvOT863180fb+20 Flags: Nonsymbolic FontBBox: 9, -208, 947, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHKOH+AdvP4C4E3A FontSubset: true FirstChar: 254 LastChar: 254 FontDescriptor: FontName: EGHKOH+AdvP4C4E3A Flags: Nonsymbolic FontBBox: -20, -937, 1322, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHKOG+AdvOT404f8e91.BI FontSubset: true FirstChar: 102 LastChar: 118 FontDescriptor: FontName: EGHKOG+AdvOT404f8e91.BI Flags: Nonsymbolic FontBBox: -166, -239, 1114, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJGD+AdvOTb0c9bf5d FontSubset: true FirstChar: 60 LastChar: 177 FontDescriptor: FontName: EGHJGD+AdvOTb0c9bf5d Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJLG+AdvOTb92eb7df.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EGHJLG+AdvOTb92eb7df.I+fb Flags: Symbolic FontBBox: -114, -208, 833, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EGHJLE+AdvOTb0c9bf5d+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: EGHJLE+AdvOTb0c9bf5d+21 Flags: Nonsymbolic FontBBox: -93, -250, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJGE+AdvOTb83ee1dd.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: EGHJGE+AdvOTb83ee1dd.B Flags: Nonsymbolic FontBBox: -93, -250, 1041, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJEL+AdvOT863180fb FontSubset: true FirstChar: 35 LastChar: 126 FontDescriptor: FontName: EGHJEL+AdvOT863180fb Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJLF+AdvP3F4C13 FontSubset: true FirstChar: 103 LastChar: 109 FontDescriptor: FontName: EGHJLF+AdvP3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EGHJEM+AdvOTb92eb7df.I FontSubset: true FirstChar: 39 LastChar: 122 FontDescriptor: FontName: EGHJEM+AdvOTb92eb7df.I Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: EGHKLE+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: EGHKLE+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: EGHKMG+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: EGHKMG+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.biomaterials.2015.02.083 The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo Houmam Kafa Julie Tzu-Wen Wang Noelia Rubio Kerrie Venner Glenn Anderson Elzbieta Pach Belén Ballesteros Jane E. Preston N. Joan Abbott Khuloud T. Al-Jamal Transcytosis Transwells PBEC BBB model TEM STEM Biomaterials, 53 (2015) 437-452. doi:10.1016/j.biomaterials.2015.02.083 Elsevier Ltd journal Biomaterials Copyright © 2015 The Authors. Published by Elsevier Ltd 0142-9612 53 C June 2015 201506 437-452 437 452 10.1016/j.biomaterials.2015.02.083 http://dx.doi.org/10.1016/j.biomaterials.2015.02.083 2010-04-23 true 10.1016/j.biomaterials.2015.02.083 elsevier.com sciencedirect.com 6.4 10.1016/j.biomaterials.2015.02.083 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2015-04-07T23:23:54+05:30 2015-04-07T23:24:36+05:30 2015-04-07T23:24:36+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:955c800e-21ee-47ae-b33a-53ba688889fa uuid:a3765570-9b07-4ea3-bd23-1d353f6fd24f Pages: Page: Label: 437 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 116, 567, 120, 578 Destination: 915 Annotation: Subtype: Link Rect: 231, 567, 235, 578 Destination: 915 Annotation: Subtype: Link Rect: 306, 567, 311, 578 Destination: 915 Annotation: Subtype: Link Rect: 388, 567, 393, 578 Destination: 915 Annotation: Subtype: Link Rect: 482, 567, 486, 578 Destination: 915 Annotation: Subtype: Link Rect: 112, 554, 117, 565 Destination: 915 