73ac73c6988359151828ac552a3f0139  pmc_27317346.pdf
3f008e0a7bcd60ed39a774f41450fa6a14f27cde  pmc_27317346.pdf
ec00e47b96464a5184f52ed3c0a0f0ec6a2e87b607cc6f5c384fb4153063dc08  pmc_27317346.pdf

Title:          Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols
Subject:        Journal of Translational Medicine, doi:10.1186/s12967-016-0935-4
Keywords:       Biomarker; Endometrial biopsy; Exosomes; Exosomes isolation protocols; Exosome-like vesicles; Extracellular vesicles; Gynecological disorders; Microvesicles; RNA; Uterine aspirates
Author:         Irene Campoy
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Tue Jun 14 15:22:26 2016 CEST
ModDate:        Sat Jun 18 02:34:35 2016 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      3137793 bytes
Optimized:      no
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
FlcvwfMyriadPro-Light                Type 1C           Custom           yes no  yes     98  0
GcfrtmMyriadPro-It                   Type 1C           WinAnsi          yes no  yes     10  0
WkxdnxMyriadPro-Semibold             Type 1C           Custom           yes no  yes     11  0
BqbvhnMyriadPro-Bold                 Type 1C           Custom           yes no  yes     12  0
LHWRGU+CcdtcbMTSY                    Type 1C           Custom           yes yes yes     14  0
GffchsOpenSans                       Type 1C           WinAnsi          yes no  no    1049  0
JscssqMyriadPro-Regular              Type 1C           Custom           yes no  yes     15  0
MrbbysWarnockPro-Regular             Type 1C           Custom           yes no  yes      9  0
LymrxqWarnockPro-It                  Type 1C           WinAnsi          yes no  yes     13  0
JymndmMyriadPro-SemiboldIt           Type 1C           Custom           yes no  yes     16  0
ATUFQX+WltpchTimes-Bold              Type 1C           WinAnsi          yes yes no      88  0
VwghhgArialMT                        Type 1C           WinAnsi          yes no  no      89  0
LrcfjqArialMT                        Type 1C           WinAnsi          yes no  no      90  0
JQDYLB+KqymckMyriadPro-Regular       Type 1C           WinAnsi          yes yes no      91  0
BydcgpArialMT                        Type 1C           WinAnsi          yes no  no      92  0
DwwqpqArial-BoldMT                   Type 1C           WinAnsi          yes no  no      93  0
CbhxxmArialMT                        Type 1C           WinAnsi          yes no  no      94  0
CxnsrrArialMT                        Type 1C           WinAnsi          yes no  no      95  0
ATUFQX+CscswyTimes-Bold              Type 1C           WinAnsi          yes yes no      96  0
LdvnxwArial-BoldMT                   Type 1C           WinAnsi          yes no  no      97  0
GEFBDK+HfgcldEuclidSymbol            Type 1C           Custom           yes yes yes    139  0
XrqljfArialMT                        Type 1C           WinAnsi          yes no  no     182  0
CxmwcwArial-BoldMT                   Type 1C           WinAnsi          yes no  no     183  0
ATUFQX+YhmytxTimes-Bold              Type 1C           WinAnsi          yes yes no     184  0
ATUFQX+DyyxkrTimes-Bold              Type 1C           WinAnsi          yes yes no     185  0
CldfyjArialMT                        Type 1C           WinAnsi          yes no  no     186  0
FhyrfvArialMT                        Type 1C           WinAnsi          yes no  no     224  0
LtpnllArialMT                        Type 1C           WinAnsi          yes no  no     225  0
NxfjxgArial-BoldMT                   Type 1C           WinAnsi          yes no  no     226  0
DncvvqArial-BoldMT                   Type 1C           WinAnsi          yes no  no     227  0
TLIPWL+LtkqqyTimes-Bold              Type 1C           WinAnsi          yes yes no     228  0
TgxpywArialMT                        Type 1C           WinAnsi          yes no  no     229  0
CptxcjTimes-Bold                     Type 1C           WinAnsi          yes no  no     289  0
VpkdhkArialMT                        Type 1C           WinAnsi          yes no  no     290  0
LmmjvdArial-BoldMT                   Type 1C           WinAnsi          yes no  no     291  0
XghbdvArialMT                        Type 1C           WinAnsi          yes no  no     292  0
KNGHUH+LhvljjMyriadPro-LightIt       Type 1C           WinAnsi          yes yes yes    293  0
ZKGUCZ+KhgxfpSTIXMath-Regular        Type 1C           Custom           yes yes yes    334  0
SkxmxgOpenSans-Light                 Type 1C           Custom           yes no  no     350  0
HbxcdmOregonLDOBook                  Type 1C           WinAnsi          yes no  no     353  0
WhbbjnOpenSans-Extrabold             Type 1C           WinAnsi          yes no  no     346  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-14 18:44:56 CET
 RepresentationInformation: pmc_27317346.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-06 08:59:02 CET
  Size: 3137793
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1309
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Methods: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusion: 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Sample collection and processing
         Item: 
          Title: Isolation of EVs
          Children: 
           Item: 
            Title: Standard protocol
           Item: 
            Title: Filtration protocol
           Item: 
            Title: Sucrose cushion protocol
           Item: 
            Title: Experimental conditions for RNA extraction
         Item: 
          Title: Particle size distribution and quantification
         Item: 
          Title: Electron microscopy
         Item: 
          Title: Protein extraction
         Item: 
          Title: Immunoblot
         Item: 
          Title: Total RNA extraction
         Item: 
          Title: Reverse transcription, pre-amplification, and RT-qPCR
         Item: 
          Title: Real-Time qPCR TaqMan probes
         Item: 
          Title: Statistical analyses
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: EVs are present in the fluid fraction of uterine aspirates and can be isolated by differential centrifugation-based protocols
         Item: 
