c53d9edb8481cd0df9fd74823b5b5506  Eurjoucan_a2017n81p191iENG.pdf
e00535ce8e922c27cdafaf747f9d30494d95c964  Eurjoucan_a2017n81p191iENG.pdf
adca63ccec13289e610449858bb283ac3495a1aa28da9611105d4511bc619f74  Eurjoucan_a2017n81p191iENG.pdf

Title:          First-line panitumumab plus FOLFOX4 or FOLFIRI in colorectal cancer with multiple or unresectable liver metastases: A randomised, phase II trial (PLANET-TTD)
Subject:        European Journal of Cancer, 81 (2017) 191-202. doi:10.1016/j.ejca.2017.04.024
Author:         Alfredo Carrato
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Wed Dec 31 23:45:16 3 LMT
ModDate:        Tue Jul  4 20:04:45 2017 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      762449 bytes
Optimized:      yes
PDF version:    1.7

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HADPFD+AdvPS497E2                    Type 1C           Custom           yes yes no     639  0
HADPFE+AdvPS497E3                    Type 1C           Custom           yes yes no     644  0
HADPFF+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no     646  0
HADPGG+AdvP4C4E59                    Type 1C           Custom           yes yes no     650  0
HADPIG+AdvPSSym                      Type 1C           Custom           yes yes yes    663  0
HADPKG+AdvOTb214af43                 Type 1C           WinAnsi          yes yes no     658  0
HADPKH+AdvOTf7c366b2.B               Type 1C           WinAnsi          yes yes no     657  0
HADPKI+AdvPSA35D                     Type 1C           WinAnsi          yes yes no     666  0
HADPML+AdvPS3FDD77                   Type 1C           WinAnsi          yes yes no     296  0
HADPMI+AdvPS497E4                    Type 1C           MacRoman         yes yes no     294  0
HADPMJ+AdvPS497E5                    Type 1C           WinAnsi          yes yes no     300  0
HADPMK+AdvP4C4E74                    Type 1C           Custom           yes yes yes    298  0
HADPNM+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     309  0
HADPPN+ArialMT                       TrueType          WinAnsi          yes yes no     317  0
HAEAAP+Arial-ItalicMT                TrueType          WinAnsi          yes yes no     312  0
HAEABA+SymbolMT                      CID TrueType      Identity-H       yes yes yes    318  0
HAEABC+Calibri                       TrueType          WinAnsi          yes yes no     319  0
HAEACD+Arial-BoldMT                  TrueType          WinAnsi          yes yes no     332  0
HAEACF+Arial-BoldItalicMT            TrueType          WinAnsi          yes yes no     338  0
HAEADH+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes no     328  0

Jhove (Rel. 1.6, 2011-01-04)
 Date: 2019-02-14 18:17:11 CET
 RepresentationInformation: Eurjoucan_a2017n81p191iENG.pdf
  ReportingModule: PDF-hul, Rel. 1.8 (2009-05-22)
  LastModified: 2018-10-17 18:52:09 CEST
  Size: 762449
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Improperly formed date
   Offset: 751494
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 732557
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  ErrorMessage: Invalid destination object
   Offset: 729976
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 739
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: 1. Introduction
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7c53a9eb
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed17bee
       Item: 
        Title: 2. Patients and methods (see extended version in Appendix)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a33fae0
        Children: 
         Item: 
          Title: 2.1. Study design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@707f7052
         Item: 
          Title: 2.2. Patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11028347
         Item: 
          Title: 2.3. Study treatment
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@14899482
         Item: 
          Title: 2.4. Study procedures
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@21588809
         Item: 
          Title: 2.5. Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2aae9190
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2f333739
        Children: 
         Item: 
          Title: 3.1. Patients' characteristics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77468bd9
         Item: 
          Title: 3.2. Treatment
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12bb4df8
         Item: 
          Title: 3.3. Efficacy in the WT-KRAS population
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4cc77c2e
         Item: 
          Title: 3.4. Efficacy according to RAS status
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a7b0070
         Item: 
          Title: 3.5. Depth of response in the WT-RAS population
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@39a054a5
         Item: 
          Title: 3.6. Impact of ETS and resection on PFS and OS in the WT-RAS population
