29e0f26e5543189404bedcd3dcba0230  pmc_27809845.pdf
1b19582cd3d12b60db8136b886320fa77d3ac216  pmc_27809845.pdf
06cff107ea3961951be03bd97a420203a1c3999f827dae833e0ca9b1eb8dfd3c  pmc_27809845.pdf

Title:          Impact of diabetes on the predictive value of heart failure biomarkers
Subject:        Cardiovascular Diabetology, doi:10.1186/s12933-016-0470-x
Keywords:       Diabetes mellitus,Heart failure,Biomarkers,ST2,Prognostic
Author:         Nuria Alonso
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Mon Oct 31 09:22:03 2016 CET
ModDate:        Thu Nov  3 09:48:37 2016 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1461267 bytes
Optimized:      no
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MbcjxnMyriadPro-Light                Type 1C           Custom           yes no  yes     71  0
RjccrvMyriadPro-It                   Type 1C           WinAnsi          yes no  yes     10  0
DxhtbqMyriadPro-Semibold             Type 1C           Custom           yes no  yes     11  0
MftqkqMyriadPro-Bold                 Type 1C           Custom           yes no  yes     12  0
AXHORB+BxrcchMTSY                    Type 1C           Custom           yes yes yes     13  0
YWCGYH+YwdhycMyriadPro-LightIt       Type 1C           WinAnsi          yes yes yes     68  0
DrnrghMyriadPro-Regular              Type 1C           Custom           yes no  yes     15  0
MdrxllOpenSans                       Type 1C           WinAnsi          yes no  no     839  0
CcgsxjWarnockPro-Regular             Type 1C           Custom           yes no  yes      9  0
CXSLLJ+DxslljWarnockPro-It           Type 1C           WinAnsi          yes yes yes     14  0
HGNZYK+QcywcfSTIXMath-Regular        Type 1C           WinAnsi          yes yes yes     60  0
BCWYVL+CdwyvlMyriadPro-SemiboldIt    Type 1C           WinAnsi          yes yes yes     69  0
PLJHUX+PljxfxSPSMTSYBBold            Type 1C           Custom           yes yes yes     70  0
DkhvqkOpenSans-Light                 Type 1C           Custom           yes no  no     143  0
GmgvytOregonLDOBook                  Type 1C           WinAnsi          yes no  no     146  0
TyssdhOpenSans-Extrabold             Type 1C           WinAnsi          yes no  no     139  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-14 18:34:07 CET
 RepresentationInformation: pmc_27809845.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-02-06 08:45:23 CET
  Size: 1461267
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1096
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Impact of diabetes on the predictive value of heart failure biomarkers
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Methods: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusions: 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study population
         Item: 
          Title: Follow-up and outcomes
         Item: 
          Title: DM diagnosis
         Item: 
          Title: NTproBNP assay
         Item: 
          Title: Hs-TnT assay
         Item: 
          Title: ST2 assay
         Item: 
          Title: hsCRP assay
         Item: 
          Title: Galectin-3 assay
         Item: 
          Title: Cystatin-C assay
         Item: 
          Title: STfR assay
         Item: 
          Title: Neprilysin assay
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Limitations
       Item: 
        Title: Conclusions
       Item: 
        Title: Authors’ contributions
       Item: 
        Title: References
   Info: 
    Title: Impact of diabetes on the predictive value of heart failure biomarkers
    Author: Nuria Alonso
    Subject: Cardiovascular Diabetology, doi:10.1186/s12933-016-0470-x
    Keywords: Diabetes mellitus,Heart failure,Biomarkers,ST2,Prognostic
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Mon Oct 31 09:52:03 CET 2016
    ModDate: Thu Nov 03 09:48:37 CET 2016
   ID: 0x0b78b4b0ac8047353d99e276767d37ea, 0x3c3f38f3dab8cd7d98e476cd51d9afc3
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 2
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 6
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 96
      ImageHeight: 90
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 46
      ImageHeight: 15
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 7
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 46
      ImageHeight: 66
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 12
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 46
      ImageHeight: 13
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 22
      ImageHeight: 8
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 5
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1961
      ImageHeight: 1158
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1961
      ImageHeight: 1048
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: YWCGYH+YwdhycMyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: YWCGYH+YwdhycMyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BCWYVL+CdwyvlMyriadPro-SemiboldIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: BCWYVL+CdwyvlMyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: PLJHUX+PljxfxSPSMTSYBBold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: PLJHUX+PljxfxSPSMTSYBBold
       Flags: Symbolic
       FontBBox: -16, -935, 987, 896
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MdrxllOpenSans
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: MdrxllOpenSans
       Flags: Nonsymbolic
       FontBBox: -550, -271, 1204, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MbcjxnMyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MbcjxnMyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CcgsxjWarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: CcgsxjWarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: RjccrvMyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: RjccrvMyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: DxhtbqMyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DxhtbqMyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MftqkqMyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MftqkqMyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AXHORB+BxrcchMTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: AXHORB+BxrcchMTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CXSLLJ+DxslljWarnockPro-It
