d77bfa10dcae97209d976888b2ce0b7e  pmc_27796539.pdf
a6e613418d0eadc5e637bc657aa71cb45a7895fa  pmc_27796539.pdf
0b90165647dcc513e46c3fd4da2166b6d7c30857b423b12b8db907e53950936f  pmc_27796539.pdf

Title:          A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function
Subject:        Cancer Chemotherapy and Pharmacology, doi:10.1007/s00280-016-3175-7
Keywords:       Cabazitaxel,Renal impairment,Pharmacokinetics,Phase I,Advanced solid tumors
Author:         Analía Azaro
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows)
CreationDate:   Thu Oct 27 17:02:37 2016 CEST
ModDate:        Mon Nov 14 07:26:15 2016 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      513304 bytes
Optimized:      yes
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GmqxwpTimes-Roman                    Type 1C           Custom           yes no  yes    261  0
MycklgTimes-Bold                     Type 1C           Custom           yes no  yes    262  0
KcylxnTimes-Italic                   Type 1C           WinAnsi          yes no  yes    263  0
KDGDTU+LdhxgjMTSY                    Type 1C           Custom           yes yes yes    264  0
PPRAKD+PprbldWingdings-Regular       Type 1C           WinAnsi          yes yes yes    283  0
NvdxqpSpringnew-Regular              Type 1C           WinAnsi          yes no  yes    293  0
QUDMAI+MmqmgvSTIX-Regular            Type 1C           Custom           yes yes yes    160  0
QUDMAI+YlrkkyArialMT                 Type 1C           WinAnsi          yes yes no     175  0
GwyhvfArial-BoldMT                   Type 1C           WinAnsi          yes no  no     174  0
XTSGXL+XtsgxmMTMI                    Type 1C           Custom           yes yes yes    180  0
WbccbpArial-BoldMT                   Type 1C           WinAnsi          yes no  no     179  0
FxxnkkArialMT                        Type 1C           WinAnsi          yes no  no     178  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-14 18:34:35 CET
 RepresentationInformation: pmc_27796539.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-06 08:45:58 CET
  Size: 513304
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1170
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Purpose 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Patient population
         Item: 
          Title: Baseline and on study assessments
         Item: 
          Title: Pharmacokinetic sampling and bioanalytical methodology
         Item: 
          Title: Pharmacokinetic endpoints and analysis
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patient characteristics
         Item: 
          Title: Treatment characteristics
         Item: 
          Title: Pharmacokinetics
         Item: 
          Title: Safety
         Item: 
          Title: Efficacy
       Item: 
        Title: Discussion and conclusions
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function
    Author: Analía Azaro
    Subject: Cancer Chemotherapy and Pharmacology, doi:10.1007/s00280-016-3175-7
    Keywords: Cabazitaxel,Renal impairment,Pharmacokinetics,Phase I,Advanced solid tumors
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows)
    CreationDate: Thu Oct 27 17:32:37 CEST 2016
    ModDate: Mon Nov 14 07:56:15 CET 2016
   ID: 0x235929eb959b074a9b384787dc01ebf1, 0xf1a689af2647fb4bb845d80cc9173285
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 4
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 5
      ImageHeight: 4
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 4
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 5
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 62
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 132
      ImageHeight: 124
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 63
      ImageHeight: 20
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 62
      ImageHeight: 9
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 63
      ImageHeight: 91
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 62
      ImageHeight: 16
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 62
      ImageHeight: 10
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 62
      ImageHeight: 17
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 29
      ImageHeight: 11
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: QUDMAI+MmqmgvSTIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 33
      FontDescriptor: 
       FontName: QUDMAI+MmqmgvSTIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FxxnkkArialMT
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: FxxnkkArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WbccbpArial-BoldMT
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WbccbpArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: XTSGXL+XtsgxmMTMI
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: XTSGXL+XtsgxmMTMI
       Flags: Serif, Symbolic, Italic
       FontBBox: 0, -213, 987, 680
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GmqxwpTimes-Roman
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GmqxwpTimes-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 898
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MycklgTimes-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MycklgTimes-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -168, -218, 1000, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KcylxnTimes-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: KcylxnTimes-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -169, -217, 1010, 883
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: KDGDTU+LdhxgjMTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: KDGDTU+LdhxgjMTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PPRAKD+PprbldWingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: PPRAKD+PprbldWingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: GwyhvfArial-BoldMT
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: GwyhvfArial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: QUDMAI+YlrkkyArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: QUDMAI+YlrkkyArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2016-10-27T20:32:37+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2016-11-14T11:56:15+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2016-11-14T11:56:15+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows)</pdf:Producer>
         <pdf:Keywords>Cabazitaxel,Renal impairment,Pharmacokinetics,Phase I,Advanced solid tumors</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1007/s00280-016-3175-7</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer Berlin Heidelberg</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Cancer Chemotherapy and Pharmacology, doi:10.1007/s00280-016-3175-7</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Cabazitaxel</rdf:li>
               <rdf:li>Renal impairment</rdf:li>
               <rdf:li>Pharmacokinetics</rdf:li>
               <rdf:li>Phase I</rdf:li>
               <rdf:li>Advanced solid tumors</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Analía Azaro</rdf:li>
               <rdf:li>Jordi Rodón</rdf:li>
               <rdf:li>Jean-Pascal Machiels</rdf:li>
               <rdf:li>Sylvie Rottey</rdf:li>
               <rdf:li>Silvia Damian</rdf:li>
               <rdf:li>Richard Baird</rdf:li>
               <rdf:li>Javier Garcia-Corbacho</rdf:li>
               <rdf:li>Ron H. J. Mathijssen</rdf:li>
               <rdf:li>Pierre-François Clot</rdf:li>
               <rdf:li>Claudine Wack</rdf:li>
               <rdf:li>Liji Shen</rdf:li>
               <rdf:li>Maja J. A. Jonge</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:DOI>10.1007/s00280-016-3175-7</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:url>"http://dx.doi.org/10.1007/s00280-016-3175-7</prism:url>
