0895d89f70bd07c65893e1334d31ef4a  pmc_26937390.pdf
85bdfef1d7966c94c45ccc24af72d85df238267d  pmc_26937390.pdf
397a472c38b8bfc09c6f32e1b971b166611eca9542d58745c95a8455b41455f9  pmc_26937390.pdf

Title:          Long-term effectiveness of agalsidase alfa enzyme replacement in Fabry disease: A Fabry Outcome Survey analysis
Creator:        Elsevier
Producer:       Acrobat Distiller 10.0.0 (Windows)
CreationDate:   Tue Oct 13 17:47:32 2015 CEST
ModDate:        Wed Oct 14 01:47:38 2015 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          7
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      422626 bytes
Optimized:      yes
PDF version:    1.7

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EPCAGF+AdvTT5235d5a9                 Type 1C           WinAnsi          yes yes no     507  0
EPCAMM+AdvTT5235d5a9+03              Type 1C           Custom           yes yes yes    488  0
EPCBGJ+AdvTTc8c83e50                 Type 1C           WinAnsi          yes yes no     489  0
EPCAGG+AdvTT5235d5a9+20              Type 1C           Custom           yes yes yes    508  0
EPCAHH+AdvTT94c8263f.I               Type 1C           WinAnsi          yes yes no     509  0
EPCAHI+AdvTT94c8263f.I+20            Type 1C           WinAnsi          yes yes no     510  0
EPCAII+AdvTT0f485e03                 Type 1C           WinAnsi          yes yes no     490  0
EPCAJJ+AdvTT5235d5a9+fb              Type 1C           Custom           yes yes yes    511  0
EPCAKK+AdvTT454a7a89                 Type 1C           WinAnsi          yes yes no     512  0
EPCAKL+AdvTT5235d5a9+22              Type 1C           Custom           yes yes yes    513  0
EPCALL+AdvTT28000ce1.B               Type 1C           WinAnsi          yes yes no     514  0
EPCCCG+Helvetica                     Type 1C           WinAnsi          yes yes no      25  0
EPCCDG+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      26  0
EPCCJF+AdvP4C4E74                    Type 1C           Custom           yes yes yes     62  0
EPCCJG+AdvTT94c8263f.I+03            Type 1C           Custom           yes yes yes     63  0
EPCCJH+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no      64  0
EPCDOA+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     321  0
EPCDOB+Helvetica                     Type 1C           WinAnsi          yes yes no     322  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-08-10 13:43:09 CEST
 RepresentationInformation: pmc_26937390.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2018-02-06 09:08:07 CET
  Size: 422626
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 552
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Long-„term effectiveness of agalsidase alfa enzyme replacement in Fabry disease: A Fabry Outcome Survey analysis
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034
       Item: 
        Title: 2. Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
        Children: 
         Item: 
          Title: 2.1. Patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
         Item: 
          Title: 2.2. Outcomes analyzed
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
         Item: 
          Title: 2.3. Statistical analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
         Item: 
          Title: 2.4. Sensitivity analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
       Item: 
        Title: 3. Results and discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
       Item: 
        Title: 4. Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: Disclosure statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: Role of the funding source
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: Appendix A. Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
   Info: 
    Title: Long-term effectiveness of agalsidase alfa enzyme replacement in Fabry disease: A Fabry Outcome Survey analysis
    Creator: Elsevier
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Tue Oct 13 17:47:32 CEST 2015
    ModDate: Wed Oct 14 01:47:38 CEST 2015
   ID: 0x70819b9808b8da27d6c2e22dc401343c, 0xaf2853fc896a3559f62f20e74c5229ee
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 67
      ImageHeight: 67
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 166
      ImageHeight: 182
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EPCAKK+AdvTT454a7a89
      FontSubset: true
      FirstChar: 78
      LastChar: 98
      FontDescriptor: 
       FontName: EPCAKK+AdvTT454a7a89
       Flags: Nonsymbolic
       FontBBox: -52, -208, 968, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCCJH+AdvP4C4E51
      FontSubset: true
      FirstChar: 58
      LastChar: 58
      FontDescriptor: 
       FontName: EPCCJH+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCAKL+AdvTT5235d5a9+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: EPCAKL+AdvTT5235d5a9+22
       Flags: Symbolic
       FontBBox: -135, -208, 1125, 1041
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPCDOA+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 167
      FontDescriptor: 
