85dc36c2dac90795aae8c2b941a10403 pmc_25675299.pdf 5048af7196e658df8020d933b511e1dc799daf42 pmc_25675299.pdf 7cd3869596de0657f1dc2fa2ecd550b955a7ead55b660ce8179b6c731984d6fd pmc_25675299.pdf Title: Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death Subject: Cell Death and Disease 6, e1639 (2015). doi:10.1038/cddis.2015.6 Author: P Carriba Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Tue Feb 3 13:57:58 2015 CET ModDate: Wed Feb 4 16:50:02 2015 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2549709 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HGNDFB+AdvOT7a027dc5.I Type 1C WinAnsi yes yes no 441 0 HGNDGB+AdvTT9ae090ab+20 Type 1C WinAnsi yes yes no 449 0 HGNDGC+AdvOTdd3b7348.I+03 Type 1C Custom yes yes yes 452 0 HGNDGD+AdvOTa3d784f0.B Type 1C WinAnsi yes yes no 458 0 HGNDGE+AdvTA42 Type 1C WinAnsi yes yes no 459 0 HGNDHF+AdvOT0d516f6c Type 1C WinAnsi yes yes no 460 0 HGNDBH+Arial-BoldMT Type 1C WinAnsi yes yes no 418 0 HGNDCH+AdvOTf3919c9c.B Type 1C WinAnsi yes yes no 412 0 HGNDCI+AdvOTd0125be5.BI+03 Type 1C Custom yes yes yes 420 0 HGNDDJ+AdvTT53da3183.B Type 1C WinAnsi yes yes no 421 0 HGNDDK+AdvTT53da3183.B+20 Type 1C WinAnsi yes yes no 422 0 HGNDDL+AdvOT8244d044.BI+03 Type 1C Custom yes yes yes 423 0 HGNDDM+AdvTT35c34d66.I Type 1C WinAnsi yes yes no 437 0 HGNDDN+AdvTT9ae090ab Type 1C WinAnsi yes yes no 438 0 HGNDEO+AdvOT82c4f4c4 Type 1C WinAnsi yes yes no 433 0 HGNDEP+AdvOT82c4f4c4+20 Type 1C WinAnsi yes yes no 432 0 HGNDFA+AdvOT65f8a23b.I+03 Type 1C Custom yes yes yes 447 0 HGNEAD+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 206 0 HGNEIB+AdvOT374f033f.I Type 1C WinAnsi yes yes no 199 0 HGNEJB+AdvOT3bf1a849.B Type 1C WinAnsi yes yes no 196 0 HGOLFG+AdvEls-ent4 Type 1C WinAnsi yes yes no 212 0 HGOLFH+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 209 0 HHHHOJ+AdvOT8b40f9c2.B Type 1C WinAnsi yes yes no 213 0 HHHIHG+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 214 0 HHHLOC+AdvTT1f293b63.BI Type 1C WinAnsi yes yes no 215 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:49:13 CEST RepresentationInformation: pmc_25675299.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-31 06:18:13 CET Size: 2549709 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bm_b67' cannot be found Offset: 2529029 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b29' cannot be found Offset: 2529029 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b32' cannot be found Offset: 2529029 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b23' cannot be found Offset: 2529029 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b23' cannot be found Offset: 2529029 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b68' cannot be found Offset: 2529029 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b23' cannot be found Offset: 2529029 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 487 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: title_link Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: FAIM-L is reduced in hippocampal samples from AD patients and in the entorhinal and hippocampal cortex in the transgenic PS1xA倀倀 洀漀甀猀攩㸾൥湤潢樍㈴㘠〠潢樍㰼⽐慲敮琠㈱㠠〠刯䑥獴⣾＀䈀㐩⽐牥瘠㈴㜠〠刯呩瑬攨FAIM-L is required for the protective effect of TNFα against Aβ-induced neuronal death Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Aβ reduces the expression of FAIM-L Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: FAIM-L does not modify Aβ toxicity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: FAIM-L is required for the protective effect of TNFα against Aβ-induced neuronal death Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Figure 1 Decrease in FAIM-L expression in hippocampal samples from AD patients. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Figure 2 Reduction of FAIM-L expression in transgenic PS1xAPP animals. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: FAIM-L expression is not regulated by TNFα Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Reduction of FAIM-L by Aβ suppresses the protective action of TNFα Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Figure 2 Reduction of FAIM-L expression in transgenic PS1xAPP animals. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Figure 4 Amyloid-β reduces FAIM-L levels. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Figure 5 FAIM-L does not modulate Aβ toxicity. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Figure 6 FAIM-L is necessary for TNFα protection against Aβ-induced death. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Figure 7 TNFα does not modulate the expression of FAIM-L. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Figure 8 The reduction of FAIM-L by Aβ impedes TNFα protection. Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Human samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: PS1M146LxAPP751sl transgenic mouse samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Table 1 Human samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Primary cortical culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Quantitative PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Lentiviral particles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Cell viability assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Western blot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Animal ethics committees Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Info: Title: Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death Author: P Carriba Subject: Cell Death and Disease 6, e1639 (2015). doi:10.1038/cddis.2015.6 Creator: Arbortext 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-135, -218, 770, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HGNDFB+AdvOT7a027dc5.I FontSubset: true FirstChar: 65 LastChar: 118 FontDescriptor: FontName: HGNDFB+AdvOT7a027dc5.I Flags: Nonsymbolic FontBBox: -166, -218, 1093, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HGNDFA+AdvOT65f8a23b.I+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: HGNDFA+AdvOT65f8a23b.I+03 Flags: Symbolic FontBBox: -72, -208, 760, 802 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/cddis.2015.6 P Carriba S Jimenez V Navarro I Moreno-Gonzalez B Barneda-Zahonero R S Moubarak J Lopez-Soriano A Gutierrez J Vitorica J X Comella Cell Death and Disease 6, e1639 (2015). doi:10.1038/cddis.2015.6 Nature Publishing Group © 2015 Macmillan Publishers Limited Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death Acrobat 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