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Title:          Identification of Siglec-1 null individuals infected with HIV-1
Subject:        Nature Communications 7,  (2016). doi:10.1038/ncomms12412
Author:         Paul J. McLaren
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       Item: 
        Title: Results
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          Title: Genetic description of SIGLEC1 variants
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
         Item: 
          Title: Functional analysis of SIGLEC1 null variant
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
         Item: 
          Title: SIGLEC1 null variant in HIV-1 acquisition
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          Title: SIGLEC1 null variant in HIV-1 progression
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       Item: 
        Title: Figure™1Location and frequency of SIGLEC1 protein truncating variants.Protein domains are represented in different colours. Data from the Exome Aggregation Consortium (exac.broadinstitute.org) identifies 70 protein truncating variants in SIGLEC1 including
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        Title: Table 1 
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        Title: Discussion
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       Item: 
        Title: Figure™2Siglec-1 expression and trans-infection across distinct SIGLEC1 genotypes.Monocytes were isolated and cultured 24thinsph in the presence of 1,000 Uthinspml-1 of IFNagr to induce Siglec-1 expression. (a) Quantification of Siglec-1 expression levels
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       Item: 
        Title: Figure™3Analysis of association between Siglec-1 Glu88Ter and HIV-1 clinical outcomes in the absence of antiretroviral treatment.(a) Set point viral load of individuals from the SHCS with or without the Glu88Ter allele (n=2,243). (b) CD4+ T- cell count dy
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       Item: 
        Title: Methods
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         Item: 
          Title: Patients
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         Item: 
          Title: Ethics statement
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         Item: 
          Title: Primary cell culture
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         Item: 
          Title: Siglec-1 surface expression analysis by FACS
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         Item: 
          Title: VLP capture and HIV-1 trans-infection assays
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          Title: Genetic analyses
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          Title: Statistical analysis
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         Item: 
          Title: Data availability
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       Item: 
        Title: CameronP. U.Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cellsScience2573833871992GeijtenbeekT. B.DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection o
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       Item: 
        Title: We thank the patients for participating in the SHCS and MACS. We thank Nimisha Chaturvedi and Victor Urrea for their excellent statistical assistance. The members of the SHCS are Aubert V., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Bur
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        Title: ACKNOWLEDGEMENTS
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        Title: Author contributions
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        Title: Additional information
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