fbce0196d7751be0d938df800700a8e8 pmc_26881258.pdf ac9dc7ebee3899590d83d42e4c8358761dbb59dd pmc_26881258.pdf ba9c8c89ad8898cad0c18034e94e48867c20bfc7c1b77a8d97bc88e64a76541c pmc_26881258.pdf Title: 7502489.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Jan 6 10:28:04 2016 CET ModDate: Wed Jan 20 08:17:38 2016 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 600.05 x 800 pts Page rot: 0 File size: 582767 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-It Type 1C Custom yes no yes 13 0 Minion-Black Type 1C WinAnsi yes no no 14 0 MinionPro-Regular Type 1C Custom yes no yes 15 0 MinionMath-Regular Type 1C Custom yes no yes 16 0 HXMSJR+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 MinionMath-Capt Type 1C Custom yes no yes 47 0 MinionMath-BoldCapt Type 1C Custom yes no yes 65 0 PCIHOK+MinionPro-Regular Type 1C WinAnsi yes yes no 82 0 PCIHOL+MinionMath-Regular-Graphic Type 1C WinAnsi yes yes no 83 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-01-24 04:49:35 CET RepresentationInformation: pmc_26881258.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-06 09:09:44 CET Size: 582767 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 155 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: 7502489.dvi Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 7.0 (Windows); modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Jan 06 10:28:04 CET 2016 ModDate: Wed Jan 20 08:17:38 CET 2016 ID: 0x4f32442993d8a892325725b217245c72, 0x70592ad32191ad1e75a72ee3a0baa19a Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: HXMSJR+MinionPro-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionMath-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Regular Flags: Symbolic FontBBox: 74, -3, 512, 514 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-BoldCapt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-BoldCapt Flags: Symbolic FontBBox: 139, 48, 500, 463 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PCIHOK+MinionPro-Regular FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: PCIHOK+MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PCIHOL+MinionMath-Regular-Graphic FontSubset: true FirstChar: 48 LastChar: 60 FontDescriptor: FontName: PCIHOL+MinionMath-Regular-Graphic Flags: Nonsymbolic FontBBox: 36, -15, 512, 641 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Minion-Black FirstChar: 0 LastChar: 237 FontDescriptor: FontName: Minion-Black Flags: Serif, Nonsymbolic, ForceBold FontBBox: -133, -250, 1120, 827 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MinionMath-Capt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionMath-Capt Flags: Symbolic FontBBox: 32, 0, 446, 635 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: HXMSJR+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HXMSJR+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfNoninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications?Ruiz-Tamayo, IreneFranch-Nadal, JosepMata-Cases, ManelMauricio, DídacCos, XavierRodriguez-Poncelas, AntonioBarrot, JoanColl-de-Tuero, GabrielMundet-Tudurí, XavierAim. To assess prescribing practices of noninsulin antidiabetic drugs (NIADs) in T2DM with several major contraindications according to prescribing information or clinical guidelines: renal failure, heart failure, liver dysfunction, or history of bladder cancer. Methods. Cross-sectional, descriptive, multicenter study. Electronic medical records were retrieved from all T2DM subjects who attended primary care centers pertaining to the Catalan Health Institute in Catalonia in 2013 and were pharmacologically treated with any NIAD alone or in combination. Results. Records were retrieved from a total of 255,499 pharmacologically treated patients. 78% of patients with some degree of renal impairment (glomerular filtration rate (GFR) < 60 mL/min) were treated with metformin and 31.2% with sulfonylureas. Even in the event of severe renal failure (GFR < 30 mL/min), 35.3% and 22.5% of patients were on metformin or sulfonylureas, respectively. Moreover, metformin was prescribed to more than 60% of patients with moderate or severe heart failure. Conclusion. Some NIADs, and in particular metformin, were frequently used in patients at high risk of complications when they were contraindicated. There is a need to increase awareness of potential inappropriate prescribing and to monitor the quality of prescribing patterns in order to help physicians and policymakers to yield better clinical outcomes in T2DM.Journal of Diabetes ResearchHindawi Publishing Corporation2016/01/06Research articledoi:10.1155/2016/7502489en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 50, 713, 175, 721 Page: Label: 2 Page: Label: 3 Page: Label: 4 Page: Label: 5 Page: Label: 6 Page: Label: 7 Page: Label: 8 Page: Label: 9 Checksum: a77af79b Type: CRC32 Checksum: fbce0196d7751be0d938df800700a8e8 Type: MD5 Checksum: ac9dc7ebee3899590d83d42e4c8358761dbb59dd Type: SHA-1