317b5d3922187a3c9ff87aa76905e190  pmc_26818947.pdf
c6c61930248b5d019a5164a091b3f47fe12f9b45  pmc_26818947.pdf
b4c56578cec18767cc35731ebe2530d64ce39c398b2bd2d3bf3dc36eef93d888  pmc_26818947.pdf

Title:          Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Subject:        Nature Communications 7,  (2016). doi:10.1038/ncomms10531
Author:         Minako Imamura
Creator:        Arbortext Advanced Print Publisher 9.0.226/W
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Tue Jan 19 10:55:14 2016 CET
ModDate:        Thu Jan 21 16:43:13 2016 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      854316 bytes
Optimized:      yes
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IECMFM+AdvOTea1a7398                 Type 1C           Custom           yes yes yes    382  0
IECMGN+AdvOT9bd21c25.I               Type 1C           Custom           yes yes yes    383  0
IECMGO+AdvEls-ent4                   Type 1C           WinAnsi          yes yes no     384  0
IECMGP+AdvP4C4E74                    Type 1C           Custom           yes yes yes    385  0
IECMHA+AdvOTf23bb480                 Type 1C           Custom           yes yes yes    402  0
IECMHB+AdvOTcb88df00                 Type 1C           Custom           yes yes yes    403  0
IECMMA+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     404  0
IECNDO+AdvTTda6f6cb8.B               Type 1C           Custom           yes yes yes    418  0
IECNKP+AdvEls-ent7                   Type 1C           WinAnsi          yes yes no     195  0
IECNLA+AdvOTb65e897d.B               Type 1C           Custom           yes yes yes    180  0
IECNLB+AdvPi2                        Type 1C           WinAnsi          yes yes no     187  0
IECNNC+AdvPi1                        Type 1C           WinAnsi          yes yes no     188  0
IECNND+AdvEls-ent5                   Type 1C           WinAnsi          yes yes no     189  0
IECNJN+AdvOT125c650c                 Type 1C           Custom           yes yes yes    173  0
IECNJO+AdvOT1ef757c0                 Type 1C           Custom           yes yes yes    174  0
IECNKO+AdvOT7d6df7ab.I               Type 1C           Custom           yes yes yes    175  0
IECOGA+Helvetica                     Type 1C           WinAnsi          yes yes no     200  0
IECOGB+Helvetica-Oblique             Type 1C           WinAnsi          yes yes no     209  0
IECOHC+Symbol                        Type 1C           Custom           yes yes yes    202  0
IECOIC+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     205  0
IEDMAB+AdvOTe75a9404.I               Type 1C           Custom           yes yes yes    219  0
IEDMDA+AdvEls-ent2                   Type 1C           WinAnsi          yes yes no     220  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-02-16 02:55:28 CET
 RepresentationInformation: pmc_26818947.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2018-02-06 09:11:45 CET
  Size: 854316
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 438
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: title_link
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4
      Children: 
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034
        Children: 
         Item: 
          Title: GWAS meta-analysis and validation in the Japanese population
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
         Item: 
          Title: Examination of seven novel loci in diverse ethnic groups
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
         Item: 
          Title: Sex- and BMI-stratified analyses in the Japanese population
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
         Item: 
          Title: Fine mapping analyses for established T2D loci
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
       Item: 
        Title: Figure™1Outline of the present study.(a) GWAS meta-analysis and subsequent validation analysis. (b) Follow-up analyses for seven novel susceptibility loci for T2D in populations other than Japanese. SNP, single nucleotide polymorphism; MAF, minor allele f
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
        Children: 
         Item: 
          Title: Drug targets search by a bioinformatics approach
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
       Item: 
        Title: Figure™2Regional association plots of the two-stage GWAS meta-analysis for seven novel T2D susceptibility loci in the Japanese.Each plot shows -log10 P-values against the chromosomal positions of SNPs in the specific region. The SNP with the strongest ass
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: Table 1 
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Table 2 
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: Figure™3Prioritized biological T2D risk genes.The gene score for each gene was calculated by summing up the number of criteria satisfied (filled red box indicates criterion satisfied; 40 genes with a score ge2 out of 286 genes included in the T2D risk loc
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: Figure™4Connection of biological T2D risk genes to drug targets.Representative connections between T2D risk SNPs (blue), T2D biological genes (green), drug target genes (purple) and targeted drugs are shown (see Supplementary Table™21). astCompounds under