Annotation: Subtype: Link Rect: 211, 554, 216, 565 Destination: 915 Annotation: Subtype: Link Rect: 300, 554, 304, 565 Destination: 915 Annotation: Subtype: Link Rect: 387, 554, 391, 565 Destination: 915 Annotation: Subtype: Link Rect: 146, 541, 150, 552 Destination: 915 Annotation: Subtype: Link Rect: 407, 301, 558, 308 Annotation: Subtype: Link Rect: 214, 223, 225, 231 Destination: 256 Annotation: Subtype: Link Rect: 281, 181, 291, 189 Destination: 256 Annotation: Subtype: Link Rect: 159, 129, 170, 137 Destination: 256 Annotation: Subtype: Link Rect: 472, 181, 483, 189 Destination: 256 Annotation: Subtype: Link Rect: 537, 108, 548, 116 Destination: 256 Annotation: Subtype: Link Rect: 101, 77, 184, 83 Annotation: Subtype: Link Rect: 503, 591, 562, 617 Annotation: Subtype: Link Rect: 329, 711, 382, 719 Annotation: Subtype: Link Rect: 259, 655, 441, 663 Annotation: Subtype: Link Rect: 42, 58, 198, 65 Annotation: Subtype: Link Rect: 390, 50, 524, 56 Annotation: Subtype: Link Rect: 255, 739, 334, 745 Annotation: Subtype: Link Rect: 339, 739, 349, 745 Page: Label: 438 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 135, 687, 146, 695 Destination: 256 Annotation: Subtype: Link Rect: 149, 614, 159, 622 Destination: 256 Annotation: Subtype: Link Rect: 126, 123, 140, 129 Destination: 256 Annotation: Subtype: Link Rect: 117, 115, 138, 121 Destination: null Annotation: Subtype: Link Rect: 88, 106, 101, 112 Destination: 256 Annotation: Subtype: Link Rect: 213, 97, 233, 104 Destination: null Annotation: Subtype: Link Rect: 406, 382, 418, 388 Destination: null Annotation: Subtype: Link Rect: 373, 373, 384, 379 Destination: null Page: Label: 439 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 153, 638, 165, 645 Destination: null Annotation: Subtype: Link Rect: 115, 342, 127, 348 Destination: null Annotation: Subtype: Link Rect: 549, 588, 561, 594 Destination: null Annotation: Subtype: Link Rect: 340, 352, 351, 359 Destination: null Page: Label: 440 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 70, 627, 111, 635 Destination: null Annotation: Subtype: Link Rect: 170, 564, 185, 572 Destination: null Annotation: Subtype: Link Rect: 166, 502, 190, 510 Destination: null Annotation: Subtype: Link Rect: 67, 397, 92, 405 Destination: null Annotation: Subtype: Link Rect: 60, 345, 86, 353 Destination: null Annotation: Subtype: Link Rect: 112, 313, 136, 321 Destination: null Annotation: Subtype: Link Rect: 207, 313, 232, 321 Destination: null Annotation: Subtype: Link Rect: 44, 272, 66, 279 Destination: 47 Annotation: Subtype: Link Rect: 129, 240, 149, 248 Destination: 47 Annotation: Subtype: Link Rect: 173, 230, 199, 238 Destination: null Annotation: Subtype: Link Rect: 32, 143, 47, 151 Destination: null Annotation: Subtype: Link Rect: 157, 143, 172, 151 Destination: null Annotation: Subtype: Link Rect: 147, 81, 168, 88 Destination: 47 Annotation: Subtype: Link Rect: 304, 551, 329, 559 Destination: null Annotation: Subtype: Link Rect: 486, 394, 511, 402 Destination: null Annotation: Subtype: Link Rect: 341, 332, 366, 340 Destination: null Annotation: Subtype: Link Rect: 364, 300, 384, 308 Destination: 69 Annotation: Subtype: Link Rect: 425, 227, 447, 235 Destination: 69 Annotation: Subtype: Link Rect: 463, 227, 528, 235 Destination: null Annotation: Subtype: Link Rect: 335, 175, 356, 183 Destination: 69 Annotation: Subtype: Link Rect: 388, 175, 412, 183 Destination: null