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@71bc1ae4
         Item: 
          Title: 3.7. Safety
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ed3ef1
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2437c6dc
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1f89ab83
       Item: 
        Title: Appendix A. Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e73f9ac
       Item: 
        Title: Funding
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@61064425
       Item: 
        Title: Conflict of interest statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b1d7fff
       Item: 
        Title: Extended methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@299a06ac
        Children: 
         Item: 
          Title: Study design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@383534aa
         Item: 
          Title: Patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6bc168e5
         Item: 
          Title: Study treatment
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b3300e5
         Item: 
          Title: Study procedures
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e5c649
         Item: 
          Title: Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@136432db
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7382f612
   Info: 
    Title: First-line panitumumab plus FOLFOX4 or FOLFIRI in colorectal cancer with multiple or unresectable liver metastases: A randomised, phase II trial (PLANET-TTD)
    Author: Alfredo Carrato
    Subject: European Journal of Cancer, 81 (2017) 191-202. doi:10.1016/j.ejca.2017.04.024
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
   ID: 0x866feed476ca2e8428af558822edd95b, 0x2a95d59f44428247aa42fd5876245abf
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 116
      ImageHeight: 116
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 296
      ImageHeight: 372
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      CompressionScheme: JPEG
      ImageWidth: 308
      ImageHeight: 340
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: HAEABA+SymbolMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: HADPFE+AdvPS497E3
      FontSubset: true
      FirstChar: 25
      LastChar: 180
      FontDescriptor: 
       FontName: HADPFE+AdvPS497E3
       Flags: Serif, Nonsymbolic
       FontBBox: -260, -239, 1093, 708
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: HADPFF+AdvPS44A44B
      FontSubset: true
      FirstChar: 101
      LastChar: 101
      FontDescriptor: 
       FontName: HADPFF+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPMI+AdvPS497E4
      FontSubset: true
      FirstChar: 37
      LastChar: 223
      FontDescriptor: 
       FontName: HADPMI+AdvPS497E4
       Flags: Nonsymbolic
       FontBBox: -187, -239, 1062, 718
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: HADPML+AdvPS3FDD77
      FontSubset: true
      FirstChar: 90
      LastChar: 90
      FontDescriptor: 
       FontName: HADPML+AdvPS3FDD77
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1145, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPGG+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: HADPGG+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: HADPMK+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: HADPMK+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HADPMJ+AdvPS497E5
      FontSubset: true
      FirstChar: 58
      LastChar: 117
      FontDescriptor: 
       FontName: HADPMJ+AdvPS497E5
       Flags: Serif, Nonsymbolic
       FontBBox: -260, -250, 1072, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPKH+AdvOTf7c366b2.B
      FontSubset: true
      FirstChar: 68
      LastChar: 116
      FontDescriptor: 
       FontName: HADPKH+AdvOTf7c366b2.B
       Flags: Nonsymbolic
       FontBBox: -62, -302, 895, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPKG+AdvOTb214af43
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: HADPKG+AdvOTb214af43
       Flags: Nonsymbolic
       FontBBox: -41, -250, 979, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPNM+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: HADPNM+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPIG+AdvPSSym
      FontSubset: true
      FirstChar: 2
      LastChar: 170
      FontDescriptor: 
       FontName: HADPIG+AdvPSSym
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HADPKI+AdvPSA35D
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: HADPKI+AdvPSA35D
       Flags: Nonsymbolic
       FontBBox: -166, -239, 989, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPFD+AdvPS497E2
      FontSubset: true
      FirstChar: 25
      LastChar: 180
      FontDescriptor: 
       FontName: HADPFD+AdvPS497E2
       Flags: Serif, Nonsymbolic
       FontBBox: -83, -239, 1000, 718
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
    TrueType: 
