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modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Mon Nov 30 13:20:46 CET 2015 ModDate: Wed Jan 20 08:01:01 CET 2016 ID: 0xa56372ff9b35b74cac8017521b7ad621, 0x7e66b3c0e3a790d6c744a394b3e7b6ab Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: IMVZNN+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HCALOA+MinionMath-Regular-Graphic FontSubset: true FirstChar: 2 LastChar: 53 FontDescriptor: FontName: HCALOA+MinionMath-Regular-Graphic Flags: Symbolic FontBBox: 22, -261, 558, 712 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Regular Flags: Symbolic FontBBox: 22, -12, 545, 448 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-Capt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Capt Flags: Symbolic FontBBox: 45, -12, 430, 635 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-BoldCapt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-BoldCapt Flags: Nonsymbolic FontBBox: 35, 0, 480, 635 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Capt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Capt Flags: Nonsymbolic FontBBox: -304, -369, 1712, 1007 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: minionblackit FirstChar: 0 LastChar: 255 FontDescriptor: FontName: minionblackit Flags: Nonsymbolic, Italic FontBBox: -192, -258, 1081, 868 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HCALNO+MinionPro-Regular FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HCALNO+MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Minion-Black FirstChar: 0 LastChar: 250 FontDescriptor: FontName: Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: IMVZNN+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IMVZNN+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfVitamin D and the Epithelial to Mesenchymal TransitionLarriba, María JesúsGarcía de Herreros, AntonioMuñoz, AlbertoSeveral studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers. Both direct and indirect regulatory mechanisms mediate these effects. Conversely, certain master EMT inducers inhibit 1,25(OH)2D3 action by repressing the transcription of VDR gene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3 effects. Consequently, the balance between the strength of 1,25(OH)2D3 signaling and the induction of EMT defines the cellular phenotype in each context. Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3 and EMT.Stem Cells InternationalHindawi Publishing Corporation2016/01/06Research articledoi:10.1155/2016/6213872en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 50, 713, 175, 721 Page: Label: 2 Page: Label: 3 Page: Label: 4 Page: Label: 5 Page: Label: 6 Page: Label: 7 Page: Label: 8 Page: Label: 9 Page: Label: 10 Page: Label: 11 Checksum: 243e4fdb Type: CRC32 Checksum: 68b0b227b03f5463148d50c46d7ab222 Type: MD5 Checksum: 4b1fb6971758c60a05885bd76dd65473daf51983 Type: SHA-1