Annotation: Subtype: Link Rect: 371, 154, 396, 162 Destination: null Page: Label: 441 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 121, 82, 136, 90 Destination: null Annotation: Subtype: Link Rect: 376, 103, 396, 111 Destination: 69 Annotation: Subtype: Link Rect: 314, 71, 334, 79 Destination: 69 Page: Label: 442 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 432, 635, 457, 643 Destination: null Page: Label: 443 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 206, 656, 230, 664 Destination: null Annotation: Subtype: Link Rect: 142, 624, 166, 632 Destination: null Annotation: Subtype: Link Rect: 173, 593, 198, 601 Destination: null Annotation: Subtype: Link Rect: 88, 436, 110, 444 Destination: 112 Annotation: Subtype: Link Rect: 222, 373, 243, 381 Destination: 112 Annotation: Subtype: Link Rect: 54, 332, 75, 340 Destination: 112 Annotation: Subtype: Link Rect: 114, 258, 134, 266 Destination: 112 Annotation: Subtype: Link Rect: 103, 154, 115, 162 Destination: null Annotation: Subtype: Link Rect: 122, 154, 134, 162 Destination: null Annotation: Subtype: Link Rect: 311, 708, 332, 716 Destination: 137 Annotation: Subtype: Link Rect: 457, 551, 477, 559 Destination: 137 Annotation: Subtype: Link Rect: 491, 394, 513, 402 Destination: 164 Annotation: Subtype: Link Rect: 511, 373, 531, 381 Destination: 164 Annotation: Subtype: Link Rect: 452, 300, 476, 308 Destination: null Annotation: Subtype: Link Rect: 407, 143, 428, 151 Destination: 164 Annotation: Subtype: Link Rect: 380, 133, 405, 141 Destination: null Page: Label: 444 Sequence: 8 Page: Label: 445 Sequence: 9 Page: Label: 446 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 223, 719, 250, 727 Destination: null Annotation: Subtype: Link Rect: 32, 677, 58, 685 Destination: null Annotation: Subtype: Link Rect: 59, 624, 79, 632 Destination: 177 Annotation: Subtype: Link Rect: 231, 488, 252, 496 Destination: 177 Annotation: Subtype: Link Rect: 131, 457, 151, 465 Destination: 177 Annotation: Subtype: Link Rect: 410, 656, 431, 664 Destination: 177 Annotation: Subtype: Link Rect: 524, 562, 552, 570 Destination: null Page: Label: 447 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 167, 227, 195, 235 Destination: null Annotation: Subtype: Link Rect: 66, 206, 95, 214 Destination: null Annotation: Subtype: Link Rect: 263, 154, 293, 162 Destination: null Annotation: Subtype: Link Rect: 207, 81, 235, 88 Destination: null Annotation: Subtype: Link Rect: 403, 216, 431, 224 Destination: 188 Page: Label: 448 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 143, 719, 164, 727 Destination: 225 Annotation: Subtype: Link Rect: 189, 719, 218, 727 Destination: null Annotation: Subtype: Link Rect: 258, 645, 278, 653 Destination: 225 Annotation: Subtype: Link Rect: 85, 562, 107, 570 Destination: 225 Annotation: Subtype: Link Rect: 61, 404, 72, 412 Destination: 256 Annotation: Subtype: Link Rect: 132, 404, 143, 412 Destination: 256 Annotation: Subtype: Link Rect: 140, 383, 151, 391 Destination: 256 Annotation: Subtype: Link Rect: 250, 383, 260, 391 Destination: 256 Annotation: Subtype: Link Rect: 216, 320, 231, 328 Destination: null Annotation: Subtype: Link Rect: 273, 258, 283, 266 Destination: 256 Annotation: Subtype: Link Rect: 141, 226, 157, 234 Destination: null Annotation: Subtype: Link Rect: 213, 205, 228, 213 Destination: null Annotation: Subtype: Link Rect: 187, 174, 202, 182 Destination: null