f51ca356586ff9aecac66f680338ce6b  pmc_26503944.pdf
2bd3f9089bd82701b65a7d8b09420d84ab2c8c55  pmc_26503944.pdf
869fd0cc5a558e7bf3d0730473d656371b5fb7b09844fed1a7c2dbd14a87b8f7  pmc_26503944.pdf

Title:          untitled
Keywords:       
Creator:        Arbortext Advanced Print Publisher 10.0.1465/W Unicode
Producer:       Acrobat Distiller 10.0.0 (Windows)
CreationDate:   Thu Oct 22 07:10:28 2015 CEST
ModDate:        Mon Oct 26 11:27:38 2015 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      4460468 bytes
Optimized:      no
PDF version:    1.3

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EDNOKO+AdvOT6520a694                 Type 1C           WinAnsi          yes yes no     327  0
EDNPNA+AdvOT8608a8d1+25              Type 1C           Custom           yes yes yes    357  0
EDNOKP+AdvOT0231c847                 Type 1C           WinAnsi          yes yes no     329  0
EDNOLA+AdvOTc9c0ed35.B               Type 1C           WinAnsi          yes yes no     330  0
EDNOLB+AdvOT0231c847+20              Type 1C           WinAnsi          yes yes no     331  0
EDNPJM+AdvOTbe4cb9cb                 Type 1C           WinAnsi          yes yes no     353  0
EDNPJN+AdvTTb20e5d60                 Type 1C           WinAnsi          yes yes no     358  0
EDNPJO+AdvTTb20e5d60+fb              Type 1C           Custom           yes yes yes    350  0
EDNPJP+AdvTTb20e5d60+20              Type 1C           WinAnsi          yes yes no     351  0
EDNPMP+AdvTT9f195b36.B               Type 1C           WinAnsi          yes yes no     352  0
EDOJJB+AdvTTb2d6d9f8.I               Type 1C           WinAnsi          yes yes no     166  0
EDOJJC+AdvOT8608a8d1+22              Type 1C           Custom           yes yes yes    161  0
EDPBIP+AdvOT6520a694+fb              Type 1C           Custom           yes yes yes    156  0
EDPBJA+AdvOT0c2f268a.I               Type 1C           WinAnsi          yes yes no     153  0
EDPBJB+AdvOT6520a694+20              Type 1C           WinAnsi          yes yes no     169  0
EDPBKB+AdvP4C4E74                    Type 1C           WinAnsi          yes yes no     170  0
EDPPCJ+AdvOT0231c847+fb              Type 1C           Custom           yes yes yes    171  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-05-10 04:57:53 CEST
 RepresentationInformation: pmc_26503944.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-01-31 05:56:28 CET
  Size: 4460468
  Format: PDF
  Version: 1.3
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  ErrorMessage: Invalid destination object
   Offset: 4439551
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 599
   FreeObjects: 2
   IncrementalUpdates: 2
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Secondary tricuspid valve regurgitation: a forgotten entity
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee
       Item: 
        Title: Anatomy
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0
       Item: 
        Title: Pathophysiology
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052
       Item: 
        Title: Clinical diagnosis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347
       Item: 
        Title: IMAGING OF TRICUSPID REGURGITATION AND RIGHT VENTRICULAR FUNCTION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482
        Children: 
         Item: 
          Title: Transthoracic echocardiography
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809
         Item: 
          Title: Transoesophageal echocardiography
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190
         Item: 
          Title: Cardiovascular magnetic resonance
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739
       Item: 
        Title: Natural history and follow-up
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9
       Item: 
        Title: Indications for surgery
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8
        Children: 
         Item: 
          Title: Perspectives of the problem
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e
         Item: 
          Title: Recommendations for TR surgery at the time of left heart valve surgery
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070
       Item: 
        Title: Surgical techniques
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5
       Item: 
        Title: Results of TV surgery
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4
       Item: 
        Title: Late-onset TR
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1
       Item: 
        Title: Future, non-surgical options
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc
       Item: 
        Title: Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac
   Info: 
    Title: untitled
    Keywords: 
    Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Thu Oct 22 07:40:28 CEST 2015
    ModDate: Mon Oct 26 11:57:38 CET 2015
   ID: 0xec7a7ca17aaba8f4356f5c5be5b6bc0d, 0x4ca5bccf8deeeb48b4b7d74e568f0d18
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 5
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 229
      ImageHeight: 229
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 91
      ImageHeight: 91
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: uncompressed
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 43
      ImageHeight: 6
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 84
