4d63df8c740dc088b91210cf64644a7d pmc_27757105.pdf c2350979736a1c06d2b8d4f216d8c5f6dadf8d52 pmc_27757105.pdf 44fe56eef003017b60ebe357d31dd2d080fd7fb76ac6b9b6e6aa424a90fa7385 pmc_27757105.pdf Title: Mycobacteria Clumping Increase Their Capacity to Damage Macrophages Subject: The rough morphotypes of non-tuberculous mycobacteria have been associated with the most severe illnesses in humans. Keywords: Mycobacterium abscessus, virulence factors, infection of macrophages, clumps, cords, rough morphotypes, smooth morphotypes Author: Marina Luquin Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri Sep 30 13:54:12 2016 CEST ModDate: Fri Sep 30 14:30:15 2016 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1194141 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IDUYMQ+MinionPro-Regular Type 1 Custom yes yes no 576 0 RQBSRK+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 579 0 ZEYJPF+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 582 0 CSXXEO+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 585 0 TTYTVP+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 588 0 OTXCXN+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 591 0 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Size Analysis of the Bacterial Suspensions Item: Title: Cell Culture Item: Title: Phagocytosis Assay Item: Title: Transmission Electron Microscopy (TEM) Item: Title: Macrophage Viability Item: Title: Granuloma-Like Structure Analysis Item: Title: Cytokine Analysis Item: Title: Assay of Bacterial Suspension Exposed*1.5pt to DPPC Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Only R Colonies Contained Attached Bacilli Forming a Cording Structure Item: Title: Macrophages Infected with R*1pt Morphotypes Phagocytosed Large*1pt Clumps of Bacilli Item: Title: Macrophages were Rapidly Damaged by*1pt Rough Morphotypes but were*1pt Unaffected by Smooth Morphotypes Item: Title: The Death of Macrophages was Preceded by the Formation of Granuloma-Like Structures and the Production of TNF- and IL-6 Item: Title: The Contact with the Major Component of Pulmonary Surfactant does not Affect the Clump Size Item: Title: Discussion Item: Title: Author Contributions Item: 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