1acbf16719d1a116167e7adf7a152c67  pmc_27991928.pdf
173e198ddc74c18f36c054de526e23edc752a119  pmc_27991928.pdf
1f712e31ac3ac1965a45103b2fd6a1aa8a9988e4d942abbbeb094ebaffd911ab  pmc_27991928.pdf

Title:          Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
Subject:        Oncogene 36, 2737 (2017). doi:10.1038/onc.2016.427
Author:         F Mateo
Creator:        Arbortext Advanced Print Publisher 10.0.1465/W Unicode
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Tue Apr 11 18:30:06 2017 CEST
ModDate:        Mon Apr 17 13:23:47 2017 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      5057565 bytes
Optimized:      yes
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HMDNBD+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     410  0
HMDNGC+AdvTT5afe5d37.B               Type 1C           WinAnsi          yes yes no     411  0
HMDNGD+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     412  0
HMDNGE+AdvTT6780a46b                 Type 1C           WinAnsi          yes yes no     413  0
HMDNHE+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     421  0
HMDNIF+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     422  0
HMDNIG+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     423  0
HMDNIH+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     424  0
HMDNPI+AdvOT7d2ebc01                 Type 1C           WinAnsi          yes yes no     199  0
HMDNNG+AdvEls-ent4                   Type 1C           WinAnsi          yes yes no     191  0
HMDNNH+AdvOT46dcae81+fb              Type 1C           Custom           yes yes yes    192  0
HMDNOH+AdvOT46dcae81+22              Type 1C           Custom           yes yes no     197  0
HMGIED+AdvOT919a0533.B               Type 1C           WinAnsi          yes yes no     213  0
HMHBCK+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes    218  0
HMHBCL+AdvTT6780a46b+fb              Type 1C           Custom           yes yes yes    219  0
HMHBCM+AdvTT6780a46b+20              Type 1C           WinAnsi          yes yes no     220  0
HMOAHD+AdvPi1                        Type 1C           WinAnsi          yes yes no     222  0
HOLFMM+AdvOT46dcae81+03              Type 1C           Custom           yes yes yes    228  0
HOMGOM+AdvOT8608a8d1+20              Type 1C           Custom           yes yes yes    229  0
HOMHFL+AdvOT65f8a23b.I+20            Type 1C           WinAnsi          yes yes no     230  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-02-16 02:57:50 CET
 RepresentationInformation: pmc_27991928.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2018-02-06 08:42:17 CET
  Size: 5057565
  Format: PDF
  Version: 1.6
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b4' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b10' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b11' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b12' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b13' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b14' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b15' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b16' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b16' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b17' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b16' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b18' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b19' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b20' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b21' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b22' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b23' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b24' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b22' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b25' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b26' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b27' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b23' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b28' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b25' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b16' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b10' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b26' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b27' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b29' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b30' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b31' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b32' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b33' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b34' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b34' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b35' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b36' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b10' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b37' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b38' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b39' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b38' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b40' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b21' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b32' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b33' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b10' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b12' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b14' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b15' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b50' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b51' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b16' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b52' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b53' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b54' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b55' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b16' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b56' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b55' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b57' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b58' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b59' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b60' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b57' cannot be found
   Offset: 5033000
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_b38' cannot be found
   Offset: 5033000
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 450
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
      Children: 
       Item: 
        Title: Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
        Children: 
         Item: 
          Title: Active mTORC1 signaling associates with distant metastasis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
         Item: 
          Title: Metastasis dependence on mTORC1 signaling
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
         Item: 
          Title: Metastatic resistance to mTOR inhibition
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
         Item: 
          Title: TSC1„/„2 expression correlates negatively with tumor-initiating features
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: Figure 1 mTORC1 activity concurrent with enhanced metastatic potential.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
        Children: 
         Item: 
          Title: EVI1 couples mTOR signaling to metastasis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Figure 2 Metastatic resistance to mTOR inhibition.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: Figure 3 Co-expression analysis and stem cell-like signatures.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: Figure 4 EVI1 couples stemness, metastatic potential and resistance to mTOR inhibition.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
        Children: 
         Item: 
          Title: EVI1 cooperates with SOX9
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: Figure 5 EVI1 cooperates with SOX9 and regulates its expression.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
        Children: 
         Item: 
          Title: In vivo evaluation of the EVI1, SOX9 and mTOR relationship
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
       Item: 
        Title: Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
        Children: 
         Item: 
          Title: Tissue microarray
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
         Item: 
          Title: Gene expression analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: Figure 6 In vivo assessment of the role of EVI1 and SOX9.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
        Children: 
         Item: 
          Title: Antibodies
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: Immunohistochemistry
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
         Item: 
          Title: Cell culture
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
         Item: 
          Title: Western blotting
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: Lung colonization assays
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: Figure 7 Proposed mechanistic model.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
        Children: 
         Item: 
          Title: Ortho-xenograft
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
         Item: 
          Title: Exome analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: 4T1 tumors
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: ChIP assays
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
         Item: 
          Title: Gene expression alterations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
         Item: 
          Title: Genomics of drug sensitivity data analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
       Item: 
        Title: Figure 7 Proposed mechanistic model.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
       Item: 
        Title: Figure 7 Proposed mechanistic model.
