98c394aa66f4e404df287db7b397205f Chest_a2017v151n1p47iENG.pdf dd6a1285c7820aa55bc8bb0959d41c4783b77c33 Chest_a2017v151n1p47iENG.pdf Title: Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD Subject: CHEST, 151 (2017) 47-59. doi:10.1016/j.chest.2016.08.1440 Author: Daiana Stolz MD MPH FCCP Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Dec 15 03:19:34 2016 CET ModDate: Thu Dec 15 03:20:06 2016 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 576 x 773.972 pts Page rot: 0 File size: 541237 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BNBNNN+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 682 0 BNBNNO+AdvOT95952aae.I Type 1C WinAnsi yes yes no 684 0 BNBNNP+AdvOT039b385c Type 1C WinAnsi yes yes no 686 0 BNBNPA+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 691 0 BNBNPB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 695 0 BNBNPC+AdvP4C4E74 Type 1C Custom yes yes yes 700 0 BNBNPD+AdvTTa9027ee7 Type 1C WinAnsi yes yes no 705 0 BNBNPE+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 703 0 BNBOBE+AdvOTaa388e57 Type 1C WinAnsi yes yes no 709 0 BNBOCF+AdvOT7f46bcb6 Type 1C WinAnsi yes yes no 713 0 BNBODG+AdvPSSym Type 1C Custom yes yes no 467 0 BNBODF+AdvOTc3d3597e.I Type 1C WinAnsi yes yes no 468 0 BNBOEH+AdvOT8817665d Type 1C WinAnsi yes yes no 471 0 BNBOFH+AdvP4C4E51 Type 1C WinAnsi yes yes no 483 0 BNBOFI+AdvOT69acd3d4 Type 1C WinAnsi yes yes no 481 0 BNBOFJ+AdvTT3a242573.I Type 1C WinAnsi yes yes no 488 0 BNBOGK+AdvOT69acd3d4+fb Type 1C Custom yes yes yes 484 0 BNBOGL+AdvOT69acd3d4+20 Type 1C WinAnsi yes yes no 485 0 BNBOJL+HelveticaNeueLTStd-Roman Type 1C Custom yes yes yes 495 0 BNBOKL+AdvOT7f46bcb6+fb Type 1C Custom yes yes yes 507 0 BNBOPK+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 514 0 BNBPCK+AdvOT7d6df7ab.I+20 Type 1C WinAnsi yes yes no 520 0 BNBPJI+HelveticaNeueLTStd-It Type 1C WinAnsi yes yes no 527 0 BNBPLJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 533 0 BNBPLK+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 534 0 Jhove (Rel. 1.6, 2011-01-04) Date: 2019-02-14 18:18:46 CET RepresentationInformation: Chest_a2017v151n1p47iENG.pdf ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22) LastModified: 2018-10-05 17:45:37 CEST Size: 541237 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 ErrorMessage: Invalid destination object Offset: 515586 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 753 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@16f65612 Children: Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@311d617d Children: Item: Title: Study Design and Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb Item: Title: Determination of Biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052 Children: Item: Title: ECM Biomarkers in Patients With COPD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347 Item: Title: ECM Biomarkers and Disease Impact Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482 Item: Title: ECM Biomarkers and Bacterial Colonization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809 Item: Title: ECM Biomarkers at Exacerbation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190 Item: Title: ECM Biomarkers and Disease Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070 Info: Title: Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD Author: Daiana Stolz MD MPH FCCP Subject: CHEST, 151 (2017) 47-59. doi:10.1016/j.chest.2016.08.1440 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Dec 15 03:49:34 CET 2016 ModDate: Thu Dec 15 03:50:06 CET 2016 ID: 0xb2e6651382f2455e3f9a59dacd3d2f16, 0x7ed5e4f4741e6e478725e49e839f2aa0 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: BNBNPD+AdvTTa9027ee7 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: BNBNPD+AdvTTa9027ee7 Flags: Nonsymbolic FontBBox: -20, -197, 1000, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOPK+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: BNBOPK+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOBE+AdvOTaa388e57 FontSubset: true FirstChar: 35 LastChar: 115 FontDescriptor: FontName: BNBOBE+AdvOTaa388e57 Flags: Nonsymbolic FontBBox: -31, -197, 937, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBPCK+AdvOT7d6df7ab.