33947551893c620101025b3a62170bb7  2016_BMCBiol_Pegueroles_etal.pdf
1c4a53813ea1d7d8a7aee15864e02f7faed0631c  2016_BMCBiol_Pegueroles_etal.pdf
e6c69c8f4f5471a83a3e09435c96076064c1e8c723a60c75d053f43131dac9d2  2016_BMCBiol_Pegueroles_etal.pdf

Title:           Secondary structure impacts patterns of selection in human lncRNAs
Subject:         BMC Biology, 2016, doi:10.1186/s12915-016-0283-0
Keywords:        lncRNA,Purifying selection,Divergence,Polymorphism,Secondary structure
Author:          Cinta Pegueroles
Creator:         Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:        Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:    Sat Jul 23 00:56:26 2016 CEST
ModDate:         Mon Jul 25 13:58:37 2016 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2349907 bytes
Optimized:       no
PDF version:     1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
NDAEIC+JvyrphAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no      56  0
NDAENB+LykdqfAdvTTe45e47d2           Type 1C           WinAnsi          yes yes no       9  0
NDAENC+SgwrtjAdvTTb5929f4c           Type 1C           WinAnsi          yes yes no      94  0
MyriadPro-Regular                    Type 1            Custom           yes no  no       8  0
NDAEOC+VstxgnAdvTT99c4c969           Type 1C           WinAnsi          yes yes no      57  0
NDAEOD+LfphvhAdvTT86d47313           Type 1C           WinAnsi          yes yes no      10  0
NDAEPE+SlkcmlAdvTT8861b38f.I         Type 1C           WinAnsi          yes yes no      11  0
NDAFNB+GjktkyAdvTT7329fd89.I         Type 1C           WinAnsi          yes yes no      12  0
NDAFAF+QrpcgyAdvTT86d47313+20        Type 1C           WinAnsi          yes yes no      13  0
NDAGFP+NmgtjsAdvTT86d47313+03        Type 1C           Custom           yes yes yes     95  0
NDAOGP+VkpxrjAdvTT1b53b5fb.I         Type 1C           WinAnsi          yes yes no      96  0
NDBLIP+TmnphdAdvTTb5929f4c+03        Type 1C           Custom           yes yes yes    124  0
NDDLMK+McpmswAdvTTb5929f4c+20        Type 1C           WinAnsi          yes yes no     172  0
NDEJEI+MdlrsvAdvTT5843c571+03        Type 1C           Custom           yes yes yes    187  0
NDEJKH+NhpmkfAdvTT86d47313+22        Type 1C           Custom           yes yes yes    219  0
NDEJKI+YxbfvdAdvTTaf7f9f4f.B+20      Type 1C           WinAnsi          yes yes no     220  0
NDEJOI+JcsrngAdvTT99c4c969+20        Type 1C           WinAnsi          yes yes no     246  0
QkhvdvOregonLDOBook                  Type 1C           WinAnsi          yes no  no     264  0
LxgfbvOpenSans-Extrabold             Type 1C           WinAnsi          yes no  no     265  0
PhhmnhOpenSans-Light                 Type 1C           MacRoman         yes no  no     266  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-01-29 03:11:01 CET
 RepresentationInformation: 2016_BMCBiol_Pegueroles_etal.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-01-28 06:15:52 CET
  Size: 2349907
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 535
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Abstract
      Destination: sectionAbs1
      Children: 
       Item: 
        Title: Background
        Destination: sectionASec1
       Item: 
        Title: Results
        Destination: sectionASec2
       Item: 
        Title: Conclusions
        Destination: sectionASec3
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Results and discussion
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Exons in lncRNAs are enriched in conserved elements but do not show overall higher conservation than introns
        Destination: sectionSec3
       Item: 
        Title: Human lncRNA exons show signatures of selection at the population level
        Destination: sectionSec4
       Item: 
        Title: Secondary structure constrains sequence variation in lncRNAs
        Destination: sectionSec5
     Item: 
      Title: Conclusions
      Destination: sectionSec6
     Item: 
      Title: Methods
      Destination: sectionSec7
      Children: 
       Item: 
        Title: Selection of intergenic lncRNA and flanking intergenic regions and protein coding genes
        Destination: sectionSec8
       Item: 
        Title: Sequence conservation of lncRNA across species
        Destination: sectionSec9
       Item: 
        Title: Sequence polymorphism
        Destination: sectionSec10
       Item: 
        Title: Secondary structure
        Destination: sectionSec11
       Item: 
        Title: Sequence repeats
        Destination: sectionSec12
       Item: 
        Title: Statistical tests and plots
        Destination: sectionSec13
     Item: 
      Title: Additional files
      Destination: sectionSec15
     Item: 
      Title: Abbreviations
      Destination: sectionSec14
     Item: 
      Title: Acknowledgements
      Destination: sections12915-016-0283-0
     Item: 
      Title: Funding
      Destination: sectionFPar1
     Item: 
      Title: Authors’ contributions
      Destination: sectionFPar2
     Item: 
      Title: Competing interests
      Destination: sectionFPar3
     Item: 
      Title: Author details
      Destination: sectionaunote1
     Item: 
      Title: References
      Destination: sectionBib1
   Info: 
    Title: Secondary structure impacts patterns of selection in human lncRNAs
    Author: Cinta Pegueroles
    Subject: BMC Biology, 2016, doi:10.1186/s12915-016-0283-0
    Keywords: lncRNA,Purifying selection,Divergence,Polymorphism,Secondary structure
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Sat Jul 23 00:56:26 CEST 2016
    ModDate: Mon Jul 25 13:58:37 CEST 2016
   ID: 0xcdd1dc61bda7d0d4814150df7235ce78, 0xdf204a6729de25e2825d959041d4636c
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 688
      ImageHeight: 126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 91
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1183
      ImageHeight: 1177
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1949
      ImageHeight: 1162
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 2089
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 1739
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1949
      ImageHeight: 1033
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: NDAOGP+VkpxrjAdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: NDAOGP+VkpxrjAdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -46, -250, 1126, 879
       FontFile: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: QkhvdvOregonLDOBook
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: QkhvdvOregonLDOBook
       Flags: Serif, Nonsymbolic
       FontBBox: 1, -308, 1045, 922
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAENB+LykdqfAdvTTe45e47d2
      FontSubset: true
      FirstChar: 32
      LastChar: 243
      FontDescriptor: 
       FontName: NDAENB+LykdqfAdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LxgfbvOpenSans-Extrabold
      FirstChar: 32
      LastChar: 149
      FontDescriptor: 
       FontName: LxgfbvOpenSans-Extrabold
       Flags: Nonsymbolic
