b5273f5cc983fae03e5c3d1824c9515f pmc_27605908.pdf d01309afad2652937b7b3ddeb1e0ad505a2b88f9 pmc_27605908.pdf e095063e43b427e0a8a55a7a56881cf19dd5d47c76a703abd229b328e54df53c pmc_27605908.pdf Title: Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy Subject: Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. Keywords: spinal muscular atrophy, c-terminal fragment of the tetanus toxin, muscle, spinal cord, autophagy, apoptosis, muscular atrophy Author: Rosario Osta Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Aug 22 09:02:30 2016 CEST ModDate: Mon Aug 22 09:04:49 2016 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3530745 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ECOKKC+MinionPro-Regular Type 1 Custom yes yes no 38 0 GDASDZ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 39 0 RMDWIR+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 40 0 YQLHNJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 41 0 JQDFTF+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 42 0 LTCGBT+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 44 0 CFZORK+MinionPro-Bold Type 1 Custom yes yes no 51 0 TMNBEG+MinionPro-It Type 1 Custom yes yes no 52 0 QHWLRN+MTGU Type 1 Builtin yes yes no 108 0 DINJMA+MTSYN Type 1 Builtin yes yes no 139 0 VOXUEH+RBLMI Type 1 Builtin yes yes no 140 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:38:34 CET RepresentationInformation: pmc_27605908.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-06 08:51:33 CET Size: 3530745 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 536 FreeObjects: 5 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy Children: Item: Title: Introduction Item: Title: Materials And Methods Children: Item: Title: Spinal Cord Organotypic Culture and TTC Supplementation Item: Title: Immunoblotting Item: Title: Immunofluorescence Item: Title: SMA Mice Item: Title: Plasmid Purification and Intramuscular Injection Item: Title: Quantitative PCR Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: TTC Treatment Increase SMN Expression in Motor Neurons Item: Title: Improvement of the Autophagy and Apoptosis Markers Under TTC Treatment Item: Title: Compensatory Response of TTC Treatment for Muscular Atrophy in SMA Mice Item: Title: Body Weight and Survival Rates Under TTC Treatment Item: Title: Discussion Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy Author: Rosario Osta Subject: Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. Keywords: spinal muscular atrophy, c-terminal fragment of the tetanus toxin, muscle, spinal cord, autophagy, apoptosis, muscular atrophy Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Aug 22 09:32:30 CEST 2016 ModDate: Mon Aug 22 09:34:49 CEST 2016 ID: 0x3bcbf56802c930585edd30edaca24e40, 0xbfaa255b9cd9c7459a27b5fdd1757d8f Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: CFZORK+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 118 FontDescriptor: FontName: CFZORK+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TMNBEG+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 225 FontDescriptor: FontName: TMNBEG+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ECOKKC+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: ECOKKC+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GDASDZ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: GDASDZ+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RMDWIR+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 225 FontDescriptor: FontName: RMDWIR+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YQLHNJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: YQLHNJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JQDFTF+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: JQDFTF+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DINJMA+MTSYN FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: DINJMA+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: LTCGBT+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 225 FontDescriptor: FontName: LTCGBT+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QHWLRN+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: QHWLRN+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: VOXUEH+RBLMI FontSubset: true FirstChar: 12 LastChar: 62 FontDescriptor: FontName: VOXUEH+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true XMP: application/pdf Rosario Osta Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. 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