     Font: 
      BaseFont: HAEACF+Arial-BoldItalicMT
      FontSubset: true
      FirstChar: 65
      LastChar: 83
      FontDescriptor: 
       FontName: HAEACF+Arial-BoldItalicMT
       Flags: Nonsymbolic, Italic
       FontBBox: -560, -376, 1390, 1018
       FontFile2: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAEAAP+Arial-ItalicMT
      FontSubset: true
      FirstChar: 65
      LastChar: 83
      FontDescriptor: 
       FontName: HAEAAP+Arial-ItalicMT
       Flags: Nonsymbolic, Italic
       FontBBox: -517, -325, 1359, 998
       FontFile2: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAEADH+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: HAEADH+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAEACD+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: HAEACD+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile2: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HADPPN+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: HADPPN+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile2: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HAEABC+Calibri
      FontSubset: true
      FirstChar: 32
      LastChar: 45
      FontDescriptor: 
       FontName: HAEABC+Calibri
       Flags: Nonsymbolic
       FontBBox: -503, -307, 1240, 964
       FontFile2: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: HAEABA+SymbolMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: HAEABA+SymbolMT
       Flags: Symbolic
       FontBBox: 0, -220, 1113, 1005
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.ejca.2017.04.024</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">First-line panitumumab plus FOLFOX4 or FOLFIRI in colorectal cancer with multiple or unresectable liver metastases: A randomised, phase II trial (PLANET-TTD)</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Alfredo Carrato</rdf:li>
               <rdf:li>Albert Abad</rdf:li>
               <rdf:li>Bartomeu Massuti</rdf:li>
               <rdf:li>Cristina Grávalos</rdf:li>
               <rdf:li>Pilar Escudero</rdf:li>
               <rdf:li>Federico Longo-Muñoz</rdf:li>
               <rdf:li>José-Luis Manzano</rdf:li>
               <rdf:li>Auxiliadora Gómez</rdf:li>
               <rdf:li>María José Safont</rdf:li>
               <rdf:li>Javier Gallego</rdf:li>
               <rdf:li>Beatriz García-Paredes</rdf:li>
               <rdf:li>Carles Pericay</rdf:li>
               <rdf:li>Rosario Dueñas</rdf:li>
               <rdf:li>Fernando Rivera</rdf:li>
               <rdf:li>Ferrán Losa</rdf:li>
               <rdf:li>Manuel Valladares-Ayerbes</rdf:li>
               <rdf:li>Encarnación González</rdf:li>
               <rdf:li>Enrique Aranda</rdf:li>
               <rdf:li>the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Panitumumab</rdf:li>
               <rdf:li>FOLFOX</rdf:li>
               <rdf:li>FOLFIRI</rdf:li>
               <rdf:li>Metastatic colorectal cancer</rdf:li>
               <rdf:li>First-line</rdf:li>
               <rdf:li>Liver-limited disease</rdf:li>
               <rdf:li>Resection</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">European Journal of Cancer, 81 (2017) 191-202. doi:10.1016/j.ejca.2017.04.024</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Ltd</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>European Journal of Cancer</prism:publicationName>
         <prism:copyright>© 2017 The Authors. Published by Elsevier Ltd.</prism:copyright>
         <prism:issn>0959-8049</prism:issn>
         <prism:volume>81</prism:volume>
         <prism:coverDisplayDate>August 2017</prism:coverDisplayDate>
         <prism:pageRange>191-202</prism:pageRange>
         <prism:startingPage>191</prism:startingPage>
         <prism:endingPage>202</prism:endingPage>
         <prism:doi>10.1016/j.ejca.2017.04.024</prism:doi>
         <prism:url>http://dx.doi.org/10.1016/j.ejca.2017.04.024</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.ejca.2017.04.024</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.ejca.2017.04.024</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>4th July 2017</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:ModifyDate>2017-07-04T23:34:45+05:30</xap:ModifyDate>
         <xap:MetadataDate>2017-07-04T23:34:45+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>4th July 2017</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:6bfa22c9-fe54-4f9d-acb8-c9ce801a0556</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:abdf6644-0a15-4c26-818e-44af83eacdea</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 191
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 513, 45, 516
      Annotation: 
       Subtype: Link
       Rect: 139, 517, 144, 530
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 147, 512, 153, 525
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 156, 517, 161, 530