Annotation: Subtype: Link Rect: 499, 708, 514, 716 Destination: null Annotation: Subtype: Link Rect: 389, 698, 415, 706 Destination: null Annotation: Subtype: Link Rect: 320, 687, 335, 695 Destination: null Annotation: Subtype: Link Rect: 350, 656, 365, 664 Destination: null Annotation: Subtype: Link Rect: 500, 656, 515, 664 Destination: null Annotation: Subtype: Link Rect: 301, 593, 316, 601 Destination: null Annotation: Subtype: Link Rect: 536, 541, 550, 549 Destination: null Annotation: Subtype: Link Rect: 498, 509, 513, 517 Destination: null Annotation: Subtype: Link Rect: 405, 426, 421, 434 Destination: null Annotation: Subtype: Link Rect: 398, 352, 413, 360 Destination: null Annotation: Subtype: Link Rect: 521, 279, 536, 287 Destination: null Annotation: Subtype: Link Rect: 340, 248, 355, 256 Destination: null Annotation: Subtype: Link Rect: 496, 248, 511, 256 Destination: null Annotation: Subtype: Link Rect: 355, 237, 370, 245 Destination: null Annotation: Subtype: Link Rect: 331, 227, 343, 235 Destination: null Annotation: Subtype: Link Rect: 349, 227, 361, 235 Destination: null Annotation: Subtype: Link Rect: 397, 185, 423, 193 Destination: null Annotation: Subtype: Link Rect: 337, 164, 352, 172 Destination: null Annotation: Subtype: Link Rect: 454, 96, 457, 102 Destination: null Annotation: Subtype: Link Rect: 544, 96, 546, 102 Destination: null Page: Label: 449 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 85, 219, 100, 227 Destination: null Annotation: Subtype: Link Rect: 276, 52, 291, 60 Destination: null Annotation: Subtype: Link Rect: 478, 219, 493, 227 Destination: null Annotation: Subtype: Link Rect: 330, 209, 345, 217 Destination: null Annotation: Subtype: Link Rect: 409, 115, 430, 123 Destination: 256 Page: Label: 450 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 266, 708, 281, 716 Destination: null Annotation: Subtype: Link Rect: 32, 614, 48, 622 Destination: null Annotation: Subtype: Link Rect: 242, 384, 258, 392 Destination: null Annotation: Subtype: Link Rect: 55, 290, 82, 298 Destination: null Annotation: Subtype: Link Rect: 166, 101, 181, 109 Destination: null Annotation: Subtype: Link Rect: 205, 60, 232, 68 Destination: null Annotation: Subtype: Link Rect: 535, 645, 550, 653 Destination: null Annotation: Subtype: Link Rect: 449, 614, 465, 622 Destination: null Annotation: Subtype: Link Rect: 338, 509, 365, 517 Destination: null Annotation: Subtype: Link Rect: 301, 363, 317, 371 Destination: null Annotation: Subtype: Link Rect: 535, 332, 550, 340 Destination: null Page: Label: 451 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 269, 360, 293, 368 Annotation: Subtype: Link Rect: 42, 350, 212, 358 Annotation: Subtype: Link Rect: 58, 305, 293, 311 Annotation: Subtype: Link Rect: 58, 297, 223, 303 Annotation: Subtype: Link Rect: 228, 297, 240, 303 Annotation: Subtype: Link Rect: 58, 289, 293, 295 Annotation: Subtype: Link Rect: 58, 281, 187, 287 Annotation: Subtype: Link Rect: 192, 281, 196, 287 Annotation: Subtype: Link Rect: 58, 273, 293, 279 Annotation: Subtype: Link Rect: 58, 265, 293, 271 Annotation: Subtype: Link Rect: 58, 257, 178, 263 Annotation: Subtype: Link Rect: 183, 257, 191, 263 Annotation: Subtype: Link Rect: 58, 249, 293, 255 Annotation: Subtype: Link Rect: 58, 241, 293, 247 Annotation: Subtype: Link Rect: 58, 233, 169, 239 Annotation: Subtype: Link Rect: 174, 233, 178, 239 Annotation: Subtype: Link Rect: 