89c73ed56f3bf8fe09a615238c53f9d5 pmc_27905925.pdf eaa96bc8c49f305c7d0ea309f41e35446e1dc032 pmc_27905925.pdf Title: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis Subject: Cardiovascular Diabetology, doi:10.1186/s12933-016-0477-3 Keywords: Atherosclerosis,Insulin receptor,Migration,Vascular smooth muscle cells Author: N. Beneit Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Nov 29 14:58:40 2016 CET ModDate: Thu Dec 1 14:22:38 2016 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 3312955 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KstbylMyriadPro-Light Type 1C Custom yes no yes 106 0 VrgyslMyriadPro-It Type 1C WinAnsi yes no yes 10 0 PydfjdMyriadPro-Semibold Type 1C Custom yes no yes 13 0 YlsrkbMyriadPro-Bold Type 1C Custom yes no yes 11 0 BSFCRH+CsfdstMTSY Type 1C Custom yes yes yes 9 0 GyyfplWarnockPro-Regular Type 1C Custom yes no yes 12 0 KjnbhqMyriadPro-Regular Type 1C Custom yes no yes 14 0 ThqgpvOpenSans Type 1C WinAnsi yes no no 1141 0 UCSWTU+RhgtswSTIXMath-Regular Type 1C WinAnsi yes yes yes 57 0 VLPYBM+VlpycnWarnockPro-It Type 1C WinAnsi yes yes yes 70 0 DjvtlvArial-BoldMT Type 1C WinAnsi yes no no 107 0 JEEYVQ+VvgmnnHelvetica-Bold Type 1C WinAnsi yes yes no 108 0 SjwmffArialMT Type 1C WinAnsi yes no no 109 0 JEEYVQ+YdfgsjCalibri Type 1C WinAnsi yes yes no 110 0 IAPSHS+JlxqphSymbolMT Type 1C WinAnsi yes yes no 111 0 VkhgtpArial-BoldMT Type 1C WinAnsi yes no no 141 0 JEEYVQ+KgyqdjCalibri Type 1C WinAnsi yes yes no 142 0 YyftdvArial-BoldMT Type 1C Custom yes no no 184 0 KtqqhsArialMT Type 1C Custom yes no no 185 0 PkhnflCalibri Type 1C WinAnsi yes no no 186 0 WdrqdcArial-BoldMT Type 1C Custom yes no no 231 0 XOLODL+XlmmnbSPSMTSYBBold Type 1C Custom yes yes yes 232 0 ThdxkgArialMT Type 1C Custom yes no no 233 0 JEEYVQ+VxbhlhHelvetica-Bold Type 1C WinAnsi yes yes no 234 0 TxrxxdCalibri Type 1C WinAnsi yes no no 235 0 DQCOPC+YsxrntSymbolMT Type 1C Custom yes yes no 236 0 JEEYVQ+NmrsgvArialMT Type 1C WinAnsi yes yes no 271 0 AOOWZI+GddwfhCalibri-Bold Type 1C WinAnsi yes yes no 272 0 YwgnpmCalibri Type 1C WinAnsi yes no no 273 0 JjrhvqCalibri Type 1C WinAnsi yes no no 274 0 WwmtvyCalibri-BoldItalic Type 1C WinAnsi yes no no 275 0 BydtrkCalibri-Italic Type 1C WinAnsi yes no no 276 0 JxdymtMyriadPro-LightIt Type 1C WinAnsi yes no yes 277 0 NnlwkxCalibri Type 1C WinAnsi yes no no 278 0 YxysvlCalibri-Bold Type 1C WinAnsi yes no no 308 0 DQCOPC+MtvbmySymbolMT Type 1C Custom yes yes no 309 0 QfnvxlArial-BoldMT Type 1C WinAnsi yes no no 310 0 BnpswsCalibri Type 1C WinAnsi yes no no 311 0 KyhvqsCalibri Type 1C WinAnsi yes no no 312 0 SprmtvCalibri-Bold Type 1C WinAnsi yes no no 398 0 RhbhtrArial-BoldMT Type 1C WinAnsi yes no no 399 0 AOOWZI+XmlcylCalibri-Bold Type 1C WinAnsi yes yes no 400 0 AOOWZI+YmbngpCalibri-Bold Type 1C Custom yes yes no 401 0 BjvrrrOpenSans-Light Type 1C Custom yes no no 440 0 VmskvsOregonLDOBook Type 1C WinAnsi yes no no 443 0 VhthdmOpenSans-Extrabold Type 1C WinAnsi yes no no 436 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:32:41 CET RepresentationInformation: pmc_27905925.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-02-06 08:43:40 CET Size: 3312955 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1407 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IRIGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Methods: Item: Title: Results: Item: Title: Conclusions: Item: Title: Background Item: Title: Methods Children: Item: Title: Tissue samples Item: Title: Experimental model Item: Title: Cell cultures Item: Title: Western blot analysis Item: Title: Wound healing assays Item: Title: RNA extraction and real-time quantitative polymerase chain reaction Item: Title: Histological analysis Item: Title: Gelatin zymography Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Differential insulin and IGFs signaling by IRA or IRB isoforms in VSMCs Item: Title: Differential contribution of IRA, IRB and IGF-IR to VSMC migration in response to insulin or IGFs Item: Title: Inhibition of IGF-IR strongly reduces VSMC migration Item: Title: Insulin and IGF-II induces the formation of IRAIGF-IR hybrid receptors in VSMCs Item: Title: Role of IR isoforms and IGF-IR in VSMC migration in an experimental model of atherosclerosis Item: Title: mRNA expression of IGF-IR and IGFs in human aortic medial layers Item: Title: Discussion Item: Title: Conclusions Item: Title: Authors’ contributions Item: Title: References Info: Title: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis Author: N. Beneit Subject: Cardiovascular Diabetology, doi:10.1186/s12933-016-0477-3 Keywords: Atherosclerosis,Insulin receptor,Migration,Vascular smooth muscle cells Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Nov 29 15:28:40 CET 2016 ModDate: Thu Dec 01 14:22:38 CET 2016 ID: 0x122ccf2c67d1b11c32dcff92b2249c02, 0x6bb8becde1cc31ccc6feb9db4f8fdb0d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 2 