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 169, 513, 169, 516
      Annotation: 
       Subtype: Link
       Rect: 243, 517, 248, 530
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 251, 517, 256, 530
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 258, 517, 263, 530
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 271, 513, 271, 516
      Annotation: 
       Subtype: Link
       Rect: 378, 517, 382, 530
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 45, 498, 45, 501
      Annotation: 
       Subtype: Link
       Rect: 148, 502, 153, 515
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 161, 498, 161, 501
      Annotation: 
       Subtype: Link
       Rect: 247, 502, 251, 515
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 259, 498, 259, 501
      Annotation: 
       Subtype: Link
       Rect: 396, 502, 401, 515
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 45, 483, 45, 486
      Annotation: 
       Subtype: Link
       Rect: 158, 487, 163, 500
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 171, 483, 171, 486
      Annotation: 
       Subtype: Link
       Rect: 285, 487, 288, 500
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 296, 483, 296, 486
      Annotation: 
       Subtype: Link
       Rect: 403, 487, 407, 500
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 45, 468, 45, 471
      Annotation: 
       Subtype: Link
       Rect: 129, 472, 134, 485
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 142, 468, 142, 471
      Annotation: 
       Subtype: Link
       Rect: 274, 472, 277, 485
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 285, 468, 285, 471
      Annotation: 
       Subtype: Link
       Rect: 368, 472, 371, 485
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 453, 45, 456
      Annotation: 
       Subtype: Link
       Rect: 139, 457, 144, 470
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 152, 453, 152, 456
      Annotation: 
       Subtype: Link
       Rect: 252, 457, 254, 470
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 262, 453, 262, 456
      Annotation: 
       Subtype: Link
       Rect: 335, 457, 343, 470
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 438, 45, 441
      Annotation: 
       Subtype: Link
       Rect: 202, 442, 208, 455
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 210, 442, 215, 455
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 222, 438, 222, 441
      Annotation: 
       Subtype: Link
       Rect: 351, 442, 357, 455
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 364, 438, 364, 441
      Annotation: 
       Subtype: Link
       Rect: 457, 442, 460, 455
       Destination: 548
      Annotation: 
       Subtype: Link
       Rect: 112, 111, 193, 119
      Annotation: 
       Subtype: Link
       Rect: 475, 578, 541, 605
      Annotation: 
       Subtype: Link
       Rect: 45, 70, 191, 78
      Annotation: 
       Subtype: Link
       Rect: 520, 60, 541, 68
      Annotation: 
       Subtype: Link
       Rect: 45, 50, 192, 58
      Annotation: 
       Subtype: Link
       Rect: 286, 726, 379, 735
      Annotation: 
       Subtype: Link
       Rect: 296, 660, 381, 668
      Annotation: 
       Subtype: Link
       Rect: 45, 751, 195, 759
      Annotation: 
       Subtype: Link
       Rect: 201, 751, 213, 759
    Page: 
     Label: 192
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 272, 389, 462, 398
      Annotation: 
       Subtype: Link
       Rect: 194, 237, 202, 247
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 209, 237, 217, 247
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 178, 178, 196, 188
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 165, 130, 176, 140
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 106, 82, 117, 92
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 452, 310, 475, 320
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 422, 286, 435, 296
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 443, 286, 455, 296
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 492, 250, 505, 260
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 512, 250, 525, 260
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 476, 238, 492, 248
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 310, 226, 321, 236
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 434, 226, 450, 236
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 190, 435, 200
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 536, 142, 547, 152
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 360, 94, 375, 104
       Destination: null
    Page: 
     Label: 193
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 143, 715, 155, 725
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 163, 715, 175, 725
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 163, 691, 178, 701
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 559, 85, 569