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: BNBPCK+AdvOT7d6df7ab.I+20 Flags: Nonsymbolic FontBBox: -156, -187, 1000, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOCF+AdvOT7f46bcb6 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: BNBOCF+AdvOT7f46bcb6 Flags: Nonsymbolic FontBBox: -20, -197, 1000, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBPJI+HelveticaNeueLTStd-It FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: BNBPJI+HelveticaNeueLTStd-It Flags: Nonsymbolic, Italic FontBBox: -166, -214, 1106, 957 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBODG+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BNBODG+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: BNBODF+AdvOTc3d3597e.I FontSubset: true FirstChar: 66 LastChar: 122 FontDescriptor: FontName: BNBODF+AdvOTc3d3597e.I Flags: Nonsymbolic FontBBox: -125, -197, 1041, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBPLJ+AdvOTb65e897d.B FontSubset: true FirstChar: 47 LastChar: 117 FontDescriptor: FontName: BNBPLJ+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBPLK+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BNBPLK+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNBOEH+AdvOT8817665d FontSubset: true FirstChar: 35 LastChar: 36 FontDescriptor: FontName: BNBOEH+AdvOT8817665d Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOFI+AdvOT69acd3d4 FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: BNBOFI+AdvOT69acd3d4 Flags: Nonsymbolic FontBBox: -41, -197, 927, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOFH+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: BNBOFH+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOGK+AdvOT69acd3d4+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BNBOGK+AdvOT69acd3d4+fb Flags: Symbolic FontBBox: 19, 0, 875, 760 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNBOGL+AdvOT69acd3d4+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: BNBOGL+AdvOT69acd3d4+20 Flags: Nonsymbolic FontBBox: -41, -197, 1145, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOFJ+AdvTT3a242573.I FontSubset: true FirstChar: 40 LastChar: 117 FontDescriptor: FontName: BNBOFJ+AdvTT3a242573.I Flags: Nonsymbolic FontBBox: -125, -197, 1041, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBNNN+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: BNBNNN+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBNNO+AdvOT95952aae.I FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: BNBNNO+AdvOT95952aae.I Flags: Nonsymbolic FontBBox: -135, -197, 979, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBNNP+AdvOT039b385c FontSubset: true FirstChar: 47 LastChar: 89 FontDescriptor: FontName: BNBNNP+AdvOT039b385c Flags: Nonsymbolic FontBBox: -20, -197, 1093, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOJL+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: BNBOJL+HelveticaNeueLTStd-Roman Flags: Symbolic FontBBox: -166, -214, 1076, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNBNPA+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BNBNPA+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNBNPB+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: BNBNPB+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BNBOKL+AdvOT7f46bcb6+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BNBOKL+AdvOT7f46bcb6+fb Flags: Symbolic FontBBox: 30, 0, 885, 760 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNBNPC+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 188 FontDescriptor: FontName: BNBNPC+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BNBNPE+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: BNBNPE+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.chest.2016.08.1440 Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD Daiana Stolz MD MPH FCCP Diana Julie Leeming PhD Jacob Hull Edfort Kristensen PhD Morten A. Karsdal PhD Wim Boersma MD Renaud Louis MD Branislava Milenkovic MD Konstantinos Kostikas MD Francesco Blasi MD Joachim Aerts MD Jannie M.B. Sand PhD Emiel F.M. Wouters MD Gernot Rohde MD Cristina Prat MD Antoni Torres MD Tobias Welte MD Michael Roth PhD Eleni Papakonstantinou MD PhD Michael Tamm MD acute exacerbations of COPD collagen COPD elastin extracellular matrix molecules CHEST, 151 (2017) 47-59. doi:10.1016/j.chest.2016.08.1440 Elsevier Inc journal CHEST © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. 0012-3692 151 1 January 2017 201701 47-59 47 59 10.1016/j.chest.2016.08.1440 http://dx.doi.org/10.1016/j.chest.2016.08.1440 2010-04-23 true 10.1016/j.chest.2016.08.1440 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.chest.2016.08.1440 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2016-12-15T07:49:34+05:30 2016-12-15T07:50:06+05:30 2016-12-15T07:50:06+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:9410e94b-cd49-41d7-8e07-f94aa2b7c15c uuid:2df9d28a-7806-42cc-abac-cb34e93cb457 Pages: Page: Label: 47 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 349, 222, 455, 232 Annotation: Subtype: Link Rect: 469, 642, 529, 664 Annotation: Subtype: Link Rect: 59, 25, 173, 32 Page: Label: 48 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 96, 611, 100, 621 Destination: 155 Annotation: Subtype: Link Rect: 263, 495, 272, 505 Destination: 155 Annotation: Subtype: Link Rect: 171, 392, 181, 402 Destination: 155 Annotation: Subtype: Link Rect: 247, 327, 260, 337 Destination: 155 Annotation: Subtype: Link Rect: 396, 663, 409, 673 Destination: 155 Annotation: Subtype: Link Rect: 496, 488, 511, 498 Destination: null Annotation: Subtype: Link Rect: 418, 398, 425, 408 Destination: null Annotation: Subtype: Link Rect: 249, 103, 272, 111 Annotation: Subtype: Link Rect: 46, 94, 87, 102 Annotation: Subtype: Link Rect: 64, 63, 209, 71 Page: Label: 49 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 180, 646, 185, 654 Destination: null Annotation: Subtype: Link Rect: 200, 359, 284, 367 Annotation: Subtype: Link Rect: 404, 702, 448, 710 Destination: null Annotation: Subtype: Link Rect: 411, 634, 417, 642 Destination: null Annotation: Subtype: Link Rect: 441, 604, 446, 612 Destination: null Annotation: Subtype: Link Rect: 190, 241, 220, 251 Destination: 39 Annotation: Subtype: Link Rect: 120, 228, 158, 238 Destination: null Annotation: Subtype: Link Rect: 145, 177, 165, 187 Destination: 52 Annotation: Subtype: Link Rect: 181, 164, 210, 174 Destination: 67 Annotation: Subtype: Link Rect: 246, 138, 282, 148 Destination: null Annotation: Subtype: Link Rect: 493, 315, 523, 325 Destination: 76 Annotation: Subtype: Link Rect: 401, 289, 439, 299 Destination: null Annotation: Subtype: Link Rect: 307, 204, 337, 214 Destination: 76 Annotation: Subtype: Link Rect: 307, 152, 347, 162 Destination: null Annotation: Subtype: Link Rect: 59, 25, 173, 32 Page: Label: 50 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 337, 387, 356, 397 Destination: 86 Annotation: Subtype: Link Rect: 345, 361, 365, 371 