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Offset: 5094918 ErrorMessage: Invalid destination object Offset: 5094918 ErrorMessage: Invalid destination object Offset: 5094918 ErrorMessage: Invalid destination object Offset: 5094918 ErrorMessage: Invalid destination object Offset: 5092513 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 870 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Children: Item: Title: LXR Activity Limits Macrophage Infection by S. Typhimurium Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Item: Title: LXR Agonists Induce the Expression of the NAD Glycohydrolase CD38 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: Cooperative Effects of LXRs and Inflammatory Signals on CD38 Expression and NADase Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: CD38 Mediates the Protective Effects of LXR Agonists on Macrophage Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: An Endogenous Pathway Can Activate the LXR-CD38 Axis during Salmonella Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: An Endogenous Pathway Can Activate the LXR-CD38 Axis during Salmonella Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Experimental Procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Children: Item: Title: Animal Strains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: Cell Cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Item: Title: In Vitro Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5 Item: Title: Determination of Macrophage Infection by Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4 Item: Title: Confocal Fluorescence Microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1 Item: Title: In Vivo Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc Item: Title: Irradiation and Bone Marrow Transfer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83 Item: Title: RNA Extraction and Quantitative Real-Time PCR Determination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac Item: Title: Protein Extraction and Western Blot Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425 Item: Title: NAD Cycling Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff Item: Title: NADase Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa Item: Title: Supplemental Information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649 Item: Title: References Destination: 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-166, -229, 1093, 812 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EBMDFA+Advhelvneue-bi FontSubset: true FirstChar: 46 LastChar: 111 FontDescriptor: FontName: EBMDFA+Advhelvneue-bi Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EBNLJE+AdvP4C4E59 FontSubset: true FirstChar: 128 LastChar: 128 FontDescriptor: FontName: EBNLJE+AdvP4C4E59 Flags: Nonsymbolic FontBBox: -31, -250, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EBMDFB+AdvHelN-L FontSubset: true FirstChar: 177 LastChar: 177 FontDescriptor: FontName: EBMDFB+AdvHelN-L Flags: Nonsymbolic FontBBox: -156, -208, 1041, 802 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.celrep.2017.01.007 The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism Jonathan Matalonga Estibaliz Glaria Mariana Bresque Carlos Escande José María Carbó Kerstin Kiefer Ruben Vicente Theresa E. León Susana Beceiro Mónica Pascual-García Joan Serret Lucía Sanjurjo Samantha Morón-Ros Antoni Riera Sonia Paytubi Antonio Juarez Fernando Sotillo Lennart Lindbom Carme Caelles Maria-Rosa Sarrias Jaime Sancho Antonio Castrillo Eduardo N. Chini Annabel F. Valledor macrophage nuclear receptor LXR bacterial infection NAD cytoskeleton CD38 CellReports, 18 (2017) 1241-1255. doi:10.1016/j.celrep.2017.01.007 ElsevierCompany. journal CellReports © 2017 The Author(s). 2211-1247 18 5 31 January 2017 2017-01-31 1241-1255 1241 1255 10.1016/j.celrep.2017.01.007 http://dx.doi.org/10.1016/j.celrep.2017.01.007 2010-04-23 true 10.1016/j.celrep.2017.01.007 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.celrep.2017.01.007 noindex true 2010-04-23 true 28th January 2017 sciencedirect.com elsevier.com Elsevier 2017-01-28T09:51:52+05:30 2017-01-28T09:51:52+05:30 True 28th January 2017 Acrobat Distiller 8.1.0 (Windows) uuid:ae8c1d31-8800-4163-b881-be4f2d450bed uuid:598e0c29-b5d0-40f8-a469-76217d29a572 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1241 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 354, 510, 482, 520 Annotation: Subtype: Link Rect: 104, 48, 282, 57 Annotation: Subtype: Link Rect: 52, 53, 97, 72 Page: Label: 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