7b9d0fe99476f05fc800161ac4be4e46 pmc_25625276.pdf 2ff04d3dc5c7fa4bb8cc7054ea8d68e98263962f pmc_25625276.pdf 36692da6f7f987aed221d4cfd4931f937a2dc5289a5c0a2a744336853765bb0c pmc_25625276.pdf Title: A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies Subject: British Journal of Cancer 112, 650 (2015). doi:10.1038/bjc.2014.653 Author: A Spreafico Creator: Arbortext Advanced Print Publisher 9.0.226/W Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Jan 30 19:41:17 2015 CET ModDate: Thu Feb 5 11:02:02 2015 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 436855 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FPCMBM+AdvOT3b9b4d35 Type 1C WinAnsi yes yes no 356 0 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yes yes no 164 0 FPDAKK+AdvOT8f428072.I Type 1C WinAnsi yes yes no 165 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-05-07 04:58:36 CEST RepresentationInformation: pmc_25625276.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-01-31 06:19:01 CET Size: 436855 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 379 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: title_link Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Children: Item: Title: Patient selection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Study design and dosing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: HSP990 formulation and administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Safety and efficacy assessments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: PK assessments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: PD assessments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: Exploratory functional imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Statistical methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: Patient characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Table 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Children: Item: Title: Dose escalation and MTD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Treatment exposure, dose delay and dose modifications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Table 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Children: Item: Title: PK analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: PD analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Response evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: FDG-PET imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: Table 3 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Table 4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Figure™1Median concentration-time profiles for plasma HSP990 on day 1 of cycle 1 (A) and day 22 of cycle 1 (B) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Table 5 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: A4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612 Item: Title: A5 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1055e4af Item: Title: A6 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3caeaf62 Info: Title: A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies Author: A 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