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 46 ImageHeight: 6 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 96 ImageHeight: 90 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 46 ImageHeight: 15 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 46 ImageHeight: 7 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 46 ImageHeight: 66 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 46 ImageHeight: 12 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 46 ImageHeight: 8 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 46 ImageHeight: 13 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 22 ImageHeight: 8 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 4 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 4 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 4 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 3 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 4 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 5 ImageHeight: 3 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 685 ImageHeight: 535 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 1064 ImageHeight: 493 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 679 ImageHeight: 532 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 763 ImageHeight: 417 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 1045 ImageHeight: 472 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 1047 ImageHeight: 435 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 698 ImageHeight: 543 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 695 ImageHeight: 543 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 394 ImageHeight: 451 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 1658 ImageHeight: 259 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 673 ImageHeight: 406 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 771 ImageHeight: 299 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 771 ImageHeight: 302 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 331 ImageHeight: 525 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 611 ImageHeight: 441 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 465 ImageHeight: 380 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 623 ImageHeight: 429 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 648 ImageHeight: 371 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 391 ImageHeight: 307 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 385 ImageHeight: 313 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 470 ImageHeight: 358 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 391 ImageHeight: 303 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 471 ImageHeight: 360 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 470 ImageHeight: 357 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1207 ImageHeight: 686 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 1805 ImageHeight: 543 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 421 ImageHeight: 321 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: ImageWidth: 638 ImageHeight: 161 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: CompressionScheme: JPEG ImageWidth: 736 ImageHeight: 323 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: VLPYBM+VlpycnWarnockPro-It FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VLPYBM+VlpycnWarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BSFCRH+CsfdstMTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: BSFCRH+CsfdstMTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VrgyslMyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VrgyslMyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: YlsrkbMyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: YlsrkbMyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GyyfplWarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GyyfplWarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PydfjdMyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: PydfjdMyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VkhgtpArial-BoldMT FirstChar: 32 LastChar: 120 FontDescriptor: FontName: VkhgtpArial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KjnbhqMyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: KjnbhqMyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JEEYVQ+KgyqdjCalibri FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: JEEYVQ+KgyqdjCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: SprmtvCalibri-Bold FirstChar: 32 LastChar: 121 FontDescriptor: FontName: SprmtvCalibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JEEYVQ+NmrsgvArialMT FontSubset: true FirstChar: 32 LastChar: 56 FontDescriptor: FontName: JEEYVQ+NmrsgvArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: RhbhtrArial-BoldMT FirstChar: 32 LastChar: 116 FontDescriptor: FontName: RhbhtrArial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOOWZI+GddwfhCalibri-Bold FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: AOOWZI+GddwfhCalibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOOWZI+XmlcylCalibri-Bold FontSubset: true FirstChar: 32 LastChar: 84 FontDescriptor: FontName: AOOWZI+XmlcylCalibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: YwgnpmCalibri FirstChar: 32 LastChar: 119 FontDescriptor: FontName: YwgnpmCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOOWZI+YmbngpCalibri-Bold FontSubset: true FirstChar: 31 LastChar: 123 FontDescriptor: FontName: AOOWZI+YmbngpCalibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JjrhvqCalibri FirstChar: 32 LastChar: 119 FontDescriptor: FontName: JjrhvqCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WwmtvyCalibri-BoldItalic FirstChar: 32 LastChar: 114 FontDescriptor: FontName: WwmtvyCalibri-BoldItalic Flags: Nonsymbolic FontBBox: -691, -306, 1265, 967 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BydtrkCalibri-Italic FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BydtrkCalibri-Italic Flags: Nonsymbolic FontBBox: -725, -276, 1260, 1014 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JxdymtMyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: JxdymtMyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NnlwkxCalibri FirstChar: 32 LastChar: 119 FontDescriptor: FontName: NnlwkxCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WdrqdcArial-BoldMT FirstChar: 14 LastChar: 31 FontDescriptor: FontName: WdrqdcArial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: XOLODL+XlmmnbSPSMTSYBBold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XOLODL+XlmmnbSPSMTSYBBold Flags: Symbolic FontBBox: -16, -935, 987, 896 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ThdxkgArialMT FirstChar: 1 LastChar: 129 FontDescriptor: FontName: ThdxkgArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KstbylMyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: KstbylMyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JEEYVQ+VxbhlhHelvetica-Bold FontSubset: true FirstChar: 32 LastChar: 100 FontDescriptor: FontName: JEEYVQ+VxbhlhHelvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DjvtlvArial-BoldMT FirstChar: 32 LastChar: 120 FontDescriptor: FontName: DjvtlvArial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: TxrxxdCalibri FirstChar: 32 LastChar: 121 FontDescriptor: FontName: TxrxxdCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JEEYVQ+VvgmnnHelvetica-Bold FontSubset: true FirstChar: 32 LastChar: 98 FontDescriptor: FontName: JEEYVQ+VvgmnnHelvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DQCOPC+YsxrntSymbolMT FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: DQCOPC+YsxrntSymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SjwmffArialMT FirstChar: 32 LastChar: 134 FontDescriptor: FontName: SjwmffArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JEEYVQ+YdfgsjCalibri FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: JEEYVQ+YdfgsjCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAPSHS+JlxqphSymbolMT FontSubset: true FirstChar: 32 LastChar: 181 FontDescriptor: FontName: IAPSHS+JlxqphSymbolMT Flags: Nonsymbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: YxysvlCalibri-Bold FirstChar: 32 LastChar: 119 FontDescriptor: FontName: YxysvlCalibri-Bold Flags: Nonsymbolic FontBBox: -519, -306, 1240, 971 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ThqgpvOpenSans FirstChar: 32 LastChar: 121 FontDescriptor: FontName: ThqgpvOpenSans Flags: Nonsymbolic FontBBox: -550, -271, 1204, 1048 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DQCOPC+MtvbmySymbolMT FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: DQCOPC+MtvbmySymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: QfnvxlArial-BoldMT FirstChar: 32 LastChar: 114 FontDescriptor: FontName: QfnvxlArial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BnpswsCalibri FirstChar: 32 LastChar: 119 FontDescriptor: FontName: BnpswsCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: YyftdvArial-BoldMT FirstChar: 2 LastChar: 31 FontDescriptor: FontName: YyftdvArial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KyhvqsCalibri FirstChar: 32 LastChar: 116 FontDescriptor: FontName: KyhvqsCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: UCSWTU+RhgtswSTIXMath-Regular FontSubset: true FirstChar: 32 LastChar: 174 FontDescriptor: FontName: UCSWTU+RhgtswSTIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: KtqqhsArialMT FirstChar: 1 LastChar: 173 FontDescriptor: FontName: KtqqhsArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PkhnflCalibri FirstChar: 32 LastChar: 120 FontDescriptor: FontName: PkhnflCalibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true Encoding: WinAnsiEncoding XMP: 2016-11-29T19:28:40+05:30 Springer 2016-12-01T14:22:38+01:00 2016-12-01T14:22:38+01:00 Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) Atherosclerosis,Insulin receptor,Migration,Vascular smooth muscle cells