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
       Item: 
        Title: REFERENCES
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
   Info: 
    Title: Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
    Author: F Mateo
    Subject: Oncogene 36, 2737 (2017). doi:10.1038/onc.2016.427
    Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Tue Apr 11 18:30:06 CEST 2017
    ModDate: Mon Apr 17 13:53:47 CEST 2017
   ID: 0x8e9bef665833d0557381d3bee7307470, 0x3d3975c70fa21d4aaa52efc2dca69bff
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4018
      ImageHeight: 2549
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4102
      ImageHeight: 2775
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3990
      ImageHeight: 4005
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4100
      ImageHeight: 3026
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4000
      ImageHeight: 3239
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4074
      ImageHeight: 3061
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 1487
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HMDNNH+AdvOT46dcae81+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HMDNNH+AdvOT46dcae81+fb
       Flags: Symbolic
       FontBBox: 0, 0, 739, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HOLFMM+AdvOT46dcae81+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HOLFMM+AdvOT46dcae81+03
       Flags: Symbolic
       FontBBox: -31, -208, 739, 802
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMDNHE+AdvOT46dcae81
      FontSubset: true
      FirstChar: 35
      LastChar: 243
      FontDescriptor: 
       FontName: HMDNHE+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNOH+AdvOT46dcae81+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: HMDNOH+AdvOT46dcae81+22
       Flags: Nonsymbolic
       FontBBox: 0, -145, 687, 822
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: HOMGOM+AdvOT8608a8d1+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HOMGOM+AdvOT8608a8d1+20
       Flags: Symbolic
       FontBBox: -968, -333, 2000, 1020
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMDNIF+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: HMDNIF+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HOMHFL+AdvOT65f8a23b.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: HOMHFL+AdvOT65f8a23b.I+20
       Flags: Nonsymbolic
       FontBBox: -177, -197, 1083, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNIG+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 44
      LastChar: 119
      FontDescriptor: 
       FontName: HMDNIG+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNPI+AdvOT7d2ebc01
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: HMDNPI+AdvOT7d2ebc01
       Flags: Nonsymbolic
       FontBBox: -31, -208, 958, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNIH+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: HMDNIH+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1125, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMGIED+AdvOT919a0533.B
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: HMGIED+AdvOT919a0533.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 656, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNBD+Arial-BoldMT
      FontSubset: true
      FirstChar: 69
      LastChar: 80
      FontDescriptor: 
       FontName: HMDNBD+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMHBCK+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HMHBCK+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMDNGC+AdvTT5afe5d37.B
      FontSubset: true
      FirstChar: 65
      LastChar: 104
      FontDescriptor: 
       FontName: HMDNGC+AdvTT5afe5d37.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 895, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMHBCL+AdvTT6780a46b+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: HMHBCL+AdvTT6780a46b+fb
       Flags: Symbolic
       FontBBox: 9, 0, 875, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HMDNGD+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 45
      LastChar: 116
      FontDescriptor: 
       FontName: HMDNGD+AdvOTa20b42a7
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMHBCM+AdvTT6780a46b+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: HMHBCM+AdvTT6780a46b+20
       Flags: Nonsymbolic
       FontBBox: 0, -114, 1156, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNGE+AdvTT6780a46b
      FontSubset: true
      FirstChar: 35
      LastChar: 243
      FontDescriptor: 
       FontName: HMDNGE+AdvTT6780a46b
       Flags: Nonsymbolic
       FontBBox: -41, -250, 875, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMOAHD+AdvPi1
      FontSubset: true
      FirstChar: 52
      LastChar: 52
      FontDescriptor: 
       FontName: HMOAHD+AdvPi1
       Flags: Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HMDNNG+AdvEls-ent4
      FontSubset: true
      FirstChar: 111
      LastChar: 111
      FontDescriptor: 
       FontName: HMDNNG+AdvEls-ent4
       Flags: Nonsymbolic
       FontBBox: 0, -343, 1166, 1218
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="doi:10.1038/onc.2016.427"
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>&#xA;            doi:10.1038/onc.2016.427</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>F Mateo</rdf:li>
               <rdf:li>E J Arenas</rdf:li>
               <rdf:li>H Aguilar</rdf:li>
               <rdf:li>J Serra-Musach</rdf:li>
               <rdf:li>G Ruiz de Garibay</rdf:li>
               <rdf:li>J Boni</rdf:li>
               <rdf:li>M Maicas</rdf:li>
               <rdf:li>S Du</rdf:li>
               <rdf:li>F Iorio</rdf:li>
