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Title:          The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria
Subject:        Microbial Cell Factories, doi:10.1186/s12934-015-0284-7
Keywords:       Inclusion bodies; Bacteria; Amyloid; Prions; Prion-like domains; Heterogeneous ribonucleoproteins; Neurodegenerative disorders
Author:         Susanna Navarro
Creator:        Springer
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     Item: 
      Title: The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusions: 
       Item: 
        Title: Background
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: HNRPDL displays a predicted amyloidogenic prion-like domain at the C-terminus
         Item: 
          Title: Aggregation of HNRPDL into IBs in bacteria
         Item: 
          Title: HNRPDL IBs bind to thioflavin-S in living cells
         Item: 
          Title: Purified HNRPDL IBs bind to amyloid dyes
         Item: 
          Title: HNRPDL IBs are enriched in intermolecular β-sheet structure
         Item: 
          Title: HNRPDL IBs posses an inner amyloid core
         Item: 
          Title: HNRPDL IBs are toxic to cultured neuronal cells
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Protein expression and purification
         Item: 
          Title: Inclusion bodies purification
         Item: 
          Title: Thioflavin-S binding in living cells
         Item: 
          Title: Thioflavin-T binding
         Item: 
          Title: Congo red binding
         Item: 
          Title: Bis-ANS binding
         Item: 
          Title: ATR-FTIR spectroscopy
         Item: 
          Title: Limited proteinase K digestion
         Item: 
          Title: Transmission electron microscopy (TEM)
         Item: 
          Title: Cell viability assay
       Item: 
        Title: Authors’ contribution
       Item: 
        Title: Received: 24 April 2015   Accepted: 16 June 2015References
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    Title: The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria
    Author: Susanna Navarro
    Subject: Microbial Cell Factories, doi:10.1186/s12934-015-0284-7
    Keywords: Inclusion bodies; Bacteria; Amyloid; Prions; Prion-like domains; Heterogeneous ribonucleoproteins; Neurodegenerative disorders
    Creator: Springer
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