c3647b631a12653f0f1891fc60b8ec61 300268.pdf 3ff9ed61376eb81d3c45284ecc3b0822624cc000 300268.pdf 6a00230f76081c80c10338cea0c038b0af449806d3d706232dcc56274deedaa6 300268.pdf Title: Subject: Parkinson's Disease Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sun Feb 22 09:18:27 2015 CET ModDate: Sun Mar 8 08:11:25 2015 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 600.05 x 792 pts Page rot: 0 File size: 585284 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-It Type 1C Custom yes no yes 14 0 Minion-Black Type 1C WinAnsi yes no no 15 0 MinionPro-Regular Type 1C Custom yes no yes 16 0 MinionMath-Regular Type 1C Custom yes no yes 17 0 JECTLG+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 MinionMath-Capt Type 1C WinAnsi yes no no 56 0 MinionPro-Regular Type 1C WinAnsi yes no no 57 0 MinionMath-Regular-Graphic Type 1C WinAnsi yes no no 58 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-13 02:58:17 CEST RepresentationInformation: 300268.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-12 20:34:20 CEST Size: 585284 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 133 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: Author: Subject: Parkinson's Disease Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sun Feb 22 09:18:27 CET 2015 ModDate: Sun Mar 08 08:11:25 CET 2015 ID: 0x9df8809e36ac8a7785a709b132f8aa0a, 0x44461d78baa96a7f2ab0a258d6275597 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: JECTLG+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Regular Flags: Symbolic FontBBox: 45, -12, 424, 635 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-Capt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Capt Flags: Nonsymbolic FontBBox: 55, -23, 556, 548 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionMath-Regular-Graphic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Regular-Graphic Flags: Nonsymbolic FontBBox: 48, -12, 431, 623 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Minion-Black FirstChar: 0 LastChar: 241 FontDescriptor: FontName: Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: JECTLG+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JECTLG+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfTransdermal Rotigotine Improves Sleep Fragmentation in Parkinson’s Disease: Results of the Multicenter, Prospective SLEEP-FRAM StudyPagonabarraga, JavierPiñol, GerardCardozo, AdrianaSanz, PilarPuente, VíctorOtermín, PilarLegarda, InésDelgado, TaniaSerrano, CarmenBalaguer, ErnestAguirregomozcorta, MaríaÁlvarez, RamiroKulisevsky, Jaime J.Sleep disturbances occur frequently in patients with Parkinson’s disease (PD). The aim of this study was to investigate the effects of rotigotine on sleep fluctuations in a sample of PD patients with self-reported complaints of nocturnal awakenings. This prospective, open-label, observational, and multicenter study enrolled consecutive outpatients with PD and administered rotigotine (mean dose 8.9 mg/day) for 3 months. The primary endpoint was the change from baseline in sleep fragmentation, assessed using the sleep maintenance subscale score of the Parkinson’s Disease Sleep Scale (PDSS). The newly designed Parkinson’s Disease Sleep Fragmentation Questionnaire (PD-SFQ) was used to measure other sleep parameters. A total of 62 patients were enrolled (mean age 70.2 years; 66% male). At 3 months, rotigotine significantly improved sleep fragmentation from baseline on the PDSS-2 sleep maintenance subscale (from 3.4±0.9 to 1.9±1.4; P<0.0001). Rotigotine also significantly improved nocturnal motor symptoms P<0.0001, restless legs-like symptoms P<0.005, and nocturia P=0.004. Rotigotine significantly improved self-reported complaints of sleep fragmentation in PD patients and could be a useful treatment to improve this specific sleep problem in PD. However, these results are based on a small and clinically heterogeneous sample so they must be taken cautiously.Parkinson’s DiseaseHindawi Publishing Corporation2015/02/22Research articledoi:10.1155/2015/131508en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 50, 705, 171, 713 Page: Label: 2 Page: Label: 3 Page: Label: 4 Page: Label: 5 Page: Label: 6 Page: Label: 7 Checksum: 9b983895 Type: CRC32 Checksum: c3647b631a12653f0f1891fc60b8ec61 Type: MD5 Checksum: 3ff9ed61376eb81d3c45284ecc3b0822624cc000 Type: SHA-1 Checksum: 6a00230f76081c80c10338cea0c038b0af449806d3d706232dcc56274deedaa6 Type: SHA-256