       Destination: 103
      Annotation: 
       Subtype: Link
       Rect: 390, 225, 415, 235
       Destination: 34
      Annotation: 
       Subtype: Link
       Rect: 326, 141, 358, 151
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 439, 82, 471, 92
       Destination: 48
    Page: 
     Label: 194
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 62, 170, 72
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 452, 62, 485, 72
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 491, 62, 549, 72
       Destination: null
    Page: 
     Label: 195
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 468, 133, 478
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 153, 373, 185, 383
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 359, 385, 384, 395
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 446, 373, 471, 383
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 305, 299, 337, 309
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 342, 299, 490, 309
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 352, 191, 377, 201
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 358, 179, 383, 189
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 386, 94, 418, 104
       Destination: 70
    Page: 
     Label: 196
     Sequence: 6
    Page: 
     Label: 197
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 148, 347, 180, 356
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 154, 323, 187, 333
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 210, 323, 236, 333
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 144, 191, 171, 201
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 91, 82, 125, 92
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 176, 70, 284, 80
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 58, 107, 68
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 347, 144, 504, 154
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 523, 58, 538, 68
       Destination: null
    Page: 
     Label: 198
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 506, 96, 516
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 163, 506, 186, 516
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 114, 494, 130, 504
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 138, 422, 154, 432
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 186, 386, 201, 396
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 206, 326, 221, 336
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 488, 494, 511, 504
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 310, 362, 326, 372
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 417, 362, 445, 372
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 482, 338, 510, 348
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 115, 198, 118, 206
       Destination: null
    Page: 
     Label: 199
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 679, 143, 689
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 156, 667, 171, 677
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 233, 572, 249, 582
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 73, 476, 89, 486
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 111, 464, 126, 474
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 73, 452, 88, 462
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 151, 440, 166, 450
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 174, 392, 189, 402
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 345, 81, 355
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 129, 309, 144, 319
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 185, 273, 200, 283
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 266, 213, 281, 223
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 85, 141, 95, 151
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 314, 207, 497, 217
    Page: 
     Label: 200
     Sequence: 10
    Page: 
     Label: 201
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 78, 207, 86
      Annotation: 
       Subtype: Link
       Rect: 318, 689, 466, 697
      Annotation: 
       Subtype: Link
       Rect: 410, 629, 541, 637
      Annotation: 
       Subtype: Link
       Rect: 318, 619, 446, 627
      Annotation: 
       Subtype: Link
       Rect: 525, 570, 541, 578
      Annotation: 
       Subtype: Link
       Rect: 318, 560, 430, 568
      Annotation: 
       Subtype: Link
       Rect: 423, 540, 541, 548
      Annotation: 
       Subtype: Link
       Rect: 318, 530, 419, 538
      Annotation: 
       Subtype: Link
       Rect: 428, 490, 541, 498
      Annotation: 
       Subtype: Link
       Rect: 318, 480, 347, 488
      Annotation: 
       Subtype: Link
       Rect: 525, 440, 541, 448
      Annotation: 
       Subtype: Link
       Rect: 318, 430, 474, 438
      Annotation: 
       Subtype: Link
       Rect: 400, 390, 538, 398
      Annotation: 
