c8b6d1276a932ce44bb445707f6eb4ee  ncomms10417.pdf
d6f920d15359afc455b70127550b0ddd4f2d81ef  ncomms10417.pdf
46d44dbb2b223e5693b3babd55ae9e644a6b4652e66e764f25de32e05f16765d  ncomms10417.pdf

Title:           Affinity and competition for TBP are molecular determinants of gene expression noise
Subject:         Nature Communications 7,  (2015). doi:10.1038/ncomms10417
Author:          Guilhem Chalancon
Creator:         Arbortext Advanced Print Publisher 9.0.226/W
Producer:        Acrobat Distiller 11.0.9(Windows)
CreationDate:    Sun Apr 28 15:17:02 2019 CEST
ModDate:         Sun Apr 28 15:17:05 2019 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       1357847 bytes
Optimized:       no
PDF version:     1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
JMIPKB+AdvOTea1a7398                 Type 1C           Custom           yes yes yes    479  0
JMIPKC+AdvEls-ent2                   Type 1C           WinAnsi          yes yes no     480  0
JMIPLC+AdvOTcb88df00                 Type 1C           Custom           yes yes yes    488  0
JMJABB+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     489  0
JMJAEB+AdvOTf23bb480                 Type 1C           Custom           yes yes yes    490  0
JMJAMP+AdvTTda6f6cb8.B               Type 1C           Custom           yes yes yes    500  0
Helvetica2                           Type 1C           Custom           yes no  no     281  0
JMKMEL+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     266  0
JMKMFM+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     284  0
JMKNEH+AdvOT9bd21c25.I               Type 1C           Custom           yes yes yes    271  0
JMJBDN+AdvOT125c650c                 Type 1C           Custom           yes yes yes    276  0
JMJBDO+AdvOT1ef757c0                 Type 1C           Custom           yes yes yes    278  0
JMJBEP+AdvEls-ent7                   Type 1C           WinAnsi          yes yes no     279  0
JMKNHH+AdvOTb65e897d.B               Type 1C           Custom           yes yes yes    294  0
JMKOBE+AdvEls-ent4                   Type 1C           WinAnsi          yes yes no     291  0
JMMECN+CourierNewPSMT                Type 1C           WinAnsi          yes yes no     296  0
JMMENK+AdvOT7d6df7ab.I               Type 1C           Custom           yes yes yes    297  0
JMPGHK+Helvetica                     Type 1C           Custom           yes yes yes    305  0
Helvetica-Oblique2                   Type 1C           Custom           yes no  yes    306  0
JMPHAJ+Symbol                        Type 1C           Custom           yes yes yes    308  0
Helvetica2                           Type 1C           Custom           yes no  no     312  0
JMKMEL+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     309  0
JMPMDM+MathPackTen                   Type 1C           Custom           yes yes no     310  0
JMPMHM+AdvPi1                        Type 1C           WinAnsi          yes yes no     313  0
JMPMLL+AdvP4C4E74                    Type 1C           Custom           yes yes yes    316  0
JNADPA+AdvItcSymbol-M                Type 1C           WinAnsi          yes yes no     321  0
JNAEBA+AdvPi2                        Type 1C           WinAnsi          yes yes no     322  0
JNAECB+Advsymbol                     Type 1C           Custom           yes yes no     320  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-02-05 04:34:03 CET
 RepresentationInformation: ncomms10417.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-02-04 06:26:18 CET
  Size: 1357847
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 561
   FreeObjects: 2
   IncrementalUpdates: 2
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Affinity and competition for TBP are molecular determinants of gene expression noise
      Destination: 1
      Children: 
       Item: 
        Title: Introduction
        Destination: 1
       Item: 
        Title: Results
        Destination: 1
        Children: 
         Item: 
          Title: Functional TBP-binding sites are accessible at a promoter
          Destination: 1
         Item: 
          Title: TBS type is linked with cofactor binding preference
          Destination: 1
         Item: 
          Title: Cofactor binding preference is linked to noise
          Destination: 1
         Item: 
          Title: TBP displays distinct preference for TBS sequences
          Destination: 1
         Item: 
          Title: TBS flexibility may determine TBP binding preference
          Destination: 1
         Item: 
          Title: TBP binding affinity drives co-factor assembly
          Destination: 1
         Item: 
          Title: TBP in TFIID is inaccessible by Mot1p
          Destination: 1
         Item: 
          Title: Mot1p can compete with SAGA for TBP
          Destination: 1
         Item: 
          Title: Mot1p binding at promoters with distinct TBS types
          Destination: 1
         Item: 
          Title: TBP residence times are longer at TATA-like promoters
          Destination: 1
         Item: 
          Title: Rapid TBP recycling by Mot1p leads to higher noise
          Destination: 1
         Item: 
          Title: Simulations to explore possible noise regimes
          Destination: 1
         Item: 
          Title: Experimental validation
          Destination: 1
       Item: 
        Title: Discussion
        Destination: 1
       Item: 
        Title: Methods
        Destination: 1
        Children: 
         Item: 
          Title: Genome-wide data set on gene expression noise
          Destination: 1
         Item: 
          Title: TBS classification
