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PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: 2. Alzheimer's disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Children: Item: Title: 2.1. Pathological features of AD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: 3. Alzheimer's disease in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Children: Item: Title: 3.1. Pathological features in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: 4. Pathogenesis of Alzheimer's disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Children: Item: Title: 4.1. Role of inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: 4.2. Clinical studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: 4.3. Inflammatory mechanisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: 5. Pathogenesis of AD in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: 5.1. Amyloid hypothesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: 5.2. Inflammatory hypothesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: 5.3. Priming of the glia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: 6. Periodontal disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Children: Item: Title: 6.1. Pathogenesis of PerioD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: 6.2. Mechanistic pathways for AD effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: 6.3. Clinical studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: 7. PerioD in DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: 8. Model of periodontal effect on AD of DS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Info: Title: Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome Author: Angela R. Kamer Subject: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2 (2016) 49-57. doi:10.1016/j.dadm.2016.01.001 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Jun 02 20:51:07 CEST 2016 ModDate: Thu Jun 02 20:51:36 CEST 2016 ID: 0xe5b67223877b49729cfe295c958263bf, 0x7aa93f055e2e934080234151a2531485 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 120 ImageHeight: 120 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 946 ImageHeight: 554 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1495 ImageHeight: 1160 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: FNBHFK+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FNBHFK+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FNBHMM+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 103 FontDescriptor: FontName: FNBHMM+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FNBHGL+AdvPSA88C FontSubset: true FirstChar: 38 LastChar: 245 FontDescriptor: FontName: FNBHGL+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FNBHGO+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FNBHGO+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FNBIEK+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FNBIEK+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FNBHGM+AdvPSA88B FontSubset: true FirstChar: 46 LastChar: 146 FontDescriptor: FontName: FNBHGM+AdvPSA88B Flags: Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FNBHGN+AdvPS586B FontSubset: true FirstChar: 46 LastChar: 53 FontDescriptor: FontName: FNBHGN+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FNBHFJ+AdvPSA88A FontSubset: true FirstChar: 30 LastChar: 150 FontDescriptor: FontName: FNBHFJ+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: application/pdf doi:10.1016/j.dadm.2016.01.001 Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome Angela R. Kamer Juan O. Fortea Sebastià Videla Angela Mayoral Malvin Janal Maria Carmona-Iragui Bessy Benejam Ronald G. Craig Deepak Saxena Patricia Corby Lidia Glodzik Kumar Raghava Chowdary Annam Miriam Robbins Mony J. de Leon Down syndrome Alzheimer's disease Infection Inflammation Dysbiosis Periodontal disease Aggressive periodontal disease Neuroinflammation Trisomy 21 Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2 (2016) 49-57. doi:10.1016/j.dadm.2016.01.001 Elsevier Inc. journal Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring  © 2016 The Authors. 