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Title:          The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
Subject:        Acta Neuropathologica Communications, 2016, doi:10.1186/s40478-016-0402-8
Keywords:       Alpha-synuclein,Parkinson’s disease,Oligomerization,Aggregation,Neurodegeneration
Author:         Diana F. Lázaro
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      Title: Abstract
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      Title: Introduction
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      Title: Materials and methods
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        Title: Protein expression and purification
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        Title: Aggregation assays
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       Item: 
        Title: Light scattering spectroscopy
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        Title: Thioflavin T binding assay
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       Item: 
        Title: Congo red binding assay
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       Item: 
        Title: Transmission electron microscopy (TEM) assays
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       Item: 
        Title: ATR-FTIR spectroscopy
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       Item: 
        Title: Aggregation kinetics
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       Item: 
        Title: Sedimentation assay
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       Item: 
        Title: Primer design
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       Item: 
        Title: Generation of A53E aSyn constructs for expression in mammalian cells
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       Item: 
        Title: Cell culture
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        Title: Cell transfection
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          Title: HEK cells
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          Title: H4 cells
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        Title: Immunocytochemistry
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       Item: 
        Title: Yeast transformation and plasmids
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        Title: Yeast growth
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        Title: Fluorescence microscopy
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        Title: Quantification of aSyn inclusions
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        Title: Thioflavin S staining
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       Item: 
        Title: Quantification of Golgi fragmentation
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       Item: 
        Title: Western blot analysis
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        Title: Native PAGE
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        Title: Proteinase K digestion
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        Title: Flow cytometry (FCM)
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        Title: Measurement of 26S Proteasome Catalytic Activity
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        Title: Statistical analyses
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      Title: Results
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        Title: A53E mutant forms protofibrils by reducing aSyn fibrilization
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        Title: The A53E mutation decreases aSyn oligomerization in cellular models
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       Item: 
        Title: The A53E mutation alters the biochemical properties of aSyn inclusions
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        Title: aSyn aggregation leads to Golgi fragmentation
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       Item: 
        Title: A53E aSyn behaves identically to WT aSyn in yeast cells
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      Title: Discussion
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      Title: Conclusions
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      Title: Additional file
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      Title: Abbreviations
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      Title: Acknowledgements
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      Title: Authors’ contributions
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      Title: References
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    Title: The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
    Author: Diana F. Lázaro
    Subject: Acta Neuropathologica Communications, 2016, doi:10.1186/s40478-016-0402-8
    Keywords: Alpha-synuclein,Parkinson’s disease,Oligomerization,Aggregation,Neurodegeneration
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                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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                           <pdfaProperty:description>Copyright </pdfaProperty:description>
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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