          Destination: 1
         Item: 
          Title: Occupancy of TBP interaction partners in promoter regions
          Destination: 1
         Item: 
          Title: Gene classification based on co-activators in promoters
          Destination: 1
         Item: 
          Title: Intrinsic TBP binding preference from PBM experiments
          Destination: 1
         Item: 
          Title: Promoter DNA shape
          Destination: 1
         Item: 
          Title: Interface properties of TBP-containing complexes
          Destination: 1
         Item: 
          Title: Turnover as a measure of dynamics of TBP at the promoter
          Destination: 1
         Item: 
          Title: Testing for statistical significance
          Destination: 1
         Item: 
          Title: Visualization of distributions
          Destination: 1
         Item: 
          Title: Markov chain modelling of promoter states and noise
          Destination: 1
         Item: 
          Title: Deletion of Spt3 and generation of the GFP tagged strains
          Destination: 1
         Item: 
          Title: Protocol for flow cytometry
          Destination: 1
       Item: 
        Title: Additional information
        Destination: 1
       Item: 
        Title: Acknowledgements
        Destination: 1
       Item: 
        Title: References
        Destination: 1
   Info: 
    Title: Affinity and competition for TBP are molecular determinants of gene expression noise
    Author: Guilhem Chalancon
    Subject: Nature Communications 7,  (2015). doi:10.1038/ncomms10417
    Creator: Arbortext Advanced Print Publisher 9.0.226/W
    Producer: Acrobat Distiller 11.0.9(Windows)
    CreationDate: Sun Apr 28 15:47:02 CEST 2019
    ModDate: Sun Apr 28 15:47:05 CEST 2019
   ID: 0x30f9a562a7dadaace668328434a16824, 0x0e45505e8c5be64bb9d11b5a56104102
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 671
      ImageHeight: 245
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 915
      ImageHeight: 238
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 88
      ImageHeight: 88
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 605
      ImageHeight: 490
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 37
      ImageHeight: 54
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 41
      ImageHeight: 28
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 560
      ImageHeight: 485
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 49
      ImageHeight: 43
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 88
      ImageHeight: 47
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 35
      ImageHeight: 30
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 60
      ImageHeight: 32
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 420
      ImageHeight: 140
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 51
      ImageHeight: 37
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 273
      ImageHeight: 134
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 51
      ImageHeight: 72
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 48
      ImageHeight: 68
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 55
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 275
      ImageHeight: 133
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 112
      ImageHeight: 72
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 658
      ImageHeight: 476
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 487
      ImageHeight: 127
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: JNAECB+Advsymbol
      FontSubset: true
      FirstChar: 2
      LastChar: 3
      FontDescriptor: 
       FontName: JNAECB+Advsymbol
       Flags: Serif, Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: JNADPA+AdvItcSymbol-M
      FontSubset: true
      FirstChar: 32
      LastChar: 177
      FontDescriptor: 
       FontName: JNADPA+AdvItcSymbol-M
       Flags: Nonsymbolic
       FontBBox: -62, -229, 1208, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JNAEBA+AdvPi2
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: JNAEBA+AdvPi2
       Flags: Serif, Nonsymbolic
       FontBBox: 16, -335, 981, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMKMEL+Helvetica-Oblique
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: JMKMEL+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMKNEH+AdvOT9bd21c25.I
      FontSubset: true
      FirstChar: 46
      LastChar: 122
      FontDescriptor: 
       FontName: JMKNEH+AdvOT9bd21c25.I
       Flags: Symbolic
       FontBBox: -83, -197, 1010, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMJBDN+AdvOT125c650c
      FontSubset: true
      FirstChar: 71
      LastChar: 72
      FontDescriptor: 
       FontName: JMJBDN+AdvOT125c650c
       Flags: Symbolic
       FontBBox: -31, -197, 979, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMJBDO+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 199
      FontDescriptor: 
       FontName: JMJBDO+AdvOT1ef757c0
       Flags: Serif, Symbolic
       FontBBox: -135, -250, 1010, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMJBEP+AdvEls-ent7
      FontSubset: true
      FirstChar: 32
      LastChar: 66
      FontDescriptor: 
       FontName: JMJBEP+AdvEls-ent7
       Flags: Nonsymbolic
       FontBBox: 51, -322, 1177, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Helvetica2
      FirstChar: 21
      LastChar: 197
      FontDescriptor: 
       FontName: Helvetica2
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JMKMFM+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JMKMFM+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMIPKB+AdvOTea1a7398