application/pdf doi:10.1186/s12933-016-0477-3 BioMed Central Cardiovascular Diabetology, doi:10.1186/s12933-016-0477-3 Atherosclerosis Insulin receptor Migration Vascular smooth muscle cells Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis N. Beneit C. E. Fernández-García J. L. Martín-Ventura L. Perdomo Ó. Escribano J. B. Michel G. García-Gómez S. Fernández S. Díaz-Castroverde J. Egido A. Gómez-Hernández M. Benito 10.1186/s12933-016-0477-3 2010-04-23 true springer.com springerlink.com "http://dx.doi.org/10.1186/s12933-016-0477-3 10.1186/s12933-016-0477-3 1475-2840 journal Cardiovascular Diabetology The Author(s) 2010-04-23 true 10.1186/s12933-016-0477-3 noindex springer.com springerlink.com VoR uuid:b7955835-52d1-463d-9882-a1920878de91 uuid:cc387ca2-9aaa-416e-9ef1-54a6d85d3062 default 1 converted uuid:b60b792c-a8dc-42cd-9f7f-7336513c6d36 converted to PDF/A-2b pdfToolbox 2016-11-29T19:21:33+05:30 converted uuid:027cea2e-eebd-4d3c-af81-dbd9f38bb402 converted to PDF/A-2b pdfToolbox 2016-11-29T19:22:14+05:30 2 B http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 182, 80, 307, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 443, 64, 525, 56 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 56, 247, 48 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 307, 198, 312, 186 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 367, 150, 372, 138 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 492, 114, 497, 102 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 484, 683, 541, 658 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 283, 692, 288, 680 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 56, 680, 61, 668 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 115, 620, 120, 608 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 126, 620, 130, 608 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 121, 560, 126, 548 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 253, 524, 258, 512 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 264, 524, 274, 512 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 147, 500, 157, 488 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 275, 428, 285, 416 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 100, 404, 110, 392 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 232, 344, 242, 332 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 122, 308, 132, 296 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 174, 284, 184, 272 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 146, 236, 156, 224 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 108, 200, 117, 188 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 81, 164, 90, 152 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 95, 164, 105, 152 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 109, 164, 119, 152 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 336, 692, 346, 680 Flags: Print AppearanceDictionary: true Destination: 426 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 242, 620, 252, 608 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 256, 320, 266, 308 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 348, 536, 357, 524 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 385, 164, 394, 152 Flags: Print AppearanceDictionary: true Destination: 426 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 229, 200, 234, 188 Flags: Print AppearanceDictionary: true Destination: 394 Annotation: Subtype: Link Rect: 283, 152, 288, 140 Flags: Print AppearanceDictionary: true Destination: 394 Annotation: Subtype: Link Rect: 372, 656, 377, 644 Flags: Print AppearanceDictionary: true Destination: 394 Annotation: Subtype: Link Rect: 531, 620, 536, 608 Flags: Print AppearanceDictionary: true Destination: 394 Annotation: Subtype: Link Rect: 418, 524, 428, 512 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 523, 440, 528, 428 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 459, 368, 464, 352 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 346, 332, 351, 320 Flags: Print AppearanceDictionary: true Destination: 134 Annotation: Subtype: Link Rect: 409, 272, 414, 260 Flags: Print AppearanceDictionary: true Destination: 134 Annotation: Subtype: Link Rect: 351, 140, 360, 128 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 366, 140, 376, 128 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 319, 92, 324, 80 Flags: Print AppearanceDictionary: true Destination: 394 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 77, 197, 82, 185 Flags: Print AppearanceDictionary: true Destination: 177 Annotation: Subtype: Link Rect: 248, 149, 253, 137 Flags: Print AppearanceDictionary: true Destination: 177 Annotation: Subtype: Link Rect: 369, 293, 374, 281 Flags: Print AppearanceDictionary: true Destination: 223 Annotation: Subtype: Link Rect: 359, 221, 363, 209 Flags: Print AppearanceDictionary: true Destination: 223 Annotation: Subtype: