64431a7f3e1b8d937aae3b7a5288e8ae  pmc_27440383.pdf
24c60ee9525673946a8d95526ad453835be26782  pmc_27440383.pdf
0f803cc8b9814a152a02a44c34525aafae28e3e8ec888da0d29e7aa82ed1e914  pmc_27440383.pdf

Title:          peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas
Creator:        Adobe InDesign CC 2014 (Windows)
Producer:       Adobe PDF Library 11.0
CreationDate:   Fri Sep  2 17:52:52 2016 CEST
ModDate:        Fri Sep  2 17:53:14 2016 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1158543 bytes
Optimized:      yes
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
RPSCZZ+Avenir-Medium                 Type 1C           WinAnsi          yes yes no      88  0
TKTDML+Frutiger-Bold                 Type 1C           WinAnsi          yes yes yes    118  0
TKTDML+Frutiger-Roman                Type 1C           WinAnsi          yes yes yes     99  0
TKTDML+Frutiger-Black                Type 1C           Custom           yes yes yes    106  0
TKTDML+Frutiger-Light                Type 1C           Custom           yes yes yes    123  0
TKTDML+Frutiger-LightItalic          Type 1C           WinAnsi          yes yes yes    131  0
TKTDML+FrutigerBold                  Type 1C           WinAnsi          yes yes yes    108  0
TKTDML+Frutiger-BoldItalic           Type 1C           Custom           yes yes yes     97  0
TKTDML+Minion-Regular                Type 1C           Custom           yes yes yes    138  0
TKTDML+Minion-Italic                 Type 1C           WinAnsi          yes yes yes    136  0
ELBRKP+Symbol                        Type 1C           Custom           yes yes yes     68  0
TKTDML+Frutiger-Light                Type 1C           WinAnsi          yes yes yes     66  0
TKTDML+Frutiger-LightItalic          Type 1C           WinAnsi          yes yes yes     54  0
TKTDML+Frutiger-Roman                Type 1C           WinAnsi          yes yes yes     59  0
ELBRKP+ArialMT                       Type 1C           WinAnsi          yes yes no      60  0
ELBRKP+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      51  0
ELBRKP+ArialMT                       Type 1C           Custom           yes yes no      20  0
ELBRKP+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      25  0
ELBRKP+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      32  0
ELBRKP+Minion-Bold                   Type 1C           WinAnsi          yes yes yes     48  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-14 18:42:59 CET
 RepresentationInformation: pmc_27440383.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-06 08:56:39 CET
  Size: 1158543
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 140
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseThumbs
   Info: 
    Title: peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas
    Creator: Adobe InDesign CC 2014 (Windows)
    Producer: Adobe PDF Library 11.0
    CreationDate: Fri Sep 02 18:22:52 CEST 2016
    ModDate: Fri Sep 02 18:23:14 CEST 2016
   ID: 0xb044de69460a3a4b964165042227170f, 0xdb290f7e44ca3314e8d3ec4f6b6644e0
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1221
      ImageHeight: 468
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1302
      ImageHeight: 985
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1302
      ImageHeight: 972
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1225
      ImageHeight: 447
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1122
      ImageHeight: 960
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1301
      ImageHeight: 486
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 1230
      ImageHeight: 446
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 808
      ImageHeight: 443
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: ELBRKP+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 70
      FontDescriptor: 
       FontName: ELBRKP+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: TKTDML+Frutiger-BoldItalic
      FontSubset: true
      FirstChar: 22
      LastChar: 31
      FontDescriptor: 
       FontName: TKTDML+Frutiger-BoldItalic
       Flags: Symbolic, Italic
       FontBBox: -168, -222, 1087, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TKTDML+Frutiger-LightItalic
      FontSubset: true
      FirstChar: 32
      LastChar: 114
      FontDescriptor: 
       FontName: TKTDML+Frutiger-LightItalic
       Flags: Nonsymbolic, Italic
       FontBBox: -143, -250, 1031, 917
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TKTDML+Frutiger-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 243
      FontDescriptor: 
       FontName: TKTDML+Frutiger-Roman