      FontSubset: true
      FirstChar: 38
      LastChar: 198
      FontDescriptor: 
       FontName: JMIPKB+AdvOTea1a7398
       Flags: Symbolic
       FontBBox: -31, -197, 979, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMIPKC+AdvEls-ent2
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: JMIPKC+AdvEls-ent2
       Flags: Nonsymbolic
       FontBBox: 9, -322, 979, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMKOBE+AdvEls-ent4
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: JMKOBE+AdvEls-ent4
       Flags: Nonsymbolic
       FontBBox: 0, -343, 1166, 1218
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMKNHH+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 44
      LastChar: 149
      FontDescriptor: 
       FontName: JMKNHH+AdvOTb65e897d.B
       Flags: Serif, Symbolic
       FontBBox: -125, -250, 1052, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMIPLC+AdvOTcb88df00
      FontSubset: true
      FirstChar: 44
      LastChar: 149
      FontDescriptor: 
       FontName: JMIPLC+AdvOTcb88df00
       Flags: Symbolic
       FontBBox: -31, -197, 968, 833
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMMECN+CourierNewPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 84
      FontDescriptor: 
       FontName: JMMECN+CourierNewPSMT
       Flags: Nonsymbolic
       FontBBox: -21, -680, 638, 1021
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMJABB+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 80
      FontDescriptor: 
       FontName: JMJABB+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMMENK+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 46
      LastChar: 122
      FontDescriptor: 
       FontName: JMMENK+AdvOT7d6df7ab.I
       Flags: Serif, Symbolic
       FontBBox: -156, -250, 1000, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMJAEB+AdvOTf23bb480
      FontSubset: true
      FirstChar: 40
      LastChar: 123
      FontDescriptor: 
       FontName: JMJAEB+AdvOTf23bb480
       Flags: Symbolic
       FontBBox: -31, -187, 968, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMPGHK+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 138
      FontDescriptor: 
       FontName: JMPGHK+Helvetica
       Flags: Symbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Helvetica-Oblique2
      FirstChar: 32
      LastChar: 102
      FontDescriptor: 
       FontName: Helvetica-Oblique2
       Flags: Symbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMJAMP+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 48
      LastChar: 58
      FontDescriptor: 
       FontName: JMJAMP+AdvTTda6f6cb8.B
       Flags: Serif, Symbolic
       FontBBox: -93, -218, 1000, 875
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMPHAJ+Symbol
      FontSubset: true
      FirstChar: 2
      LastChar: 177
      FontDescriptor: 
       FontName: JMPHAJ+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JMKMEL+Helvetica-Oblique
      FontSubset: true
      FirstChar: 110
      LastChar: 110
      FontDescriptor: 
       FontName: JMKMEL+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMPMDM+MathPackTen
      FontSubset: true
      FirstChar: 2
      LastChar: 3
      FontDescriptor: 
       FontName: JMPMDM+MathPackTen
       Flags: Symbolic, Italic
       FontBBox: 22, -307, 996, 808
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: Helvetica2
      FirstChar: 21
      LastChar: 150
      FontDescriptor: 
       FontName: Helvetica2
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JMPMHM+AdvPi1
      FontSubset: true
      FirstChar: 32
      LastChar: 109
      FontDescriptor: 
       FontName: JMPMHM+AdvPi1
       Flags: Serif, Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JMPMLL+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 255
      FontDescriptor: 
       FontName: JMPMLL+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>&#xA;            doi:10.1038/ncomms10417</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">© 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications 7,  (2015). doi:10.1038/ncomms10417</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Affinity and competition for TBP are molecular determinants of gene expression noise</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Guilhem Chalancon</rdf:li>
               <rdf:li>Michal Breker</rdf:li>
               <rdf:li>Natalia Sanchez de Groot</rdf:li>
               <rdf:li>Charles N. J. Ravarani</rdf:li>
               <rdf:li>M. Madan Babu</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 11.0.9(Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:copyright>&#xA;            © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</prism:copyright>
         <prism:doi>10.1038/ncomms10417</prism:doi>
         <prism:issn/>
         <prism:publicationName>Nature Communications</prism:publicationName>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.0.226/W</xmp:CreatorTool>
         <xmp:Label>--</xmp:Label>
         <xmp:MetadataDate>2019-04-28T18:47:05+05:30</xmp:MetadataDate>
         <xmp:ModifyDate>2019-04-28T18:47:05+05:30</xmp:ModifyDate>
         <xmp:CreateDate>2019-04-28T18:47:02+05:30</xmp:CreateDate>
         <xmp:Identifier>
            <rdf:Bag>
               <rdf:li>&#xA;                doi:10.1038/ncomms10417</rdf:li>
            </rdf:Bag>