               <rdf:li>C Herranz-Ors</rdf:li>
               <rdf:li>A Islam</rdf:li>
               <rdf:li>X Prado</rdf:li>
               <rdf:li>A Llorente</rdf:li>
               <rdf:li>A Petit</rdf:li>
               <rdf:li>A Vidal</rdf:li>
               <rdf:li>I Catal&amp;agrave;</rdf:li>
               <rdf:li>T Soler</rdf:li>
               <rdf:li>G Venturas</rdf:li>
               <rdf:li>A Rojo-Sebastian</rdf:li>
               <rdf:li>H Serra</rdf:li>
               <rdf:li>D Cuadras</rdf:li>
               <rdf:li>I Blanco</rdf:li>
               <rdf:li>J Lozano</rdf:li>
               <rdf:li>F Canals</rdf:li>
               <rdf:li>A M Sieuwerts</rdf:li>
               <rdf:li>V de Weerd</rdf:li>
               <rdf:li>M P Look</rdf:li>
               <rdf:li>S Puertas</rdf:li>
               <rdf:li>N Garc&amp;iacute;a</rdf:li>
               <rdf:li>A S Perkins</rdf:li>
               <rdf:li>N Bonifaci</rdf:li>
               <rdf:li>M Skowron</rdf:li>
               <rdf:li>L G&amp;oacute;mez-Bald&amp;oacute;</rdf:li>
               <rdf:li>V Hern&amp;aacute;ndez</rdf:li>
               <rdf:li>A Mart&amp;iacute;nez-Aranda</rdf:li>
               <rdf:li>M Mart&amp;iacute;nez-Iniesta</rdf:li>
               <rdf:li>X Serrat</rdf:li>
               <rdf:li>J Cer&amp;oacute;n</rdf:li>
               <rdf:li>J Brunet</rdf:li>
               <rdf:li>M P Barretina</rdf:li>
               <rdf:li>M Gil</rdf:li>
               <rdf:li>C Falo</rdf:li>
               <rdf:li>A Fern&amp;aacute;ndez</rdf:li>
               <rdf:li>I Morilla</rdf:li>
               <rdf:li>S Pernas</rdf:li>
               <rdf:li>M J Pl&amp;agrave;</rdf:li>
               <rdf:li>X Andreu</rdf:li>
               <rdf:li>M A Segu&amp;iacute;</rdf:li>
               <rdf:li>R Ballester</rdf:li>
               <rdf:li>E Castell&amp;agrave;</rdf:li>
               <rdf:li>M Nellist</rdf:li>
               <rdf:li>S Morales</rdf:li>
               <rdf:li>J Valls</rdf:li>
               <rdf:li>A Velasco</rdf:li>
               <rdf:li>X Matias-Guiu</rdf:li>
               <rdf:li>A Figueras</rdf:li>
               <rdf:li>J V S&amp;aacute;nchez-Mut</rdf:li>
               <rdf:li>M S&amp;aacute;nchez-C&amp;eacute;spedes</rdf:li>
               <rdf:li>A Cordero</rdf:li>
               <rdf:li>J G&amp;oacute;mez-Miragaya</rdf:li>
               <rdf:li>L Palomero</rdf:li>
               <rdf:li>A G&amp;oacute;mez</rdf:li>
               <rdf:li>T F Gajewski</rdf:li>
               <rdf:li>E E W Cohen</rdf:li>
               <rdf:li>M Jesiotr</rdf:li>
               <rdf:li>L Bodnar</rdf:li>
               <rdf:li>M Quintela-Fandino</rdf:li>
               <rdf:li>N L&amp;oacute;pez-Bigas</rdf:li>
               <rdf:li>R Vald&amp;eacute;s-Mas</rdf:li>
               <rdf:li>X S Puente</rdf:li>
               <rdf:li>F Vi&amp;ntilde;als</rdf:li>
               <rdf:li>O Casanovas</rdf:li>
               <rdf:li>M Graupera</rdf:li>
               <rdf:li>J Hern&amp;aacute;ndez-Losa</rdf:li>
               <rdf:li>S Ram&amp;oacute;n y Cajal</rdf:li>
               <rdf:li>L Garc&amp;iacute;a-Alonso</rdf:li>
               <rdf:li>J Saez-Rodriguez</rdf:li>
               <rdf:li>M Esteller</rdf:li>
               <rdf:li>A Sierra</rdf:li>
               <rdf:li>N Mart&amp;iacute;n-Mart&amp;iacute;n</rdf:li>
               <rdf:li>A Matheu</rdf:li>
               <rdf:li>A Carracedo</rdf:li>
               <rdf:li>E Gonz&amp;aacute;lez-Su&amp;aacute;rez</rdf:li>
               <rdf:li>M Nanjundan</rdf:li>
               <rdf:li>J Cort&amp;eacute;s</rdf:li>
               <rdf:li>C L&amp;aacute;zaro</rdf:li>
               <rdf:li>M D Odero</rdf:li>
               <rdf:li>J W M Martens</rdf:li>
               <rdf:li>G Moreno-Bueno</rdf:li>
               <rdf:li>M H Barcellos-Hoff</rdf:li>
               <rdf:li>A Villanueva</rdf:li>
               <rdf:li>R R Gomis</rdf:li>
               <rdf:li>M A Pujana</rdf:li>
               <rdf:li> </rdf:li>
               <rdf:li> </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Oncogene 36, 2737 (2017). doi:10.1038/onc.2016.427</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">© 2017 The Author(s)</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition</rdf:li>
            </rdf:Alt>
         </dc:title>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/onc.2016.427"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/onc.2016.427"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:copyright>&#xA;            ©  </prism:copyright>
         <prism:doi>10.1038/onc.2016.427</prism:doi>
         <prism:eIssn>1476-5594</prism:eIssn>
         <prism:endingPage>2749</prism:endingPage>
         <prism:issn>0950-9232</prism:issn>
         <prism:number>19</prism:number>
         <prism:publicationName/>
         <prism:rightsAgent>permissions@nature.com</prism:rightsAgent>
         <prism:startingPage>2737</prism:startingPage>
         <prism:volume>36</prism:volume>
         <prism:publicationDate>
            <rdf:Bag>
               <rdf:li>2016-12-19</rdf:li>
            </rdf:Bag>
         </prism:publicationDate>
         <prism:url>
            <rdf:Bag>
               <rdf:li>&#xA;                http://dx.doi.org/10.1038/onc.2016.427</rdf:li>
            </rdf:Bag>
         </prism:url>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/onc.2016.427"
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreateDate>2017-04-11T16:30:06Z</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher 10.0.1465/W Unicode</xap:CreatorTool>
         <xap:Label>Oncogene 36, 2737 (2016). doi:10.1038/onc.2016.427</xap:Label>