          Title: Optimization of EVs isolation protocols for RNA analysis
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: Authors’ contributions
       Item: 
        Title: References
   Info: 
    Title: Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols
    Author: Irene Campoy
    Subject: Journal of Translational Medicine, doi:10.1186/s12967-016-0935-4
    Keywords: Biomarker; Endometrial biopsy; Exosomes; Exosomes isolation protocols; Exosome-like vesicles; Extracellular vesicles; Gynecological disorders; Microvesicles; RNA; Uterine aspirates
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Tue Jun 14 15:52:26 CEST 2016
    ModDate: Sat Jun 18 02:34:35 CEST 2016
   ID: 0x50147431f89e0ba1a8a525b25ef1d4fd, 0x15e1d591ba601009b289f7a362e92c6b
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 2
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 6
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 96
      ImageHeight: 90
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 46
      ImageHeight: 15
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 7
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 46
      ImageHeight: 66
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 12
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 13
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 22
      ImageHeight: 8
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 5
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 395
      ImageHeight: 287
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 395
      ImageHeight: 287
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1124
      ImageHeight: 441
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 395
      ImageHeight: 287
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 394
      ImageHeight: 287
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 395
      ImageHeight: 287
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 394
      ImageHeight: 287
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1068
      ImageHeight: 562
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 516
      ImageHeight: 1435
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MrbbysWarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MrbbysWarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GcfrtmMyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GcfrtmMyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WkxdnxMyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WkxdnxMyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GEFBDK+HfgcldEuclidSymbol
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GEFBDK+HfgcldEuclidSymbol
       Flags: Symbolic
       FontBBox: -166, -253, 1090, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BqbvhnMyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: BqbvhnMyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LymrxqWarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: LymrxqWarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: LHWRGU+CcdtcbMTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: LHWRGU+CcdtcbMTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ZKGUCZ+KhgxfpSTIXMath-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 33
      FontDescriptor: 
       FontName: ZKGUCZ+KhgxfpSTIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JscssqMyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: JscssqMyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JymndmMyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: JymndmMyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ATUFQX+WltpchTimes-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 102
      FontDescriptor: 
       FontName: ATUFQX+WltpchTimes-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GffchsOpenSans
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: GffchsOpenSans
       Flags: Nonsymbolic
       FontBBox: -550, -271, 1204, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: VwghhgArialMT
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: VwghhgArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LrcfjqArialMT
      FirstChar: 32
      LastChar: 186
      FontDescriptor: 
       FontName: LrcfjqArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JQDYLB+KqymckMyriadPro-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: JQDYLB+KqymckMyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BydcgpArialMT
      FirstChar: 32
      LastChar: 186
      FontDescriptor: 
       FontName: BydcgpArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DwwqpqArial-BoldMT
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: DwwqpqArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CbhxxmArialMT
      FirstChar: 32
      LastChar: 186
      FontDescriptor: 
       FontName: CbhxxmArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CxnsrrArialMT
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: CxnsrrArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ATUFQX+CscswyTimes-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 101
      FontDescriptor: 
       FontName: ATUFQX+CscswyTimes-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FhyrfvArialMT
      FirstChar: 32
      LastChar: 181
      FontDescriptor: 
       FontName: FhyrfvArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LdvnxwArial-BoldMT
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: LdvnxwArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LtpnllArialMT
      FirstChar: 32
      LastChar: 186
      FontDescriptor: 
       FontName: LtpnllArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CptxcjTimes-Bold
      FirstChar: 32
      LastChar: 99
      FontDescriptor: 
       FontName: CptxcjTimes-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FlcvwfMyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: FlcvwfMyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NxfjxgArial-BoldMT
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: NxfjxgArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: VpkdhkArialMT
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: VpkdhkArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: DncvvqArial-BoldMT
