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Invalid destination object Offset: 2933686 ErrorMessage: Invalid destination object Offset: 2933686 ErrorMessage: Invalid destination object Offset: 2933686 MIMEtype: application/pdf PDFMetadata: Objects: 491 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16f65612 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@311d617d Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Children: Item: Title: GPCR sequences retrieval and alignment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Construction of GPCRtm Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: Database searching and pairwise alignments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: Results and Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Children: Item: Title: Amino acid compositional bias in the rhodopsin family of GPCRs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: GPCRtm: a substitution matrix for the transmembrane regions of GPCRs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Functional similarities of amino acids in GPCRtm. Comparison with other matrices Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: Evaluation of the GPCRtm matrix Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Children: Item: Title: Availability of supporting data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Additional files Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Info: Title: GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors Author: Santiago Rios Subject: BMC Bioinformatics, 2015, doi:10.1186/s12859-015-0639-4 Keywords: Amino acid substitution matrix,G protein-coupled receptors,GPCR,Transmembrane,Evolution,Membrane protein Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Jun 27 12:20:04 CEST 2015 ModDate: Wed Jul 01 13:11:04 CEST 2015 ID: 0x6b171180fe2d895efd1e34dfbcfd2c48, 0x9784eab8c0e49154d5358b84e39bf703 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: 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modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) 2015-06-27 true 10.1186/s12859-015-0639-4 springer.com springerlink.com http://dx.doi.org/10.1186/s12859-015-0639-4 10.1186/s12859-015-0639-4 1471-2105 journal BMC Bioinformatics Rios et al. application/pdf 10.1186/s12859-015-0639-4 BMC Bioinformatics BMC Bioinformatics, 2015, doi:10.1186/s12859-015-0639-4 Amino acid substitution matrix G protein-coupled receptors GPCR Transmembrane Evolution Membrane protein GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors Santiago Rios Marta F. 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