1ac3c7b67eb38023d98cf6dbf3bced18 pmc_27799900.pdf be741f836cb96ccc5f6f5c17e9f4d74e284825df pmc_27799900.pdf 12efb902f2556864bc66faa63b26851f7f9002261d41c4501c75316e88e749be pmc_27799900.pdf Title: VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome Subject: Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. Keywords: Down syndrome, PFC-dependent cognition, dopamine, COMTVal158Met, VNTR-DAT1 Author: Mara Dierssen and Rafael de la Torre Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Oct 13 13:19:51 2016 CEST ModDate: Thu Oct 13 13:57:31 2016 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 915680 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OXLMDD+MinionPro-Regular Type 1 Custom yes yes no 45 0 UHMDKP+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 46 0 NBOCDV+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 47 0 UQYTGE+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 48 0 UAZNZV+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 49 0 BLPOAS+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 51 0 TPXMTO+MinionPro-It Type 1 Custom yes yes no 115 0 GHPUHS+MTSYN Type 1 Builtin yes yes no 124 0 AEKXNR+MTGU Type 1 Builtin yes yes no 184 0 XJRMPB+MinionPro-Bold Type 1 Custom yes yes no 197 0 PAARCL+RBLMI Type 1 Builtin yes yes no 198 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:34:31 CET RepresentationInformation: pmc_27799900.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-06 08:45:52 CET Size: 915680 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 492 FreeObjects: 11 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome Children: Item: Title: Introduction Item: Title: Materials And Methods Children: Item: Title: Subjects Item: Title: Genotype Analysis Item: Title: Neuropsychological Testing Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Distribution of Polymorphisms Item: Title: VNTR-DAT1 and COMTVal158Met Effects on Cognitive and Functional Performance Item: Title: Discussion Children: Item: Title: Limitations Item: Title: Conclusion Item: Title: Ethical Standards Item: Title: Members Of The Tesdad Study Group Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome Author: Mara Dierssen and Rafael de la Torre Subject: Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. Keywords: Down syndrome, PFC-dependent cognition, dopamine, COMTVal158Met, VNTR-DAT1 Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Oct 13 13:49:51 CEST 2016 ModDate: Thu Oct 13 14:27:31 CEST 2016 ID: 0xd48da59154a708ae9e720d1b9e2d776a, 0x7b99a34746b2334aa85b9b84aef53b89 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: UQYTGE+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: UQYTGE+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UAZNZV+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: UAZNZV+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BLPOAS+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: BLPOAS+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TPXMTO+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: TPXMTO+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XJRMPB+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 250 FontDescriptor: FontName: XJRMPB+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PAARCL+RBLMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: PAARCL+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: AEKXNR+MTGU FontSubset: true FirstChar: 36 LastChar: 109 FontDescriptor: FontName: AEKXNR+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: GHPUHS+MTSYN FontSubset: true FirstChar: 14 LastChar: 68 FontDescriptor: FontName: GHPUHS+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: OXLMDD+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: OXLMDD+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UHMDKP+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: UHMDKP+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NBOCDV+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: NBOCDV+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true XMP: application/pdf Mara Dierssen and Rafael de la Torre Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. 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