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: DncvvqArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LmmjvdArial-BoldMT
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: LmmjvdArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: TLIPWL+LtkqqyTimes-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 68
      FontDescriptor: 
       FontName: TLIPWL+LtkqqyTimes-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: XghbdvArialMT
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: XghbdvArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: TgxpywArialMT
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: TgxpywArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KNGHUH+LhvljjMyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: KNGHUH+LhvljjMyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: XrqljfArialMT
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: XrqljfArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CxmwcwArial-BoldMT
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: CxmwcwArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ATUFQX+YhmytxTimes-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 98
      FontDescriptor: 
       FontName: ATUFQX+YhmytxTimes-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ATUFQX+DyyxkrTimes-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 101
      FontDescriptor: 
       FontName: ATUFQX+DyyxkrTimes-Bold
       Flags: Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CldfyjArialMT
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: CldfyjArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2016-06-14T18:52:26+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2016-06-18T02:34:35+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2016-06-18T02:34:35+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
         <pdf:Keywords>Biomarker; Endometrial biopsy; Exosomes; Exosomes isolation protocols; Exosome-like vesicles; Extracellular vesicles; Gynecological disorders; Microvesicles; RNA; Uterine aspirates</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1186/s12967-016-0935-4</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Translational Medicine, doi:10.1186/s12967-016-0935-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Biomarker; Endometrial biopsy; Exosomes; Exosomes isolation protocols; Exosome-like vesicles; Extracellular vesicles; Gynecological disorders; Microvesicles; RNA; Uterine aspirates</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Irene Campoy</rdf:li>
               <rdf:li>Lucia Lanau</rdf:li>
               <rdf:li>Tatiana Altadill</rdf:li>
               <rdf:li>Tamara Sequeiros</rdf:li>
               <rdf:li>Silvia Cabrera</rdf:li>
               <rdf:li>Montserrat Cubo-Abert</rdf:li>
               <rdf:li>Assumpción Pérez-Benavente</rdf:li>
               <rdf:li>Angel Garcia</rdf:li>
               <rdf:li>Salvador Borrós</rdf:li>
               <rdf:li>Anna Santamaria</rdf:li>
               <rdf:li>Jordi Ponce</rdf:li>
               <rdf:li>Xavier Matias-Guiu</rdf:li>
               <rdf:li>Jaume Reventós</rdf:li>
               <rdf:li>Antonio Gil-Moreno</rdf:li>
               <rdf:li>Marina Rigau</rdf:li>
               <rdf:li>Eva Colas</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:DOI>10.1186/s12967-016-0935-4</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:url>"http://dx.doi.org/10.1186/s12967-016-0935-4</prism:url>
         <prism:doi>10.1186/s12967-016-0935-4</prism:doi>
         <prism:issn>1479-5876</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Translational Medicine</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12967-016-0935-4</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:35bd97b6-9ea1-4c5d-b419-d40fa9aaa3ec</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:e10f29f3-8880-4fc8-a1a9-6a21376b2835</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:223463b5-a271-4c2e-9f06-e944d2f2d829</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-06-14T18:48:28+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:872baed5-5ece-419e-b38e-a7659e52decd</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-06-14T18:49:03+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springer.com/ns/xmpExtensions/1.0/authorinfo/" xmlns:springer="http://springer.com/ns/xmpExtensions/1.0/">
         <springer:authorInfo>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Eva Colas</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4439-4254</author:orcid>
               </rdf:li>
            </rdf:Seq>
         </springer:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer ORCiD Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springer.com/ns/xmpExtensions/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>springer</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>seq AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springer.com/ns/xmpExtensions/1.0/authorinfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 482, 558, 494, 546
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 80, 307, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 64, 525, 56
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 56, 247, 48
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 683, 541, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 185, 607, 190, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 59, 571, 64, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 70, 571, 75, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 59, 535, 64, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 70, 535, 75, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 176, 487, 181, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 186, 487, 191, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 196, 487, 201, 475
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 272, 439, 276, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 282, 439, 287, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 86, 415, 95, 403
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 102, 415, 111, 403