      ImageHeight: 9
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 43
      ImageHeight: 10
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 43
      ImageHeight: 14
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 43
      ImageHeight: 12
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 43
      ImageHeight: 55
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 43
      ImageHeight: 7
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 43
      ImageHeight: 11
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1764
      ImageHeight: 1289
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1756
      ImageHeight: 1215
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1756
      ImageHeight: 1277
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1506
      ImageHeight: 657
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1751
      ImageHeight: 579
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EDNPMP+AdvTT9f195b36.B
      FontSubset: true
      FirstChar: 65
      LastChar: 116
      FontDescriptor: 
       FontName: EDNPMP+AdvTT9f195b36.B
       Flags: Nonsymbolic
       FontBBox: -52, -229, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDNPJM+AdvOTbe4cb9cb
      FontSubset: true
      FirstChar: 65
      LastChar: 121
      FontDescriptor: 
       FontName: EDNPJM+AdvOTbe4cb9cb
       Flags: Nonsymbolic
       FontBBox: -125, -250, 833, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDOJJC+AdvOT8608a8d1+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EDOJJC+AdvOT8608a8d1+22
       Flags: Symbolic
       FontBBox: 0, -322, 1218, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EDNPNA+AdvOT8608a8d1+25
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EDNPNA+AdvOT8608a8d1+25
       Flags: Symbolic
       FontBBox: -10, -302, 1208, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EDNPJN+AdvTTb20e5d60
      FontSubset: true
      FirstChar: 37
      LastChar: 177
      FontDescriptor: 
       FontName: EDNPJN+AdvTTb20e5d60
       Flags: Serif, Nonsymbolic
       FontBBox: -52, -229, 979, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDOJJB+AdvTTb2d6d9f8.I
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: EDOJJB+AdvTTb2d6d9f8.I
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -229, 937, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDNOKO+AdvOT6520a694
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: EDNOKO+AdvOT6520a694
       Flags: Nonsymbolic
       FontBBox: -20, -250, 781, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDNOKP+AdvOT0231c847
      FontSubset: true
      FirstChar: 40
      LastChar: 252
      FontDescriptor: 
       FontName: EDNOKP+AdvOT0231c847
       Flags: Nonsymbolic
       FontBBox: -20, -250, 760, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDPBJB+AdvOT6520a694+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: EDPBJB+AdvOT6520a694+20
       Flags: Nonsymbolic
       FontBBox: -104, -125, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDNOLA+AdvOTc9c0ed35.B
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: EDNOLA+AdvOTc9c0ed35.B
       Flags: Nonsymbolic
       FontBBox: -20, -250, 812, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDPBKB+AdvP4C4E74
      FontSubset: true
      FirstChar: 48
      LastChar: 48
      FontDescriptor: 
       FontName: EDPBKB+AdvP4C4E74
       Flags: Nonsymbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDNOLB+AdvOT0231c847+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: EDNOLB+AdvOT0231c847+20
       Flags: Nonsymbolic
       FontBBox: -93, -125, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDPPCJ+AdvOT0231c847+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EDPPCJ+AdvOT0231c847+fb
       Flags: Symbolic
       FontBBox: 0, 0, 510, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EDPBJA+AdvOT0c2f268a.I
      FontSubset: true
      FirstChar: 68
      LastChar: 118
      FontDescriptor: 
       FontName: EDPBJA+AdvOT0c2f268a.I
       Flags: Nonsymbolic
       FontBBox: -125, -250, 854, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EDPBIP+AdvOT6520a694+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EDPBIP+AdvOT6520a694+fb
       Flags: Symbolic
       FontBBox: 0, 0, 510, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EDNPJO+AdvTTb20e5d60+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EDNPJO+AdvTTb20e5d60+fb
       Flags: Symbolic
       FontBBox: 30, -166, 541, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EDNPJP+AdvTTb20e5d60+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: EDNPJP+AdvTTb20e5d60+20
       Flags: Nonsymbolic
       FontBBox: 0, -187, 1260, 708
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.2-c001 63.139439, 2010/09/27-13:37:26        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2015-10-22T10:40:28+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 10.0.1465/W Unicode</xmp:CreatorTool>
         <xmp:ModifyDate>2015-10-26T15:57:38+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2015-10-26T15:57:38+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.0.0 (Windows)</pdf:Producer>
         <pdf:Keywords/>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:;</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">untitled</rdf:li>
