8ef252452d16152b494aeb0272903c91 pmc_27983675.pdf f62b385c499d1cc60008c554ce18ecf3bc17c892 pmc_27983675.pdf d2ec1920bf909be186e9073b8645a9eacca832ed8a00d9ae9238d488cea64789 pmc_27983675.pdf Title: Assessing Motor Fluctuations in Parkinson’s Disease Patients Based on a Single Inertial Sensor Subject: Altered movement control is typically the first noticeable symptom manifested by Parkinson’s disease (PD) patients. Once under treatment, the effect of the medication is very patent and patients often recover correct movement control over several hours. Nonetheless, as the disease advances, patients present motor complications. Obtaining precise information on the long-term evolution of these motor complications and their short-term fluctuations is crucial to provide optimal therapy to PD patients and to properly measure the outcome of clinical trials. This paper presents an algorithm based on the accelerometer signals provided by a waist sensor that has been validated in the automatic assessment of patient’s motor fluctuations (ON and OFF motor states) during their activities of daily living. A total of 15 patients have participated in the experiments in ambulatory conditions during 1 to 3 days. The state recognised by the algorithm and the motor state annotated by patients in standard diaries are contrasted. Results show that the average specificity and sensitivity are higher than 90%, while their values are higher than 80% of all patients, thereby showing that PD motor status is able to be monitored through a single sensor during daily life of patients in a precise and objective way. Keywords: inertial sensors; Support Vector Machine; Parkinson’s disease; motor fluctuations; ambulatory monitoring Author: Carlos Pérez-López, Albert Samà, Daniel Rodríguez-Martín, Andreu Català, Joan Cabestany, Juan Manuel Moreno-Arostegui, Eva de Mingo and Alejandro Rodríguez-Molinero Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Dec 15 08:29:09 2016 CET ModDate: Thu Dec 15 08:29:09 2016 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2933506 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SINARR+URWPalladioL-Ital Type 1 Custom yes yes no 87 0 HRHWDB+URWPalladioL-Bold Type 1 Custom yes yes no 88 0 BPYUFK+URWPalladioL-Roma Type 1 Custom yes yes no 89 0 RVSEMT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 93 0 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yes no 1120 0 LJIGFG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 1121 0 LJIGFI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 1122 0 LJIHIE+TimesNewRoman TrueType WinAnsi yes yes no 1152 0 LJIGAG+PalatinoLinotype TrueType WinAnsi yes yes no 1153 0 LJIGFG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 1154 0 LJIGFI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 1155 0 LJIHIE+TimesNewRoman TrueType WinAnsi yes yes no 1207 0 LJIGAG+PalatinoLinotype TrueType WinAnsi yes yes no 1208 0 LJIGFG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 1209 0 LJIGFI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 1210 0 LJIHIE+TimesNewRoman TrueType WinAnsi yes yes no 1228 0 LJIGAG+PalatinoLinotype TrueType WinAnsi yes yes no 1229 0 LJIGFG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 1230 0 LJIGFI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 1231 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-16 02:57:55 CET RepresentationInformation: pmc_27983675.pdf 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Title: こづのびはひぜ〴ぜ〰いづぶどっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぃはぬぬづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Item: Title: いちぴちぜ〴ぜ〰ぃはぬぬづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Children: Item: Title: ぅぶちぬふちぴどはのぜ〴ぜ〰いちぴちぢちびづぜ〴ぜ〰はてぜ〴ぜ〰ぉのづひぴどちぬぜ〴ぜ〰こどでのちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸲ Item: Title: がづちひのどのでぜ〴ぜ〰いちぴちぢちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: こどでのちぬぜ〴ぜ〰ぐひはっづびびどのでぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰いべびにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こづぬて〭ぁつちばぴどのでぜ〴ぜ〰あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴ぜ〰ぁぬではひどぴとねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰くぎ〯くううぜ〴ぜ〰きはぴはひぜ〴ぜ〰こぴちぴづびぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: いべびにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こづぬて〭ぁつちばぴどのでぜ〴ぜ〰あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴ぜ〰ぁぬではひどぴとねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰くぎ〯くううぜ〴ぜ〰きはぴはひぜ〴ぜ〰こぴちぴづびぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こづぬて〭ぁつちばぴどのでぜ〴ぜ〰あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴ぜ〰ぁぬではひどぴとねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰くぎ〯くううぜ〴ぜ〰きはぴはひぜ〴ぜ〰こぴちぴづびぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: こづぬて〭ぁつちばぴどのでぜ〴ぜ〰あひちつべにどのづびどちぜ〴ぜ〰いづぴづっぴどはのぜ〴ぜ〰ぁぬではひどぴとねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰くぎ〯くううぜ〴ぜ〰きはぴはひぜ〴ぜ〰こぴちぴづびぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: くぎ〯くううぜ〴ぜ〰きはぴはひぜ〴ぜ〰こぴちぴづびぜ〴ぜ〰いづぴづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぅぶちぬふちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづびふぬぴびぜ〴ぜ〰ちのつぜ〴ぜ〰いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠嬷〠〠删⽆楴䡝‾㸊㰼ਯ呹灥 偡来ਯ䍯湴敮瑳‸㐠〠刊⽒敳潵牣敳‸㌠〠刊⽍敤楡䉯砠嬰‰‵㤵⸲㜶‸㐱⸸㥝ਯ偡牥湴‹〠〠刊⽁湮潴猠嬠㜱‰⁒‷㌠〠删㜵‰⁒‷㘠〠删㜷‰⁒‷㠠〠删㠲‰⁒⁝ਾ㸊㰼ਯ偲潤畣敲
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