         <xap:MetadataDate>2017-04-17T16:53:47+05:30</xap:MetadataDate>
         <xap:ModifyDate>2017-04-17T16:53:47+05:30</xap:ModifyDate>
         <xap:Identifier>
            <rdf:Bag>
               <rdf:li>&#xA;                doi:10.1038/onc.2016.427</rdf:li>
            </rdf:Bag>
         </xap:Identifier>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/onc.2016.427"
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/onc.2016.427"
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:89b71039-ad5c-43df-b996-8797b88c815c</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:1588e3eb-3010-4139-a439-f5dfeffe9399</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 188, 395, 270, 404
      Annotation: 
       Subtype: Link
       Rect: 56, 73, 141, 80
      Annotation: 
       Subtype: Link
       Rect: 152, 73, 228, 80
      Annotation: 
       Subtype: Link
       Rect: 278, 734, 353, 742
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 695, 216, 704
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 106, 675, 110, 684
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 170, 655, 174, 663
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 259, 624, 262, 633
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 105, 604, 109, 613
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 191, 564, 195, 573
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 234, 554, 238, 563
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 131, 514, 135, 523
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 289, 494, 293, 503
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 84, 463, 91, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 92, 463, 99, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 73, 433, 80, 442
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 207, 413, 214, 422
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 254, 403, 261, 412
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 89, 383, 96, 392
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 289, 230, 293, 239
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 233, 170, 236, 179
       Destination: 177
      Annotation: 
       Subtype: Link
       Rect: 140, 146, 176, 155
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 419, 685, 426, 694
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 417, 651, 453, 660
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 423, 611, 462, 620
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 513, 555, 520, 564
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 449, 431, 485, 440
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 511, 290, 518, 299
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 459, 256, 493, 265
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 482, 216, 518, 224
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 543, 199, 550, 208
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 552, 199, 559, 208
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 514, 175, 555, 184
       Destination: 48
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 93, 267, 131, 276
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 174, 247, 213, 256
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 196, 187, 231, 196
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 155, 156, 189, 165
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 193, 140, 200, 149
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 80, 228, 89
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 522, 143, 529, 152
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 385, 111, 391, 120
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 326, 91, 332, 100
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 543, 91, 549, 100
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 431, 59, 448, 68
       Destination: null
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 220, 240, 256, 249
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 111, 209, 147, 218
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 152, 213, 159, 222
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 71, 182, 78, 191
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 79, 182, 86, 191
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 196, 127, 232, 136
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 217, 121, 224, 130
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 193, 107, 229, 116
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 105, 66, 141, 75
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 518, 240, 555, 249
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 313, 220, 348, 229
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 404, 214, 411, 223
       Destination: null
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 403, 59, 410, 68
       Destination: null
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 727, 121, 736
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 104, 717, 111, 726
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 118, 706, 125, 715
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 126, 706, 133, 715
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 143, 702, 183, 711
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 47, 661, 83, 670
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 128, 644, 135, 653
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 269, 614, 276, 623
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 98, 583, 105, 592
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 311, 723, 348, 732
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 472, 713, 508, 722