         </xmp:Identifier>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:DocumentID>uuid:8b84271e-d72b-4673-a895-526da68f28cd</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:9945a2b0-7be8-4bb2-86f3-f640ac477873</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:3c9326aa-dbc0-4e2c-a9fb-c1fec076c0c5</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-04-28T18:47:02+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d5ee827e-f5a3-4049-9c10-c6fdbd9777ae</stEvt:instanceID>
                  <stEvt:parameters>PDF/A conversion failed; Version and conformance level identification removed</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-04-28T18:47:05+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10417"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmp</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Basic</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>A word or short phrase that identifies a document as a member of a user-defined collection. Used to organize documents in a file browser.</pdfaProperty:description>
                           <pdfaProperty:name>Label</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 410, 53, 504, 61
      Annotation: 
       Subtype: Link
       Rect: 68, 43, 165, 51
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 695, 95, 702
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 92, 674, 101, 681
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 152, 663, 155, 671
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 69, 653, 78, 661
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 159, 642, 162, 650
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 285, 632, 289, 640
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 224, 611, 242, 619
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 137, 580, 155, 587
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 172, 565, 197, 575
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 223, 559, 231, 566
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 144, 486, 162, 493
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 441, 716, 457, 723
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 421, 705, 429, 713
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 383, 674, 390, 681
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 405, 663, 424, 671
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 353, 649, 384, 658
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 341, 642, 348, 650
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 447, 618, 474, 627
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 475, 601, 482, 608
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 454, 590, 461, 598
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 358, 580, 365, 587
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 398, 559, 406, 566
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 453, 482, 484, 491
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 117, 684, 124, 692
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 81, 653, 88, 661
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 195, 622, 202, 629
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 43, 607, 69, 617
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 207, 469, 214, 476
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 215, 458, 222, 466
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 130, 448, 147, 455
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 72, 427, 88, 435
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 69, 406, 94, 414
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 202, 375, 219, 382
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 544, 695, 551, 702
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 471, 532, 478, 539
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 478, 521, 485, 529
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 323, 469, 326, 476
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 332, 465, 358, 474
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 330, 381, 357, 391
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 530, 130, 537, 136
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 312, 119, 317, 126
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 471, 98, 479, 105
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 116, 684, 134, 692
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 138, 663, 153, 671
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 237, 639, 266, 648
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 105, 586, 130, 596
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 183, 576, 208, 585
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 172, 569, 179, 577
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 338, 611, 345, 619
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 376, 586, 405, 596
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 409, 590, 416, 598
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 306, 555, 336, 564
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 259, 712, 286, 721
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 198, 619, 205, 627
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 46, 573, 73, 583
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 260, 563, 286, 572
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 77, 504, 93, 511
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 262, 393, 288, 402
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 146, 355, 153, 363
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 389, 726, 396, 734
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 506, 712, 532, 721
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 535, 716, 551, 723
