510a03374dbca49b47ce088e8266eafd 12895_2015_Article_36.pdf 956b8e1f8acf7cfbe573c250d68b45d72f473266 12895_2015_Article_36.pdf 5f7d23de11cffc6c3112f557e524c40858ba49270f74e091ddfc9eed24ebcfb3 12895_2015_Article_36.pdf Title: Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne: the ACTUO observational prospective multicenter cohort trial in 643 patients Subject: BMC Dermatology, 2015, doi:10.1186/s12895-015-0036-8 Keywords: Acne vulgaris,Emollients,Observational study,Patient adherence,Topical administration Author: Raúl de Lucas Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Sep 10 17:43:58 2015 CEST ModDate: Fri Sep 11 15:48:59 2015 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 6 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 551700 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AJBKIO+GcchsjTvywqrAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 10 0 AJBKMN+NthxfsVnxgpyAdvTTe45e47d2 Type 1C WinAnsi yes yes no 11 0 AJBKMO+NgcnjyHqmxymAdvTTb5929f4c Type 1C WinAnsi yes yes no 76 0 MyriadPro-Regular Type 1 Custom yes no no 13 0 AJBKMP+RlkhrvGdghrqAdvTT99c4c969 Type 1C WinAnsi yes yes no 111 0 AJBKNA+DkbjkxTftwycAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 77 0 AJBKOB+GldcynYhtdmlAdvTTb5929f4c+22 Type 1C Custom yes yes yes 89 0 AJBNHC+BpytprNlcpwyAdvTT7329fd89.I Type 1C WinAnsi yes yes no 17 0 AJBNKE+WpwqmsVjqccvAdvTT86d47313+20 Type 1C WinAnsi yes yes no 12 0 AJBNLF+TbdyvjYpydvcAdvTT43ccf47d Type 1C WinAnsi yes yes no 14 0 AJBNJD+PxfhjkGchqxnAdvTT86d47313 Type 1C WinAnsi yes yes no 15 0 AJBNLG+LbqtmtVdymrxAdvTT8861b38f.I Type 1C WinAnsi yes yes no 16 0 AJBNLH+BsmrgwXtvvtmAdvTT86d47313+22 Type 1C Custom yes yes yes 18 0 AJCAAJ+WhvgpcXytkkxAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 112 0 VcwngkLswyyhFrutigerLTStd-Bold Type 1C Custom yes no yes 113 0 XmntysMhrsxsFrutigerLTStd-Roman Type 1C Custom yes no yes 114 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-09 02:48:30 CEST RepresentationInformation: 12895_2015_Article_36.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-07-08 16:20:03 CEST Size: 551700 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 287 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: sectionAbs1 Children: Item: Title: Background Destination: sectionASec1 Item: Title: Methods Destination: sectionASec2 Item: Title: Results Destination: sectionASec3 Item: Title: Conclusions Destination: sectionASec4 Item: Title: Background Destination: sectionSec1 Item: Title: Methods Destination: sectionSec2 Item: Title: Results Destination: sectionSec3 Item: Title: Discussion Destination: sectionSec4 Item: Title: Conclusions Destination: sectionSec5 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Competing interests Destination: ArtNote1 Item: Title: Authors’ contributions Destination: ArtNote2 Item: Title: Acknowledgements Destination: sections12895-015-0036-8 Item: Title: Author details Destination: sectionaunote1 Item: Title: References Destination: sectionBib1 Info: Title: Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne: the ACTUO observational prospective multicenter cohort trial in 643 patients Author: Raúl de Lucas Subject: BMC Dermatology, 2015, doi:10.1186/s12895-015-0036-8 Keywords: Acne vulgaris,Emollients,Observational study,Patient adherence,Topical administration Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Sep 10 17:43:58 CEST 2015 ModDate: Fri Sep 11 15:48:59 CEST 2015 ID: 0x4f07201f4e0acacc2cbcbaed0812605a, 0xfe1d3e8f2d8656a81eda8b0e5da93c94 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 897 ImageHeight: 800 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1162 ImageHeight: 845 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: AJBKIO+GcchsjTvywqrAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: AJBKIO+GcchsjTvywqrAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBKMN+NthxfsVnxgpyAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AJBKMN+NthxfsVnxgpyAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBKMO+NgcnjyHqmxymAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: AJBKMO+NgcnjyHqmxymAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBNKE+WpwqmsVjqccvAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: AJBNKE+WpwqmsVjqccvAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -218, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AJBKNA+DkbjkxTftwycAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: AJBKNA+DkbjkxTftwycAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -218, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBNLF+TbdyvjYpydvcAdvTT43ccf47d FontSubset: true FirstChar: 32 LastChar: 99 FontDescriptor: FontName: AJBNLF+TbdyvjYpydvcAdvTT43ccf47d Flags: Nonsymbolic FontBBox: -20, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBKMP+RlkhrvGdghrqAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AJBKMP+RlkhrvGdghrqAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBNJD+PxfhjkGchqxnAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 224 FontDescriptor: FontName: AJBNJD+PxfhjkGchqxnAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBNLG+LbqtmtVdymrxAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AJBNLG+LbqtmtVdymrxAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJCAAJ+WhvgpcXytkkxAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: AJCAAJ+WhvgpcXytkkxAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -218, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AJBNHC+BpytprNlcpwyAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: AJBNHC+BpytprNlcpwyAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VcwngkLswyyhFrutigerLTStd-Bold FirstChar: 32 LastChar: 147 FontDescriptor: FontName: VcwngkLswyyhFrutigerLTStd-Bold Flags: Symbolic, ForceBold FontBBox: -166, -250, 1000, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AJBNLH+BsmrgwXtvvtmAdvTT86d47313+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AJBNLH+BsmrgwXtvvtmAdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -270, 1031, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: XmntysMhrsxsFrutigerLTStd-Roman FirstChar: 32 LastChar: 121 FontDescriptor: FontName: XmntysMhrsxsFrutigerLTStd-Roman Flags: Symbolic FontBBox: -169, -250, 1000, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AJBKOB+GldcynYhtdmlAdvTTb5929f4c+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: AJBKOB+GldcynYhtdmlAdvTTb5929f4c+22 Flags: Symbolic FontBBox: -10, -218, 1083, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 10.1186/s12895-015-0036-8 2015-09-10 true springer.com springerlink.com Acne vulgaris,Emollients,Observational study,Patient adherence,Topical administration Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) 2015-09-10 true 10.1186/s12895-015-0036-8 springer.com springerlink.com http://dx.doi.org/10.1186/s12895-015-0036-8 10.1186/s12895-015-0036-8 1471-5945 journal BMC Dermatology de Lucas et al. application/pdf 10.1186/s12895-015-0036-8 BMC Dermatology BMC Dermatology, 2015, doi:10.1186/s12895-015-0036-8 Acne vulgaris Emollients Observational study Patient adherence Topical administration Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne: the ACTUO observational prospective multicenter cohort trial in 643 patients Raúl de Lucas Gerardo Moreno-Arias Montserrat Perez-López Ángel Vera-Casaño Sonia Aladren Massimo Milani Arbortext Advanced Print Publisher 9.1.440/W Unicode 2015-09-11T15:48:59+02:00 2015-09-10T23:43:58+08:00 2015-09-11T15:48:59+02:00 uuid:b2edf051-b12e-461b-88e1-1364c7e06bd9 uuid:026fcb7f-115d-4ead-b353-92091703bb7c default 1 converted uuid:f4c5ddb1-91ee-4c35-bd7d-213f8086c471 converted to PDF/A-2b pdfToolbox 2015-09-10T23:49:36+08:00 converted uuid:c2aeedad-6607-4ff8-a69b-4280aeaa15ff converted to PDF/A-2b pdfToolbox 2015-09-11T00:33:45+08:00 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer ORCiD Schema http://springer.com/ns/xmpExtensions/1.0/ springer authorInfo AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springer.com/ns/xmpExtensions/1.0/authorinfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyrigh copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 484, 658, 538, 680 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 110, 194, 117 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 67, 357, 74 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 43, 321, 50 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 185, 670, 190, 680 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 59, 658, 64, 668 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 253, 658, 258, 668 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 59, 598, 64, 608 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 71, 598, 76, 608 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 191, 586, 196, 596 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 213, 562, 218, 572 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 224, 562, 229, 572 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 264, 550, 269, 560 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 193, 526, 198, 536 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 128, 466, 137, 476 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 183, 418, 188, 428 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 83, 382, 88, 392 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 82, 370, 91, 380 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 88, 346, 98, 356 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 130, 298, 140, 308 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 146, 298, 156, 308 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 277, 274, 287, 284 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 83, 250, 92, 260 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 175, 214, 185, 224 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 133, 178, 138, 188 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 144, 178, 154, 188 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 459, 430, 468, 440 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 480, 118, 490, 128 Flags: Print AppearanceDictionary: true Destination: 102 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 277, 598, 287, 608 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 275, 586, 285, 596 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 81, 262, 86, 272 Flags: Print AppearanceDictionary: true Destination: 74 Annotation: Subtype: Link Rect: 200, 70, 205, 80 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 368, 490, 373, 500 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 392, 370, 397, 380 Flags: Print AppearanceDictionary: true Destination: 83 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 217, 118, 226, 128 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 94, 58, 104, 68 Flags: Print AppearanceDictionary: true Destination: 102 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 243, 334, 248, 344 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 326, 430, 330, 440 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 335, 430, 345, 440 Flags: Print AppearanceDictionary: true Destination: 102 Thumb: true Page: Sequence: 6 Thumb: true Checksum: 47518144 Type: CRC32 Checksum: 510a03374dbca49b47ce088e8266eafd Type: MD5 Checksum: 956b8e1f8acf7cfbe573c250d68b45d72f473266 Type: SHA-1 Checksum: 5f7d23de11cffc6c3112f557e524c40858ba49270f74e091ddfc9eed24ebcfb3 Type: SHA-256