Destination: 86 Annotation: Subtype: Link Rect: 100, 167, 103, 175 Destination: 39 Annotation: Subtype: Link Rect: 380, 671, 384, 679 Destination: 39 Annotation: Subtype: Link Rect: 389, 658, 392, 665 Destination: 39 Annotation: Subtype: Link Rect: 357, 634, 361, 641 Destination: 39 Annotation: Subtype: Link Rect: 385, 620, 388, 628 Destination: 39 Annotation: Subtype: Link Rect: 387, 593, 391, 601 Destination: 39 Annotation: Subtype: Link Rect: 374, 580, 377, 587 Destination: 39 Page: Label: 51 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 110, 321, 131, 331 Destination: 98 Annotation: Subtype: Link Rect: 136, 321, 166, 331 Destination: 98 Annotation: Subtype: Link Rect: 314, 431, 343, 441 Destination: 113 Annotation: Subtype: Link Rect: 440, 334, 460, 344 Destination: 113 Annotation: Subtype: Link Rect: 59, 25, 173, 32 Page: Label: 52 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 477, 218, 497, 228 Destination: 125 Annotation: Subtype: Link Rect: 408, 192, 428, 202 Destination: 125 Annotation: Subtype: Link Rect: 390, 70, 422, 79 Destination: 125 Annotation: Subtype: Link Rect: 153, 387, 156, 394 Destination: null Annotation: Subtype: Link Rect: 456, 407, 479, 414 Destination: 39 Page: Label: 53 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 156, 400, 173, 410 Destination: null Annotation: Subtype: Link Rect: 218, 63, 241, 71 Destination: 39 Annotation: Subtype: Link Rect: 257, 63, 261, 71 Destination: 76 Annotation: Subtype: Link Rect: 199, 528, 221, 535 Destination: 39 Annotation: Subtype: Link Rect: 59, 25, 173, 32 Page: Label: 54 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 135, 93, 142, 103 Destination: null Annotation: Subtype: Link Rect: 362, 106, 369, 116 Destination: null Annotation: Subtype: Link Rect: 46, 650, 72, 658 Destination: 52 Page: Label: 55 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 439, 170, 446, 180 Destination: null Annotation: Subtype: Link Rect: 73, 63, 95, 71 Destination: 39 Annotation: Subtype: Link Rect: 111, 63, 115, 71 Destination: 76 Annotation: Subtype: Link Rect: 367, 391, 392, 399 Destination: 52 Annotation: Subtype: Link Rect: 59, 25, 173, 32 Page: Label: 56 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 465, 528, 481, 538 Destination: null Annotation: Subtype: Link Rect: 311, 561, 333, 569 Destination: 39 Annotation: Subtype: Link Rect: 349, 561, 353, 569 Destination: 76 Page: Label: 57 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 162, 314, 170, 324 Destination: null Annotation: Subtype: Link Rect: 439, 392, 446, 402 Destination: null Annotation: Subtype: Link Rect: 466, 340, 473, 350 Destination: null Annotation: Subtype: Link Rect: 382, 288, 389, 298 Destination: null Annotation: Subtype: Link Rect: 496, 190, 513, 200 Destination: null Annotation: Subtype: Link Rect: 375, 457, 401, 465 Destination: 52 Annotation: Subtype: Link Rect: 418, 457, 422, 465 Destination: 113 Annotation: Subtype: Link Rect: 59, 25, 173, 32 Page: Label: 58 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 100, 281, 107, 291 Destination: null Annotation: Subtype: Link Rect: 369, 650, 376, 660 Destination: null Annotation: Subtype: Link Rect: 463, 637, 478, 647 Destination: null Annotation: Subtype: Link Rect: 447, 559, 454, 569 Destination: null Page: Label: 59 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 151, 252, 198, 260 Annotation: Subtype: Link Rect: 73, 150, 202, 158 Annotation: Subtype: Link Rect: 73, 142, 204, 150 Annotation: Subtype: Link Rect: 73, 133, 185, 141 Annotation: Subtype: Link Rect: 73, 125, 176, 133 Annotation: Subtype: Link Rect: 73, 116, 204, 124 Annotation: Subtype: Link Rect: 73, 108, 177, 116 Annotation: Subtype: Link Rect: 73, 96, 174, 