58, 225, 293, 231 Annotation: Subtype: Link Rect: 58, 217, 293, 223 Annotation: Subtype: Link Rect: 58, 209, 239, 215 Annotation: Subtype: Link Rect: 244, 209, 248, 215 Annotation: Subtype: Link Rect: 58, 201, 293, 207 Annotation: Subtype: Link Rect: 58, 193, 293, 199 Annotation: Subtype: Link Rect: 58, 185, 132, 191 Annotation: Subtype: Link Rect: 137, 185, 145, 191 Annotation: Subtype: Link Rect: 58, 177, 293, 183 Annotation: Subtype: Link Rect: 58, 169, 293, 175 Annotation: Subtype: Link Rect: 58, 161, 224, 167 Annotation: Subtype: Link Rect: 229, 161, 237, 167 Annotation: Subtype: Link Rect: 58, 153, 293, 159 Annotation: Subtype: Link Rect: 58, 145, 293, 152 Annotation: Subtype: Link Rect: 58, 137, 269, 144 Annotation: Subtype: Link Rect: 274, 137, 282, 144 Annotation: Subtype: Link Rect: 58, 129, 293, 136 Annotation: Subtype: Link Rect: 58, 121, 293, 128 Annotation: Subtype: Link Rect: 58, 113, 140, 120 Annotation: Subtype: Link Rect: 145, 113, 149, 120 Annotation: Subtype: Link Rect: 58, 105, 293, 112 Annotation: Subtype: Link Rect: 58, 97, 240, 104 Annotation: Subtype: Link Rect: 245, 97, 252, 104 Annotation: Subtype: Link Rect: 58, 89, 293, 96 Annotation: Subtype: Link Rect: 58, 81, 293, 88 Annotation: Subtype: Link Rect: 58, 73, 228, 80 Annotation: Subtype: Link Rect: 233, 73, 241, 80 Annotation: Subtype: Link Rect: 58, 65, 293, 72 Annotation: Subtype: Link Rect: 58, 57, 293, 64 Annotation: Subtype: Link Rect: 58, 50, 185, 56 Annotation: Subtype: Link Rect: 190, 50, 198, 56 Annotation: Subtype: Link Rect: 327, 720, 562, 727 Annotation: Subtype: Link Rect: 327, 712, 562, 719 Annotation: Subtype: Link Rect: 327, 704, 407, 711 Annotation: Subtype: Link Rect: 412, 704, 416, 711 Annotation: Subtype: Link Rect: 327, 696, 562, 703 Annotation: Subtype: Link Rect: 327, 688, 531, 695 Annotation: Subtype: Link Rect: 535, 688, 543, 695 Annotation: Subtype: Link Rect: 327, 680, 562, 687 Annotation: Subtype: Link Rect: 327, 672, 562, 679 Annotation: Subtype: Link Rect: 327, 664, 366, 671 Annotation: Subtype: Link Rect: 371, 664, 375, 671 Annotation: Subtype: Link Rect: 327, 656, 562, 663 Annotation: Subtype: Link Rect: 327, 648, 562, 655 Annotation: Subtype: Link Rect: 327, 640, 562, 647 Annotation: Subtype: Link Rect: 327, 632, 366, 639 Annotation: Subtype: Link Rect: 371, 632, 375, 639 Annotation: Subtype: Link Rect: 327, 625, 562, 631 Annotation: Subtype: Link Rect: 327, 617, 562, 623 Annotation: Subtype: Link Rect: 327, 609, 494, 615 Annotation: Subtype: Link Rect: 499, 609, 502, 615 Annotation: Subtype: Link Rect: 327, 601, 562, 607 Annotation: Subtype: Link Rect: 327, 593, 562, 599 Annotation: Subtype: Link Rect: 327, 585, 562, 591 Annotation: Subtype: Link Rect: 327, 577, 392, 583 Annotation: Subtype: Link Rect: 397, 577, 405, 583 Annotation: Subtype: Link Rect: 327, 569, 562, 575 Annotation: Subtype: Link Rect: 327, 561, 562, 567 Annotation: Subtype: Link Rect: 327, 553, 374, 559 Annotation: Subtype: Link Rect: 379, 553, 386, 559 Annotation: Subtype: Link Rect: 327, 545, 562, 551 Annotation: Subtype: Link Rect: 327, 537, 562, 543 Annotation: Subtype: Link Rect: 327, 529, 370, 535 Annotation: Subtype: Link Rect: 375, 529, 382, 535 Annotation: Subtype: Link Rect: 327, 521, 562, 527 Annotation: Subtype: Link Rect: 327, 513, 562, 519 Annotation: Subtype: Link Rect: 327, 505, 450, 511 Annotation: Subtype: Link Rect: 455, 505, 463, 511 Annotation: Subtype: Link