       FontName: EPCDOA+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCALL+AdvTT28000ce1.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: EPCALL+AdvTT28000ce1.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCDOB+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: EPCDOB+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCAMM+AdvTT5235d5a9+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EPCAMM+AdvTT5235d5a9+03
       Flags: Symbolic
       FontBBox: -843, -291, 1062, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPCBGJ+AdvTTc8c83e50
      FontSubset: true
      FirstChar: 45
      LastChar: 119
      FontDescriptor: 
       FontName: EPCBGJ+AdvTTc8c83e50
       Flags: Nonsymbolic
       FontBBox: -62, -250, 968, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCAII+AdvTT0f485e03
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: EPCAII+AdvTT0f485e03
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCCCG+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: EPCCCG+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCCDG+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: EPCCDG+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCAGF+AdvTT5235d5a9
      FontSubset: true
      FirstChar: 37
      LastChar: 174
      FontDescriptor: 
       FontName: EPCAGF+AdvTT5235d5a9
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCAGG+AdvTT5235d5a9+20
      FontSubset: true
      FirstChar: 1
      LastChar: 133
      FontDescriptor: 
       FontName: EPCAGG+AdvTT5235d5a9+20
       Flags: Symbolic
       FontBBox: -875, -270, 1312, 979
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPCAHH+AdvTT94c8263f.I
      FontSubset: true
      FirstChar: 34
      LastChar: 242
      FontDescriptor: 
       FontName: EPCAHH+AdvTT94c8263f.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCAHI+AdvTT94c8263f.I+20
      FontSubset: true
      FirstChar: 147
      LastChar: 150
      FontDescriptor: 
       FontName: EPCAHI+AdvTT94c8263f.I+20
       Flags: Nonsymbolic
       FontBBox: -875, -270, 1333, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPCCJF+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 254
      FontDescriptor: 
       FontName: EPCCJF+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPCAJJ+AdvTT5235d5a9+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EPCAJJ+AdvTT5235d5a9+fb
       Flags: Symbolic
       FontBBox: 9, -291, 1333, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPCCJG+AdvTT94c8263f.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 9
      FontDescriptor: 
       FontName: EPCCJG+AdvTT94c8263f.I+03
       Flags: Symbolic
       FontBBox: -552, -312, 1166, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" 
	xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" 
	xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" 
	xmlns:xap="http://ns.adobe.com/xap/1.0/" 
	xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/" 
	xmlns:dc="http://purl.org/dc/elements/1.1/" 
	xmlns:dcterms="http://purl.org/dc/terms/" 
	xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" 
	xmlns:crossmark="http://crossref.org/crossmark/1.0/">
<rdf:Description rdf:about="">
	<dc:format>application/pdf</dc:format>
	<dc:title>Long-term effectiveness of agalsidase alfa enzyme replacement in Fabry disease: A Fabry Outcome Survey analysis</dc:title>
	<dc:creator>
		<rdf:Seq>
			<rdf:li>Michael Beck</rdf:li>
			<rdf:li>Derralynn Hughes</rdf:li>
			<rdf:li>Christoph Kampmann</rdf:li>
			<rdf:li>Sylvain Larroque</rdf:li>
			<rdf:li>Atul Mehta</rdf:li>
			<rdf:li>Guillem Pintos-Morell</rdf:li>
			<rdf:li>Uma Ramaswami</rdf:li>
			<rdf:li>Michael West</rdf:li>
			<rdf:li>Anna Wijatyk</rdf:li>
			<rdf:li>Roberto Giugliani</rdf:li>
			<rdf:li>the Fabry Outcome Survey Study Group</rdf:li>
		</rdf:Seq>
	</dc:creator>
	<dc:subject>
		<rdf:Bag>
			<rdf:li>Fabry disease</rdf:li>
			<rdf:li>Enzyme replacement therapy</rdf:li>
			<rdf:li>Agalsidase alfa</rdf:li>
			<rdf:li>Long-term effectiveness</rdf:li>
		</rdf:Bag>
	</dc:subject>
	<dc:description>YMGMR, 3 (2015) 21-27. doi:10.1016/j.ymgmr.2015.02.002</dc:description>
	<prism:aggregationType>journal</prism:aggregationType>
	<prism:publicationName>YMGMR</prism:publicationName>
	<prism:copyright>Copyright (c) 2015 The Authors All rights reserved</prism:copyright>
	<dc:publisher>The Authors</dc:publisher>
	<prism:issn>2214-4269</prism:issn>
	<prism:volume>3</prism:volume>
	<prism:issueIdentifier>C</prism:issueIdentifier>
	<prism:coverDisplayDate>June 2015</prism:coverDisplayDate>
	<prism:pageRange>21-27</prism:pageRange>
	<prism:startingPage>21</prism:startingPage>
	<prism:endingPage>27</prism:endingPage>
	<prism:doi>10.1016/j.ymgmr.2015.02.002</prism:doi>
	<prism:url>http://dx.doi.org/10.1016/j.ymgmr.2015.02.002</prism:url>
	<dc:identifier>doi:10.1016/j.ymgmr.2015.02.002</dc:identifier>
	<crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
	<crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
	<crossmark:DOI>10.1016/j.ymgmr.2015.02.002</crossmark:DOI>
	<crossmark:CrossMarkDomains>
		<rdf:Seq>
			<rdf:li>elsevier.com</rdf:li>
			<rdf:li>sciencedirect.com</rdf:li>
		</rdf:Seq>
	</crossmark:CrossMarkDomains>