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 239, 391, 248, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 254, 391, 264, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 100, 355, 109, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 159, 331, 169, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 204, 331, 213, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 80, 319, 89, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 207, 295, 217, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 155, 259, 165, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 171, 259, 180, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 245, 247, 255, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 260, 247, 270, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 275, 247, 285, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 189, 199, 198, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 475, 644, 480, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 435, 452, 440, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 526, 404, 530, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 427, 356, 432, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 243
      Annotation: 
       Subtype: Link
       Rect: 523, 296, 533, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
     Thumb: true
    Page: 
     Sequence: 3
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 126, 392, 131, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 243
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 214, 644, 224, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 230, 644, 240, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 472, 583, 477, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 435, 559, 445, 547
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 327, 547, 331, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 526, 499, 531, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 386, 367, 391, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 390, 295, 395, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 415, 235, 425, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 431, 235, 441, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 447, 235, 457, 223
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 374, 211, 379, 193
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 523, 199, 533, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 307, 175, 317, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 324, 175, 334, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 342, 139, 352, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 692, 151, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 117, 560, 122, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 275, 524, 280, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 159, 476, 164, 457
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 171, 464, 176, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 236, 440, 241, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 442, 692, 447, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 484, 548, 489, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 243
      Annotation: 
       Subtype: Link
       Rect: 326, 476, 336, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 342, 476, 351, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 357, 476, 367, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 588, 82, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 243
      Annotation: 
       Subtype: Link
       Rect: 166, 552, 171, 540
       Flags: Print
       AppearanceDictionary: true
       Destination: 243
      Annotation: 
       Subtype: Link
       Rect: 129, 540, 134, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 243
      Annotation: 
       Subtype: Link
       Rect: 187, 384, 192, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 121, 348, 126, 336
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 162, 336, 167, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 287
      Annotation: 
       Subtype: Link
       Rect: 189, 300, 194, 288
       Flags: Print
       AppearanceDictionary: true
       Destination: 306
      Annotation: 
       Subtype: Link
       Rect: 278, 276, 283, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 287
      Annotation: 
       Subtype: Link
       Rect: 78, 216, 88, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 93, 216, 103, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 130, 216, 135, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 287
      Annotation: 
       Subtype: Link
       Rect: 159, 168, 169, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 223, 168, 233, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 239, 168, 248, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 162, 120, 172, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 204, 108, 214, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 400, 432, 410, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 425, 276, 434, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 440, 276, 450, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 307, 216, 317, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
     Thumb: true
    Page: 
     Sequence: 9
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 596, 269, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 275, 596, 285, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 93, 464, 103, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 259, 464, 269, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 340
      Annotation: 
       Subtype: Link
       Rect: 62, 253, 148, 244
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 62, 204, 152, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 62, 182, 152, 173
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 62, 160, 152, 151
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 62, 138, 152, 129
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 62, 98, 152, 89
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
  Checksum: 538b6cd5
   Type: CRC32
  Checksum: 73ac73c6988359151828ac552a3f0139
   Type: MD5
  Checksum: 3f008e0a7bcd60ed39a774f41450fa6a14f27cde
   Type: SHA-1