104 Annotation: Subtype: Link Rect: 73, 87, 204, 95 Annotation: Subtype: Link Rect: 73, 79, 148, 87 Annotation: Subtype: Link Rect: 236, 712, 358, 720 Annotation: Subtype: Link Rect: 236, 704, 334, 711 Annotation: Subtype: Link Rect: 236, 695, 364, 703 Annotation: Subtype: Link Rect: 236, 687, 291, 694 Annotation: Subtype: Link Rect: 236, 674, 359, 682 Annotation: Subtype: Link Rect: 236, 665, 357, 673 Annotation: Subtype: Link Rect: 236, 657, 358, 665 Annotation: Subtype: Link Rect: 236, 648, 345, 656 Annotation: Subtype: Link Rect: 236, 640, 346, 648 Annotation: Subtype: Link Rect: 236, 632, 270, 639 Annotation: Subtype: Link Rect: 236, 619, 359, 626 Annotation: Subtype: Link Rect: 236, 610, 364, 618 Annotation: Subtype: Link Rect: 236, 602, 356, 609 Annotation: Subtype: Link Rect: 236, 593, 362, 601 Annotation: Subtype: Link Rect: 236, 585, 336, 592 Annotation: Subtype: Link Rect: 236, 576, 349, 584 Annotation: Subtype: Link Rect: 236, 563, 332, 571 Annotation: Subtype: Link Rect: 236, 555, 365, 563 Annotation: Subtype: Link Rect: 236, 546, 357, 554 Annotation: Subtype: Link Rect: 236, 538, 350, 546 Annotation: Subtype: Link Rect: 236, 529, 361, 537 Annotation: Subtype: Link Rect: 236, 521, 271, 529 Annotation: Subtype: Link Rect: 236, 508, 356, 516 Annotation: Subtype: Link Rect: 236, 500, 352, 507 Annotation: Subtype: Link Rect: 236, 491, 348, 499 Annotation: Subtype: Link Rect: 236, 483, 347, 490 Annotation: Subtype: Link Rect: 236, 470, 366, 478 Annotation: Subtype: Link Rect: 236, 461, 359, 469 Annotation: Subtype: Link Rect: 236, 453, 356, 461 Annotation: Subtype: Link Rect: 236, 444, 366, 452 Annotation: Subtype: Link Rect: 236, 436, 355, 444 Annotation: Subtype: Link Rect: 236, 427, 305, 435 Annotation: Subtype: Link Rect: 236, 415, 355, 422 Annotation: Subtype: Link Rect: 236, 406, 366, 414 Annotation: Subtype: Link Rect: 236, 398, 356, 405 Annotation: Subtype: Link Rect: 236, 389, 346, 397 Annotation: Subtype: Link Rect: 236, 381, 269, 388 Annotation: Subtype: Link Rect: 235, 368, 366, 375 Annotation: Subtype: Link Rect: 235, 359, 356, 367 Annotation: Subtype: Link Rect: 235, 351, 340, 359 Annotation: Subtype: Link Rect: 235, 342, 362, 350 Annotation: Subtype: Link Rect: 235, 334, 268, 342 Annotation: Subtype: Link Rect: 235, 321, 366, 329 Annotation: Subtype: Link Rect: 235, 313, 353, 320 Annotation: Subtype: Link Rect: 235, 304, 330, 312 Annotation: Subtype: Link Rect: 235, 296, 366, 303 Annotation: Subtype: Link Rect: 235, 287, 351, 295 Annotation: Subtype: Link Rect: 235, 279, 359, 286 Annotation: Subtype: Link Rect: 235, 270, 260, 278 Annotation: Subtype: Link Rect: 235, 257, 356, 265 Annotation: Subtype: Link Rect: 235, 249, 353, 256 Annotation: Subtype: Link Rect: 235, 240, 363, 248 Annotation: Subtype: Link Rect: 235, 232, 362, 240 Annotation: Subtype: Link Rect: 235, 223, 351, 231 Annotation: Subtype: Link Rect: 235, 215, 364, 223 Annotation: Subtype: Link Rect: 235, 206, 354, 214 Annotation: Subtype: Link Rect: 235, 194, 364, 201 Annotation: Subtype: Link Rect: 235, 185, 365, 193 Annotation: Subtype: Link Rect: 235, 177, 345, 184 Annotation: Subtype: Link Rect: 235, 168, 355, 176 Annotation: Subtype: Link Rect: 235, 160, 346, 167 Annotation: Subtype: Link Rect: 235, 151, 347, 159 Annotation: Subtype: Link Rect: 235, 143, 301, 150 Annotation: Subtype: Link Rect: 235, 130, 351, 138 Annotation: Subtype: Link Rect: 235, 121, 357, 129 Annotation: Subtype: Link Rect: 235, 113, 352, 121 Annotation: Subtype: Link Rect: 235, 104, 361, 112 Annotation: Subtype: Link Rect: 235, 96, 347, 104 Annotation: Subtype: Link Rect: 235, 87, 354, 95 Annotation: Subtype: Link Rect: 235, 79, 277, 87 Annotation: Subtype: Link Rect: 398, 712, 521, 