         <prism:doi>10.1007/s00280-016-3175-7</prism:doi>
         <prism:issn>1432-0843</prism:issn>
         <prism:volume>78</prism:volume>
         <prism:number>6</prism:number>
         <prism:startingPage>1185</prism:startingPage>
         <prism:endingPage>1197</prism:endingPage>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Cancer Chemotherapy and Pharmacology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s00280-016-3175-7</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:DocumentID>uuid:39f76989-ee68-4017-bbfb-65b54c49b9a9</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:17ae5718-4e63-4af6-96a7-9f920d4c8314</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:5d1d67b3-f524-4dd0-98e5-442bc03d068f</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-11-14T11:55:32+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:3e45c940-991d-48cd-869c-893b2d576591</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-11-14T11:56:15+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1185
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 469, 769, 546, 736
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1186
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 207, 683, 212, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 217, 683, 222, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 120, 633, 125, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 134, 633, 139, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 144, 633, 154, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 212, 595, 217, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 188, 545, 193, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 90, 470, 100, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 105, 470, 115, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 194, 383, 199, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 206, 383, 211, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 232, 345, 242, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 241, 320, 251, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 257, 320, 267, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 273, 320, 283, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 54, 283, 64, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 70, 283, 80, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 170, 258, 180, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 214, 158, 224, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 309, 521, 319, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 324, 521, 334, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
     Thumb: true
    Page: 
     Label: 1187
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 671, 64, 660
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 359, 284, 369, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 375, 284, 385, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
     Thumb: true
    Page: 
     Label: 1188
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 246, 634, 256, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 261, 634, 271, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 187, 434, 197, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 204, 434, 214, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 358, 633, 363, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 338, 595, 343, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 355, 408, 360, 397
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 510, 333, 515, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 425, 270, 430, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
     Thumb: true
    Page: 
     Label: 1189
     Sequence: 5
     Thumb: true
    Page: 
     Label: 1190
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 368, 334, 373, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 366, 121, 371, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 54
     Thumb: true
    Page: 
     Label: 1191
     Sequence: 7
     Thumb: true
    Page: 
     Label: 1192
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 396, 211, 385
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
     Thumb: true
    Page: 
     Label: 1193
     Sequence: 9
     Thumb: true
    Page: 
     Label: 1194
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 259, 611, 264, 599
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 231, 498, 236, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 155, 436, 160, 424
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 217, 361, 222, 349
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 114, 273, 119, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 366, 486, 376, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 465, 361, 475, 349
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 480, 361, 490, 349
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 385, 298, 395, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 402, 298, 412, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 380, 261, 390, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 395, 261, 405, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 410, 261, 420, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 528, 236, 538, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 375, 111, 385, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
     Thumb: true
    Page: 
     Label: 1195
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 230, 646, 240, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 245, 646, 255, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 261, 646, 271, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 181, 621, 191, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 198, 621, 208, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 137, 559, 147, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 237, 546, 247, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 253, 546, 263, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 78, 459, 88, 448
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 93, 459, 103, 448
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 108, 459, 118, 448
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
      Annotation: 
       Subtype: Link
       Rect: 448, 609, 458, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 489, 446, 499, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 123
     Thumb: true
    Page: 
     Label: 1196
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 225, 571, 289, 562
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 561, 137, 552
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 364, 654, 544, 644
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 381, 634
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 465, 614, 544, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 604, 544, 594
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 594, 385, 584
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 432, 364, 544, 354
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 354, 429, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 224, 544, 214
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 214, 423, 204
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1197
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 476, 584, 544, 574
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 574, 421, 564
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 389, 514, 542, 504
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 5ff5ceb9
   Type: CRC32
  Checksum: d77bfa10dcae97209d976888b2ce0b7e
   Type: MD5
  Checksum: a6e613418d0eadc5e637bc657aa71cb45a7895fa
   Type: SHA-1