       FontBBox: -728, -293, 1407, 1124
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAEOD+LfphvhAdvTT86d47313
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: NDAEOD+LfphvhAdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PhhmnhOpenSans-Light
      FirstChar: 32
      LastChar: 222
      FontDescriptor: 
       FontName: PhhmnhOpenSans-Light
       Flags: Nonsymbolic
       FontBBox: -521, -269, 1140, 1048
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: NDAEPE+SlkcmlAdvTT8861b38f.I
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: NDAEPE+SlkcmlAdvTT8861b38f.I
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAFNB+GjktkyAdvTT7329fd89.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: NDAFNB+GjktkyAdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDDLMK+McpmswAdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: NDDLMK+McpmswAdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -218, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAFAF+QrpcgyAdvTT86d47313+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: NDAFAF+QrpcgyAdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDEJOI+JcsrngAdvTT99c4c969+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: NDEJOI+JcsrngAdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAEIC+JvyrphAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: NDAEIC+JvyrphAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAEOC+VstxgnAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: NDAEOC+VstxgnAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDEJEI+MdlrsvAdvTT5843c571+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: NDEJEI+MdlrsvAdvTT5843c571+03
       Flags: Symbolic
       FontBBox: -437, -229, 875, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NDEJKH+NhpmkfAdvTT86d47313+22
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: NDEJKH+NhpmkfAdvTT86d47313+22
       Flags: Symbolic
       FontBBox: -166, -270, 1031, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NDBLIP+TmnphdAdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: NDBLIP+TmnphdAdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NDEJKI+YxbfvdAdvTTaf7f9f4f.B+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: NDEJKI+YxbfvdAdvTTaf7f9f4f.B+20
       Flags: Nonsymbolic
       FontBBox: -218, -197, 1656, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAENC+SgwrtjAdvTTb5929f4c
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: NDAENC+SgwrtjAdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NDAGFP+NmgtjsAdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: NDAGFP+NmgtjsAdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -135, -250, 906, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 4.2.1-c041 52.342996, 2008/05/07-20:48:00        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:DOI>10.1186/s12915-016-0283-0</crossmark:DOI>
         <crossmark:MajorVersionDate>2016-07-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>lncRNA,Purifying selection,Divergence,Polymorphism,Secondary structure</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:CrossmarkMajorVersionDate>2016-07-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12915-016-0283-0</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:url>http://dx.doi.org/10.1186/s12915-016-0283-0</prism:url>
         <prism:doi>10.1186/s12915-016-0283-0</prism:doi>
         <prism:issn>1741-7007</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BMC Biology</prism:publicationName>
         <prism:copyright>Pegueroles and Gabaldon.</prism:copyright>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1186/s12915-016-0283-0</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BMC Biology</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Biology, 2016, doi:10.1186/s12915-016-0283-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>lncRNA</rdf:li>
               <rdf:li>Purifying selection</rdf:li>
               <rdf:li>Divergence</rdf:li>
               <rdf:li>Polymorphism</rdf:li>
               <rdf:li>Secondary structure</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Secondary structure impacts patterns of selection in human lncRNAs</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Cinta Pegueroles</rdf:li>
               <rdf:li>Toni Gabaldón</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:ModifyDate>2016-07-25T13:58:37+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2016-07-25T13:58:37+02:00</xmp:MetadataDate>
         <xmp:CreateDate>2016-07-23T06:56:26+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:d7264b08-930b-4b68-a10a-4c64034bc1c1</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:60775e82-1f14-4fc9-a9cf-018e76b6d527</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d7264b08-930b-4b68-a10a-4c64034bc1c1</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-07-23T07:00:44+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer ORCiD Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springer.com/ns/xmpExtensions/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>springer</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springer.com/ns/xmpExtensions/1.0/authorinfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyrigh</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 484, 657, 538, 679
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 143, 296, 148, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 155, 296, 160, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 163, 260, 168, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 175, 260, 180, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 230, 188, 235, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 489, 308, 494, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 466, 284, 470, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 450, 272, 454, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 339, 248, 343, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 351, 248, 360, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 339, 188, 349, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 458, 128, 468, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 114, 135, 167, 143
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 279, 65, 397, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 201, 41, 340, 48