            </rdf:Alt>
         </dc:title>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:c2fd8ca5-5cef-4429-a0c2-8b262c1ebf64</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:a31cc4e8-3ff9-437d-b938-14407ac89ef3</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:url>http://dx.doi.org/</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2015-10-22</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>false</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>http://heart.bmj.com/</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:CrossmarkMajorVersionDate>2015-10-22</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>http://heart.bmj.com/</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 40, 96, 133, 136
      Annotation: 
       Subtype: Link
       Rect: 165, 574, 169, 583
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 173, 574, 176, 583
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 201, 376, 205, 385
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 208, 376, 212, 385
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 187, 244, 191, 253
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 193, 244, 197, 253
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 308, 113, 312, 122
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 209, 43, 239, 52
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 474, 365, 478, 374
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 537, 244, 540, 253
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 473, 189, 480, 198
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 483, 189, 490, 198
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 545, 102, 553, 111
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 69, 20, 104, 35
      Annotation: 
       Subtype: Link
       Rect: 531, 20, 553, 32
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 171, 356, 178, 365
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 224, 43, 254, 52
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 474, 157, 482, 166
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 402, 120, 425, 129
       Destination: 10
      Annotation: 
       Subtype: Link
       Rect: 504, 80, 511, 89
       Destination: null
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 183, 309, 209, 318
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 212, 313, 219, 322
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 515, 335, 519, 344
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 545, 236, 553, 245
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 440, 225, 447, 234
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 545, 135, 553, 144
       Destination: null
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 313, 328, 321, 337
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 211, 273, 215, 281
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 225, 225, 251, 234
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 253, 229, 261, 237
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 184, 140, 192, 150
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 278, 86, 286, 95
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 374, 707, 381, 716
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 467, 652, 474, 661
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 412, 509, 420, 518
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 384, 432, 391, 441
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 394, 432, 402, 441
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 511, 410, 514, 419
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 517, 410, 524, 419
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 521, 289, 529, 298
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 486, 256, 494, 265
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 481, 120, 511, 129
       Destination: 41
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 266, 136, 273, 145
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 549, 367, 553, 376
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 514, 102, 527, 111
       Destination: null
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 203, 529, 210, 538
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 179, 386, 186, 395
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 192, 386, 205, 395
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 211, 386, 223, 395
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 238, 342, 251, 351
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 248, 331, 260, 340
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 180, 298, 192, 307
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 377, 496, 390, 505
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 471, 452, 484, 461
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 490, 448, 521, 457
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 455, 430, 468, 439
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 505, 360, 534, 369
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 540, 364, 552, 373
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 461, 305, 494, 314
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 523, 254, 536, 263
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 540, 254, 553, 263
       Destination: null
