8b24a42611c788a1c11ac7510f476bde pmc_26355258.pdf 0ef0ba18971baf36ae8bf12e1569b45b5e6a9d17 pmc_26355258.pdf 87b747dc79b26674507306ab691395b702bba04dc880313b505191ba7f52e16d pmc_26355258.pdf Title: 569714.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 19 10:25:25 2015 CEST ModDate: Wed Sep 2 08:05:40 2015 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 600.05 x 792 pts Page rot: 0 File size: 552337 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-It Type 1C Custom yes no yes 14 0 Minion-Black Type 1C WinAnsi yes no no 15 0 MinionPro-Regular Type 1C Custom yes no yes 16 0 MinionMath-Regular Type 1C Custom yes no yes 17 0 KQIWJG+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 MinionMath-Capt Type 1C Custom yes no no 45 0 MinionPro-Bold Type 1C WinAnsi yes no no 65 0 MinionPro-BoldCapt Type 1C WinAnsi yes no no 66 0 OEBJOB+MinionPro-Regular Type 1C WinAnsi yes yes no 67 0 MinionMath-Regular-Graphic Type 1C WinAnsi yes no no 68 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:45:01 CEST RepresentationInformation: pmc_26355258.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-31 06:01:15 CET Size: 552337 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 127 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: 569714.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 19 10:25:25 CEST 2015 ModDate: Wed Sep 02 08:05:40 CEST 2015 ID: 0x4231ad577b4f9f1fc28413b53340ec90, 0x10b1b711d613213a62a4f39c7289c48b Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: KQIWJG+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Regular Flags: Symbolic FontBBox: 12, -257, 570, 518 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Nonsymbolic, ForceBold FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-BoldCapt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-BoldCapt Flags: Nonsymbolic, ForceBold FontBBox: -327, -369, 1712, 1041 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OEBJOB+MinionPro-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: OEBJOB+MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionMath-Regular-Graphic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Regular-Graphic Flags: Nonsymbolic FontBBox: 34, -12, 443, 635 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionMath-Capt FirstChar: 0 LastChar: 53 FontDescriptor: FontName: MinionMath-Capt Flags: Nonsymbolic FontBBox: 32, 0, 446, 635 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Minion-Black FirstChar: 0 LastChar: 241 FontDescriptor: FontName: Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: KQIWJG+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KQIWJG+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfAn Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke SubtypesMuiño, ElenaKrupinski, JurekCarrera, CatyGallego-Fabrega, CristinaMontaner, JoanFernández-Cadenas, IsraelInflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke. Different genetic risk factors have been specifically associated with the subtypes of ischemic stroke (cardioembolic, atherothrombotic, and lacunar). However, there are no studies that have generated genetic risk scores for the different subtypes of ischemic stroke using polymorphisms associated with inflammation. Methods. We have analyzed 68 polymorphisms of 30 inflammatory mediator genes in 2,685 subjects: 1,987 stroke cases and 698 controls. We generated a genetic scoring system with the most significant polymorphisms weighted by the odds ratio of every polymorphism and taken into consideration the stroke subtype. Results. Three polymorphisms, rs1205 (CRP gene), rs1800779, and rs2257073 (NOS3 gene), were associated with cardioembolic stroke (p value <0.05). The score generated was only associated with the cardioembolic stroke subtype (p value: 0.001) and was replicated in an independent cohort (p value: 0.017). The subjects with the highest score presented a cardioembolic stroke in 92.2% of the cases (p value: 0.002). Conclusion. The genetics of inflammatory markers is more closely associated with cardioembolic strokes than with atherothrombotic or lacunar strokes. The genetic risk scoring system could be useful in the prediction and differentiation of ischemic stroke; however, it might be specific to particular ischemic stroke subtypes.Mediators of InflammationHindawi Publishing Corporation2015/08/19Research articledoi:10.1155/2015/569714en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 50, 705, 171, 713 Page: Label: 2 Page: Label: 3 Page: Label: 4 Page: Label: 5 Page: Label: 6 Page: Label: 7 Checksum: b56aaeec Type: CRC32 Checksum: 8b24a42611c788a1c11ac7510f476bde Type: MD5 Checksum: 0ef0ba18971baf36ae8bf12e1569b45b5e6a9d17 Type: SHA-1