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destination object Offset: 1962675 ErrorMessage: Invalid destination object Offset: 1962675 ErrorMessage: Invalid destination object Offset: 1960598 ErrorMessage: Invalid destination object Offset: 1964430 ErrorMessage: Invalid destination object Offset: 1964430 MIMEtype: application/pdf PDFMetadata: Objects: 770 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16f65612 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@311d617d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Children: Item: Title: Cell development Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: Cytotoxicity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Children: Item: Title: Effects of functionalized NPs on the cell membrane integrity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Effects of functionalized NPs on cell viability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Oxidative stress Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Children: Item: Title: Induction of intracellular ROS production by functionalized NPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: ROS production in a cell-free system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Effects of biological solutions on ROS production in a cell-free system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: Effects of cell culture components on the NPs surface charge Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Children: Item: Title: Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Transepithelial electrical resistance measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Tight junction staining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Nanoparticles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Children: Item: Title: Synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Gold Nanoparticles (Au NPs) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Silver Nanoparticles (Ag NPs) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Nanoparticle characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Exposure conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: Cytotoxicity assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Children: Item: Title: In house lactate dehydrogenase assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Item: Title: CellTiter-Blue ® (CTB) assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af Item: Title: Interference control for LDH and CTB assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3caeaf62 Item: Title: Detection of reactive oxygen species Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e6ea0c6 Children: Item: Title: DCFH-DA assay for cellular ROS production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a38e57f Item: Title: Cell-free ROS production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5577140b Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1c6b6478 Item: Title: Additional files Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@67f89fa3 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4ac68d3e Item: Title: Authors’ contributions Destination: 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