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FontName: GHAHEB+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GHAHAM+AdvPS7C81 FontSubset: true FirstChar: 44 LastChar: 184 FontDescriptor: FontName: GHAHAM+AdvPS7C81 Flags: Nonsymbolic FontBBox: -197, -229, 989, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GHAHFF+AdvPSA403 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: GHAHFF+AdvPSA403 Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.jaad.2017.01.052 Long-term safety and tolerability of apremilast in patients with psoriasis: Pooled safety analysis for ≥156 weeks from 2 phase 3, randomized, controlled trials (ESTEEM 1 and 2) Jeffrey Crowley MD Diamant Thaçi MD Pascal Joly MD Ketty Peris MD Kim A. Papp MD PhD Joana Goncalves MD Robert M. Day PhD Rongdean Chen PhD Kamal Shah MD Carlos Ferrándiz MD Jennifer C. Cather MD apremilast clinical trial ESTEEM phosphodiesterase 4 inhibitor psoriasis psoriatic arthritis safety Journal of American Dermatology, 77 (2017) 310-318. doi:10.1016/j.jaad.2017.01.052 Elsevier Inc journal Journal of American Dermatology © 2017 by the American Academy of Dermatology, Inc. 0190-9622 77 2 August 2017 310-317.e1 310 317.e1 10.1016/j.jaad.2017.01.052 http://dx.doi.org/10.1016/j.jaad.2017.01.052 2010-04-23 true 10.1016/j.jaad.2017.01.052 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.jaad.2017.01.052 noindex 2010-04-23 true 11th July 2017 sciencedirect.com elsevier.com Elsevier 2017-07-11T03:53:29+05:30 2017-07-11T03:53:29+05:30 True 11th July 2017 Acrobat Distiller 8.1.0 (Windows) uuid:e0c9caf3-8517-48d2-ac66-782577dd5859 uuid:330a96d1-9871-4992-ad28-09345257d91e Pages: Page: Label: 310 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 64, 567, 64, 569 Annotation: Subtype: Link Rect: 154, 570, 158, 580 Destination: 433 Annotation: Subtype: Link Rect: 161, 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