Rect: 327, 497, 562, 503 Annotation: Subtype: Link Rect: 327, 489, 562, 495 Annotation: Subtype: Link Rect: 327, 481, 335, 487 Annotation: Subtype: Link Rect: 340, 481, 344, 487 Annotation: Subtype: Link Rect: 327, 473, 562, 479 Annotation: Subtype: Link Rect: 327, 465, 562, 472 Annotation: Subtype: Link Rect: 327, 457, 432, 464 Annotation: Subtype: Link Rect: 437, 457, 444, 464 Annotation: Subtype: Link Rect: 327, 449, 562, 456 Annotation: Subtype: Link Rect: 327, 441, 495, 448 Annotation: Subtype: Link Rect: 500, 441, 503, 448 Annotation: Subtype: Link Rect: 327, 433, 562, 440 Annotation: Subtype: Link Rect: 327, 425, 562, 432 Annotation: Subtype: Link Rect: 327, 417, 548, 424 Annotation: Subtype: Link Rect: 553, 417, 561, 424 Annotation: Subtype: Link Rect: 327, 409, 562, 416 Annotation: Subtype: Link Rect: 327, 401, 562, 408 Annotation: Subtype: Link Rect: 327, 393, 481, 400 Annotation: Subtype: Link Rect: 327, 385, 562, 392 Annotation: Subtype: Link Rect: 327, 377, 562, 384 Annotation: Subtype: Link Rect: 327, 369, 542, 376 Annotation: Subtype: Link Rect: 547, 369, 555, 376 Annotation: Subtype: Link Rect: 327, 362, 562, 368 Annotation: Subtype: Link Rect: 327, 354, 562, 360 Annotation: Subtype: Link Rect: 327, 346, 562, 352 Annotation: Subtype: Link Rect: 327, 338, 382, 344 Annotation: Subtype: Link Rect: 387, 338, 395, 344 Annotation: Subtype: Link Rect: 327, 330, 562, 336 Annotation: Subtype: Link Rect: 327, 322, 562, 328 Annotation: Subtype: Link Rect: 327, 314, 477, 320 Annotation: Subtype: Link Rect: 482, 314, 490, 320 Annotation: Subtype: Link Rect: 327, 306, 562, 312 Annotation: Subtype: Link Rect: 327, 298, 562, 304 Annotation: Subtype: Link Rect: 327, 290, 468, 296 Annotation: Subtype: Link Rect: 473, 290, 480, 296 Annotation: Subtype: Link Rect: 327, 282, 562, 288 Annotation: Subtype: Link Rect: 327, 274, 562, 280 Annotation: Subtype: Link Rect: 327, 266, 476, 272 Annotation: Subtype: Link Rect: 481, 266, 488, 272 Annotation: Subtype: Link Rect: 327, 258, 562, 264 Annotation: Subtype: Link Rect: 327, 250, 562, 256 Annotation: Subtype: Link Rect: 327, 242, 530, 248 Annotation: Subtype: Link Rect: 535, 242, 542, 248 Annotation: Subtype: Link Rect: 327, 234, 562, 240 Annotation: Subtype: Link Rect: 327, 226, 562, 232 Annotation: Subtype: Link Rect: 327, 218, 562, 224 Annotation: Subtype: Link Rect: 327, 210, 415, 216 Annotation: Subtype: Link Rect: 420, 210, 428, 216 Annotation: Subtype: Link Rect: 327, 202, 562, 208 Annotation: Subtype: Link Rect: 327, 194, 562, 201 Annotation: Subtype: Link Rect: 327, 186, 427, 193 Annotation: Subtype: Link Rect: 327, 178, 562, 185 Annotation: Subtype: Link Rect: 327, 170, 529, 177 Annotation: Subtype: Link Rect: 534, 170, 541, 177 Annotation: Subtype: Link Rect: 327, 162, 562, 169 Annotation: Subtype: Link Rect: 327, 154, 562, 161 Annotation: Subtype: Link Rect: 327, 146, 562, 153 Annotation: Subtype: Link Rect: 327, 138, 350, 145 Annotation: Subtype: Link Rect: 327, 130, 562, 137 Annotation: Subtype: Link Rect: 327, 122, 562, 129 Annotation: Subtype: Link Rect: 327, 114, 562, 121 Annotation: Subtype: Link Rect: 327, 106, 435, 113 Annotation: Subtype: Link Rect: 440, 106, 448, 113 Annotation: Subtype: Link Rect: 327, 98, 562, 105 Annotation: Subtype: Link Rect: 327, 91, 562, 97 Annotation: Subtype: Link Rect: 327, 83, 535, 89 Annotation: Subtype: Link Rect: 327, 75, 562, 81 Annotation: Subtype: Link Rect: 327, 67, 