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Title:          Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics
Subject:        Nature Communications 7,  (2016). doi:10.1038/ncomms11889
Author:         Eloy F. Robles
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        Title: Results
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          Title: NKX2-3 expression in marginal-zone B- cell &!QJ;lymphomas
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
         Item: 
          Title: Characterization of NKX2-3 deficiency in B cells
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          Title: NKX2-3 promotes expansion of splenic marginal-zone B cells
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        Title: Figure™1NKX2-3 expression is deregulated in marginal-zone B- cell lymphomas.(a) Partial G- banded karyotype showing a t(10;14)(q24;q32) translocation in a patient with SMZL (case 1). Arrows mark the derivative chromosomes 10 and 14. (b,d) Interphase FISH 
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        Title: Figure™2Nkx2-3-sol- and Emgr-NKX2-3 transgenic (TG) mice show abnormal lymphopoiesis.(a) Murine Nkx2-3 expression measured by quantitative RT-PCR in haematopoietic cell subpopulations isolated from healthy C57BLsol6 mice. Haematopoietic stem cells (HSC, l
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         Item: 
          Title: Emgr-NKX2-3 mice develop human-like marginal-zone lymphomas
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         Item: 
          Title: NKX2-3 induces constitutive BCR signalling in young mice
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       Item: 
        Title: Figure™3Emgr-NKX2-3 mice develop human-like marginal-zone lymphomas.(a) Kaplan-Meier overall survival curves for the two Emgr-NKX2-3 transgenic lines and WT mice. (b) Haematoxilin-eosin (H&E) staining of formalin-fixed paraffin-embedded spleen tissues of 
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         Item: 
          Title: NKX2-3 regulates B cells dynamics in lymphoid tissues
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        Title: Figure™4NKX2-3 induces B- cell receptor signalling in B cells from young mice.(a) Cell survival of in™vitro cell cultures containing isolated CD19+ cells from WT and transgenic (TG) mice. Data from three experiments are shown. (b) BrdU staining of WT and 
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          Title: NKX2-3-expressing B cells are sensitive to BCR blockade
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        Title: Discussion
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        Title: Figure™5NKX2-3 induces activation of BCR and downstream signalling pathways in mouse B- cell lymphomas.(a) Western blot analysis showed increase in AKT phosphorylation levels in splenic CD19+ cells isolated from 18-month-old transgenic (TG) mice in compar
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        Title: Methods
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          Title: Human primary samples
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          Title: Long-distance inverse PCR
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         Item: 
          Title: Quantitative real-time PCR
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        Title: Figure™6Phenotypic analysis and characterization of cell dynamics in NKX2-3-expressing B cells.(a) Representative flow cytometry profiles (grey filled histogram) of forward side scatter (FSC) and the indicated molecules at the surface of WT B cells and NK
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        Title: Figure™7Functional characterization of cell dynamic changes in Emgr-NKX2-3 transgenic mice.(a) Migration frequencies of transgenic B cells non-treated (none) or treated with the indicated chemical inhibitors (AMD, CXCR4 antagonist, 10thinspmgrM; A286, LFA
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          Title: Fluorescence in™situ hybridization
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         Item: 
          Title: Generation of NKX2-3 mAb
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          Title: IHC and western blot analyses
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          Title: Generation and characterization of NKX2-3-deficient mice and Emgr-NKX2-3 transgenic mice
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          Title: Mouse blood cell count
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          Title: Measurement of spleen size using ultrasounds
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          Title: Flow cytometry analyses
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          Title: Cell isolation
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          Title: Cell survival and proliferation
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         Item: 
          Title: V(D)J Recombination analysis of mouse B- cell tumours
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         Item: 
          Title: Gene expression microarray data analysis
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         Item: 
          Title: Functional and pathway analysis of gene expression signatures
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         Item: 
          Title: High-resolution comparative genomic hybridization (aCGH) to microarray
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         Item: 
          Title: Chemotaxis assays
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         Item: 
          Title: Calcium mobilization assay
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         Item: 
          Title: Adhesion assays and time-lapse microscopy on planar lipid bilayers
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         Item: 
          Title: IF studies
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          Title: Chemical inhibitors
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          Title: Electrophoretic mobility gel shift array
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          Title: Statistical analysis
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       Item: 
        Title: McGinnisW.KrumlaufR.Homeobox genes and axial patterningCell682833021992Garcia-FernandezJ.The genesis and evolution of homeobox gene clustersNat. Rev. Genet.68818922005BibenC.WangC. C.HarveyR. P.NK-2 class homeobox genes and pharyngealsoloral patterning: N
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       Item: 
        Title: We thank Jerry Adams (WEHI, Melbourne, Australia) for providing the pEmgrSR vector, Vincent Dubus (Genoway, Lyon, France) for support during transgenic mouse generation, Carlos Ortiz de Solorzano (CIMA, Pamplona, Spain) for spleen ultrasound studies in mi
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        Title: ACKNOWLEDGEMENTS
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       Item: 
        Title: Additional information
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    Title: Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics
    Author: Eloy F. Robles
    Subject: Nature Communications 7,  (2016). doi:10.1038/ncomms11889
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   Type: MD5
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