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
        Children: 
         Item: 
          Title: Subjects
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
         Item: 
          Title: Genotyping and quality control in the discovery stage
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: Imputation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: Genotyping and quality control in the Stage-2 analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: Follow-up analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
         Item: 
          Title: Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: Drug discovery
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
       Item: 
        Title: McCarthyM. I.Genomics, type 2 diabetes, and obesityN. Engl. J. Med.363233923502010ImamuraM.Genetics of type 2 diabetes: the GWAS era and future perspectivesEndocr. J.587237392011UnokiH.SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: The MexicansolLatino association data were provided by SIGMA T2D Consortium (see Supplementary Note for the contributors list). Data on glycaemic traits in European populations have been contributed by MAGIC investigators and have been downloaded from www
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: ACKNOWLEDGEMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: Author contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: Additional information
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
   Info: 
    Title: Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
    Author: Minako Imamura
    Subject: Nature Communications 7,  (2016). doi:10.1038/ncomms10531
    Creator: Arbortext Advanced Print Publisher 9.0.226/W
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Tue Jan 19 10:55:14 CET 2016
    ModDate: Thu Jan 21 17:13:13 CET 2016
   ID: 0xb716676950f87be3798361f0b3f193e3, 0xc64b13bcff9527498cc80f09086762ca
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 628
      ImageHeight: 661
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 615
      ImageHeight: 649
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 642
      ImageHeight: 678
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 628
      ImageHeight: 665
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 617
      ImageHeight: 649
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 629
      ImageHeight: 663
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 623
      ImageHeight: 657
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IECMGO+AdvEls-ent4
      FontSubset: true
      FirstChar: 111
      LastChar: 111
      FontDescriptor: 
       FontName: IECMGO+AdvEls-ent4
       Flags: Nonsymbolic
       FontBBox: 0, -343, 1166, 1218
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECMGP+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 188
      FontDescriptor: 
       FontName: IECMGP+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECNDO+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: IECNDO+AdvTTda6f6cb8.B
       Flags: Serif, Symbolic
       FontBBox: -93, -218, 1000, 875
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECNKP+AdvEls-ent7
      FontSubset: true
      FirstChar: 66
      LastChar: 66
      FontDescriptor: 
       FontName: IECNKP+AdvEls-ent7
       Flags: Nonsymbolic
       FontBBox: 51, -322, 1177, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECOGA+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: IECOGA+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECOHC+Symbol
      FontSubset: true
      FirstChar: 2
      LastChar: 215
      FontDescriptor: 
       FontName: IECOHC+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECNJN+AdvOT125c650c
      FontSubset: true
      FirstChar: 84
      LastChar: 84
      FontDescriptor: 
       FontName: IECNJN+AdvOT125c650c
       Flags: Symbolic
       FontBBox: -31, -197, 979, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECOIC+Helvetica-Bold
      FontSubset: true
      FirstChar: 97
      LastChar: 103
      FontDescriptor: 
       FontName: IECOIC+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECNJO+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 248
      FontDescriptor: 
       FontName: IECNJO+AdvOT1ef757c0
       Flags: Serif, Symbolic
       FontBBox: -135, -250, 1010, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECNKO+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 40
      LastChar: 133
      FontDescriptor: 
       FontName: IECNKO+AdvOT7d6df7ab.I
       Flags: Serif, Symbolic
       FontBBox: -156, -250, 1000, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECOGB+Helvetica-Oblique
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: IECOGB+Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECMHA+AdvOTf23bb480
      FontSubset: true
      FirstChar: 35
      LastChar: 180
      FontDescriptor: 
       FontName: IECMHA+AdvOTf23bb480
       Flags: Symbolic
       FontBBox: -31, -187, 968, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECMHB+AdvOTcb88df00
      FontSubset: true
      FirstChar: 37
      LastChar: 147
      FontDescriptor: 
       FontName: IECMHB+AdvOTcb88df00