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: CXSLLJ+DxslljWarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: DrnrghMyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DrnrghMyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HGNZYK+QcywcfSTIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: HGNZYK+QcywcfSTIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2016-10-31T13:52:03+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2016-11-03T09:48:37+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2016-11-03T09:48:37+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
         <pdf:Keywords>Diabetes mellitus,Heart failure,Biomarkers,ST2,Prognostic</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1186/s12933-016-0470-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Cardiovascular Diabetology, doi:10.1186/s12933-016-0470-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Diabetes mellitus</rdf:li>
               <rdf:li>Heart failure</rdf:li>
               <rdf:li>Biomarkers</rdf:li>
               <rdf:li>ST2</rdf:li>
               <rdf:li>Prognostic</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Impact of diabetes on the predictive value of heart failure biomarkers</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Nuria Alonso</rdf:li>
               <rdf:li>Josep Lupón</rdf:li>
               <rdf:li>Jaume Barallat</rdf:li>
               <rdf:li>Marta de Antonio</rdf:li>
               <rdf:li>Mar Domingo</rdf:li>
               <rdf:li>Elisabet Zamora</rdf:li>
               <rdf:li>Pedro Moliner</rdf:li>
               <rdf:li>Amparo Galán</rdf:li>
               <rdf:li>Javier Santesmases</rdf:li>
               <rdf:li>Cruz Pastor</rdf:li>
               <rdf:li>Dídac Mauricio</rdf:li>
               <rdf:li>Antoni Bayes-Genis</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:DOI>10.1186/s12933-016-0470-x</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:url>"http://dx.doi.org/10.1186/s12933-016-0470-x</prism:url>
         <prism:doi>10.1186/s12933-016-0470-x</prism:doi>
         <prism:issn>1475-2840</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Cardiovascular Diabetology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12933-016-0470-x</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:bca92f6f-1ebd-4bd3-a915-f9caea45f374</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:0eb22c92-1dbb-445b-9258-b5ce3a8b0642</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:0c5521af-0f40-4af1-8856-34a3ea3db450</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-10-31T13:45:28+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:cd0ad0d3-805e-44c7-9fb9-0a87da664c07</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2016-10-31T13:46:17+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/">
         <sn:authorInfo>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Nuria Alonso</author:name>
                  <author:orcid>http://orcid.org/0000-0001-5844-2221</author:orcid>
               </rdf:li>
            </rdf:Seq>
         </sn:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>seq AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 612, 136, 600
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 80, 307, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 443, 64, 525, 56
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 56, 247, 48
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 683, 541, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 211, 667, 216, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 221, 667, 226, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 133, 643, 138, 631
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 222, 607, 227, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 279, 535, 284, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 56, 523, 61, 511
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 252, 499, 257, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 165, 439, 170, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 175, 439, 185, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 236, 415, 246, 403
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 75, 391, 85, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 90, 391, 100, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 242, 379, 252, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 258, 379, 267, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 122, 355, 132, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 176, 127, 186, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 192, 127, 202, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 149, 79, 154, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 160, 79, 165, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 497, 116, 507, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
     Thumb: true
    Page: 
     Sequence: 3
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 145, 620, 150, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 120, 464, 125, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 133, 416, 138, 397
       Flags: Print
       AppearanceDictionary: true
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 218, 152, 223, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 94, 116, 99, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 88
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 159, 196, 164, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 147, 172, 152, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 330, 304, 335, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 103
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 283, 141, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 206, 247, 216, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 59, 199, 69, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 211, 163, 220, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 275, 139, 285, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 474, 656, 484, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 523, 596, 533, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 505, 428, 515, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 528, 272, 533, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 692, 138, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
     Thumb: true
    Page: 
     Sequence: 9
     Thumb: true
  Checksum: efaee01a
   Type: CRC32
  Checksum: 29e0f26e5543189404bedcd3dcba0230
   Type: MD5
  Checksum: 1b19582cd3d12b60db8136b886320fa77d3ac216
   Type: SHA-1