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 330, 692, 365, 701
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 350, 599, 385, 608
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 449, 579, 485, 588
       Destination: 69
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 723, 142, 732
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 227, 712, 262, 721
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 128, 660, 164, 668
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 325, 693, 360, 701
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 364, 696, 371, 705
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 372, 696, 379, 705
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 327, 656, 334, 665
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 497, 656, 504, 665
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 446, 636, 453, 645
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 500, 92, 533, 100
       Destination: 69
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 47, 723, 120, 732
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 183, 697, 190, 706
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 106, 673, 143, 682
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 278, 657, 285, 665
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 286, 657, 293, 665
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 165, 637, 172, 646
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 148, 532, 187, 541
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 136, 422, 171, 431
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 254, 402, 291, 411
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 245, 361, 279, 370
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 253, 341, 290, 350
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 253, 331, 289, 340
       Destination: 87
      Annotation: 
       Subtype: Link
       Rect: 126, 206, 191, 215
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 234, 116, 272, 125
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 96, 86, 158, 94
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 97, 65, 163, 74
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 358, 723, 421, 732
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 410, 603, 441, 612
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 449, 577, 456, 586
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 328, 567, 335, 576
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 533, 538, 540, 547
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 401, 518, 407, 527
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 371, 508, 378, 517
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 379, 498, 386, 507
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 436, 448, 443, 457
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 347, 388, 353, 397
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 518, 388, 525, 397
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 457, 378, 464, 387
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 329, 318, 336, 327
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 513, 308, 520, 317
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 503, 298, 510, 307
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 552, 279, 559, 288
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 330, 249, 337, 258
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 503, 229, 510, 238
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 477, 219, 484, 228
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 504, 209, 511, 218
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 474, 189, 480, 198
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 527, 179, 534, 188
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 365, 99, 369, 108
       Destination: 177
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 208, 234, 215, 243
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 165, 214, 172, 223
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 428, 212, 434, 220
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 304, 199, 463, 207
      Annotation: 
       Subtype: Link
       Rect: 466, 203, 472, 211
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 416, 88, 422, 96
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 424, 88, 430, 96
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 59, 499, 67
       Destination: null
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 234, 92, 293, 100
      Annotation: 
       Subtype: Link
       Rect: 45, 83, 64, 91
      Annotation: 
       Subtype: Link
       Rect: 553, 707, 559, 715
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 331, 689, 337, 696
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 542, 535, 548, 543
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 382, 322, 388, 330
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 403, 86, 409, 94
       Destination: null
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 224, 388, 230, 396
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 508, 700, 514, 708
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 418, 621, 424, 629
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 543, 371, 549, 379
       Destination: null
     Thumb: true
    Page: 
     Label: 12
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 531, 427, 549, 434
      Annotation: 
       Subtype: Link
       Rect: 301, 419, 431, 425
     Thumb: true
  Checksum: d14c295b
   Type: CRC32
  Checksum: 1acbf16719d1a116167e7adf7a152c67
   Type: MD5
  Checksum: 173e198ddc74c18f36c054de526e23edc752a119
   Type: SHA-1