68478048aef3c97fd177568201e73574 pmc_25705176.pdf a5acaef0879733d088057317ae0a3ec4ca87cf37 pmc_25705176.pdf 644d4b6163d46c5e94e084db752f9c524f88ac6e16ac6514e74c00358fe63fff pmc_25705176.pdf Title: Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease Subject: Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer's disease (AD). Keywords: Alzheimer disease, 3xTg-AD mice, choroid plexus, dysfunction, amyloid-β, collagen-IV, transthyretin, aquaporin-1 Author: Rafael Castro-Fuentes Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Wed Feb 4 08:30:15 2015 CET ModDate: Wed Feb 4 10:21:56 2015 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1839488 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MGBZTS+Minion-Italic Type 1 Custom yes yes no 546 0 ELWPSO+Univers-Black Type 1 Custom yes yes no 547 0 HQVHWJ+Univers-Light Type 1 Custom yes yes no 548 0 CEGZQI+Univers Type 1 Custom yes yes no 549 0 JLSSRO+Univers-BoldOblique Type 1 Custom yes yes no 550 0 ONPUNA+Univers-LightOblique Type 1 Custom yes yes no 551 0 MISHUY+MTGU Type 1 Builtin yes yes no 552 0 AFLENN+Univers-Bold Type 1 Custom yes yes no 553 0 WLTEQU+MTGUB Type 1 Builtin yes yes no 554 0 YEDRGH+Univers-CondensedBold Type 1 Custom yes yes no 555 0 OHXKCV+Minion-Regular Type 1 Custom yes yes no 556 0 ELWPSO+Univers-Black Type 1 Custom yes yes no 588 0 EIONFW+MTSYN Type 1 Builtin yes yes no 287 0 IACHMT+Minion-Bold Type 1 Custom yes yes no 291 0 JKHHUW+RMTMI Type 1 Builtin yes yes no 294 0 LTZATI+MTSY Type 1 Builtin yes yes no 300 0 LWHAQO+Minion-BoldItalic Type 1 Custom yes yes no 301 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-03-20 04:54:25 CET RepresentationInformation: pmc_25705176.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-01-31 06:17:59 CET Size: 1839488 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 680 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease Children: Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Animal model of AD Item: Title: Immunofluorescence Item: Title: Collagen-IV immunohistochemistry Item: Title: Quantification of immunostaining Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Amyloid-beta distribution in CP of 3xTg-AD and Non-Tg mice Item: Title: LRP1 and RAGE expression in CP epithelium Item: Title: Collagen-IV deposition in CP basement membrane Item: Title: AQP-1 and TTR expression in CP Item: Title: Discussion Children: Item: Title: Choroid epithelial cell A Item: Title: A transporters in CP Item: Title: A uptake from CSF by CP Item: Title: Metabolic processing of CP A Item: Title: Do plasma increased A and soluble LRP1 also affect CP-CSF A? Item: Title: Altered basement membranes in the BCSFB and BBB of 3xTg-AD mice Item: Title: CSF bulk flow attenuation: reduced excretion of CSF A Item: Title: Lower expression of CP transthyretin: implications for reduced A removal Item: Title: Conclusions Item: Title: Acknowledgments Item: Title: References Info: Title: Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease Subject: Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumul愀琀椀漀渀 漀昀 戀攀琀愀ⴀ愀洀礀氀漀椀搀 䄃눀 瀀攀瀀琀椀搀攀猀 愀琀 琀栀攀 戀氀漀漀搀ⴀ䌀匀䘀 戀愀爀爀椀攀爀 䈀䌀匀䘀䈀Ⰰ 挀漀渀琀爀椀戀甀琀攀 琀漀 挀漀洀瀀氀椀挀愀琀椀漀渀猀 漀昀 䄀氀稀栀攀椀洀攀爀✀猀 搀椀猀攀愀猀攀 䄀䐀ഀ⸩⽁畴桯爨剡晡敬⁃慳瑲漭䙵敮瑥猩⽃牥慴潲⡌慔敘⁷楴栠桹灥牲敦⁰慣歡来 Keywords: Alzheimer disease, 3xTg-AD mice, choroid plexus, dysfunction, amyloid-β, collagen-IV, transthyretin, aquaporin-1 Producer: pdfTeX-1.40.12 CreationDate: Wed Feb 04 09:00:15 CET 2015 ModDate: Wed Feb 04 10:51:56 CET 2015 ID: 0x43bf361ba4005624f617060929ed40c0, 0xa3c582f74016804899d9da0f8e29eb03 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: MGBZTS+Minion-Italic FontSubset: true FirstChar: 39 LastChar: 241 FontDescriptor: FontName: MGBZTS+Minion-Italic Flags: Symbolic FontBBox: -139, -250, 1101, 812 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ELWPSO+Univers-Black FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: ELWPSO+Univers-Black Flags: Symbolic FontBBox: -153, -250, 992, 986 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IACHMT+Minion-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: IACHMT+Minion-Bold Flags: Symbolic FontBBox: -148, -250, 1147, 830 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HQVHWJ+Univers-Light FontSubset: true FirstChar: 2 LastChar: 225 FontDescriptor: FontName: HQVHWJ+Univers-Light Flags: Symbolic FontBBox: -151, -250, 1000, 957 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CEGZQI+Univers FontSubset: true FirstChar: 39 LastChar: 122 FontDescriptor: FontName: CEGZQI+Univers Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JLSSRO+Univers-BoldOblique FontSubset: true FirstChar: 42 LastChar: 241 FontDescriptor: FontName: JLSSRO+Univers-BoldOblique Flags: Symbolic FontBBox: -167, -250, 995, 938 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JKHHUW+RMTMI FontSubset: true FirstChar: 11 LastChar: 60 FontDescriptor: FontName: JKHHUW+RMTMI Flags: Symbolic FontBBox: 0, -213, 987, 680 FontFile: true Font: BaseFont: ONPUNA+Univers-LightOblique FontSubset: true FirstChar: 40 LastChar: 233 FontDescriptor: FontName: ONPUNA+Univers-LightOblique Flags: Symbolic FontBBox: -151, -250, 1000, 957 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MISHUY+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: MISHUY+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: AFLENN+Univers-Bold FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: AFLENN+Univers-Bold Flags: Symbolic FontBBox: -167, -250, 995, 938 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WLTEQU+MTGUB FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: WLTEQU+MTGUB Flags: Symbolic FontBBox: 0, -205, 879, 699 FontFile: true Font: BaseFont: YEDRGH+Univers-CondensedBold FontSubset: true FirstChar: 45 LastChar: 120 FontDescriptor: FontName: YEDRGH+Univers-CondensedBold Flags: Symbolic FontBBox: -83, -250, 1000, 969 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OHXKCV+Minion-Regular FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: OHXKCV+Minion-Regular Flags: Symbolic FontBBox: -141, -250, 1104, 812 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LTZATI+MTSY FontSubset: true FirstChar: 6 LastChar: 6 FontDescriptor: FontName: LTZATI+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile: true Font: BaseFont: LWHAQO+Minion-BoldItalic FontSubset: true FirstChar: 57 LastChar: 57 FontDescriptor: FontName: LWHAQO+Minion-BoldItalic Flags: Symbolic FontBBox: -189, -250, 1148, 821 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EIONFW+MTSYN FontSubset: true FirstChar: 3 LastChar: 24 FontDescriptor: FontName: EIONFW+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true XMP: 2015-02-04T13:00:15+05:30 LaTeX with hyperref package 2015-02-04T14:51:56+05:30 2015-02-04T14:51:56+05:30 application/pdf Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer's disease (AD). 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