	<pdfx:ElsevierWebPDFSpecifications>6.4</pdfx:ElsevierWebPDFSpecifications>
	<pdfx:doi>10.1016/j.ymgmr.2015.02.002</pdfx:doi>
	<pdfx:robots>noindex</pdfx:robots>
	<pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
	<pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
	<pdfx:CrossMarkDomains>
		<rdf:Seq>
			<rdf:li>elsevier.com</rdf:li>
			<rdf:li>sciencedirect.com</rdf:li>
		</rdf:Seq>
	</pdfx:CrossMarkDomains>
	<xap:CreatorTool>Elsevier</xap:CreatorTool>
	<xapRights:Marked>True</xapRights:Marked>
</rdf:Description>
<rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/"><pdf:Keywords>Fabry disease;  Enzyme replacement therapy;  Agalsidase alfa;  Long-term effectiveness</pdf:Keywords></rdf:Description></rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 21
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 506, 603, 561, 627
      Annotation: 
       Subtype: Link
       Rect: 107, 577, 111, 588
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 112, 573, 117, 585
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 211, 577, 215, 588
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 327, 577, 331, 588
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 418, 577, 421, 588
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 482, 577, 486, 588
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 149, 564, 154, 575
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 244, 564, 248, 575
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 321, 564, 325, 575
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 397, 564, 400, 575
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 490, 564, 494, 575
       Destination: 442
      Annotation: 
       Subtype: Link
       Rect: 393, 239, 556, 246
      Annotation: 
       Subtype: Link
       Rect: 446, 209, 456, 217
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 447, 157, 466, 165
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 402, 136, 426, 144
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 216, 749, 387, 755
      Annotation: 
       Subtype: Link
       Rect: 98, 84, 200, 90
      Annotation: 
       Subtype: Link
       Rect: 42, 56, 176, 63
      Annotation: 
       Subtype: Link
       Rect: 385, 48, 530, 54
      Annotation: 
       Subtype: Link
       Rect: 318, 721, 367, 729
      Annotation: 
       Subtype: Link
       Rect: 205, 677, 474, 685
      Annotation: 
       Subtype: Link
       Rect: 251, 666, 343, 674
    Page: 
     Label: 22
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 728, 136, 736
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 133, 707, 177, 715
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 113, 644, 129, 652
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 123, 602, 144, 610
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 73, 456, 122, 464
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 334, 717, 353, 725
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 358, 717, 390, 725
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 443, 696, 457, 704
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 411, 675, 422, 683
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 462, 633, 476, 641
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 407, 602, 426, 610
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 538, 539, 552, 547
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 386, 497, 401, 505
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 431, 466, 442, 474
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 363, 382, 378, 390
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 434, 57, 446, 64
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 498, 57, 505, 64
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 48, 49, 60, 55
       Destination: 139
    Page: 
     Label: 23
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 73, 717, 87, 725
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 152, 686, 167, 694
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 64, 529, 79, 537
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 103, 508, 118, 516
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 430, 665, 445, 673
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 526, 665, 541, 673
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 536, 539, 556, 547
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 495, 445, 521, 453
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 363, 403, 384, 411
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 408, 393, 423, 401
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 431, 340, 445, 348
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 434, 330, 460, 338
       Destination: 75
      Annotation: 
       Subtype: Link
       Rect: 476, 320, 487, 328
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 329, 299, 354, 307
       Destination: 75
      Annotation: 
       Subtype: Link
       Rect: 373, 278, 388, 286
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 430, 267, 457, 275
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 371, 257, 385, 265
