1254ca45760ab4954ad728f67ea78ffb Chehaibi_2017_compressed.pdf 2bd3de5e74b3e23d67b55ba161e00f458ed548e3 Chehaibi_2017_compressed.pdf 88f4bb55150864ac5826e9f20c9a227afd2ce01fbefb5ab66bced0b9f0f723dd Chehaibi_2017_compressed.pdf Title: Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury Subject: Translational Research, 182 (2017) 27-48. doi:10.1016/j.trsl.2016.10.004 Author: Khouloud Chehaibi Creator: Elsevier Producer: www.ilovepdf.com CreationDate: 16th March 2017 ModDate: Thu Sep 19 11:33:14 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 593.972 x 792 pts Page rot: 0 File size: 585119 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HIIJGN+AdvPSAG-B Type 1C Custom yes yes no 28 0 HIIJGO+AdvPS3D56D5 Type 1C WinAnsi yes yes no 32 0 HIIJGP+AdvPS4721B4 Type 1C WinAnsi yes yes no 35 0 HIIJIA+AdvPSAG-D Type 1C Custom yes yes no 38 0 HIIJIB+AdvPS3D85E2 Type 1C WinAnsi yes yes no 41 0 HIIJIC+AdvPS3ECA66 Type 1C WinAnsi yes yes no 44 0 HIIJID+AdvP4C4E74 Type 1C Custom yes yes yes 47 0 HIIJIE+AdvPSA88A Type 1C Custom yes yes no 52 0 HIIJIF+AdvP4C4E59 Type 1C Custom yes yes no 55 0 HIIJIG+AdvPSSym Type 1C Custom yes yes no 59 0 HIIJKG+AdvPS0521 Type 1C MacRoman yes yes no 83 0 HIIJKH+AdvPS40668 Type 1C MacRoman yes yes no 86 0 HIIJKI+AdvPS3F4C13 Type 1C WinAnsi yes yes no 89 0 HIIJMI+AdvPS586B Type 1C WinAnsi yes yes no 125 0 HIIJNJ+AdvPSA88C Type 1C WinAnsi yes yes no 134 0 HIIJOJ+AdvHelN-L Type 1C MacRoman yes yes no 142 0 HIIJOK+AdvPSAG-BO Type 1C WinAnsi yes yes no 145 0 HIIJPL+AdvPSAG-DO Type 1C WinAnsi yes yes no 154 0 HIINAI+AdvPSA88B Type 1C WinAnsi yes yes no 168 0 HIJGKK+AdvHelN-LI Type 1C WinAnsi yes yes no 244 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-08 03:11:55 CET RepresentationInformation: Chehaibi_2017_compressed.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-01-13 01:36:33 CET Size: 585119 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 10 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability fol ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Materials and Methods Destination: flink2 Children: Item: Title: Animals and PPAR-β/δ agonist GW0742 administration Destination: slink1 Item: Title: Focal cerebral ischemia Destination: slink2 Item: Title: Pharmacokinetic study in mice Destination: slink3 Item: Title: Neurological deficit evaluation Destination: slink4 Item: Title: Measurement of infarct volume, and brain edema Destination: slink5 Item: Title: Blood-brain barrier permeability measurement Destination: slink6 Item: Title: Western blotting of zonula occludens-1 (ZO-1), Claudin-5, and occludin protein expression Destination: slink7 Item: Title: Western blotting of MMP-9 protein expression Destination: slink8 Item: Title: Western blot analysis of PPAR-β/δ protein expression Destination: slink9 Item: Title: Enzyme-linked immunosorbent assay Destination: slink10 Item: Title: Tissue processing Destination: slink11 Item: Title: Immunohistochemistry staining Destination: slink12 Item: Title: RNA extraction and reverse transcription Destination: slink13 Item: Title: Reverse transcriptase-polymerase chain (RT-PCR) analysis of PPAR-β/δ mRNA Destination: slink14 Item: Title: RT-PCR detection of MMP-9 mRNA expression Destination: slink15 Item: Title: Gelatin zymography assay for MMP-9 activity Destination: slink16 Item: Title: Statistical analysis Destination: slink17 Item: Title: Results Destination: flink3 Children: Item: Title: Physiological parameters Destination: slink18 Item: Title: Quantification of GW0742 levels Destination: slink19 Item: Title: Determination of GW0742 fractional occupancy Destination: slink20 Item: Title: PPAR-β/δ agonist GW0742 treatment improved the neurological deficits and decreased ischemic infarcted area and b ... Destination: slink21 Item: Title: Effect of MCAO and GW0742 on reperfusion CBF Destination: slink22 Item: Title: Effect of PPAR-β/δ agonist GW0742 on the hepatic protein level of inflammatory factors Destination: slink23 Item: Title: Effect of PPAR-β/δ agonist GW0742 on the hepatic mRNA expression levels of inflammatory factors following focal ... Destination: slink24 Item: Title: PPAR-β/δ agonist GW0742 treatment reduced hepatic and brain neutrophil infiltration Destination: slink25 Item: Title: Effect of GW0742 on PPAR-β/δ mRNA and protein expression Destination: slink26 Item: Title: PPAR-β/δ agonist GW0742 decreased BBB permeability Destination: slink27 Item: Title: PPAR-β/δ agonist GW0742 increased expression of zonula occludens-1 (ZO-1), Claudin-5, and occludin Destination: slink28 Item: Title: Effect of GW0742 on MMP-9 mRNA and protein expression Destination: slink29 Item: Title: Effect of GW0742 on MMP-9 activity Destination: slink30 Item: Title: Correlation Destination: slink31 Item: Title: Discussion Destination: flink4 Item: Title: Conclusions Destination: flink5 Item: Title: Acknowledgments Destination: blink1 Item: Title: References Destination: blink2 Filters: FilterPipeline: FlateDecode FilterPipeline: FlateDecode DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 925 ImageHeight: 889 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Subtype: Link Rect: 75, 661, 283, 669 Annotation: Subtype: Link Rect: 75, 651, 283, 659 Annotation: Subtype: Link Rect: 326, 721, 534, 728 Annotation: Subtype: Link Rect: 326, 711, 407, 718 Annotation: Subtype: Link Rect: 407, 711, 419, 718 Annotation: Subtype: Link Rect: 326, 701, 534, 709 Annotation: Subtype: Link Rect: 326, 691, 520, 699 Annotation: Subtype: Link Rect: 520, 691, 532, 699 Annotation: Subtype: Link Rect: 326, 681, 534, 689 Annotation: Subtype: Link Rect: 326, 671, 534, 679 Annotation: Subtype: Link Rect: 326, 661, 534, 669 Annotation: Subtype: Link Rect: 326, 651, 425, 659 Annotation: Subtype: Link Rect: 425, 651, 441, 659 Annotation: Subtype: Link Rect: 448, 760, 534, 768 Checksum: b5c2d362 Type: CRC32 Checksum: 1254ca45760ab4954ad728f67ea78ffb Type: MD5 Checksum: 2bd3de5e74b3e23d67b55ba161e00f458ed548e3 Type: SHA-1 Checksum: 88f4bb55150864ac5826e9f20c9a227afd2ce01fbefb5ab66bced0b9f0f723dd Type: SHA-256