c0fa66df98d05415ffadd991a1858178 pmc_26857456.pdf 25d07465ead027c12fd755244491c6939c076709 pmc_26857456.pdf a26a0420bb629dcda97e0c139a78eee52ef06dbcef88482ed8be81f7350819ff pmc_26857456.pdf Title: Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 Subject: Breast Cancer Research, 2016, doi:10.1186/s13058-016-0671-y Keywords: Male breast cancer,BRCA1/2,Pathology,Histologic grade,Genotype&,#x26,#x2013,phenotype correlations Author: Valentina Silvestri Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Feb 2 15:17:57 2016 CET ModDate: Thu Feb 4 19:09:13 2016 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 784072 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GJHMFG+HhdfsfAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 11 0 GJHMJF+GcdlndAdvTTe45e47d2 Type 1C WinAnsi yes yes no 12 0 GJHMJG+KkdlrkAdvTT7329fd89.I Type 1C WinAnsi yes yes no 14 0 GJHMJH+LfymlbAdvTTb5929f4c Type 1C WinAnsi yes yes no 16 0 GJHMKI+RsjwctAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 17 0 GJHNMC+JdwtkbAdvTT99c4c969 Type 1C WinAnsi yes yes no 18 0 MyriadPro-Regular Type 1 Custom yes no no 19 0 GJHNOE+LmtxcjAdvTTb5929f4c+22 Type 1C Custom yes yes no 9 0 GJHNOD+RpcyvwAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 10 0 GJHNPF+FtcsdmAdvTT86d47313 Type 1C WinAnsi yes yes no 13 0 GJHNPG+SfgkqrAdvTT8861b38f.I Type 1C WinAnsi yes yes no 15 0 GJHNPH+XclqmfAdvTT86d47313+20 Type 1C WinAnsi yes yes no 20 0 GJHOAH+BcqnsvAdvTT86d47313+22 Type 1C Custom yes yes yes 21 0 GJHOEH+WfjdsrAdvTT83913201.I Type 1C WinAnsi yes yes no 87 0 GJJCJL+NsqhntAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 97 0 GJJDDI+WplfwjAdvTTb5929f4c+01 Type 1C Custom yes yes yes 159 0 GkmsclOpenSans-Light Type 1C MacRoman yes no no 205 0 PlfrqkOregonLDOBook Type 1C WinAnsi yes no no 206 0 JcpvtdOpenSans-Extrabold Type 1C WinAnsi yes no no 207 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-10-29 02:27:31 CEST RepresentationInformation: pmc_26857456.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2018-02-06 09:10:39 CET Size: 784072 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM1' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM2' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM3' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM3' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM1' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM4' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM4' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab1' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Tab2' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM5' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM6' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM3' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 505925 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 505925 MIMEtype: application/pdf PDFMetadata: Objects: 423 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: CIMBA study participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Tumour pathology data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: SEER data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Statistical methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Pathologic characteristics of MBC in BRCA1 and BRCA2 mutation carriers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Characterisation of BRCA2 MBCs: comparison with BRCA2 FBC and with MBC in the general population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Characterisation of BRCA1 MBCs: comparison with BRCA1 FBC and with MBC in the general population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Additional files Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 Author: Valentina Silvestri Subject: Breast Cancer Research, 2016, doi:10.1186/s13058-016-0671-y Keywords: Male breast cancer,BRCA1/2,Pathology,Histologic grade,Genotype&,#x26,#x2013,phenotype correlations Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Feb 02 15:17:57 CET 2016 ModDate: Thu Feb 04 19:09:13 CET 2016 ID: 0x6db9b5ec749242b504669ee1dc990368, 0xd27c02401a03c4810a6b7166c7439aab Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 91 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1949 ImageHeight: 1365 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: GJJCJL+NsqhntAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GJJCJL+NsqhntAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -218, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHNOE+LmtxcjAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: GJHNOE+LmtxcjAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 906 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GJHNOD+RpcyvwAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: GJHNOD+RpcyvwAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHMFG+HhdfsfAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: GJHMFG+HhdfsfAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHMJF+GcdlndAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: GJHMJF+GcdlndAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHNPF+FtcsdmAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: GJHNPF+FtcsdmAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GkmsclOpenSans-Light FirstChar: 32 LastChar: 222 FontDescriptor: FontName: GkmsclOpenSans-Light Flags: Nonsymbolic FontBBox: -521, -269, 1140, 1048 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: GJHMJG+KkdlrkAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: GJHMJG+KkdlrkAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PlfrqkOregonLDOBook FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PlfrqkOregonLDOBook Flags: Serif, Nonsymbolic FontBBox: 1, -308, 1045, 922 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHNPG+SfgkqrAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: GJHNPG+SfgkqrAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JcpvtdOpenSans-Extrabold FirstChar: 32 LastChar: 149 FontDescriptor: FontName: JcpvtdOpenSans-Extrabold Flags: Nonsymbolic FontBBox: -728, -293, 1407, 1124 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHMJH+LfymlbAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 246 FontDescriptor: FontName: GJHMJH+LfymlbAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHMKI+RsjwctAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GJHMKI+RsjwctAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -218, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHNMC+JdwtkbAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: GJHNMC+JdwtkbAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -46, -250, 1126, 879 FontFile: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GJHNPH+XclqmfAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GJHNPH+XclqmfAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -218, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJHOAH+BcqnsvAdvTT86d47313+22 FontSubset: true FirstChar: 2 LastChar: 22 FontDescriptor: FontName: GJHOAH+BcqnsvAdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -270, 1031, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GJHOEH+WfjdsrAdvTT83913201.I FontSubset: true FirstChar: 32 LastChar: 82 FontDescriptor: FontName: GJHOEH+WfjdsrAdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GJJDDI+WplfwjAdvTTb5929f4c+01 FontSubset: true FirstChar: 2 LastChar: 155 FontDescriptor: FontName: GJJDDI+WplfwjAdvTTb5929f4c+01 Flags: Symbolic FontBBox: -41, -218, 1114, 1062 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 10.1186/s13058-016-0671-y 2016-02-02 true springer.com springerlink.com Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) Male breast cancer,BRCA1/2,Pathology,Histologic grade,Genotype&#x26,#x26,#x2013,phenotype correlations 2016-02-02 true 10.1186/s13058-016-0671-y springer.com springerlink.com http://dx.doi.org/10.1186/s13058-016-0671-y 10.1186/s13058-016-0671-y 1465-542X journal Breast Cancer Research Silvestri et al. application/pdf 10.1186/s13058-016-0671-y Breast Cancer Research Breast Cancer Research, 2016, doi:10.1186/s13058-016-0671-y Male breast cancer BRCA1/2 Pathology Histologic grade Genotype&#x26 #x26 #x2013 phenotype correlations Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 Valentina Silvestri Daniel Barrowdale Anna Marie Mulligan Susan L. Neuhausen Stephen Fox Beth Y. Karlan Gillian Mitchell Paul James Darcy L. Thull Kristin K. Zorn Natalie J. Carter Katherine L. Nathanson Susan M. Domchek Timothy R. Rebbeck Susan J. Ramus Robert L. Nussbaum Olufunmilayo I. Olopade Johanna Rantala Sook-Yee Yoon Maria A. Caligo Laura Spugnesi Anders Bojesen Inge Sokilde Pedersen Mads Thomassen Uffe Birk Jensen Amanda Ewart Toland Leigha Senter Irene L. Andrulis Gord Glendon Peter J. Hulick Evgeny N. Imyanitov Mark H. Greene Phuong L. Mai Christian F. Singer Christine Rappaport-Fuerhauser Gero Kramer Joseph Vijai Kenneth Offit Mark Robson Anne Lincoln Lauren Jacobs Eva Machackova Lenka Foretova Marie Navratilova Petra Vasickova Fergus J. Couch Emily Hallberg Kathryn J. Ruddy Priyanka Sharma Sung-Won Kim Manuel R. Teixeira Pedro Pinto Marco Montagna Laura Matricardi Adalgeir Arason Oskar Th Johannsson Rosa B. Barkardottir Anna Jakubowska Jan Lubinski Angel Izquierdo Miguel Angel Pujana Judith Balmaña Orland Diez Gabriella Ivady Janos Papp Edith Olah Ava Kwong Heli Nevanlinna Kristiina Aittomäki Pedro Perez Segura Trinidad Caldes Tom Van Maerken Bruce Poppe Kathleen B. M. Claes Claudine Isaacs Camille Elan Christine Lasset Dominique Stoppa-Lyonnet Laure Barjhoux Muriel Belotti Alfons Meindl Andrea Gehrig Christian Sutter Christoph Engel Dieter Niederacher Doris Steinemann Eric Hahnen Karin Kast Norbert Arnold Raymonda Varon-Mateeva Dorothea Wand Andrew K. Godwin D. Gareth Evans Debra Frost Jo Perkins Julian Adlard Louise Izatt Radka Platte Ros Eeles Steve Ellis Ute Hamann Judy Garber Florentia Fostira George Fountzilas Barbara Pasini Giuseppe Giannini Piera Rizzolo Antonio Russo Laura Cortesi Laura Papi Liliana Varesco Domenico Palli Ines Zanna Antonella Savarese Paolo Radice Siranoush Manoukian Bernard Peissel Monica Barile Bernardo Bonanni Alessandra Viel Valeria Pensotti Stefania Tommasi Paolo Peterlongo Jeffrey N. Weitzel Ana Osorio Javier Benitez Lesley McGuffog Sue Healey Anne-Marie Gerdes Bent Ejlertsen Thomas V. O. Hansen Linda Steele Yuan Chun Ding Nadine Tung Ramunas Janavicius David E. Goldgar Saundra S. Buys Mary B. Daly Anita Bane Mary Beth Terry Esther M. John Melissa Southey Douglas F. Easton Georgia Chenevix-Trench Antonis C. Antoniou Laura Ottini Arbortext Advanced Print Publisher 9.1.440/W Unicode 2016-02-04T19:09:13+01:00 2016-02-02T22:17:57+08:00 2016-02-04T19:09:13+01:00 uuid:00d2f162-1589-4139-be48-488682612168 uuid:3c4f1d00-05d6-4ee1-a301-5f0c4cfffca0 default 1 converted uuid:9de6c6d5-75c0-4a4c-967d-28373c19782e converted to PDF/A-2b pdfToolbox 2016-02-02T22:46:42+08:00 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer ORCiD Schema http://springer.com/ns/xmpExtensions/1.0/ springer authorInfo AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springer.com/ns/xmpExtensions/1.0/authorinfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyrigh copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 484, 657, 538, 679 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 128, 184, 135 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 65, 357, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 41, 321, 48 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 227, 345, 231, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 249, 309, 254, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 190, 273, 195, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 202, 273, 207, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 164, 213, 168, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 262, 177, 266, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 272, 177, 277, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 129, 69, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 57, 124, 67 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 357, 317, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 225, 351, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 431, 177, 440, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 446, 177, 456, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 117, 317, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 93, 533, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 335, 57, 345, 67 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 350, 57, 360, 67 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 125, 525, 134, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 121, 477, 125, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 258, 321, 263, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 249, 246, 258 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 141, 285, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 501, 609, 510, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 463, 525, 473, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 465, 317, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 367, 405, 377, 414 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 371, 333, 376, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 381, 333, 391, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 397, 333, 406, 342 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 71, 561, 76, 570 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 501, 125, 510 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 573, 533, 582 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 270, 657, 274, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 461, 645, 466, 654 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 528, 597, 533, 606 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 193, 465, 198, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 309, 187, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 261, 57, 271, 66 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 447, 633, 457, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 489, 533, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 470, 273, 480, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 403, 237, 413, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 423, 153, 428, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 433, 153, 442, 162 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 263, 669, 273, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 278, 669, 288, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 657, 66, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 240, 585, 250, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 256, 585, 266, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 525, 69, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 68, 369, 77, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 82, 369, 91, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 369, 105, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 321, 285, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 621, 533, 630 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 376, 585, 385, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 412, 453, 417, 462 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 308, 201, 318, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 105, 452, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 458, 105, 467, 114 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 143, 693, 148, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 154, 693, 163, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 693, 178, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 204, 543, 214, 552 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 61, 323, 118, 331 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 302, 118, 310 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 281, 118, 289 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 260, 118, 268 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 239, 118, 247 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 209, 118, 217 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Thumb: true Page: Label: 11 Thumb: true Page: Label: 12 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 138, 405, 267, 413 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 2765770b Type: CRC32 Checksum: c0fa66df98d05415ffadd991a1858178 Type: MD5 Checksum: 25d07465ead027c12fd755244491c6939c076709 Type: SHA-1