Link Rect: 503, 197, 508, 181 Flags: Print AppearanceDictionary: true Destination: 223 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 224, 310, 229, 298 Flags: Print AppearanceDictionary: true Destination: 223 Annotation: Subtype: Link Rect: 160, 262, 165, 250 Flags: Print AppearanceDictionary: true Destination: 394 Annotation: Subtype: Link Rect: 80, 226, 85, 214 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 95, 226, 100, 214 Flags: Print AppearanceDictionary: true Destination: 134 Annotation: Subtype: Link Rect: 155, 118, 160, 106 Flags: Print AppearanceDictionary: true Destination: 223 Annotation: Subtype: Link Rect: 498, 298, 503, 282 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 357, 202, 366, 190 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 351, 154, 356, 142 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 457, 130, 462, 114 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 325, 94, 329, 78 Flags: Print AppearanceDictionary: true Destination: 263 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 78, 279, 83, 267 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 237, 255, 242, 243 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 239, 219, 244, 203 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 162, 111, 167, 99 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 275, 87, 280, 71 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 406, 279, 411, 267 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 321, 243, 326, 231 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 450, 171, 460, 159 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 531, 111, 536, 99 Flags: Print AppearanceDictionary: true Destination: 394 Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 458, 217, 467, 205 Flags: Print AppearanceDictionary: true Destination: 426 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 169, 243, 179, 231 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 59, 207, 69, 195 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 169, 195, 179, 183 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 144, 87, 154, 75 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 369, 231, 379, 219 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 466, 195, 476, 183 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 481, 195, 491, 183 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 350, 147, 360, 135 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 395, 75, 405, 63 Flags: Print AppearanceDictionary: true Destination: 426 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 143, 668, 152, 656 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 238, 644, 248, 632 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 253, 644, 262, 632 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 101, 608, 106, 596 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 192, 488, 197, 476 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 201, 488, 211, 476 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 215, 488, 224, 476 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 223, 464, 228, 452 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 164, 332, 174, 320 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 179, 332, 189, 320 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 161, 236, 171, 224 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 229, 152, 239, 140 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 244, 152, 253, 140 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 82, 116, 92, 104 Flags: Print AppearanceDictionary: true Destination: 426 Annotation: Subtype: Link Rect: 183, 80, 193, 68 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 450, 632, 459, 620 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 375, 572, 385, 560 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 397, 524, 407, 512 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 455, 476, 465, 464 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 470, 476, 480, 464 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 329, 416, 339, 404 Flags: Print AppearanceDictionary: true Destination: 430 Annotation: Subtype: Link Rect: 307, 368, 317, 356 Flags: Print AppearanceDictionary: true Destination: 430 Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 126, 402, 131, 390 Flags: Print AppearanceDictionary: true Destination: 394 Annotation: Subtype: Link Rect: 62, 324, 117, 315 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 62, 248, 117, 239 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 62, 217, 117, 208 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 62, 186, 117, 177 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 13 Thumb: true Page: Sequence: 14 Thumb: true Checksum: 0d925e3e Type: CRC32 Checksum: 89c73ed56f3bf8fe09a615238c53f9d5 Type: MD5 Checksum: eaa96bc8c49f305c7d0ea309f41e35446e1dc032 Type: SHA-1