       Subtype: Link
       Rect: 318, 380, 541, 388
      Annotation: 
       Subtype: Link
       Rect: 318, 370, 541, 378
      Annotation: 
       Subtype: Link
       Rect: 318, 360, 541, 368
      Annotation: 
       Subtype: Link
       Rect: 318, 351, 377, 358
      Annotation: 
       Subtype: Link
       Rect: 383, 351, 391, 358
      Annotation: 
       Subtype: Link
       Rect: 318, 341, 541, 349
      Annotation: 
       Subtype: Link
       Rect: 318, 331, 541, 339
      Annotation: 
       Subtype: Link
       Rect: 318, 321, 541, 329
      Annotation: 
       Subtype: Link
       Rect: 318, 311, 541, 319
      Annotation: 
       Subtype: Link
       Rect: 318, 301, 429, 309
      Annotation: 
       Subtype: Link
       Rect: 435, 301, 439, 309
      Annotation: 
       Subtype: Link
       Rect: 525, 261, 541, 269
      Annotation: 
       Subtype: Link
       Rect: 318, 251, 450, 259
      Annotation: 
       Subtype: Link
       Rect: 525, 211, 541, 219
      Annotation: 
       Subtype: Link
       Rect: 318, 201, 451, 209
      Annotation: 
       Subtype: Link
       Rect: 353, 151, 493, 159
      Annotation: 
       Subtype: Link
       Rect: 419, 111, 541, 119
      Annotation: 
       Subtype: Link
       Rect: 318, 101, 344, 109
    Page: 
     Label: 202
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 729, 292, 737
      Annotation: 
       Subtype: Link
       Rect: 70, 719, 124, 727
      Annotation: 
       Subtype: Link
       Rect: 186, 679, 292, 687
      Annotation: 
       Subtype: Link
       Rect: 70, 669, 115, 677
      Annotation: 
       Subtype: Link
       Rect: 206, 619, 292, 627
      Annotation: 
       Subtype: Link
       Rect: 70, 610, 131, 618
      Annotation: 
       Subtype: Link
       Rect: 120, 560, 263, 568
      Annotation: 
       Subtype: Link
       Rect: 224, 500, 292, 508
      Annotation: 
       Subtype: Link
       Rect: 70, 490, 149, 498
      Annotation: 
       Subtype: Link
       Rect: 276, 450, 292, 458
      Annotation: 
       Subtype: Link
       Rect: 70, 440, 192, 448
      Annotation: 
       Subtype: Link
       Rect: 70, 430, 292, 438
      Annotation: 
       Subtype: Link
       Rect: 70, 420, 292, 428
      Annotation: 
       Subtype: Link
       Rect: 70, 410, 292, 418
      Annotation: 
       Subtype: Link
       Rect: 70, 400, 242, 408
      Annotation: 
       Subtype: Link
       Rect: 248, 400, 252, 408
      Annotation: 
       Subtype: Link
       Rect: 100, 360, 246, 368
      Annotation: 
       Subtype: Link
       Rect: 276, 321, 292, 329
      Annotation: 
       Subtype: Link
       Rect: 70, 311, 201, 319
      Annotation: 
       Subtype: Link
       Rect: 100, 251, 264, 259
      Annotation: 
       Subtype: Link
       Rect: 481, 699, 549, 707
      Annotation: 
       Subtype: Link
       Rect: 327, 689, 404, 697
      Annotation: 
       Subtype: Link
       Rect: 327, 679, 549, 687
      Annotation: 
       Subtype: Link
       Rect: 327, 669, 549, 677
      Annotation: 
       Subtype: Link
       Rect: 327, 659, 381, 667
      Annotation: 
       Subtype: Link
       Rect: 388, 659, 549, 667
      Annotation: 
       Subtype: Link
       Rect: 327, 649, 549, 657
      Annotation: 
       Subtype: Link
       Rect: 327, 639, 549, 647
      Annotation: 
       Subtype: Link
       Rect: 327, 629, 390, 637
      Annotation: 
       Subtype: Link
       Rect: 481, 580, 549, 588
      Annotation: 
       Subtype: Link
       Rect: 327, 570, 402, 578
      Annotation: 
       Subtype: Link
       Rect: 463, 530, 549, 538
      Annotation: 
       Subtype: Link
       Rect: 327, 520, 369, 528
      Annotation: 
       Subtype: Link
       Rect: 327, 510, 549, 518
      Annotation: 
       Subtype: Link
       Rect: 327, 500, 549, 508
      Annotation: 
       Subtype: Link
       Rect: 327, 490, 549, 498
      Annotation: 
       Subtype: Link
       Rect: 327, 480, 549, 488
      Annotation: 
       Subtype: Link
       Rect: 327, 470, 431, 478
      Annotation: 
       Subtype: Link
       Rect: 436, 470, 444, 478
      Annotation: 
       Subtype: Link
       Rect: 347, 440, 490, 448
      Annotation: 
       Subtype: Link
       Rect: 463, 380, 549, 388
      Annotation: 
       Subtype: Link
       Rect: 327, 370, 405, 378
      Annotation: 
       Subtype: Link
       Rect: 363, 331, 482, 339
      Annotation: 
       Subtype: Link
       Rect: 327, 281, 467, 289
      Annotation: 
       Subtype: Link
       Rect: 327, 271, 549, 279
      Annotation: 
       Subtype: Link
       Rect: 327, 261, 549, 269
      Annotation: 
       Subtype: Link
       Rect: 327, 251, 519, 259
      Annotation: 
       Subtype: Link
       Rect: 525, 251, 532, 259
  Checksum: 206f43f2
   Type: CRC32
  Checksum: c53d9edb8481cd0df9fd74823b5b5506
   Type: MD5
  Checksum: e00535ce8e922c27cdafaf747f9d30494d95c964
   Type: SHA-1