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 161, 597, 173, 606
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 176, 597, 189, 606
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 197, 432, 210, 441
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 162, 366, 175, 375
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 309, 355, 321, 364
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 330, 157, 343, 166
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 510, 696, 522, 705
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 525, 696, 537, 705
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 425, 619, 438, 628
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 372, 597, 380, 606
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 475, 560, 506, 569
       Destination: 41
      Annotation: 
       Subtype: Link
       Rect: 398, 366, 411, 375
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 413, 366, 426, 375
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 540, 311, 553, 320
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 465, 223, 477, 232
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 395, 113, 407, 122
       Destination: null
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 594, 200, 603
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 281, 447, 289, 456
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 504, 594, 521, 602
      Annotation: 
       Subtype: Link
       Rect: 355, 585, 470, 593
      Annotation: 
       Subtype: Link
       Rect: 456, 440, 499, 447
      Annotation: 
       Subtype: Link
       Rect: 415, 413, 460, 420
      Annotation: 
       Subtype: Link
       Rect: 432, 386, 480, 393
      Annotation: 
       Subtype: Link
       Rect: 435, 368, 463, 375
      Annotation: 
       Subtype: Link
       Rect: 481, 332, 509, 339
      Annotation: 
       Subtype: Link
       Rect: 463, 296, 491, 303
      Annotation: 
       Subtype: Link
       Rect: 457, 278, 498, 285
      Annotation: 
       Subtype: Link
       Rect: 457, 260, 527, 267
      Annotation: 
       Subtype: Link
       Rect: 479, 188, 540, 195
      Annotation: 
       Subtype: Link
       Rect: 371, 179, 393, 186
      Annotation: 
       Subtype: Link
       Rect: 504, 143, 529, 150
      Annotation: 
       Subtype: Link
       Rect: 371, 134, 406, 141
      Annotation: 
       Subtype: Link
       Rect: 478, 107, 506, 114
      Annotation: 
       Subtype: Link
       Rect: 467, 71, 553, 78
      Annotation: 
       Subtype: Link
       Rect: 429, 44, 499, 51
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 711, 249, 718
      Annotation: 
       Subtype: Link
       Rect: 161, 675, 191, 682
      Annotation: 
       Subtype: Link
       Rect: 240, 648, 270, 655
      Annotation: 
       Subtype: Link
       Rect: 253, 630, 288, 637
      Annotation: 
       Subtype: Link
       Rect: 223, 603, 270, 610
      Annotation: 
       Subtype: Link
       Rect: 199, 549, 214, 556
      Annotation: 
       Subtype: Link
       Rect: 256, 522, 271, 529
      Annotation: 
       Subtype: Link
       Rect: 247, 486, 314, 493
      Annotation: 
       Subtype: Link
       Rect: 193, 432, 241, 439
      Annotation: 
       Subtype: Link
       Rect: 161, 405, 229, 412
      Annotation: 
       Subtype: Link
       Rect: 224, 387, 254, 394
      Annotation: 
       Subtype: Link
       Rect: 267, 324, 331, 331
      Annotation: 
       Subtype: Link
       Rect: 263, 297, 342, 304
      Annotation: 
       Subtype: Link
       Rect: 297, 270, 342, 277
      Annotation: 
       Subtype: Link
       Rect: 315, 234, 341, 241
      Annotation: 
       Subtype: Link
       Rect: 162, 225, 165, 232
      Annotation: 
       Subtype: Link
       Rect: 305, 207, 336, 214
      Annotation: 
       Subtype: Link
       Rect: 162, 198, 174, 205
      Annotation: 
       Subtype: Link
       Rect: 240, 180, 285, 187
      Annotation: 
       Subtype: Link
       Rect: 431, 648, 499, 655
      Annotation: 
       Subtype: Link
       Rect: 403, 621, 448, 628
      Annotation: 
       Subtype: Link
       Rect: 513, 603, 544, 610
      Annotation: 
       Subtype: Link
       Rect: 372, 594, 384, 601
      Annotation: 
       Subtype: Link
       Rect: 372, 558, 420, 565
      Annotation: 
       Subtype: Link
       Rect: 372, 513, 449, 520
      Annotation: 
       Subtype: Link
       Rect: 431, 486, 498, 493
      Annotation: 
       Subtype: Link
       Rect: 518, 450, 531, 457
      Annotation: 
       Subtype: Link
       Rect: 372, 441, 421, 448
      Annotation: 
       Subtype: Link
       Rect: 372, 414, 387, 421
      Annotation: 
       Subtype: Link
       Rect: 411, 396, 425, 403
      Annotation: 
       Subtype: Link
       Rect: 490, 360, 536, 367
      Annotation: 
       Subtype: Link
       Rect: 496, 333, 541, 340
      Annotation: 
       Subtype: Link
       Rect: 372, 270, 431, 277
      Annotation: 
       Subtype: Link
       Rect: 487, 243, 536, 250
      Annotation: 
       Subtype: Link
       Rect: 465, 207, 495, 214
      Annotation: 
       Subtype: Link
       Rect: 402, 171, 456, 178
     Thumb: true
  Checksum: ea80d325
   Type: CRC32
  Checksum: f51ca356586ff9aecac66f680338ce6b
   Type: MD5
  Checksum: 2bd3f9089bd82701b65a7d8b09420d84ab2c8c55
   Type: SHA-1