       Flags: Symbolic
       FontBBox: -31, -197, 968, 833
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECMMA+Arial-BoldMT
      FontSubset: true
      FirstChar: 69
      LastChar: 80
      FontDescriptor: 
       FontName: IECMMA+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECNLA+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 44
      LastChar: 147
      FontDescriptor: 
       FontName: IECNLA+AdvOTb65e897d.B
       Flags: Serif, Symbolic
       FontBBox: -125, -250, 1052, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECNLB+AdvPi2
      FontSubset: true
      FirstChar: 108
      LastChar: 108
      FontDescriptor: 
       FontName: IECNLB+AdvPi2
       Flags: Serif, Nonsymbolic
       FontBBox: 16, -335, 981, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IEDMAB+AdvOTe75a9404.I
      FontSubset: true
      FirstChar: 48
      LastChar: 84
      FontDescriptor: 
       FontName: IEDMAB+AdvOTe75a9404.I
       Flags: Symbolic
       FontBBox: -83, -197, 1020, 833
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECNNC+AdvPi1
      FontSubset: true
      FirstChar: 52
      LastChar: 98
      FontDescriptor: 
       FontName: IECNNC+AdvPi1
       Flags: Serif, Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IEDMDA+AdvEls-ent2
      FontSubset: true
      FirstChar: 119
      LastChar: 119
      FontDescriptor: 
       FontName: IEDMDA+AdvEls-ent2
       Flags: Nonsymbolic
       FontBBox: 9, -322, 979, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECNND+AdvEls-ent5
      FontSubset: true
      FirstChar: 90
      LastChar: 90
      FontDescriptor: 
       FontName: IECNND+AdvEls-ent5
       Flags: Serif, Nonsymbolic
       FontBBox: 9, -343, 1166, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IECMFM+AdvOTea1a7398
      FontSubset: true
      FirstChar: 35
      LastChar: 248
      FontDescriptor: 
       FontName: IECMFM+AdvOTea1a7398
       Flags: Symbolic
       FontBBox: -31, -197, 979, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IECMGN+AdvOT9bd21c25.I
      FontSubset: true
      FirstChar: 46
      LastChar: 116
      FontDescriptor: 
       FontName: IECMGN+AdvOT9bd21c25.I
       Flags: Symbolic
       FontBBox: -83, -197, 1010, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="doi:10.1038/ncomms10531"
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>&#xA;            doi:10.1038/ncomms10531</dc:identifier>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Minako Imamura</rdf:li>
               <rdf:li>Atsushi Takahashi</rdf:li>
               <rdf:li>Toshimasa Yamauchi</rdf:li>
               <rdf:li>Kazuo Hara</rdf:li>
               <rdf:li>Kazuki Yasuda</rdf:li>
               <rdf:li>Niels Grarup</rdf:li>
               <rdf:li>Wei Zhao</rdf:li>
               <rdf:li>Xu Wang</rdf:li>
               <rdf:li>Alicia Huerta-Chagoya</rdf:li>
               <rdf:li>Cheng Hu</rdf:li>
               <rdf:li>Sanghoon Moon</rdf:li>
               <rdf:li>Jirong Long</rdf:li>
               <rdf:li>Soo Heon Kwak</rdf:li>
               <rdf:li>Asif Rasheed</rdf:li>
               <rdf:li>Richa Saxena</rdf:li>
               <rdf:li>Ronald C W Ma</rdf:li>
               <rdf:li>Yukinori Okada</rdf:li>
               <rdf:li>Minoru Iwata</rdf:li>
               <rdf:li>Jun Hosoe</rdf:li>
               <rdf:li>Nobuhiro Shojima</rdf:li>
               <rdf:li>Minaka Iwasaki</rdf:li>
               <rdf:li>Hayato Fujita</rdf:li>
               <rdf:li>Ken Suzuki</rdf:li>
               <rdf:li>John Danesh</rdf:li>
               <rdf:li>Torben J&amp;oslash;rgensen</rdf:li>
               <rdf:li>Marit E J&amp;oslash;rgensen</rdf:li>
               <rdf:li>Daniel R Witte</rdf:li>
               <rdf:li>Ivan Brandslund</rdf:li>
               <rdf:li>Cramer Christensen</rdf:li>
               <rdf:li>Torben Hansen</rdf:li>
               <rdf:li>Josep M Mercader</rdf:li>
               <rdf:li>Jason Flannick</rdf:li>
               <rdf:li>Hortensia Moreno-Mac&amp;iacute;as</rdf:li>
               <rdf:li>No&amp;euml;l P Burtt</rdf:li>
               <rdf:li>Rong Zhang</rdf:li>
               <rdf:li>Young Jin Kim</rdf:li>
               <rdf:li>Wei Zheng</rdf:li>
               <rdf:li>Jai Rup Singh</rdf:li>
               <rdf:li>Claudia H T Tam</rdf:li>
               <rdf:li>Hiroshi Hirose</rdf:li>
               <rdf:li>Hiroshi Maegawa</rdf:li>
               <rdf:li>Chikako Ito</rdf:li>
               <rdf:li>Kohei Kaku</rdf:li>
               <rdf:li>Hirotaka Watada</rdf:li>
               <rdf:li>Yasushi Tanaka</rdf:li>
               <rdf:li>Kazuyuki Tobe</rdf:li>
               <rdf:li>Ryuzo Kawamori</rdf:li>
               <rdf:li>Michiaki Kubo</rdf:li>
               <rdf:li>Yoon Shin Cho</rdf:li>
               <rdf:li>Juliana C N Chan</rdf:li>
               <rdf:li>Dharambir Sanghera</rdf:li>
               <rdf:li>Philippe Frossard</rdf:li>
               <rdf:li>Kyong Soo Park</rdf:li>
               <rdf:li>Xiao-Ou Shu</rdf:li>
               <rdf:li>Bong-Jo Kim</rdf:li>
               <rdf:li>Jose C Florez</rdf:li>
               <rdf:li>Teresa Tusi&amp;eacute;-Luna</rdf:li>
               <rdf:li>Weiping Jia</rdf:li>
               <rdf:li>E Shyong Tai</rdf:li>
