d1ebd61077bd7298cc9f694473209ed1 pmc_26999113.pdf 10520c0b9641a953dbbd118f3d38853f34e6fdc8 pmc_26999113.pdf 268b5845509219c4149d217315ca45504198bffbebb01fa7ac8f973856c5857d pmc_26999113.pdf Title: Long-Term Treatment with Citicoline Prevents Cognitive Decline and Predicts a Better Quality of Life after a First Ischemic Stroke Subject: Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients’ quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. usual treatment. All subjects were selected 6 weeks after suffering a first ischemic stroke and randomized into parallel arms. Neuropsychological evaluation was performed at 1 month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the EuroQoL-5D questionnaire at 2 years. 163 patients were followed during 2 years. The mean age was 67.5 years-old, and 50.9% were women. Age and absence of citicoline treatment were independent predictors of both utility and poor quality of life. Patients with cognitive impairment had a poorer QoL at 2 years (0.55 vs. 0.66 in utility, p = 0.015). Citicoline treatment improved significantly cognitive status during follow-up (p = 0.005). In conclusion, treatment with long-term citicoline is associated with a better QoL and improves cognitive status 2 years after a first ischemic stroke. Keywords: quality of life; ischemic stroke; citicoline; cognitive impairment Author: Jose Alvarez-Sabín, Estevo Santamarina, Olga Maisterra, Carlos Jacas, Carlos Molina and Manuel Quintana Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Wed Mar 16 04:58:40 2016 CET ModDate: Wed Mar 16 04:58:40 2016 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 934150 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KFZXTG+URWPalladioL-Ital Type 1 Custom yes yes no 53 0 DSUZNG+URWPalladioL-Bold Type 1 Custom yes yes no 54 0 TYVZHF+URWPalladioL-Roma Type 1 Custom yes yes no 55 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 59 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 60 0 NFPIJY+TeX-matha10 Type 1 Builtin yes yes no 88 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 90 0 CATNBG+TeX-matha9 Type 1 Builtin yes yes no 91 0 JDOGKI+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 98 0 JDOFOF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 99 0 JDOFOH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 100 0 JDOFOJ+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 JDOGJH+TimesNewRoman TrueType WinAnsi yes yes no 102 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 123 0 JDOGKI+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 139 0 JDOFOF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 140 0 JDOFOH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 141 0 JDOFOJ+PalatinoLinotype TrueType WinAnsi yes yes no 142 0 JDOGJH+TimesNewRoman TrueType WinAnsi yes yes no 143 0 JDOFOF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 180 0 JDOFOH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 181 0 JDOFOJ+PalatinoLinotype TrueType WinAnsi yes yes no 182 0 JDOGJH+TimesNewRoman TrueType WinAnsi yes yes no 183 0 JDOFOF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 203 0 JDOFOH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 204 0 JDOFOJ+PalatinoLinotype TrueType WinAnsi yes yes no 205 0 JDOGJH+TimesNewRoman TrueType WinAnsi yes yes no 206 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-16 02:53:03 CET RepresentationInformation: pmc_26999113.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-10 03:45:45 CEST Size: 934150 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: None Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐちぴどづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰けふちぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰がどてづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠嬳㐠〠删⽆楴䡝‾㸊㰼ਯ呹灥 偡来ਯ䍯湴敮瑳‵〠〠刊⽒敳潵牣敳‴㤠〠刊⽍敤楡䉯砠嬰‰‵㤵⸲㜶‸㐱⸸㥝ਯ偡牥湴‵㘠〠刊⽁湮潴猠嬠㌵‰⁒″㜠〠删㌹‰⁒‴〠〠删㐱‰⁒‴㈠〠删㐳‰⁒‴㐠〠删㐵‰⁒‴㘠〠删㐷‰⁒‴㠠〠删崊㸾਼㰊⽐牯摵捥爠⡇偌⁇桯獴獣物灴‹⸱〩ਯ䍲敡瑩潮䑡瑥
䐺㈰ㄶ〳ㄶㄱ〹㐹⬰㠧〰✩ਯ䵯摄慴攠⡄㨲〱㘰㌱㘱㄰㤴㤫〸✰〧 Children: Item: Title: ぐちぴどづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰けふちぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰がどてづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠嬳㐠〠删⽆楴䡝‾㸊㰼ਯ呹灥 偡来ਯ䍯湴敮瑳‵〠〠刊⽒敳潵牣敳‴㤠〠刊⽍敤楡䉯砠嬰‰‵㤵⸲㜶‸㐱⸸㥝ਯ偡牥湴‵㘠〠刊⽁湮潴猠嬠㌵‰⁒″㜠〠删㌹‰⁒‴〠〠删㐱‰⁒‴㈠〠删㐳‰⁒‴㐠〠删㐵‰⁒‴㘠〠删㐷‰⁒‴㠠〠删崊㸾਼㰊⽐牯摵捥爠⡇偌⁇桯獴獣物灴‹⸱〩ਯ䍲敡瑩潮䑡瑥
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