854d36696353cdf5188995a97b2dc0d3 pmc_25649611.pdf 35b53dd7d07d9c8579c104a57aab481c5441390e pmc_25649611.pdf a3672ced72dc8a1d45cfbe0d5ac27db7e1d81bfacbaa533697d5f1188ae4ec80 pmc_25649611.pdf Title: Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT Subject: Nature Communications 6, (2015). doi:10.1038/ncomms7177 Author: Klaus Wimmer Creator: Arbortext Advanced Print Publisher 9.0.226/W Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Jan 27 17:33:40 2015 CET ModDate: Thu Jan 29 10:04:17 2015 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1942326 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DJCNKJ+AdvOTea1a7398 Type 1C Custom yes yes yes 561 0 DJCNLJ+AdvOTcb88df00 Type 1C Custom yes yes yes 569 0 DJCOEH+Arial-BoldMT Type 1C WinAnsi yes yes no 570 0 DJCOLF+AdvOTf23bb480 Type 1C Custom yes yes yes 571 0 DJDBGG+AdvTTda6f6cb8.B Type 1C Custom yes yes yes 581 0 DJDBGH+AdvTA42 Type 1C Custom yes yes yes 582 0 DJDBHH+AdvPAD33 Type 1C WinAnsi yes yes no 583 0 DJDBHI+AdvPAD35 Type 1C WinAnsi yes yes no 584 0 DJDEGK+AdvOTb65e897d.B Type 1C Custom yes yes yes 319 0 DJDEEI+AdvOT125c650c Type 1C Custom yes yes yes 320 0 DJDEEJ+AdvOT1ef757c0 Type 1C Custom yes yes yes 321 0 DJDEGJ+AdvEls-ent4 Type 1C WinAnsi yes yes no 326 0 DJFNAC+Helvetica Type 1C Custom yes yes no 338 0 MathPackTen Type 1C Custom yes no no 339 0 DJFNGC+Helvetica-Oblique Type 1C WinAnsi yes yes no 336 0 DJGEPE+AdvOT9bd21c25.I Type 1C Custom yes yes yes 341 0 DJGEPF+AdvPi2 Type 1C WinAnsi yes yes no 342 0 DJGFDF+AdvP4C4E74 Type 1C Custom yes yes yes 353 0 DJGKLE+AdvOT7d6df7ab.I Type 1C Custom yes yes yes 358 0 DJGKLF+AdvItcSymbol-M Type 1C WinAnsi yes yes no 362 0 DJHAEE+AdvEls-ent7 Type 1C WinAnsi yes yes no 370 0 DJHAFE+AdvPi1 Type 1C WinAnsi yes yes no 375 0 DJKOAK+AdvP4C4E51 Type 1C Custom yes yes yes 382 0 DJKOGJ+AdvP4C4E46 Type 1C Custom yes yes yes 383 0 DJKPBG+Advsymbol Type 1C Custom yes yes no 389 0 DJKPFF+AdvP4C4E59 Type 1C Custom yes yes yes 390 0 DJKPHG+AdvEls-ent5 Type 1C WinAnsi yes yes no 392 0 DJLAMO+AdvTimes-i Type 1C Custom yes yes yes 394 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-02 02:43:10 CET RepresentationInformation: pmc_25649611.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-31 06:18:40 CET Size: 1942326 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 615 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: title_link Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Mechanisms underlying correlations and CP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Figure™1Model architecture and single-trial response.(a) Network model composed of a sensory circuit (MT) with two opposite stimulus-selective excitatory populations E1 and E2 that are coupled to two choice-associated populations D1 and D2 in an integrati Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Figure™2Impact of bottom-up and top-down correlations on choice probability.(a-c) Network without top-down connections receiving non-replicate zero-coherence stimuli that cause bottom-up correlations (see Methods and Supplementary Fig.™1; bFB=0, sgr=1). A Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: CP in MT during a motion discrimination task Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Figure™3Bottom-up correlations together with top-down signals can lead to sustained CP and a decaying psychophysical kernel.(a) CP obtained in the network with top-down connections receiving non-replicate stimuli (sgr=1, bFB=1; black) is sustained through Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Stability of individual CPs increases through the trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Figure™4Stimulus fluctuations impact neuronal variability and reveal a bottom-up component of choice probability in MT.Left panels show the time-course of the spike count Fano factor (a), spike count correlation (b) and CP (c) obtained from responses to n Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Figure™5Heterogeneity of individual choice probabilities reveals increased stability towards the end of the stimulus interval.(a,b) Individual CP traces of four example cells (a) and CP correlation matrix C(ti, tj) (b) obtained from the homogeneous networ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: Lagged correlations predict late CP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Top-down feedback enhances the stability of the categorization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Figure™6MT neuron pairs with rising lagged correlations exhibit enhanced late CP.(a-c) Spike count correlations obtained from neuron pairs in the homogeneous network with bottom-up correlations but no top-down inputs (a), with top-down inputs and no botto Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Figure™7Top-down inputs strengthen the categorization dynamics and increase their stability.(a,b) Spike rastergram and population rates of the decision populations D1 and D2 (240+240 neurons) during an example trial for the network without (a) and with (b Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Network model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Simulation details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Physiological data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Spike count statistics and choice probabilities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Psychophysical data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Psychophysical reverse correlation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: GoldJ. I.ShadlenM. N.The neural basis of decision makingAnnu. Rev. Neurosci.305355742007BrittenK. H.NewsomeW. T.ShadlenM. N.CelebriniS.MovshonJ. A.A relationship between behavioral choice and the visual responses of neurons in macaque MTVis. Neurosci.1387 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: We thank K.H. Britten, J.A. Movshon, W.T. Newsome, M.N. Shadlen and E. Zohary for making their data available in the ’Neural Signal ArchiveCloseCurlyQuote (http://www.neuralsignal.org/), and W. Bair for maintaining this database. We thank B. Cumming, H. 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-31, -187, 968, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DJKOAK+AdvP4C4E51 FontSubset: true FirstChar: 58 LastChar: 61 FontDescriptor: FontName: DJKOAK+AdvP4C4E51 Flags: Symbolic FontBBox: -31, -239, 1041, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DJDEGK+AdvOTb65e897d.B FontSubset: true FirstChar: 44 LastChar: 147 FontDescriptor: FontName: DJDEGK+AdvOTb65e897d.B Flags: Serif, Symbolic FontBBox: -125, -250, 1052, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DJKOGJ+AdvP4C4E46 FontSubset: true FirstChar: 2 LastChar: 113 FontDescriptor: FontName: DJKOGJ+AdvP4C4E46 Flags: Serif, Symbolic FontBBox: -15, -1760, 1387, 40 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/ncomms7177 Klaus Wimmer Albert Compte Alex Roxin Diogo Peixoto Alfonso Renart Jaime de la Rocha Nature Communications 6, (2015). doi:10.1038/ncomms7177 Nature Publishing Group © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT Acrobat Distiller 8.1.0 (Windows) © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. 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