3e63063d300672eb1b3cf9dfd50e6289 pmc_27322259.pdf a9262f4b8283a8f88a6f96d6393e71e5de3d287a pmc_27322259.pdf b2ef9d9de8ee5005b15235519b7c6fec4b7677e8dd9fe38f9ca2c48545751990 pmc_27322259.pdf Title: Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation Subject: Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic -cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus. In type II diabetes patients, amylin is abnormally increased, self-assembled into amyloid aggregates, and ultimately contributes to the apoptotic death of -cells by mechanisms that are not completely understood. We have screened a library of approved drugs in order to identify inhibitors of amylin aggregation that could be used as tools to investigate the role of amylin aggregation in type II diabetes or as therapeutics in order to reduce -cell damage. Interestingly, three of the compounds analyzed—benzbromarone, quercetin, and folic acid—are able to slow down amylin fiber formation according to Thioflavin T binding, turbidimetry, and Transmission Electron Microscopy assays. In addition to the in vitro assays, we have tested the effect of these compounds in an amyloid toxicity cell culture model and we have found that one of them, quercetin, has the ability to partly protect cultured pancreatic insulinoma cells from the cytotoxic effect of amylin. Our data suggests that quercetin can contribute to reduce oxidative damage in pancreatic insulinoma cells by modulating the aggregation propensity of amylin. Keywords: quercetin; benzbromarone; folic acid; amylin; amyloid; aggregation; type II diabetes Author: Laura C. López, Olga Varea, Susanna Navarro, José A. Carrodeguas, Natalia Sanchez de Groot, Salvador Ventura and Javier Sancho Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Sat Jun 18 04:16:10 2016 CEST ModDate: Sat Jun 18 04:16:10 2016 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2215331 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- APNNWB+URWPalladioL-Ital Type 1 Custom yes yes no 95 0 XGRRAE+URWPalladioL-Bold Type 1 Custom yes yes no 96 0 PFDXSX+URWPalladioL-Roma Type 1 Custom yes yes no 97 0 VVSYYB+EURM10 Type 1 Builtin yes yes no 98 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 102 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 103 0 BKJFOP+PalatinoLinotype TrueType WinAnsi yes yes no 170 0 BKJGKN+PalatinoLinotype,Italic TrueType WinAnsi yes 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2020-08-10 03:44:14 CEST Size: 2215331 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴ぜ〰ちのつぜ〴ぜ〰いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぉつづのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのとどぢどぴはひぜ〴ぜ〰ぃちのつどつちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉつづのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ごひふづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰ぢべぜ〴ぜ〰ごふひぢどつどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴ぜ〰ぜ〵ぜ〰ごぅきぜ〵ㅜ〰ぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとづねどっちぬぜ〴ぜ〰ぎちぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ごとひづづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐちひぴどちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぢべぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げちぴぜ〴ぜ〰ぉのびふぬどのはねちぜ〴ぜ〰ぐちのっひづちぴどっぜ〴ぜ〰ぜ〵ぜ〰げぉぎ〭ね〵うぜ〵ㅜ〰ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こはねづぜ〴ぜ〰ぐひづぶどはふびぜ〴ぜ〰ぅぶどつづのっづびぜ〴ぜ〰げづぬちぴどのでぜ〴ぜ〰あづのぺぢひはねちひはのづ〬ぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はひぜ〴ぜ〰うはぬどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰いどちぢづぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぉつづのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのとどぢどぴはひぜ〴ぜ〰ぃちのつどつちぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉつづのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ごひふづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰ぢべぜ〴ぜ〰ごふひぢどつどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴ぜ〰ぜ〵ぜ〰ごぅきぜ〵ㅜ〰ぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとづねどっちぬぜ〴ぜ〰ぎちぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ごとひづづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐちひぴどちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぢべぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げちぴぜ〴ぜ〰ぉのびふぬどのはねちぜ〴ぜ〰ぐちのっひづちぴどっぜ〴ぜ〰ぜ〵ぜ〰げぉぎ〭ね〵うぜ〵ㅜ〰ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こはねづぜ〴ぜ〰ぐひづぶどはふびぜ〴ぜ〰ぅぶどつづのっづびぜ〴ぜ〰げづぬちぴどのでぜ〴ぜ〰あづのぺぢひはねちひはのづ〬ぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はひぜ〴ぜ〰うはぬどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰いどちぢづぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉつづのぴどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ごひふづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰ぢべぜ〴ぜ〰ごふひぢどつどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴ぜ〰ぜ〵ぜ〰ごぅきぜ〵ㅜ〰ぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとづねどっちぬぜ〴ぜ〰ぎちぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ごとひづづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐちひぴどちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぢべぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げちぴぜ〴ぜ〰ぉのびふぬどのはねちぜ〴ぜ〰ぐちのっひづちぴどっぜ〴ぜ〰ぜ〵ぜ〰げぉぎ〭ね〵うぜ〵ㅜ〰ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こはねづぜ〴ぜ〰ぐひづぶどはふびぜ〴ぜ〰ぅぶどつづのっづびぜ〴ぜ〰げづぬちぴどのでぜ〴ぜ〰あづのぺぢひはねちひはのづ〬ぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はひぜ〴ぜ〰うはぬどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰いどちぢづぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃとづねどっちぬぜ〴ぜ〰ぎちぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ごとひづづぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐちひぴどちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぢべぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げちぴぜ〴ぜ〰ぉのびふぬどのはねちぜ〴ぜ〰ぐちのっひづちぴどっぜ〴ぜ〰ぜ〵ぜ〰げぉぎ〭ね〵うぜ〵ㅜ〰ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こはねづぜ〴ぜ〰ぐひづぶどはふびぜ〴ぜ〰ぅぶどつづのっづびぜ〴ぜ〰げづぬちぴどのでぜ〴ぜ〰あづのぺぢひはねちひはのづ〬ぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はひぜ〴ぜ〰うはぬどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰いどちぢづぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぐちひぴどちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぉのつふっづつぜ〴ぜ〰ぢべぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げちぴぜ〴ぜ〰ぉのびふぬどのはねちぜ〴ぜ〰ぐちのっひづちぴどっぜ〴ぜ〰ぜ〵ぜ〰げぉぎ〭ね〵うぜ〵ㅜ〰ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こはねづぜ〴ぜ〰ぐひづぶどはふびぜ〴ぜ〰ぅぶどつづのっづびぜ〴ぜ〰げづぬちぴどのでぜ〴ぜ〰あづのぺぢひはねちひはのづ〬ぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はひぜ〴ぜ〰うはぬどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰いどちぢづぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こはねづぜ〴ぜ〰ぐひづぶどはふびぜ〴ぜ〰ぅぶどつづのっづびぜ〴ぜ〰げづぬちぴどのでぜ〴ぜ〰あづのぺぢひはねちひはのづ〬ぜ〴ぜ〰けふづひっづぴどのぜ〴ぜ〰はひぜ〴ぜ〰うはぬどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ごべばづぜ〴ぜ〰ぉぉぜ〴ぜ〰いどちぢづぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰きちぴづひどちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰えどでとぜ〴ぜ〰ごとひはふでとばふぴぜ〴ぜ〰こっひづづのどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごふひぢどつどぴべぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰どのぜ〴ぜ〰えづがちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: きちぴづひどちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰えどでとぜ〴ぜ〰ごとひはふでとばふぴぜ〴ぜ〰こっひづづのどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごふひぢどつどぴべぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰どのぜ〴ぜ〰えづがちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: えどでとぜ〴ぜ〰ごとひはふでとばふぴぜ〴ぜ〰こっひづづのどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごふひぢどつどぴべぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰どのぜ〴ぜ〰えづがちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ごふひぢどつどぴべぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰どのぜ〴ぜ〰えづがちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ごひちのびねどびびどはのぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰どのぜ〴ぜ〰えづがちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴ぜ〰どのぜ〴ぜ〰えづがちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべびぜ〴ぜ〰はてぜ〴ぜ〰ぁねべぬどのぜ〴ぜ〰ぜ〵ぜ〰〸ぜ〲㍜〰〳〷ぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰げぉぎ〭ね〵うぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぁぢびづのっづぜ〴ぜ〰はひぜ〴ぜ〰ぐひづびづのっづぜ〴ぜ〰はてぜ〴ぜ〰ぁででひづでちぴどはのぜ〴ぜ〰ぉのとどぢどぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠嬶㘠〠删⽆楴䡝‾㸊㰼ਯ呹灥 偡来ਯ䍯湴敮瑳‹㈠〠刊⽒敳潵牣敳‹ㄠ〠刊⽍敤楡䉯砠嬰‰‵㤵⸲㜶‸㐱⸸㥝ਯ偡牥湴‹㤠〠刊⽁湮潴猠嬠㘷‰⁒‶㤠〠删㜱‰⁒‷㈠〠删㜳‰⁒‷㐠〠删㜵‰⁒‷㘠〠删㜷‰⁒‷㠠〠删㜹‰⁒‸〠〠删㤰‰⁒⁝ਾ㸊㰼ਯ偲潤畣敲
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