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Title:          Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
Subject:        Nature Communications 7,  (2016). doi:10.1038/ncomms10787
Author:         Ricardo Sant'Anna
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      Title: Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
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        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: Tolcapone inhibits TTR aggregation
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         Item: 
          Title: Tolcapone kinetically stabilizes TTR
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         Item: 
          Title: Tolcapone binds with high affinity to TTR
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         Item: 
          Title: Tolcapone stabilizes the TTR dimer dimer interface
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         Item: 
          Title: Tolcapone selectively binds to TTR in human plasma
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         Item: 
          Title: Tolcapone stabilizes WT-TTR and V30M-TTR in human plasma
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         Item: 
          Title: Tolcapone prevents TTR-induced cytotoxicity in cell culture
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          Title: Tolcapone binds to and stabilizes TTR in transgenic mice
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          Title: Orally administered tolcapone stabilizes TTR in humans
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        Title: Discussion
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        Title: Methods
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          Title: Recombinant TTR expression and purification
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          Title: TTR in vitro aggregation inhibition assays
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          Title: Sedimentation assay
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          Title: TTR stabilization by tolcapone in the presence of urea
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          Title: Isothermal titration calorimetry
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          Title: Crystallography and structure determination
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          Title: Binding competition assays using radioactive T4
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          Title: Stability studies by native PAGE and isoelectric focusing (IEF)
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          Title: Ex vivo stability studies by immunoturbidity
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          Title: Cell toxicity assays
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          Title: Dot-blot filter assay for quantification of TTR aggregation
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          Title: Tolcapone oral administration in mice
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          Title: Tolcapone oral administration in humans
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          Title: TTR stabilization after oral administrations in humans
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          Title: Tolcapone quantification in human plasma
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