               <rdf:li>Oluf Pedersen</rdf:li>
               <rdf:li>Danish Saleheen</rdf:li>
               <rdf:li>Shiro Maeda</rdf:li>
               <rdf:li>Takashi Kadowaki</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications 7,  (2016). doi:10.1038/ncomms10531</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">© 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes</rdf:li>
            </rdf:Alt>
         </dc:title>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10531"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10531"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:copyright>&#xA;            © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</prism:copyright>
         <prism:doi>10.1038/ncomms10531</prism:doi>
         <prism:eIssn>2041-1723</prism:eIssn>
         <prism:endingPage>12</prism:endingPage>
         <prism:issn/>
         <prism:number/>
         <prism:publicationName>Nature Communications</prism:publicationName>
         <prism:rightsAgent>permissions@nature.com</prism:rightsAgent>
         <prism:startingPage>1</prism:startingPage>
         <prism:volume>7</prism:volume>
         <prism:publicationDate>
            <rdf:Bag>
               <rdf:li>--</rdf:li>
            </rdf:Bag>
         </prism:publicationDate>
         <prism:url>
            <rdf:Bag>
               <rdf:li>&#xA;                http://dx.doi.org/10.1038/ncomms10531</rdf:li>
            </rdf:Bag>
         </prism:url>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10531"
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreateDate>2016-01-19T09:55:14Z</xap:CreateDate>
         <xap:CreatorTool>Arbortext Advanced Print Publisher 9.0.226/W</xap:CreatorTool>
         <xap:Label>--</xap:Label>
         <xap:MetadataDate>2016-01-21T21:13:13+05:30</xap:MetadataDate>
         <xap:ModifyDate>2016-01-21T21:13:13+05:30</xap:ModifyDate>
         <xap:Identifier>
            <rdf:Bag>
               <rdf:li>&#xA;                doi:10.1038/ncomms10531</rdf:li>
            </rdf:Bag>
         </xap:Identifier>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10531"
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="doi:10.1038/ncomms10531"
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:0770132a-b681-45f7-a021-97d924a9cc40</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:e2c0d19d-0077-4657-88a3-90801a8bea72</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 302, 53, 392, 61
      Annotation: 
       Subtype: Link
       Rect: 451, 53, 547, 61
      Annotation: 
       Subtype: Link
       Rect: 243, 23, 357, 30
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 153, 705, 167, 713
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 273, 695, 289, 702
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 112, 653, 146, 661
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 199, 632, 207, 640
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 176, 601, 179, 608
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 197, 548, 204, 556
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 70, 507, 77, 514
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 247, 444, 255, 451
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 46, 429, 73, 439
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 118, 429, 137, 439
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 216, 433, 219, 441
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 267, 429, 286, 439
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 205, 370, 208, 378
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 155, 350, 162, 357
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 192, 297, 195, 305
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 222, 140, 226, 148
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 108, 115, 139, 125
       Destination: 41
      Annotation: 
       Subtype: Link
       Rect: 80, 88, 87, 96
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 415, 695, 424, 702
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 393, 597, 419, 606
       Destination: 41
      Annotation: 
       Subtype: Link
       Rect: 410, 576, 440, 585
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 447, 576, 470, 585
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 425, 429, 476, 439
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 306, 408, 335, 418
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 323, 391, 330, 399
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 399, 308, 403, 315
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 446, 203, 471, 211
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 527, 199, 551, 209
      Annotation: 
       Subtype: Link
       Rect: 303, 189, 409, 198
      Annotation: 
       Subtype: Link
       Rect: 319, 46, 326, 54
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 240, 180, 268, 189
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 243, 23, 357, 30
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 163, 182, 176, 190
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 112, 172, 125, 179
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 262, 172, 266, 179
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 542, 193, 549, 200