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Subtype: Link Rect: 317, 347, 484, 355 Annotation: Subtype: Link Rect: 317, 337, 539, 345 Annotation: Subtype: Link Rect: 317, 327, 539, 335 Annotation: Subtype: Link Rect: 317, 317, 351, 325 Annotation: Subtype: Link Rect: 317, 307, 539, 315 Annotation: Subtype: Link Rect: 317, 297, 539, 305 Annotation: Subtype: Link Rect: 317, 287, 349, 295 Annotation: Subtype: Link Rect: 317, 277, 539, 285 Annotation: Subtype: Link Rect: 317, 267, 539, 275 Annotation: Subtype: Link Rect: 317, 257, 436, 265 Annotation: Subtype: Link Rect: 317, 247, 539, 255 Annotation: Subtype: Link Rect: 317, 237, 539, 245 Annotation: Subtype: Link Rect: 317, 227, 515, 235 Annotation: Subtype: Link Rect: 317, 217, 539, 225 Annotation: Subtype: Link Rect: 317, 207, 539, 215 Annotation: Subtype: Link Rect: 317, 197, 539, 205 Annotation: Subtype: Link Rect: 317, 187, 351, 195 Annotation: Subtype: Link Rect: 317, 178, 539, 186 Annotation: Subtype: Link Rect: 317, 168, 498, 176 Annotation: Subtype: Link Rect: 317, 158, 539, 166 Annotation: Subtype: Link Rect: 317, 148, 539, 156 Annotation: Subtype: Link Rect: 317, 138, 444, 146 Annotation: Subtype: Link Rect: 317, 128, 539, 136 Annotation: Subtype: Link Rect: 317, 118, 539, 126 Annotation: Subtype: Link Rect: 317, 108, 539, 116 Annotation: Subtype: Link Rect: 317, 98, 537, 106 Annotation: Subtype: Link Rect: 317, 88, 539, 96 Annotation: Subtype: Link Rect: 317, 78, 534, 86 Annotation: Subtype: Link Rect: 317, 68, 539, 76 Annotation: Subtype: Link Rect: 317, 58, 539, 66 Annotation: Subtype: Link Rect: 317, 48, 508, 56 Page: Label: 57 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 54, 696, 276, 704 Annotation: Subtype: Link Rect: 54, 686, 276, 694 Annotation: Subtype: Link Rect: 54, 676, 196, 684 Annotation: Subtype: Link Rect: 54, 666, 276, 674 Annotation: Subtype: Link Rect: 54, 656, 276, 664 Annotation: Subtype: Link Rect: 54, 646, 241, 654 Annotation: Subtype: Link Rect: 54, 636, 276, 644 Annotation: Subtype: Link Rect: 54, 626, 276, 634 Annotation: Subtype: Link Rect: 54, 616, 264, 624 Annotation: Subtype: Link Rect: 54, 606, 276, 614 Annotation: Subtype: Link Rect: 54, 596, 276, 604 Annotation: Subtype: Link Rect: 54, 586, 276, 594 Annotation: Subtype: Link Rect: 54, 576, 186, 584 Annotation: Subtype: Link Rect: 54, 566, 276, 574 Annotation: Subtype: Link Rect: 54, 556, 220, 564 Annotation: Subtype: Link Rect: 54, 546, 276, 554 Annotation: Subtype: Link Rect: 54, 536, 276, 544 Annotation: Subtype: Link Rect: 54, 526, 137, 534 Annotation: Subtype: Link Rect: 54, 516, 276, 524 Annotation: Subtype: Link Rect: 54, 506, 235, 514 Annotation: Subtype: Link Rect: 54, 496, 276, 504 Annotation: Subtype: Link Rect: 54, 486, 142, 494 Annotation: Subtype: Link Rect: 54, 476, 276, 484 Annotation: Subtype: Link Rect: 54, 466, 276, 474 Annotation: Subtype: Link Rect: 54, 457, 184, 464 Annotation: Subtype: Link Rect: 317, 696, 539, 704 Annotation: Subtype: Link Rect: 317, 686, 449, 694 Annotation: Subtype: Link Rect: 317, 676, 539, 684 Annotation: Subtype: Link Rect: 317, 666, 539, 674 Annotation: Subtype: Link Rect: 317, 656, 464, 664 Annotation: Subtype: Link Rect: 317, 646, 539, 654 Annotation: Subtype: Link Rect: 317, 636, 539, 644 Annotation: Subtype: Link Rect: 317, 626, 412, 634 Annotation: Subtype: Link Rect: 317, 616, 539, 624 Annotation: Subtype: Link Rect: 317, 606, 539, 614 Annotation: Subtype: Link Rect: 317, 596, 494, 604 Annotation: Subtype: Link Rect: 317, 586, 539, 594 Annotation: Subtype: Link Rect: 317, 576, 539, 584 Annotation: Subtype: Link Rect: 317, 566, 405, 574 Annotation: Subtype: Link Rect: 317, 556, 539, 564 Annotation: Subtype: Link Rect: 317, 546, 539, 554 Annotation: Subtype: Link Rect: 317, 536, 519, 544 Annotation: Subtype: Link Rect: 317, 526, 539, 534 Annotation: Subtype: Link Rect: 317, 516, 539, 524 Annotation: Subtype: Link Rect: 317, 506, 539, 514 Annotation: Subtype: Link Rect: 317, 496, 331, 504 Annotation: Subtype: Link Rect: 317, 486, 539, 494 Annotation: Subtype: Link Rect: 317, 476, 539, 484 Annotation: Subtype: Link Rect: 317, 466, 539, 474 Annotation: Subtype: Link Rect: 317, 457, 343, 464 Checksum: 7321edf3 Type: CRC32 Checksum: 7d58dbbcbbce94d2ff3164a00a86ec66 Type: MD5 Checksum: 145f539f121d1c69854844a2c845cabcbeb07e1d Type: SHA-1