1a8ab7e9bab459c7ebe1d91e5135ebe5 pmc_27616993.pdf a2ba57020ed8297a63081ba40e0b1a0c715d0227 pmc_27616993.pdf Title: Killer Immunoglobulin-Like Receptor Profiles are not Associated with Risk of Amoxicillin-Clavulanate–Induced Liver Injury in Spanish Patients Subject: Natural killer cells are an integral part of the immune system and represent a large proportion of the lymphocyte population in the liver. Keywords: hepatotoxicity, drug-induced liver injury, pharmacogenetics, immune response, HLA, receptor/ligand Author: M. Isabel Lucena Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Wed Aug 24 11:33:54 2016 CEST ModDate: Wed Aug 24 12:43:11 2016 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1778215 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TKOLNU+MinionPro-Regular Type 1 Custom yes yes no 39 0 LOFLGL+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 40 0 WXFGMZ+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 41 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 42 0 CTZGMD+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 43 0 OBCIDI+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 45 0 GVCNKU+MTSYN Type 1 Builtin yes yes no 46 0 WLGNUD+MinionPro-It Type 1 Custom yes yes no 92 0 XODHDR+RBLMI Type 1 Builtin yes yes no 139 0 UDTJPE+MinionPro-Bold Type 1 Custom yes yes no 146 0 WGFDNG+MTSYB Type 1 Builtin yes yes no 151 0 IEQUAM+HelveticaNeueLTStd-Roman Type 1 Custom yes yes no 245 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:38:25 CET RepresentationInformation: pmc_27616993.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-06 08:51:18 CET Size: 1778215 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 425 FreeObjects: 6 IncrementalUpdates: 4 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Killer Immunoglobulin-Like Receptor Profiles are not Associated with Risk of Amoxicillin-Clavulanate Induced Liver Injury in Spanish Patients Children: Item: Title: Introduction Item: Title: Materials And Methods Children: Item: Title: Subjects and Study Protocol Item: Title: Ethics Statement Item: Title: DNA Extraction and Genotyping Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: DILI Patient Characteristics Item: Title: KIR Gene Distribution Item: Title: HLA Ligand Distribution Item: Title: KIR Receptor-HLA Ligand Distributions Item: Title: Discussion Item: Title: Author Contributions Item: Title: Funding Item: Title: References Info: Title: Killer Immunoglobulin-Like Receptor Profiles are not Associated with Risk of Amoxicillin-Clavulanate Induced Liver Injury in Spanish Patients Author: M. Isabel Lucena Subject: Natural killer cells are an integral part of the immune system and represent a large proportion of the lymphocyte population in the liver. Keywords: hepatotoxicity, drug-induced liver injury, pharmacogenetics, immune response, HLA, receptor/ligand Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Wed Aug 24 12:03:54 CEST 2016 ModDate: Wed Aug 24 13:13:11 CEST 2016 ID: 0x45f7a14ce7ec7c4556c24161bc15ec8f, 0x11442a1bddc4cc4f800799c1f20138a7 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: UDTJPE+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: UDTJPE+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IEQUAM+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 35 LastChar: 98 FontDescriptor: FontName: IEQUAM+HelveticaNeueLTStd-Roman Flags: Symbolic FontBBox: -166, -214, 1076, 952 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TKOLNU+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: TKOLNU+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WGFDNG+MTSYB FontSubset: true FirstChar: 3 LastChar: 67 FontDescriptor: FontName: WGFDNG+MTSYB Flags: Symbolic FontBBox: -16, -935, 1043, 896 FontFile: true Font: BaseFont: LOFLGL+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: LOFLGL+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WXFGMZ+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: WXFGMZ+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CTZGMD+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: CTZGMD+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XODHDR+RBLMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: XODHDR+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: WLGNUD+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: WLGNUD+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OBCIDI+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 250 FontDescriptor: FontName: OBCIDI+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GVCNKU+MTSYN FontSubset: true FirstChar: 3 LastChar: 68 FontDescriptor: FontName: GVCNKU+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true XMP: application/pdf M. Isabel Lucena Natural killer cells are an integral part of the immune system and represent a large proportion of the lymphocyte population in the liver. Killer Immunoglobulin-Like Receptor Profiles are not Associated with Risk of Amoxicillin-Clavulanate–Induced Liver Injury in Spanish Patients hepatotoxicity drug-induced liver injury pharmacogenetics immune response HLA receptor/ligand 2016-08-24T15:03:54+05:30 LaTeX with hyperref package 2016-08-24T16:13:11+05:30 2016-08-24T16:13:11+05:30 hepatotoxicity, drug-induced liver injury, pharmacogenetics, immune response, HLA, receptor/ligand pdfTeX-1.40.15 False This is MiKTeX-pdfTeX 2.9.5496 (1.40.15) uuid:060edf5e-4e61-4694-a6f2-cf774be45320 uuid:9d33eab8-96ba-4b81-8436-571a75cf1063 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 169, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 467, 727, 551, 737 Annotation: Subtype: Link Rect: 454, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 432, 160, 442 Annotation: Subtype: Link Rect: 77, 65, 160, 74 Annotation: Subtype: Link Rect: 522, 676, 553, 708 Annotation: Subtype: Link Rect: 176, 529, 551, 619 Annotation: Subtype: Link Rect: 176, 506, 251, 518 Annotation: Subtype: Link Rect: 370, 506, 483, 518 Annotation: Subtype: Link Rect: 342, 484, 443, 494 Annotation: Subtype: Link Rect: 450, 484, 523, 494 Annotation: Subtype: Link Rect: 194, 473, 263, 485 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 252, 500, 292, 511 ActionDest: 273 Annotation: Subtype: Link Rect: 43, 489, 89, 500 ActionDest: 273 Annotation: Subtype: Link Rect: 93, 489, 113, 500 ActionDest: 273 Annotation: Subtype: Link Rect: 116, 489, 187, 500 ActionDest: 297 Annotation: Subtype: Link Rect: 190, 489, 210, 500 ActionDest: 297 Annotation: Subtype: Link Rect: 216, 408, 267, 420 ActionDest: 297 Annotation: Subtype: Link Rect: 270, 408, 290, 420 ActionDest: 297 Annotation: Subtype: Link Rect: 43, 397, 100, 408 ActionDest: 297 Annotation: Subtype: Link Rect: 102, 397, 122, 408 ActionDest: 297 Annotation: Subtype: Link Rect: 125, 397, 193, 408 ActionDest: 273 Annotation: Subtype: Link Rect: 195, 397, 215, 408 ActionDest: 273 Annotation: Subtype: Link Rect: 186, 248, 242, 259 ActionDest: 297 Annotation: Subtype: Link Rect: 247, 248, 267, 259 ActionDest: 297 Annotation: Subtype: Link Rect: 47, 133, 103, 145 ActionDest: 297 Annotation: Subtype: Link Rect: 106, 133, 127, 145 ActionDest: 297 Annotation: Subtype: Link Rect: 305, 592, 373, 603 ActionDest: 297 Annotation: Subtype: Link Rect: 376, 592, 396, 603 ActionDest: 297 Annotation: Subtype: Link Rect: 399, 592, 450, 603 ActionDest: 297 Annotation: Subtype: Link Rect: 452, 592, 473, 603 ActionDest: 297 Annotation: Subtype: Link Rect: 461, 557, 522, 568 ActionDest: 273 Annotation: Subtype: Link Rect: 525, 557, 545, 568 ActionDest: 273 Annotation: Subtype: Link Rect: 455, 466, 521, 477 ActionDest: 273 Annotation: Subtype: Link Rect: 525, 466, 545, 477 ActionDest: 273 Annotation: Subtype: Link Rect: 502, 431, 549, 442 ActionDest: 297 Annotation: Subtype: Link Rect: 302, 420, 322, 431 ActionDest: 297 Annotation: Subtype: Link Rect: 334, 385, 385, 397 ActionDest: 297 Annotation: Subtype: Link Rect: 387, 385, 407, 397 ActionDest: 297 Annotation: Subtype: Link Rect: 394, 328, 442, 339 ActionDest: 273 Annotation: Subtype: Link Rect: 446, 328, 466, 339 ActionDest: 273 Annotation: Subtype: Link Rect: 315, 76, 364, 87 ActionDest: 273 Annotation: Subtype: Link Rect: 369, 76, 389, 87 ActionDest: 273 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 47, 695, 96, 706 ActionDest: 273 Annotation: Subtype: Link Rect: 100, 695, 120, 706 ActionDest: 273 Annotation: Subtype: Link Rect: 158, 672, 214, 683 ActionDest: 273 Annotation: Subtype: Link Rect: 217, 672, 237, 683 ActionDest: 