562, 73 Annotation: Subtype: Link Rect: 327, 59, 526, 65 Annotation: Subtype: Link Rect: 531, 59, 562, 65 Annotation: Subtype: Link Rect: 327, 51, 417, 57 Page: Label: 452 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 49, 720, 283, 727 Annotation: Subtype: Link Rect: 49, 712, 283, 719 Annotation: Subtype: Link Rect: 49, 704, 269, 711 Annotation: Subtype: Link Rect: 274, 704, 282, 711 Annotation: Subtype: Link Rect: 49, 696, 283, 703 Annotation: Subtype: Link Rect: 49, 688, 283, 695 Annotation: Subtype: Link Rect: 49, 680, 122, 687 Annotation: Subtype: Link Rect: 126, 680, 134, 687 Annotation: Subtype: Link Rect: 49, 672, 283, 679 Annotation: Subtype: Link Rect: 49, 664, 283, 671 Annotation: Subtype: Link Rect: 49, 656, 132, 663 Annotation: Subtype: Link Rect: 137, 656, 141, 663 Annotation: Subtype: Link Rect: 49, 648, 283, 655 Annotation: Subtype: Link Rect: 49, 640, 283, 647 Annotation: Subtype: Link Rect: 49, 632, 123, 639 Annotation: Subtype: Link Rect: 128, 632, 136, 639 Annotation: Subtype: Link Rect: 49, 625, 283, 631 Annotation: Subtype: Link Rect: 49, 617, 283, 623 Annotation: Subtype: Link Rect: 49, 609, 105, 615 Annotation: Subtype: Link Rect: 110, 609, 117, 615 Annotation: Subtype: Link Rect: 49, 601, 283, 607 Annotation: Subtype: Link Rect: 49, 593, 283, 599 Annotation: Subtype: Link Rect: 49, 585, 185, 591 Annotation: Subtype: Link Rect: 189, 585, 193, 591 Annotation: Subtype: Link Rect: 49, 577, 283, 583 Annotation: Subtype: Link Rect: 49, 569, 283, 575 Annotation: Subtype: Link Rect: 49, 561, 283, 567 Annotation: Subtype: Link Rect: 49, 553, 116, 559 Annotation: Subtype: Link Rect: 121, 553, 129, 559 Annotation: Subtype: Link Rect: 49, 545, 283, 551 Annotation: Subtype: Link Rect: 49, 537, 283, 543 Annotation: Subtype: Link Rect: 49, 529, 60, 535 Annotation: Subtype: Link Rect: 65, 529, 69, 535 Annotation: Subtype: Link Rect: 318, 720, 552, 727 Annotation: Subtype: Link Rect: 318, 712, 552, 719 Annotation: Subtype: Link Rect: 318, 704, 382, 711 Annotation: Subtype: Link Rect: 387, 704, 395, 711 Annotation: Subtype: Link Rect: 318, 696, 552, 703 Annotation: Subtype: Link Rect: 318, 688, 552, 695 Annotation: Subtype: Link Rect: 318, 680, 511, 687 Annotation: Subtype: Link Rect: 318, 672, 552, 679 Annotation: Subtype: Link Rect: 318, 664, 552, 671 Annotation: Subtype: Link Rect: 318, 656, 444, 663 Annotation: Subtype: Link Rect: 448, 656, 456, 663 Annotation: Subtype: Link Rect: 318, 648, 552, 655 Annotation: Subtype: Link Rect: 318, 640, 552, 647 Annotation: Subtype: Link Rect: 318, 632, 552, 639 Annotation: Subtype: Link Rect: 318, 625, 400, 631 Annotation: Subtype: Link Rect: 405, 625, 413, 631 Annotation: Subtype: Link Rect: 318, 617, 552, 623 Annotation: Subtype: Link Rect: 318, 609, 552, 615 Annotation: Subtype: Link Rect: 318, 601, 431, 607 Annotation: Subtype: Link Rect: 436, 601, 444, 607 Annotation: Subtype: Link Rect: 318, 593, 552, 599 Annotation: Subtype: Link Rect: 318, 585, 552, 591 Annotation: Subtype: Link Rect: 318, 577, 446, 583 Annotation: Subtype: Link Rect: 451, 577, 459, 583 Annotation: Subtype: Link Rect: 318, 569, 552, 575 Annotation: Subtype: Link Rect: 318, 561, 552, 567 Annotation: Subtype: Link Rect: 318, 553, 356, 559 Annotation: Subtype: Link Rect: 361, 553, 369, 559 Checksum: 80998256 Type: CRC32 Checksum: c53d39deafa93e336ebdb3f8b5060454 Type: MD5 Checksum: a325c3b35ad759b11cfbf30222d12c04a7fb6f6b Type: SHA-1