       Flags: Nonsymbolic
       FontBBox: -169, -250, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ELBRKP+Symbol
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: ELBRKP+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TKTDML+Minion-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: TKTDML+Minion-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -139, -250, 1101, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TKTDML+Minion-Regular
      FontSubset: true
      FirstChar: 30
      LastChar: 243
      FontDescriptor: 
       FontName: TKTDML+Minion-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -141, -250, 1104, 812
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TKTDML+Frutiger-Black
      FontSubset: true
      FirstChar: 1
      LastChar: 173
      FontDescriptor: 
       FontName: TKTDML+Frutiger-Black
       Flags: Symbolic
       FontBBox: -164, -222, 1000, 954
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TKTDML+FrutigerBold
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: TKTDML+FrutigerBold
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ELBRKP+Minion-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: ELBRKP+Minion-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -148, -250, 1147, 830
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ELBRKP+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 74
      FontDescriptor: 
       FontName: ELBRKP+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ELBRKP+ArialMT
      FontSubset: true
      FirstChar: 31
      LastChar: 115
      FontDescriptor: 
       FontName: ELBRKP+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: TKTDML+Frutiger-Bold
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: TKTDML+Frutiger-Bold
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: RPSCZZ+Avenir-Medium
      FontSubset: true
      FirstChar: 32
      LastChar: 115
      FontDescriptor: 
       FontName: RPSCZZ+Avenir-Medium
       Flags: Nonsymbolic
       FontBBox: -166, -282, 1036, 924
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ELBRKP+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 68
      FontDescriptor: 
       FontName: ELBRKP+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: TKTDML+Frutiger-Light
      FontSubset: true
      FirstChar: 31
      LastChar: 243
      FontDescriptor: 
       FontName: TKTDML+Frutiger-Light
       Flags: Nonsymbolic
       FontBBox: -152, -250, 1000, 911
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ELBRKP+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: ELBRKP+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 4.1.1">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2016-09-02T21:22:52+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2016-09-02T21:23:14+05:30</xmp:MetadataDate>
         <xmp:ModifyDate>2016-09-02T21:23:14+05:30</xmp:ModifyDate>
         <xmp:CreatorTool>Adobe InDesign CC 2014 (Windows)</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#">
         <xmpMM:InstanceID>uuid:99fd72d4-a95f-4963-a4da-c7d2950eec41</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>xmp.did:6F27DC154F48E311BD729BDA5DD34355</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:31b6fa54-fa72-7a4b-aa23-e9767c046c4a</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign CC 2014 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2016-09-02T21:22:52+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:efc0a521-317e-7d4f-86e5-c88bf15b2191</stRef:instanceID>
            <stRef:documentID>xmp.did:0ec7bdd9-9ab5-014f-a728-d393e2a2761f</stRef:documentID>
            <stRef:originalDocumentID>xmp.did:6F27DC154F48E311BD729BDA5DD34355</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Adobe PDF Library 11.0</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 2501
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 442, 161, 434
      Annotation: 
       Subtype: Link
       Rect: 80, 379, 149, 371
    Page: 
     Label: 2502
     Sequence: 2
    Page: 
     Label: 2503
     Sequence: 3
    Page: 
     Label: 2504
     Sequence: 4
    Page: 
     Label: 2505
     Sequence: 5
    Page: 
     Label: 2506
     Sequence: 6
    Page: 
     Label: 2507
     Sequence: 7
    Page: 
     Label: 2508
     Sequence: 8
    Page: 
     Label: 2509
     Sequence: 9
    Page: 
     Label: 2510
     Sequence: 10
    Page: 
     Label: 2511
     Sequence: 11
    Page: 
     Label: 2512
     Sequence: 12
  Checksum: d82240e1
   Type: CRC32
  Checksum: 64431a7f3e1b8d937aae3b7a5288e8ae
   Type: MD5
  Checksum: 24c60ee9525673946a8d95526ad453835be26782
   Type: SHA-1