365f440f116959bbcbb9ebf153a304ed pmc_26463438.pdf 30079fe7ec19c0e117437844ef2783f97ae7cec9 pmc_26463438.pdf 26bbc6cdac30bc0bf741d33f9b6fbc488ad98e3f35b94079eee6f9d393fa8d4e pmc_26463438.pdf Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Dec 16 04:42:01 2015 CET ModDate: Wed Dec 16 04:42:06 2015 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2366776 bytes Optimized: yes PDF version: 1.7 Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight Syntax Warning: Invalid Font Weight name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PGDSAU+National-Book Type 1C Custom yes yes yes 430 0 POMKQU+National-Bold Type 1C Custom yes yes yes 431 0 NLNYOY+QuadraatOT Type 1C Custom yes yes yes 442 0 EVXWSQ+QuadraatOT-Ita Type 1C Custom yes yes yes 443 0 XILBYE+National-Semibold Type 1C Custom yes yes yes 456 0 VFMPWI+National-Medium Type 1C WinAnsi yes yes yes 457 0 UGXJIK+National-Light Type 1C Custom yes yes yes 458 0 PGDSAU+National-Book Type 1C Custom yes yes yes 481 0 SDYXGO+National-LightItalic Type 1C WinAnsi yes yes yes 318 0 PGDSAU+National-Book Type 1C Custom yes yes yes 19 0 POMKQU+National-Bold Type 1C Custom yes yes yes 21 0 PGDSAU+National-Book Type 1C Custom yes yes yes 320 0 POMKQU+National-Bold Type 1C Custom yes yes yes 322 0 RZJRSQ+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 337 0 PWKFQU+National-BookItalic Type 1C Custom yes yes yes 341 0 PGDSAU+National-Book Type 1C Custom yes yes yes 329 0 POMKQU+National-Bold Type 1C Custom yes yes yes 327 0 VFMPWI+National-Medium Type 1C WinAnsi yes yes yes 343 0 PGDSAU+National-Book Type 1C Custom yes yes no 342 0 MPWNAA+National-BoldItalic Type 1C Custom yes yes yes 347 0 PGDSAU+National-Book Type 1C Custom yes yes no 352 0 VFMPWI+National-Medium Type 1C WinAnsi yes yes yes 348 0 JNIVKG+ArialMT TrueType WinAnsi yes yes no 351 0 PGDSAU+National-Book Type 1C Custom yes yes no 355 0 VFMPWI+National-Medium Type 1C WinAnsi yes yes yes 354 0 JNIVKG+ArialMT TrueType WinAnsi yes yes no 353 0 CAWFQU+National-Thin Type 1C WinAnsi yes yes yes 357 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 13:43:44 CEST RepresentationInformation: pmc_26463438.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-01-31 05:57:27 CET Size: 2366776 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 503 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients Children: Item: Title: ABSTRACT Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: 1. Patients and tumors Item: Title: 2. Immunohistochemical analysis Item: Title: 3. GTF2H5 immunohistochemical staining and survival Item: Title: 4. Validation at the global gene expression level Item: Title: 5. Evaluation of NER alterations in TCGA dataset Item: Title: 6. Cell lines and cultures Item: Title: 7. shRNA mediated GTF2H5 silencing in ovarian cancer cell lines Item: Title: 8. Real-time quantitative polymerase chain reaction Item: Title: 9. WST-1 cytotoxicity assay Item: Title: RESULTS Children: Item: Title: 1. IHC analysis of GTF2H5 expression Item: Title: 2. Low GTF2H5 IHC staining is associated with better survival in HGSOC Item: Title: 3. Decreased GTF2H5 expression levels are associated with better prognosis in a multi-institution HGSOC validation dataset Item: Title: 4. GTF2H5 low expression reinforces the recently described association of NER alterations with improved PFS in HGSOCs Item: Title: 5. GTF2H5 downregulation increases platinum sensitivity in HGSOC cell lines Item: Title: DISCUSSION Item: Title: ACKNOWLEDGMENTS Item: Title: REFERENCES Info: Creator: Adobe InDesign CC 2015 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Dec 16 04:42:01 CET 2015 ModDate: Wed Dec 16 04:42:06 CET 2015 ID: 0x947c0b2d107d4141be3b41dd10cfbb09, 0x9d94e31b751c034294506e6602d9177d Filters: FilterPipeline: FlateDecode FilterPipeline: JPXDecode Images: Image: NisoImageMetadata: FormatName: image/jpx ImageWidth: 99 ImageHeight: 99 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: JPXDecode Intent: RelativeColorimetric Decode: 0, 1, 0, 1, 0, 1 Name: X Image: NisoImageMetadata: FormatName: image/jpx ImageWidth: 1469 ImageHeight: 1001 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: JPXDecode Intent: RelativeColorimetric Decode: 0, 1, 0, 1, 0, 1 Name: X Fonts: Type0: Font: BaseFont: RZJRSQ+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: 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