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 354, 246, 380, 254
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 310, 184, 336, 192
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 414, 163, 442, 171
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 425, 152, 440, 160
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 420, 89, 446, 97
       Destination: 94
    Page: 
     Label: 24
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 52, 414, 66, 422
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 57, 320, 84, 328
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 77, 246, 103, 254
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 483, 435, 498, 443
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 305, 424, 325, 432
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 509, 341, 528, 348
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 317, 299, 331, 307
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 337, 299, 356, 307
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 387, 173, 461, 181
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 307, 720, 319, 727
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 434, 693, 446, 699
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 428, 589, 440, 595
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 342, 145, 350, 151
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 439, 130, 447, 136
       Destination: 139
    Page: 
     Label: 25
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 60, 414, 74, 422
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 505, 424, 519, 432
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 396, 393, 411, 401
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 381, 361, 395, 369
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 414, 320, 428, 328
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 379, 288, 393, 296
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 502, 278, 526, 286
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 523, 257, 537, 265
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 478, 131, 493, 139
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 326, 121, 341, 129
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 410, 121, 420, 129
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 551, 110, 561, 118
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 188, 720, 200, 727
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 263, 720, 274, 727
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 234, 680, 246, 686
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 137, 610, 139, 616
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 250, 547, 262, 553
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 254, 346, 266, 352
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 230, 336, 233, 342
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 504, 689, 512, 695
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 514, 678, 517, 685
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 506, 609, 509, 616
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 506, 549, 509, 556
       Destination: 94
      Annotation: 
       Subtype: Link
       Rect: 360, 499, 368, 506
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 496, 491, 508, 497
       Destination: 139
    Page: 
     Label: 26
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 58, 202, 66
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 138, 381, 149, 387
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 452, 381, 464, 387
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 342, 372, 354, 379
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 525, 372, 537, 379
       Destination: 139
    Page: 
     Label: 27
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 259, 194, 293, 202
      Annotation: 
       Subtype: Link
       Rect: 42, 184, 176, 192
      Annotation: 
       Subtype: Link
       Rect: 57, 147, 293, 153
      Annotation: 
       Subtype: Link
       Rect: 57, 139, 238, 146
      Annotation: 
       Subtype: Link
       Rect: 58, 131, 293, 138
      Annotation: 
       Subtype: Link
       Rect: 58, 123, 293, 130
      Annotation: 
       Subtype: Link
       Rect: 58, 115, 104, 122
      Annotation: 
       Subtype: Link
       Rect: 325, 730, 561, 737
      Annotation: 
       Subtype: Link
       Rect: 325, 722, 561, 729
      Annotation: 
       Subtype: Link
       Rect: 325, 715, 381, 721
      Annotation: 
       Subtype: Link
       Rect: 325, 707, 561, 713
      Annotation: 
       Subtype: Link
       Rect: 325, 699, 561, 705
      Annotation: 
       Subtype: Link
       Rect: 325, 691, 380, 697
      Annotation: 
       Subtype: Link
       Rect: 325, 683, 561, 689
      Annotation: 
       Subtype: Link
       Rect: 325, 675, 469, 681
      Annotation: 
       Subtype: Link
       Rect: 326, 667, 561, 673
      Annotation: 
       Subtype: Link
       Rect: 326, 659, 561, 665
      Annotation: 
       Subtype: Link
       Rect: 326, 651, 472, 657
      Annotation: 
       Subtype: Link
