95a5323e324db0602a19bcbbe86064c0 pmc_28078289.pdf 75285990aa3cde1eb4c1850d0b1f30ae0f0e869c pmc_28078289.pdf 078417d2c66b18c02d0e5bb44a9955538a4aa48a9be7a8d31f3efba3c8ba13fe pmc_28078289.pdf Title: 4380845.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 15.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sun Dec 18 14:14:01 2016 CET ModDate: Sun Jan 1 09:28:56 2017 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 600.05 x 800 pts Page rot: 0 File size: 520972 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DMAOJP+MinionPro-It Type 1C Custom yes yes yes 13 0 DMAOLA+Minion-Black Type 1C WinAnsi yes yes no 14 0 DMAOLB+MinionPro-Regular Type 1C Custom yes yes yes 15 0 DMAOMC+MinionMath-Regular Type 1C Custom yes yes yes 16 0 DMAOMD+MinionMath-Capt Type 1C Custom yes yes yes 17 0 TSJGRX+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 DMAOOD+MinionPro-Bold Type 1C Custom yes yes yes 82 0 DMAOPE+MinionPro-Regular Type 1C WinAnsi yes yes no 83 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-16 03:05:56 CET RepresentationInformation: pmc_28078289.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-02-08 08:15:13 CET Size: 520972 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: ISO PDF/A-1, Level B PDFMetadata: Objects: 135 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: 4380845.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 15.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sun Dec 18 14:14:01 CET 2016 ModDate: Sun Jan 01 09:28:56 CET 2017 ID: 0xd7b3af90706b1d5d03df665ce34a16bf, 0x49122130cede1512d0e9d00229757204 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: TSJGRX+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: DMAOMC+MinionMath-Regular FontSubset: true FirstChar: 2 LastChar: 62 FontDescriptor: FontName: DMAOMC+MinionMath-Regular Flags: Symbolic FontBBox: 12, -261, 570, 641 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DMAOMD+MinionMath-Capt FontSubset: true FirstChar: 2 LastChar: 50 FontDescriptor: FontName: DMAOMD+MinionMath-Capt Flags: Symbolic FontBBox: 23, -12, 504, 635 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DMAOOD+MinionPro-Bold FontSubset: true FirstChar: 2 LastChar: 46 FontDescriptor: FontName: DMAOOD+MinionPro-Bold Flags: Symbolic, ForceBold FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DMAOPE+MinionPro-Regular FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DMAOPE+MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DMAOJP+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: DMAOJP+MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DMAOLA+Minion-Black FontSubset: true FirstChar: 44 LastChar: 250 FontDescriptor: FontName: DMAOLA+Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DMAOLB+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: DMAOLB+MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: TSJGRX+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TSJGRX+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfProspective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to NephrotoxicityBonjoch, AnnaEcheverría, PatriciaPerez-Alvarez, NúriaPuig, JordiEstany, CarlaClotet, BonaventuraNegredo, EugèniaBackground. Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce. Methods. This is an observational prospective study including all patients that presented at our HIV Unit who interrupted TDF owing to nephrotoxicity. We assessed the evolution of renal parameters after discontinuation of this drug. Results. We included 59 patients, who were followed up for 72 weeks. Most were male (41, 69.5%), median (IQR) age was 53 (44; 58) years, and median time receiving TDF-containing regimens was 55.4 (28; 87.7) months. Most patients were receiving PI-based treatments (67%). At the final visit, most of the subjects showed complete recovery (35, 59.3%) or improvement (13 subjects, 22%). Significant improvements were observed in creatinine levels (from 84.9 [73.8; 97.5] to 78 [69.6; 91] μmol/L, p=0.013), estimated glomerular filtration rate (eGFR, CKD EPI equation, from 87.7 [67; 99] to 89.9 [73.6; 99.3] mL/min/1.73 m2, p=0.017), and number of patients with eGFR <60 mL/min/1.73 m2 (from 9 [15.3%] to 1 [1.7%], p=0.031). A trend toward significance was observed in abnormal urine proteinuria/creatinine ratio (from 22 [37%] to 8 [13.6%], p=0.057). Conclusions. Our results corroborate the high frequency of complete or partial renal recovery in patients receiving TDF-containing regimens who discontinued therapy owing to nephrotoxicity.BioMed Research InternationalHindawi Publishing Corporation2016/12/18Research articledoi:10.1155/2016/4380845en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 86, 172, 90, 182 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 95, 172, 101, 182 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 131, 138, 137, 148 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 141, 138, 147, 148 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 464, 95, 470, 105 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 50, 713, 175, 721 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 95, 532, 101, 543 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 149, 335, 155, 346 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 307, 409, 462, 420 Flags: Print, NoZoom, NoRotate Annotation: Subtype: Link Rect: 513, 286, 541, 295 Flags: Print, NoZoom, NoRotate Destination: 44 Annotation: Subtype: Link Rect: 323, 238, 356, 249 Flags: Print, NoZoom, NoRotate Destination: 44 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 423, 490, 429, 500 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 432, 490, 438, 500 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 311, 479, 316, 489 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 401, 319, 407, 330 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 347, 229, 353, 239 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 470, 217, 476, 228 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 404, 194, 413, 205 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 419, 194, 426, 205 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 344, 172, 353, 182 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 500, 138, 509, 148 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 514, 138, 524, 148 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 359, 115, 368, 125 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 331, 58, 340, 68 Flags: Print, NoZoom, NoRotate Destination: 46 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 103, 672, 109, 682 Flags: Print, NoZoom, NoRotate Destination: 45 Annotation: Subtype: Link Rect: 171, 593, 180, 603 Flags: Print, NoZoom, NoRotate Destination: 46 Annotation: Subtype: Link Rect: 93, 365, 102, 376 Flags: Print, NoZoom, NoRotate Destination: 46 Annotation: Subtype: Link Rect: 95, 320, 104, 330 Flags: Print, NoZoom, NoRotate Destination: 46 Page: Label: 5 Checksum: dfaf52c6 Type: CRC32 Checksum: 95a5323e324db0602a19bcbbe86064c0 Type: MD5 Checksum: 75285990aa3cde1eb4c1850d0b1f30ae0f0e869c Type: SHA-1