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Destination: Title Children: Item: Title: 1 Introduction Destination: Section1 Item: Title: 2 Methods Destination: Section2 Children: Item: Title: 2.1 Patients Destination: Section3 Children: Item: Title: 2.1.1 Overall study population Destination: Section4 Item: Title: 2.1.2 First add-on cohort Destination: Section5 Item: Title: 2.1.3 Later add-on cohort Destination: Section6 Item: Title: 2.2 Treatment Destination: Section7 Item: Title: 2.3 Patient analysis sets Destination: Section8 Item: Title: 2.4 Outcome measures and statistical analysis Destination: Section9 Item: Title: 3 Results Destination: Section10 Children: Item: Title: 3.1 First add-on cohort Destination: Section11 Children: Item: Title: 3.1.1 Efficacy Destination: Section12 Item: Title: 3.1.2 Quality of life Destination: Section13 Item: Title: 3.1.3 Safety and tolerability Destination: Section14 Item: Title: 3.2 Later add-on cohort Destination: Section15 Children: Item: Title: 3.2.1 Efficacy Destination: Section16 Item: Title: 3.2.2 Quality of life Destination: Section17 Item: Title: 3.2.3 Safety and tolerability Destination: Section18 Item: Title: 4 Discussion Destination: Section19 Item: Title: 5 Conclusion Destination: Section20 Item: Title: Conflicts of interest Destination: Section21 Item: Title: Acknowledgements Destination: Acknowldgment Item: Title: Appendix A Supplementary data Destination: SectionApp22 Item: Title: References Destination: Section23 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 272 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 91 ImageHeight: 91 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 299 ColorSpace: RGB BitsPerSample: 8 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ONNNBO+AdvPAC3D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ONNIKF+AdvP4DF60E FontSubset: true FirstChar: 24 LastChar: 184 FontDescriptor: FontName: ONNIKF+AdvP4DF60E Flags: Serif, Symbolic FontBBox: -104, -239, 1041, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf 10.1016/j.seizure.2015.07.001 Efficacy and safety of lacosamide as first add-on or later adjunctive treatment for uncontrolled partial-onset seizures: A multicentre open-label trial Wendy Waldman Zadeh Antonio Escartin William Byrnes Frank Tennigkeit Simon Borghs Ting Li Peter Dedeken Marc De Backer on behalf of the SP0954 Study Group1 Focal epilepsy Quality of life Seizure freedom Lacosamide Seizure: European Journal of Epilepsy, 31 (2015) 72-79. doi:10.1016/j.seizure.2015.07.001 BEA Trading Ltd journal Seizure: European Journal of Epilepsy © 2015 The Authors Published by Elsevier Ltd on behalf of British Epilepsy Association All rights reserved. 1059-1311 31 September 2015 2015-09 72-79 72 79 10.1016/j.seizure.2015.07.001 http://dx.doi.org/10.1016/j.seizure.2015.07.001 2010-04-23 true 10.1016/j.seizure.2015.07.001 elsevier.com sciencedirect.com 10.1016/j.seizure.2015.07.001 noindex 2010-04-23 true elsevier.com sciencedirect.com sciencedirect.com elsevier.com Elsevier 2016-01-08T15:06:18+05:30 2015-08-31T15:55:06+05:30 2016-01-08T15:06:18+05:30 True True Acrobat Distiller 9.0.0 (Windows) uuid:6cb66e73-1c7b-40f2-9305-92b04746cd2a uuid:4b7755cd-9024-43d3-a6c9-685a9c2d24ad Pages: Page: Label: 72 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 497, 604, 553, 629 Flags: Print Annotation: Subtype: Link Rect: 497, 604, 553, 629 Flags: Print Annotation: Subtype: Link Rect: 157, 561, 161, 572 Flags: Print Destination: 304 Annotation: Subtype: Link Rect: 163, 559, 168, 569 Flags: Print Destination: 304 Annotation: Subtype: Link Rect: 260, 561, 265, 572 Flags: Print Destination: 304 Annotation: 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