5d6bdb574d9373e0974dc6a8dcf03744 pmc_25781069.pdf e9ce1507c60cf0de77564ffde1b8752fbce0e87a pmc_25781069.pdf 118a04666d236ae4f987bee7f584d3d0bfee591b488b15a068291dd42112cb8f pmc_25781069.pdf Title: Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases Subject: Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers’ attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases. Keywords: olive oil; phenolic compounds; hydroxytyrosol; tyrosol; neurodegenerative diseases; prevention; neuroprotective agents Author: Jose Rodríguez-Morató, Laura Xicota, Montse Fitó, Magí Farré, Mara Dierssen, Rafael de la Torre Creator: Microsoft® Word 2013 Producer: Microsoft® Word 2013 CreationDate: Thu Mar 19 13:03:32 2015 CET ModDate: Thu Mar 19 13:05:07 2015 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 26 Encrypted: no Page size: 595.62 x 841.68 pts Page rot: 0 File size: 575743 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Times New Roman TrueType WinAnsi no no no 5 0 Times New Roman,Italic TrueType WinAnsi no no no 7 0 Times New Roman,Bold TrueType WinAnsi no no no 9 0 Times New Roman,BoldItalic TrueType WinAnsi no no no 11 0 Times New Roman CID TrueType Identity-H yes no yes 13 0 Times New Roman,Italic CID TrueType Identity-H yes no yes 52 0 Arial TrueType WinAnsi no no no 62 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2019-11-27 05:13:00 CET RepresentationInformation: pmc_25781069.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2019-01-14 03:36:30 CET Size: 575743 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: ISO PDF/A-1, Level B PDFMetadata: Objects: 97 FreeObjects: 2 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Language: en-US Info: Title: Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases Author: Jose Rodríguez-Morató, Laura Xicota, Montse Fitó, Magí Farré, Mara Dierssen, Rafael de la Torre Subject: Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers’ attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases. Keywords: olive oil; phenolic compounds; hydroxytyrosol; tyrosol; neurodegenerative diseases; prevention; neuroprotective agents Creator: Microsoft® Word 2013 Producer: Microsoft® Word 2013 CreationDate: Thu Mar 19 13:03:32 CET 2015 ModDate: Thu Mar 19 13:05:07 CET 2015 ID: 0xe781a14dd3dac04fb0896b7867ce32ef, 0xe3ff807953dae9429e0336e8d2a9ca49 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: Times New Roman,Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: Times New Roman Encoding: Identity-H ToUnicode: true TrueType: Font: Name: F1 BaseFont: Times New Roman FirstChar: 32 LastChar: 250 FontDescriptor: FontName: Times New Roman Flags: Nonsymbolic FontBBox: -568, -216, 2000, 693 Encoding: WinAnsiEncoding Font: Name: F2 BaseFont: Times New Roman,Italic FirstChar: 32 LastChar: 122 FontDescriptor: FontName: Times New Roman,Italic Flags: Nonsymbolic FontBBox: -498, -216, 1333, 694 Encoding: WinAnsiEncoding Font: Name: F3 BaseFont: Times New Roman,Bold FirstChar: 32 LastChar: 243 FontDescriptor: FontName: Times New Roman,Bold Flags: Nonsymbolic FontBBox: -558, -216, 2000, 677 Encoding: WinAnsiEncoding Font: Name: F4 BaseFont: Times New Roman,BoldItalic FirstChar: 32 LastChar: 117 FontDescriptor: FontName: Times New Roman,BoldItalic Flags: Nonsymbolic FontBBox: -547, -216, 1401, 677 Encoding: WinAnsiEncoding Font: Name: F7 BaseFont: Arial FirstChar: 32 LastChar: 32 FontDescriptor: FontName: Arial Flags: Nonsymbolic FontBBox: -665, -210, 2000, 728 Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: Times New Roman,Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: Times New Roman,Italic Flags: Nonsymbolic FontBBox: -498, -216, 1333, 694 FontFile2: true Font: BaseFont: Times New Roman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: Times New Roman Flags: Nonsymbolic FontBBox: -568, -216, 2000, 693 FontFile2: true XMP: application/pdf Jose Rodríguez-Morató, Laura Xicota, Montse Fitó, Magí Farré, Mara Dierssen, Rafael de la Torre Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers’ attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases. olive oil phenolic compounds hydroxytyrosol tyrosol neurodegenerative diseases prevention neuroprotective agents 2015-03-19T20:03:32+08:00 Microsoft® Word 2013 2015-03-19T20:05:07+08:00 2015-03-19T20:05:07+08:00 Microsoft® Word 2013 olive oil; phenolic compounds; hydroxytyrosol; tyrosol; neurodegenerative diseases; prevention; neuroprotective agents uuid:982154f2-bbde-4662-a56f-34d1c50e4c30 uuid:1703686e-6433-460b-a17d-d17dacaeecad Pages: Page: Sequence: 1 Page: Sequence: 2 Page: Sequence: 3 Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Page: Sequence: 7 Page: Sequence: 8 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Page: Sequence: 12 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Page: Sequence: 20 Page: Sequence: 21 Page: Sequence: 22 Page: Sequence: 23 Page: Sequence: 24 Page: Sequence: 25 Page: Sequence: 26 Checksum: a475f328 Type: CRC32 Checksum: 5d6bdb574d9373e0974dc6a8dcf03744 Type: MD5 Checksum: e9ce1507c60cf0de77564ffde1b8752fbce0e87a Type: SHA-1