8fc1fdf832952eec7315d4bd9e94404d pmc_26927105.pdf 0bd890ec17cdf23967370c51ccfe23f45b388182 pmc_26927105.pdf 26203de8b258c27cd1250cf26968cdb20ece4ee847f2a4b29781b94721564d9c pmc_26927105.pdf Title: Last Advances in Silicon-Based Optical Biosensors Subject: We review the most important achievements published in the last five years in the field of silicon-based optical biosensors. We focus specially on label-free optical biosensors and their implementation into lab-on-a-chip platforms, with an emphasis on developments demonstrating the capability of the devices for real bioanalytical applications. We report on novel transducers and materials, improvements of existing transducers, new and improved biofunctionalization procedures as well as the prospects for near future commercialization of these technologies. Keywords: photonic biosensors; label-free detection; silicon photonics; waveguide devices Author: Adrián Fernández Gavela, Daniel Grajales García, Jhonattan C. Ramirez and Laura M. Lechuga Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Wed Feb 24 08:50:20 2016 CET ModDate: Wed Feb 24 08:50:20 2016 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2790832 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IHOZOA+URWPalladioL-Ital Type 1 Custom yes yes no 52 0 FWQUUI+URWPalladioL-Bold Type 1 Custom yes yes no 53 0 YJUMJK+URWPalladioL-Roma Type 1 Custom yes yes no 54 0 RVSEMT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 58 0 JBCRLF+PazoMath Type 1 Builtin yes yes no 85 0 LSSAYA+PazoMath-Italic Type 1 Builtin yes yes no 86 0 FKGMBN+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 91 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 92 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 93 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 94 0 FKGNEL+Symbol CID TrueType Identity-H yes yes yes 95 0 FKGNEM+CambriaMath CID TrueType Identity-H yes yes yes 96 0 RRYFAD+TeX-matha10 Type 1 Builtin yes yes no 168 0 TCSMAU+TeX-matha8 Type 1 Builtin yes yes no 171 0 XNSZMW+EURM10 Type 1 Builtin yes yes no 172 0 FKGMBN+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 178 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 179 0 FKGMBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 180 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 181 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 182 0 FKGNEM+CambriaMath CID TrueType Identity-H yes yes yes 183 0 FKGMBN+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 213 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 214 0 FKGMBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 215 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 216 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 217 0 FKGNEM+CambriaMath CID TrueType Identity-H yes yes yes 218 0 IKJTBM+TeX-mathx10 Type 1 Builtin yes yes no 275 0 FKGMBN+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 281 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 282 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 283 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 284 0 FKGNEL+Symbol CID TrueType Identity-H yes yes yes 285 0 FKGNEM+CambriaMath CID TrueType Identity-H yes yes yes 286 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 345 0 FKGMBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 346 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 347 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 348 0 FKGMBN+PalatinoLinotype,Italic CID TrueType Identity-H yes yes yes 447 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 448 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 449 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 450 0 FKGNEM+CambriaMath CID TrueType Identity-H yes yes yes 451 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 504 0 FKGMBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 505 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 506 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 507 0 FKGMBO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 527 0 FKGMBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 528 0 FKGMCA+PalatinoLinotype TrueType WinAnsi yes yes no 529 0 FKGMCC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 530 0 GEJDFJ+TeX-matha6 Type 1 Builtin yes yes no 579 0 edu.harvard.hul.ois.jhove.module.pdf.PdfMalformedException: Invalid object number or object stream at edu.harvard.hul.ois.jhove.module.PdfModule.getObject(PdfModule.java:2356) at edu.harvard.hul.ois.jhove.module.PdfModule.resolveIndirectObject(PdfModule.java:2292) at edu.harvard.hul.ois.jhove.module.PdfModule.readDocCatalogDict(PdfModule.java:1284) at edu.harvard.hul.ois.jhove.module.PdfModule.parse(PdfModule.java:525) at edu.harvard.hul.ois.jhove.JhoveBase.processFile(JhoveBase.java:825) at edu.harvard.hul.ois.jhove.JhoveBase.process(JhoveBase.java:614) at edu.harvard.hul.ois.jhove.JhoveBase.dispatch(JhoveBase.java:465) at Jhove.main(Jhove.java:296) Jhove (Rel. 1.6, 2011-01-04) Date: 2018-06-12 04:45:41 CEST RepresentationInformation: pmc_26927105.pdf ReportingModule: BYTESTREAM, Rel. 1.3 (2007-04-10) LastModified: 2018-02-06 09:08:24 CET Size: 2790832 Format: bytestream Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/octet-stream Checksum: c3f5f96c Type: CRC32 Checksum: 8fc1fdf832952eec7315d4bd9e94404d Type: MD5 Checksum: 0bd890ec17cdf23967370c51ccfe23f45b388182 Type: SHA-1