273 Annotation: Subtype: Link Rect: 184, 344, 219, 355 ActionDest: 297 Annotation: Subtype: Link Rect: 221, 344, 241, 355 ActionDest: 297 Annotation: Subtype: Link Rect: 178, 126, 183, 137 ActionDest: 126 Annotation: Subtype: Link Rect: 244, 103, 290, 115 ActionDest: 297 Annotation: Subtype: Link Rect: 43, 93, 64, 103 ActionDest: 297 Annotation: Subtype: Link Rect: 47, 64, 243, 77 Annotation: Subtype: Link Rect: 346, 486, 376, 495 ActionDest: 126 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 338, 706, 368, 717 ActionDest: 164 Annotation: Subtype: Link Rect: 443, 534, 481, 545 ActionDest: 175 Annotation: Subtype: Link Rect: 392, 374, 428, 385 ActionDest: 175 Annotation: Subtype: Link Rect: 404, 87, 439, 99 ActionDest: 200 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 237, 388, 268, 400 ActionDest: 200 Annotation: Subtype: Link Rect: 305, 146, 336, 156 ActionDest: 242 Annotation: Subtype: Link Rect: 507, 76, 549, 87 ActionDest: 297 Annotation: Subtype: Link Rect: 302, 64, 322, 76 ActionDest: 297 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 186, 339, 228, 351 ActionDest: 297 Annotation: Subtype: Link Rect: 231, 339, 252, 351 ActionDest: 297 Annotation: Subtype: Link Rect: 169, 293, 230, 305 ActionDest: 273 Annotation: Subtype: Link Rect: 234, 293, 254, 305 ActionDest: 273 Annotation: Subtype: Link Rect: 246, 167, 292, 179 ActionDest: 273 Annotation: Subtype: Link Rect: 43, 156, 64, 167 ActionDest: 273 Annotation: Subtype: Link Rect: 67, 156, 87, 167 ActionDest: 273 Annotation: Subtype: Link Rect: 230, 122, 290, 133 ActionDest: 297 Annotation: Subtype: Link Rect: 43, 110, 64, 121 ActionDest: 297 Annotation: Subtype: Link Rect: 305, 683, 360, 694 ActionDest: 273 Annotation: Subtype: Link Rect: 363, 683, 383, 694 ActionDest: 273 Annotation: Subtype: Link Rect: 450, 591, 489, 603 ActionDest: 273 Annotation: Subtype: Link Rect: 491, 591, 512, 603 ActionDest: 273 Annotation: Subtype: Link Rect: 514, 591, 551, 603 ActionDest: 273 Annotation: Subtype: Link Rect: 302, 581, 322, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 325, 581, 345, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 348, 581, 419, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 421, 581, 442, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 444, 581, 498, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 501, 581, 521, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 524, 581, 551, 591 ActionDest: 273 Annotation: Subtype: Link Rect: 302, 568, 322, 580 ActionDest: 273 Annotation: Subtype: Link Rect: 324, 568, 344, 580 ActionDest: 273 Annotation: Subtype: Link Rect: 517, 500, 551, 511 ActionDest: 273 Annotation: Subtype: Link Rect: 302, 489, 322, 500 ActionDest: 273 Annotation: Subtype: Link Rect: 324, 489, 345, 500 ActionDest: 273 Annotation: Subtype: Link Rect: 414, 339, 419, 351 ActionDest: 242 Annotation: Subtype: Link Rect: 505, 328, 551, 339 ActionDest: 273 Annotation: Subtype: Link Rect: 302, 316, 323, 328 ActionDest: 273 Annotation: Subtype: Link Rect: 326, 316, 347, 328 ActionDest: 273 Annotation: Subtype: Link Rect: 305, 99, 361, 110 ActionDest: 273 Annotation: Subtype: Link Rect: 365, 99, 385, 110 ActionDest: 273 Annotation: Subtype: Link Rect: 305, 64, 385, 77 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 116, 706, 173, 717 ActionDest: 297 Annotation: Subtype: Link Rect: 177, 706, 197, 717 ActionDest: 297 Annotation: Subtype: Link Rect: 240, 683, 290, 694 ActionDest: 273 Annotation: Subtype: Link Rect: 43, 672, 64, 683 ActionDest: 273 Annotation: Subtype: Link Rect: 183, 534, 235, 545 ActionDest: 273 Annotation: Subtype: Link Rect: 239, 534, 260, 545 ActionDest: 273 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 492, 479, 519, 489 Annotation: Subtype: Link Rect: 519, 479, 551, 489 Annotation: Subtype: Link Rect: 302, 470, 337, 479 Annotation: Subtype: Link Rect: 338, 470, 361, 479 Annotation: Subtype: Link Rect: 361, 470, 388, 479 Annotation: Subtype: Link Rect: 43, 29, 124, 38 Annotation: Subtype: Link Rect: 127, 29, 187, 38 Annotation: Subtype: Link Rect: 439, 29, 551, 38 Checksum: 1fd2d897 Type: CRC32 Checksum: 1a8ab7e9bab459c7ebe1d91e5135ebe5 Type: MD5 Checksum: a2ba57020ed8297a63081ba40e0b1a0c715d0227 Type: SHA-1