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García Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Jan 17 00:11:21 2015 CET ModDate: Wed Oct 19 02:16:33 2016 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2711930 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IJBFPI+AdvPSAD5A Type 1C MacRoman yes yes no 1388 0 IJBGGP+AdvP2A83 Type 1C WinAnsi yes yes no 1365 0 IJBGJO+AdvPSSym Type 1C WinAnsi yes yes no 1389 0 IJBGJP+AdvPSA708 Type 1C WinAnsi yes yes no 1387 0 IJBFPJ+AdvPS44A44B Type 1C WinAnsi yes yes no 1386 0 IJBFPK+AdvCaeciliaBdIt Type 1C MacRoman yes yes no 1391 0 IJBFPL+AdvP4C4E59 Type 1C Custom yes yes yes 1385 0 IJBFPM+AdvCaeciliaRm Type 1C MacRoman yes yes no 1384 0 IJBFPN+AdvCaeciliaIt Type 1C MacRoman yes yes no 1383 0 IJBGAO+AdvP4C4E74 Type 1C Custom yes yes yes 1382 0 IJBGGN+AdvOTb214af43 Type 1C WinAnsi yes yes no 1364 0 IJBGGO+AdvOTf7c366b2.B Type 1C WinAnsi yes yes no 1363 0 IJBGKA+AdvPS3FDD77 Type 1C WinAnsi yes yes no 1070 0 IJBGLB+AdvP4C4E51 Type 1C WinAnsi yes yes no 1072 0 IJBGMC+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1071 0 IJBGMD+AdvCaeciliaBd Type 1C WinAnsi yes yes no 1073 0 IJBKKK+AdvPSAD5B Type 1C WinAnsi yes yes no 1074 0 IJCCFJ+AdvPS7DED Type 1C WinAnsi yes yes no 181 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-07 03:05:59 CEST RepresentationInformation: 300242.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-06 16:05:25 CEST Size: 2711930 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 2677184 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1439 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Deletion at 6q24.2–26 predicts longer survival of high-grade serous epithelial ovarian cancer patients Destination: titlink1 Children: Item: Title: 1. Introduction Destination: flink1 Item: Title: 2. Materials and methods Destination: flink2 Children: Item: Title: 2.1. Patients and tumors Destination: slink1 Item: Title: 2.2. Independent validation series Destination: slink2 Item: Title: 2.3. Immunohistochemistry Destination: slink3 Item: Title: 2.4. Definition of regions differentiating DNA copy number-based clusters Destination: slink4 Item: Title: 2.5. Association of defined regions with survival Destination: slink5 Item: Title: 2.6. Validation by fluorescence in situ hybridization (FISH) Destination: slink6 Item: Title: 2.7. Validation at the global gene expression level Destination: slink7 Item: Title: 2.8. Definition of candidate genes at 6q24–q26 Destination: slink8 Item: Title: 2.9. Statistical analyses Destination: slink9 Item: Title: 3. Results Destination: flink3 Children: Item: Title: 3.1. Immunohistochemical characterization of DNA copy number-based tumor clusters Destination: slink10 Item: Title: 3.2. DNA copy number-based tumor clusters and survival Destination: slink11 Item: Title: 3.3. Validation of the prognostic value of 6q24.2–q26 in an independent ovarian cancer series by FISH analysis Destination: slink12 Item: Title: 3.4. Validation of the prognostic value of the 6q24–26 deletion in the TCGA ovarian cancer series Destination: slink13 Item: Title: 3.5. Expression of genes at 6q24.2–q26 and survival Destination: slink14 Item: Title: 4. Discussion Destination: flink4 Item: Title: 5. Conclusions Destination: flink5 Item: Title: Conflict of interests Destination: flink6 Item: Title: Acknowledgments Destination: aclink2 Item: Title: Appendix A. Supplementary data Destination: flink7 Item: Title: References Destination: blink1 Info: Title: Deletion at 6q24.2 26 predicts longer survival of high-grade serous epithelial ovarian cancer patients Author: Marta M. Kamieniak, Daniel Rico, Roger L. Milne, Ivan Muñoz-Repeto, Kristina Ibáñez, Miguel A. Grillo, Samuel Domingo, Salud Borrego, Alicia Cazorla, José M. García-Bueno, Susana Hernando, Jesús García-Donas, Elena Hernández-Agudo, Teresa Ramón y Cajal, Luis Robles-Díaz, Ivan Márquez-Rodas, Maite Cusidó, Raquel Sáez, Carmen Lacambra-Calvet, Ana Osorio, Miguel Urioste, Juan C. Cigudosa, Luis Paz-Ares, José Palacios, Javier Benítez, María J. García Subject: Keywords: 10.1016/j.molonc.2014.09.010 and HGSOC; CGH; Survival; 6q24.2 26 deletion; Prognosis Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Jan 17 00:41:21 CET 2015 ModDate: Wed Oct 19 02:16:33 CEST 2016 ID: 0x25717ed750e67a0698b5c52cbf680fb9, 0xa41476304669c65e40e92aca7e51e545 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 108 ImageHeight: 108 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 296 ImageHeight: 367 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1889 ImageHeight: 2587 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1652 ImageHeight: 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Kamieniak, Daniel Rico, Roger L. Milne, Ivan Muñoz-Repeto, Kristina Ibáñez, Miguel A. Grillo, Samuel Domingo, Salud Borrego, Alicia Cazorla, José M. García-Bueno, Susana Hernando, Jesús García-Donas, Elena Hernández-Agudo, Teresa Ramón y Cajal, Luis Robles-Díaz, Ivan Márquez-Rodas, Maite Cusidó, Raquel Sáez, Carmen Lacambra-Calvet, Ana Osorio, Miguel Urioste, Juan C. Cigudosa, Luis Paz-Ares, José Palacios, Javier Benítez, María J. 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