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 136, 350, 143, 358
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 149, 315, 170, 324
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 153, 183, 160, 190
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 159, 172, 166, 180
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 100, 151, 107, 159
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 66, 57, 73, 65
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 249, 47, 256, 54
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 484, 231, 507, 241
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 243, 23, 357, 30
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 132, 161, 139
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 46, 107, 70, 116
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 112, 69, 153, 77
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 88, 48, 95, 56
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 376, 69, 384, 77
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 85, 151, 93, 159
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 282, 151, 289, 159
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 89, 57, 97, 64
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 392, 141, 399, 148
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 483, 109, 490, 117
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 243, 23, 357, 30
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 184, 440, 213, 449
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 218, 360, 225, 368
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 154, 308, 161, 315
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 264, 276, 272, 284
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 92, 255, 99, 263
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 86, 234, 93, 242
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 237, 147, 270, 156
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 110, 99, 117, 106
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 72, 46, 79, 54
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 333, 182, 340, 190
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 503, 109, 510, 117
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 478, 67, 486, 75
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 104, 663, 112, 671
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 271, 622, 289, 629
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 231, 548, 238, 556
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 178, 513, 201, 522
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 101, 496, 108, 504
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 143, 339, 150, 347
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 121, 46, 124, 52
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 543, 635, 548, 641
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 419, 443, 435, 449
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 538, 387, 551, 393
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 506, 370, 511, 376
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 521, 353, 533, 359
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 365, 314, 378, 320
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 525, 187, 543, 194
      Annotation: 
       Subtype: Link
       Rect: 303, 178, 427, 186
      Annotation: 
       Subtype: Link
       Rect: 429, 181, 435, 187
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 450, 173, 456, 179
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 516, 173, 522, 179
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 328, 164, 334, 170
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 511, 164, 517, 170
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 243, 23, 357, 30
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 203, 692, 209, 698
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 145, 684, 151, 689
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 103, 597, 116, 603
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 161, 597, 182, 603
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 154, 588, 159, 594
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 490, 140, 497
      Annotation: 
       Subtype: Link
       Rect: 79, 472, 167, 479
      Annotation: 
       Subtype: Link
       Rect: 219, 263, 274, 270
      Annotation: 
       Subtype: Link
       Rect: 227, 237, 274, 244
      Annotation: 
       Subtype: Link
       Rect: 431, 371, 537, 378
      Annotation: 
       Subtype: Link
       Rect: 464, 356, 531, 363
      Annotation: 
       Subtype: Link
       Rect: 303, 347, 368, 354
      Annotation: 
       Subtype: Link
       Rect: 475, 318, 538, 325
      Annotation: 
       Subtype: Link
       Rect: 303, 309, 371, 316
      Annotation: 
       Subtype: Link
       Rect: 406, 211, 528, 218
      Annotation: 
       Subtype: Link
       Rect: 243, 23, 357, 30
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 436, 23, 551, 30
     Thumb: true
  Checksum: f2c42130
   Type: CRC32
  Checksum: 317b5d3922187a3c9ff87aa76905e190
   Type: MD5
  Checksum: c6c61930248b5d019a5164a091b3f47fe12f9b45
   Type: SHA-1