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 657, 110, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 116, 657, 126, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 132, 657, 141, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 275, 597, 285, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 85, 561, 95, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 257, 513, 267, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 275, 513, 285, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 190, 465, 200, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 206, 465, 216, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 86, 417, 96, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 104, 309, 113, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 169, 285, 179, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 260, 273, 269, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 97, 261, 106, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 225, 201, 235, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 236, 177, 246, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 94, 129, 103, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 108, 129, 117, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 372, 321, 382, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 346, 273, 356, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 224, 549, 229, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 236, 549, 241, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 200, 513, 210, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 234, 465, 239, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 138, 441, 148, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 245, 333, 254, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 59, 297, 69, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 85, 261, 90, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 72, 165, 77, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 233, 93, 243, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 486, 609, 490, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 321, 597, 358, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 370, 561, 375, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 354, 417, 359, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 364, 417, 374, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 379, 417, 389, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 307, 381, 317, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 488, 225, 497, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 322, 177, 327, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 345, 69, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 190, 285, 200, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 209, 225, 219, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 193, 165, 198, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 254, 141, 264, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 275, 141, 285, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 123, 93, 128, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 188, 69, 193, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 366, 321, 371, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 399, 297, 408, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 308, 153, 317, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 360, 153, 369, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 105, 151, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 422, 297, 432, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 523, 165, 533, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 413, 117, 423, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 120
      Annotation: 
       Subtype: Link
       Rect: 370, 69, 375, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 633, 192, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 211, 585, 220, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 226, 585, 236, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 83, 381, 93, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 181, 345, 191, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 169, 273, 205, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 59, 165, 69, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 174, 117, 179, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 475, 633, 480, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 446, 537, 451, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 325, 453, 330, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 169
      Annotation: 
       Subtype: Link
       Rect: 398, 453, 403, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 319, 417, 324, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 502, 81, 507, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 81, 132, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 400, 105, 410, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 418, 105, 428, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 215, 165, 225, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 230, 165, 240, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 72, 153, 82, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 72, 69, 77, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 372, 105, 377, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 76, 244, 103, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 380, 234, 383, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 209, 549, 218, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 246, 549, 265, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 184
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 177, 285, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 275, 69, 285, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 465, 645, 475, 654
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 411, 549, 421, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 375, 537, 385, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 531, 333, 536, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 464, 273, 474, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 335, 249, 345, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 464, 201, 474, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 337, 93, 347, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 470, 69, 480, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 633, 197, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 219, 429, 229, 438
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 210, 333, 220, 342
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 75, 165, 85, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 133, 129, 143, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 461, 525, 466, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 216
      Annotation: 
       Subtype: Link
       Rect: 423, 464, 433, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 406, 416, 416, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 412, 404, 422, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 254
      Annotation: 
       Subtype: Link
       Rect: 309, 350, 421, 358
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 690, 166, 697
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 244, 666, 278, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 657, 120, 664
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 648, 389, 656
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: feb3b57b
   Type: CRC32
  Checksum: 33947551893c620101025b3a62170bb7
   Type: MD5
  Checksum: 1c4a53813ea1d7d8a7aee15864e02f7faed0631c
   Type: SHA-1
  Checksum: e6c69c8f4f5471a83a3e09435c96076064c1e8c723a60c75d053f43131dac9d2
   Type: SHA-256