       Rect: 325, 643, 561, 649
      Annotation: 
       Subtype: Link
       Rect: 325, 635, 541, 641
      Annotation: 
       Subtype: Link
       Rect: 325, 627, 561, 633
      Annotation: 
       Subtype: Link
       Rect: 325, 619, 535, 625
      Annotation: 
       Subtype: Link
       Rect: 325, 611, 561, 617
      Annotation: 
       Subtype: Link
       Rect: 325, 603, 520, 609
      Annotation: 
       Subtype: Link
       Rect: 325, 595, 561, 601
      Annotation: 
       Subtype: Link
       Rect: 325, 587, 548, 593
      Annotation: 
       Subtype: Link
       Rect: 325, 579, 561, 585
      Annotation: 
       Subtype: Link
       Rect: 325, 571, 561, 577
      Annotation: 
       Subtype: Link
       Rect: 325, 563, 357, 569
      Annotation: 
       Subtype: Link
       Rect: 326, 555, 561, 561
      Annotation: 
       Subtype: Link
       Rect: 326, 547, 538, 554
      Annotation: 
       Subtype: Link
       Rect: 325, 539, 561, 546
      Annotation: 
       Subtype: Link
       Rect: 325, 531, 561, 538
      Annotation: 
       Subtype: Link
       Rect: 325, 523, 515, 530
      Annotation: 
       Subtype: Link
       Rect: 325, 515, 561, 522
      Annotation: 
       Subtype: Link
       Rect: 325, 507, 561, 514
      Annotation: 
       Subtype: Link
       Rect: 325, 499, 507, 506
      Annotation: 
       Subtype: Link
       Rect: 326, 491, 561, 498
      Annotation: 
       Subtype: Link
       Rect: 326, 483, 470, 490
      Annotation: 
       Subtype: Link
       Rect: 326, 475, 561, 482
      Annotation: 
       Subtype: Link
       Rect: 326, 467, 561, 474
      Annotation: 
       Subtype: Link
       Rect: 326, 459, 482, 466
      Annotation: 
       Subtype: Link
       Rect: 326, 451, 561, 458
      Annotation: 
       Subtype: Link
       Rect: 326, 444, 561, 450
      Annotation: 
       Subtype: Link
       Rect: 326, 436, 414, 442
      Annotation: 
       Subtype: Link
       Rect: 325, 428, 561, 434
      Annotation: 
       Subtype: Link
       Rect: 325, 420, 561, 426
      Annotation: 
       Subtype: Link
       Rect: 325, 412, 379, 418
      Annotation: 
       Subtype: Link
       Rect: 325, 404, 561, 410
      Annotation: 
       Subtype: Link
       Rect: 325, 396, 561, 402
      Annotation: 
       Subtype: Link
       Rect: 325, 388, 350, 394
      Annotation: 
       Subtype: Link
       Rect: 326, 380, 561, 386
      Annotation: 
       Subtype: Link
       Rect: 326, 372, 527, 378
      Annotation: 
       Subtype: Link
       Rect: 326, 364, 561, 370
      Annotation: 
       Subtype: Link
       Rect: 326, 356, 561, 362
      Annotation: 
       Subtype: Link
       Rect: 326, 348, 525, 354
      Annotation: 
       Subtype: Link
       Rect: 325, 340, 561, 346
      Annotation: 
       Subtype: Link
       Rect: 325, 332, 498, 338
      Annotation: 
       Subtype: Link
       Rect: 326, 324, 561, 330
      Annotation: 
       Subtype: Link
       Rect: 326, 316, 561, 322
      Annotation: 
       Subtype: Link
       Rect: 326, 308, 357, 314
      Annotation: 
       Subtype: Link
       Rect: 326, 300, 561, 306
      Annotation: 
       Subtype: Link
       Rect: 326, 292, 561, 298
      Annotation: 
       Subtype: Link
       Rect: 326, 284, 521, 291
      Annotation: 
       Subtype: Link
       Rect: 326, 276, 561, 283
      Annotation: 
       Subtype: Link
       Rect: 326, 268, 561, 275
      Annotation: 
       Subtype: Link
       Rect: 326, 260, 561, 267
      Annotation: 
       Subtype: Link
       Rect: 326, 252, 405, 259
      Annotation: 
       Subtype: Link
       Rect: 326, 244, 561, 251
      Annotation: 
       Subtype: Link
       Rect: 326, 236, 561, 243
      Annotation: 
       Subtype: Link
       Rect: 326, 228, 561, 235
      Annotation: 
       Subtype: Link
       Rect: 326, 220, 372, 227
      Annotation: 
       Subtype: Link
       Rect: 325, 212, 561, 219
      Annotation: 
       Subtype: Link
       Rect: 325, 204, 561, 211
      Annotation: 
       Subtype: Link
       Rect: 325, 196, 467, 203
      Annotation: 
       Subtype: Link
       Rect: 326, 188, 561, 195
      Annotation: 
       Subtype: Link
       Rect: 326, 181, 561, 187
      Annotation: 
       Subtype: Link
       Rect: 326, 173, 437, 179
      Annotation: 
       Subtype: Link
       Rect: 326, 165, 561, 171
      Annotation: 
       Subtype: Link
       Rect: 326, 157, 561, 163
      Annotation: 
       Subtype: Link
       Rect: 326, 149, 340, 155
      Annotation: 
       Subtype: Link
       Rect: 326, 141, 561, 147
      Annotation: 
       Subtype: Link
       Rect: 326, 133, 561, 139
      Annotation: 
       Subtype: Link
       Rect: 326, 125, 516, 131
      Annotation: 
       Subtype: Link
       Rect: 183, 439, 194, 445
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 42, 430, 57, 437
       Destination: 139
      Annotation: 
       Subtype: Link
       Rect: 164, 430, 176, 437
       Destination: 139
  Checksum: 76b1ce77
   Type: CRC32
  Checksum: 0895d89f70bd07c65893e1334d31ef4a
   Type: MD5
  Checksum: 85bdfef1d7966c94c45ccc24af72d85df238267d
   Type: SHA-1