720 Annotation: Subtype: Link Rect: 398, 704, 529, 711 Annotation: Subtype: Link Rect: 398, 695, 517, 703 Annotation: Subtype: Link Rect: 398, 687, 523, 694 Annotation: Subtype: Link Rect: 398, 678, 506, 686 Annotation: Subtype: Link Rect: 398, 666, 512, 673 Annotation: Subtype: Link Rect: 398, 657, 501, 665 Annotation: Subtype: Link Rect: 398, 649, 524, 657 Annotation: Subtype: Link Rect: 398, 640, 518, 648 Annotation: Subtype: Link Rect: 398, 632, 529, 640 Annotation: Subtype: Link Rect: 398, 623, 479, 631 Annotation: Subtype: Link Rect: 398, 611, 521, 619 Annotation: Subtype: Link Rect: 398, 602, 498, 610 Annotation: Subtype: Link Rect: 398, 594, 514, 602 Annotation: Subtype: Link Rect: 398, 585, 525, 593 Annotation: Subtype: Link Rect: 398, 577, 526, 585 Annotation: Subtype: Link Rect: 398, 569, 516, 576 Annotation: Subtype: Link Rect: 398, 556, 505, 564 Annotation: Subtype: Link Rect: 398, 548, 526, 555 Annotation: Subtype: Link Rect: 398, 539, 529, 547 Annotation: Subtype: Link Rect: 398, 531, 431, 538 Annotation: Subtype: Link Rect: 398, 518, 525, 526 Annotation: Subtype: Link Rect: 398, 510, 522, 517 Annotation: Subtype: Link Rect: 398, 501, 509, 509 Annotation: Subtype: Link Rect: 398, 493, 528, 500 Annotation: Subtype: Link Rect: 398, 484, 521, 492 Annotation: Subtype: Link Rect: 398, 476, 472, 483 Annotation: Subtype: Link Rect: 398, 463, 518, 471 Annotation: Subtype: Link Rect: 398, 455, 528, 462 Annotation: Subtype: Link Rect: 398, 446, 527, 454 Annotation: Subtype: Link Rect: 398, 438, 523, 446 Annotation: Subtype: Link Rect: 398, 429, 521, 437 Annotation: Subtype: Link Rect: 398, 421, 502, 429 Annotation: Subtype: Link Rect: 398, 412, 519, 420 Annotation: Subtype: Link Rect: 398, 404, 470, 412 Annotation: Subtype: Link Rect: 398, 391, 522, 399 Annotation: Subtype: Link Rect: 398, 383, 522, 391 Annotation: Subtype: Link Rect: 398, 374, 519, 382 Annotation: Subtype: Link Rect: 398, 366, 527, 374 Annotation: Subtype: Link Rect: 398, 353, 525, 361 Annotation: Subtype: Link Rect: 398, 345, 521, 353 Annotation: Subtype: Link Rect: 398, 336, 525, 344 Annotation: Subtype: Link Rect: 398, 328, 511, 336 Annotation: Subtype: Link Rect: 398, 320, 456, 327 Annotation: Subtype: Link Rect: 398, 307, 511, 315 Annotation: Subtype: Link Rect: 398, 299, 529, 306 Annotation: Subtype: Link Rect: 398, 290, 512, 298 Annotation: Subtype: Link Rect: 398, 282, 529, 289 Annotation: Subtype: Link Rect: 398, 273, 512, 281 Annotation: Subtype: Link Rect: 398, 265, 516, 272 Annotation: Subtype: Link Rect: 398, 256, 457, 264 Annotation: Subtype: Link Rect: 398, 244, 526, 251 Annotation: Subtype: Link Rect: 398, 235, 514, 243 Annotation: Subtype: Link Rect: 398, 227, 529, 234 Annotation: Subtype: Link Rect: 398, 218, 457, 226 Annotation: Subtype: Link Rect: 398, 206, 521, 213 Annotation: Subtype: Link Rect: 398, 197, 515, 205 Annotation: Subtype: Link Rect: 398, 189, 529, 197 Annotation: Subtype: Link Rect: 398, 180, 524, 188 Annotation: Subtype: Link Rect: 398, 172, 415, 180 Annotation: Subtype: Link Rect: 398, 159, 527, 167 Annotation: Subtype: Link Rect: 398, 151, 529, 159 Annotation: Subtype: Link Rect: 398, 142, 518, 150 Annotation: Subtype: Link Rect: 398, 134, 529, 142 Annotation: Subtype: Link Rect: 398, 125, 461, 133 Annotation: Subtype: Link Rect: 398, 113, 510, 121 Annotation: Subtype: Link Rect: 398, 104, 512, 112 Annotation: Subtype: Link Rect: 398, 96, 527, 104 Annotation: Subtype: Link Rect: 398, 87, 520, 95 Annotation: Subtype: Link Rect: 398, 79, 472, 87 Annotation: Subtype: Link Rect: 59, 25, 173, 32 Checksum: 303fa2e4 Type: CRC32 Checksum: 98c394aa66f4e404df287db7b397205f Type: MD5 Checksum: dd6a1285c7820aa55bc8bb0959d41c4783b77c33 Type: SHA-1