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 335, 639, 362, 648
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 382, 601, 389, 608
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 335, 535, 351, 543
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 463, 525, 479, 532
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 443, 510, 469, 520
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 306, 479, 331, 489
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 368, 462, 375, 470
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 337, 441, 353, 449
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 722, 118, 732
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 148, 674, 155, 681
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 165, 486, 181, 493
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 521, 722, 546, 732
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 388, 606, 395, 613
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 403, 602, 430, 611
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 485, 549, 509, 559
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 477, 497, 503, 507
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 333, 419, 359, 428
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 75, 283, 100, 292
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 56, 262, 84, 272
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 192, 235, 199, 242
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 168, 137, 193, 146
       Destination: 111
      Annotation: 
       Subtype: Link
       Rect: 498, 273, 526, 282
       Destination: 130
      Annotation: 
       Subtype: Link
       Rect: 331, 189, 357, 198
       Destination: 130
      Annotation: 
       Subtype: Link
       Rect: 424, 95, 449, 104
       Destination: 130
      Annotation: 
       Subtype: Link
       Rect: 306, 42, 331, 52
       Destination: 130
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 141, 213, 148
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 46, 63, 74, 73
       Destination: 169
      Annotation: 
       Subtype: Link
       Rect: 505, 241, 533, 251
       Destination: 169
      Annotation: 
       Subtype: Link
       Rect: 387, 214, 394, 221
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 520, 189, 546, 198
       Destination: 169
      Annotation: 
       Subtype: Link
       Rect: 306, 126, 340, 136
       Destination: 169
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 46, 555, 67, 564
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 138, 408, 165, 418
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 186, 381, 203, 389
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 115, 325, 141, 334
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 177, 329, 184, 336
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 181, 287, 189, 294
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 126, 266, 145, 273
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 246, 241, 273, 250
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 91, 105, 117, 114
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 428, 653, 435, 661
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 409, 642, 416, 650
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 425, 622, 433, 629
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 410, 392, 413, 398
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 332, 301, 338, 307
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 545, 236, 551, 242
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 477, 51, 541, 59
      Annotation: 
       Subtype: Link
       Rect: 303, 43, 417, 50
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 183, 650, 196, 656
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 163, 593, 169, 599
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 153, 510, 158, 516
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 208, 510, 214, 516
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 127, 457, 197, 464
      Annotation: 
       Subtype: Link
       Rect: 270, 431, 291, 439
      Annotation: 
       Subtype: Link
       Rect: 43, 423, 123, 430
      Annotation: 
       Subtype: Link
       Rect: 73, 409, 79, 415
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 155, 406, 289, 413
      Annotation: 
       Subtype: Link
       Rect: 231, 352, 236, 358
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 471, 706, 489, 713
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 469, 624, 474, 630
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 395, 531, 398, 537
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 455, 531, 460, 537
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 522, 531, 527, 537
       Destination: 247
      Annotation: 
       Subtype: Link
       Rect: 503, 463, 509, 469
       Destination: 220
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 464, 66, 531, 73
      Annotation: 
       Subtype: Link
       Rect: 303, 58, 368, 65
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 215, 725, 278, 732
      Annotation: 
       Subtype: Link
       Rect: 43, 716, 111, 723
      Annotation: 
       Subtype: Link
       Rect: 406, 678, 528, 685
      Annotation: 
       Subtype: Link
       Rect: 244, 23, 358, 30
     Thumb: true
  Checksum: 0e01a106
   Type: CRC32
  Checksum: c8b6d1276a932ce44bb445707f6eb4ee
   Type: MD5
  Checksum: d6f920d15359afc455b70127550b0ddd4f2d81ef
   Type: SHA-1
  Checksum: 46d44dbb2b223e5693b3babd55ae9e644a6b4652e66e764f25de32e05f16765d
   Type: SHA-256